GB1111447A - 13-alkyl gonatrienes - Google Patents

13-alkyl gonatrienes

Info

Publication number
GB1111447A
GB1111447A GB3628265A GB3628265A GB1111447A GB 1111447 A GB1111447 A GB 1111447A GB 3628265 A GB3628265 A GB 3628265A GB 3628265 A GB3628265 A GB 3628265A GB 1111447 A GB1111447 A GB 1111447A
Authority
GB
United Kingdom
Prior art keywords
group
etherification
hydroxy
compounds
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3628265A
Inventor
Gordon Alan Hughes
Herchel Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB3628265A priority Critical patent/GB1111447A/en
Publication of GB1111447A publication Critical patent/GB1111447A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of formula <FORM:1111447/C2/1> wherein RO is a free or etherized hydroxy group or an acyloxy group, R1 is an alkyl group having at least 2 carbon atoms, R2 is a C1- 6 aliphatic hydrocarbon group optionally substituted by a halogen atom or an hydroxy, alkoxy, amino or substituted amino group, and R2 and the hydrogen atoms H are transto the group R1, including racemates of the 13b - and 13a -enantiomers, and their preparation by reaction of a corresponding 17-ketone with an organometallic reagent, followed if desired by (a) total or partial hydrogenation of an unsaturated group R2; or (b) 3-acylation, etherification or hydrolysis. (\sB) - 13b - ethyl - 3 - (21 - tetrahydropyranyloxy) - 8, - iso - gona - 1,3,5(10) - trien - 17 - one is prepared by etherification. The compounds of the invention have estrogenic and anti-lipenic activity and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for oral, parenteral or rectal administration.
GB3628265A 1965-08-24 1965-08-24 13-alkyl gonatrienes Expired GB1111447A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3628265A GB1111447A (en) 1965-08-24 1965-08-24 13-alkyl gonatrienes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3628265A GB1111447A (en) 1965-08-24 1965-08-24 13-alkyl gonatrienes

Publications (1)

Publication Number Publication Date
GB1111447A true GB1111447A (en) 1968-04-24

Family

ID=10386686

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3628265A Expired GB1111447A (en) 1965-08-24 1965-08-24 13-alkyl gonatrienes

Country Status (1)

Country Link
GB (1) GB1111447A (en)

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