GB1111489A - Pseudo-indole derivatives - Google Patents
Pseudo-indole derivativesInfo
- Publication number
- GB1111489A GB1111489A GB3629966A GB3629966A GB1111489A GB 1111489 A GB1111489 A GB 1111489A GB 3629966 A GB3629966 A GB 3629966A GB 3629966 A GB3629966 A GB 3629966A GB 1111489 A GB1111489 A GB 1111489A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- alkyl
- formula
- halogen
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Novel compounds of formula <FORM:1111489/C2/1> and acid addition salts thereof where R1 is CH3 or phenyl, R2 is H, halogen, CH3 or methoxy R3 is C1- 4 alkyl or phenyl optionally substituted by halogen atoms or C1- 4 alkyl or alkoxy groups, R4 is C2- 4 alkenyl and R5 is an alkyl group substituted by a C3- 8 cycloalkyl group, aralkyl or alkenyl or R4 and R5 together with the nitrogen atom to which they are attached form a saturated or partly saturated heterocyclic ring which may contain an additional oxygen or nitrogen atom and is substituted by phenyl which may itself be substituted by halogen, hydroxy, C1- 4 alkoxy or C1- 4 alkyl and A is a straight or branched chain C2- 4 hydrocarbon group are prepared by cyclisation of a hydrazone of formula <FORM:1111489/C2/2> optionally followed by salt formation. Hydrazones of the last formula above are prepared by reacting the appropriate phenyl hydrazine with a ketone of formula <FORM:1111489/C2/3> which has been prepared for example by reaction of a phenyl acetone and a compound halogen -A-NR4.R5. Pharmaceutical compositions in conventional forms for oral, rectal and parenteral administration and having analgesic, antiphlogistic, antitussive and spasmolytic activity comprise an above novel compound and a carrier or excipient.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL133995D NL133995C (en) | 1965-08-21 | ||
DE19661620565 DE1620565A1 (en) | 1965-08-21 | 1966-09-20 | Process for the production of new basic substituted pseudoindoles |
FR292D FR292F (en) | 1965-08-21 | 1967-01-31 | |
BE693450D BE693450A (en) | 1965-08-21 | 1967-01-31 | |
NL6710605A NL6710605A (en) | 1965-08-21 | 1967-08-01 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DET0029248 | 1965-08-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1111489A true GB1111489A (en) | 1968-04-24 |
Family
ID=7554736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3629966A Expired GB1111489A (en) | 1965-08-19 | 1966-08-12 | Pseudo-indole derivatives |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE1620511A1 (en) |
FR (1) | FR212F (en) |
GB (1) | GB1111489A (en) |
-
0
- FR FR212D patent/FR212F/fr active Active
-
1965
- 1965-08-19 DE DE19651620511 patent/DE1620511A1/en active Pending
-
1966
- 1966-08-12 GB GB3629966A patent/GB1111489A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE1620511A1 (en) | 1970-04-30 |
FR212F (en) |
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