GB1111447A - 13-alkyl gonatrienes - Google Patents
13-alkyl gonatrienesInfo
- Publication number
- GB1111447A GB1111447A GB3628265A GB3628265A GB1111447A GB 1111447 A GB1111447 A GB 1111447A GB 3628265 A GB3628265 A GB 3628265A GB 3628265 A GB3628265 A GB 3628265A GB 1111447 A GB1111447 A GB 1111447A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- etherification
- hydroxy
- compounds
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000006266 etherification reaction Methods 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 241001653109 Isogona Species 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002524 organometallic group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises compounds of formula <FORM:1111447/C2/1> wherein RO is a free or etherized hydroxy group or an acyloxy group, R1 is an alkyl group having at least 2 carbon atoms, R2 is a C1- 6 aliphatic hydrocarbon group optionally substituted by a halogen atom or an hydroxy, alkoxy, amino or substituted amino group, and R2 and the hydrogen atoms H are transto the group R1, including racemates of the 13b - and 13a -enantiomers, and their preparation by reaction of a corresponding 17-ketone with an organometallic reagent, followed if desired by (a) total or partial hydrogenation of an unsaturated group R2; or (b) 3-acylation, etherification or hydrolysis. (\sB) - 13b - ethyl - 3 - (21 - tetrahydropyranyloxy) - 8, - iso - gona - 1,3,5(10) - trien - 17 - one is prepared by etherification. The compounds of the invention have estrogenic and anti-lipenic activity and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for oral, parenteral or rectal administration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3628265A GB1111447A (en) | 1965-08-24 | 1965-08-24 | 13-alkyl gonatrienes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3628265A GB1111447A (en) | 1965-08-24 | 1965-08-24 | 13-alkyl gonatrienes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1111447A true GB1111447A (en) | 1968-04-24 |
Family
ID=10386686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3628265A Expired GB1111447A (en) | 1965-08-24 | 1965-08-24 | 13-alkyl gonatrienes |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1111447A (en) |
-
1965
- 1965-08-24 GB GB3628265A patent/GB1111447A/en not_active Expired
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