GB1100936A - Phenoxy-acetic acid derivatives - Google Patents

Phenoxy-acetic acid derivatives

Info

Publication number
GB1100936A
GB1100936A GB4102266A GB4102266A GB1100936A GB 1100936 A GB1100936 A GB 1100936A GB 4102266 A GB4102266 A GB 4102266A GB 4102266 A GB4102266 A GB 4102266A GB 1100936 A GB1100936 A GB 1100936A
Authority
GB
United Kingdom
Prior art keywords
phenyl
alkoxy
quaternary ammonium
formula
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4102266A
Inventor
Paul Rumpf
Germaine Thuillier
Jean-Eugene Thuillier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of GB1100936A publication Critical patent/GB1100936A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Abstract

Novel compounds of Formula (I) A-O-CH2-CONH-CH2CH2 -N(C2H5)2 wherein A represents a p-nitrophenyl, p-hydroxyphenyl, p - (C1-4 alkyl) phenyl, p-(C2-4 alkoxy) phenyl, p-(C1-4 carboxylic acyl) phenyl, m - (C1-4 alkoxy) phenyl, 3,5 - di-(C1-4 alkoxy) phenyl, o-(C1-4 alkoxy) phenyl, o - hydroxy - p - chlorophenyl or o - (C1-4 alkoxy)-p-chlorophenyl group, their acid addition and quaternary ammonium salts, as well as the quaternary ammonium salts of those compounds in which A is a p-chlorophenyl group, are prepared by reacting BETA-diethylaminoethylamine with an ester of a phenoxyacetic acid of formula A-O-CH2COOH, and, when required, converting the base into its acid addition or quaternary ammonium salt. The phenoxyacetic acid esters are made by reacting the appropriate phenol or sodium salt thereof with ethyl chloroacetate. 4-Butoxy-phenol is made by treating hydroquinone with butyl bromide. 2-Metoxy-4-chlorophenol is prepared by etherification of 4-chloropyrocatechol. Therapeutic compositions, some of which have local anaesthetic properties, the others having analgesic and anti-inflammatory activity, contain as active ingredient a compound of Formula (I) above or an acid addition or quaternary ammonium salt thereof. Reference has been directed by the Comptroller to Specification 942,761.
GB4102266A 1965-09-15 1966-09-14 Phenoxy-acetic acid derivatives Expired GB1100936A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR31512A FR4963M (en) 1965-09-15 1965-09-15

Publications (1)

Publication Number Publication Date
GB1100936A true GB1100936A (en) 1968-01-24

Family

ID=8588401

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4102266A Expired GB1100936A (en) 1965-09-15 1966-09-14 Phenoxy-acetic acid derivatives

Country Status (5)

Country Link
BE (1) BE686763A (en)
CH (1) CH468353A (en)
DE (1) DE1543496A1 (en)
FR (1) FR4963M (en)
GB (1) GB1100936A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0327379A2 (en) * 1988-02-05 1989-08-09 CRODA INTERNATIONAL plc Humectants
WO2006080040A1 (en) * 2005-01-25 2006-08-03 Università Degli Studi Di Siena New potent and selective ligands of cannabinoid receptors
CN104610092A (en) * 2015-02-10 2015-05-13 齐齐哈尔大学 Quaternary ammonium salt cationic surfactant and preparation method thereof
WO2018231795A1 (en) * 2017-06-13 2018-12-20 Afecta Pharmaceuticals, Inc. Ccl2 inhibitors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1415295A (en) * 1971-10-14 1975-11-26 Orchimed Sa Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0327379A2 (en) * 1988-02-05 1989-08-09 CRODA INTERNATIONAL plc Humectants
EP0327379A3 (en) * 1988-02-05 1991-01-09 CRODA INTERNATIONAL plc Humectants
WO2006080040A1 (en) * 2005-01-25 2006-08-03 Università Degli Studi Di Siena New potent and selective ligands of cannabinoid receptors
CN104610092A (en) * 2015-02-10 2015-05-13 齐齐哈尔大学 Quaternary ammonium salt cationic surfactant and preparation method thereof
WO2018231795A1 (en) * 2017-06-13 2018-12-20 Afecta Pharmaceuticals, Inc. Ccl2 inhibitors
US11130729B2 (en) 2017-06-13 2021-09-28 Lapko Inc. CCL2 inhibitors
US11858876B2 (en) 2017-06-13 2024-01-02 Lapko Inc. CCL2 inhibitors

Also Published As

Publication number Publication date
CH468353A (en) 1969-02-15
DE1543496A1 (en) 1969-07-31
FR4963M (en) 1967-05-08
BE686763A (en) 1967-02-15

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