ES314976A1 - Amine salts of nopinic acid - Google Patents

Amine salts of nopinic acid

Info

Publication number
ES314976A1
ES314976A1 ES0314976A ES314976A ES314976A1 ES 314976 A1 ES314976 A1 ES 314976A1 ES 0314976 A ES0314976 A ES 0314976A ES 314976 A ES314976 A ES 314976A ES 314976 A1 ES314976 A1 ES 314976A1
Authority
ES
Spain
Prior art keywords
acid
nopinic
nopinic acid
alkyl
alkanols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0314976A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FHARMATEC Inc
Original Assignee
FHARMATEC Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FHARMATEC Inc filed Critical FHARMATEC Inc
Publication of ES314976A1 publication Critical patent/ES314976A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/12—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/02—Saturated compounds containing hydroxy or O-metal groups
    • C07C62/06—Saturated compounds containing hydroxy or O-metal groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S585/00—Chemistry of hydrocarbon compounds
    • Y10S585/929—Special chemical considerations
    • Y10S585/947—Terpene manufacture or recovery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel compounds of the formulae <FORM:1117782/C2/1> <FORM:1117782/C2/2> (wherein X1 is an ammonium cation, a C1- 4 alkyl radical or the group -(CH2)n-NRR1 in which n is 1, 2 or 3 and R and R1 are each hydrogen or C1- 4 alkyl) and acid-addition salts of the amino-esters are prepared (1) by reaction of nopinic acid with ammonia to give ammonium nopinate (2) by esterification of nopinic acid or transesterification of its alkyl esters with alkanols or aminoalkanols to give corresponding esters of nopinic acid, or by reaction of alkali metal salts of nopinic acid with alkyl halides or aminoalkyl halides and (3) by mixing nopinic acid and amino-alkanols in suitable solvents to give salts of nopinic acid with the amino-alkanols. Examples are given. The novel nopinic acid derivatives may be made up into pharmaceutical compositions for the prevention and control of ulcers and/or of pain due to ulcers. The compositions may be for peroral, topical or parentaral use.
ES0314976A 1964-07-06 1965-07-05 Amine salts of nopinic acid Expired ES314976A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB27788/64A GB1117782A (en) 1964-07-06 1964-07-06 Nopinic acid derivatives, their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ES314976A1 true ES314976A1 (en) 1966-04-01

Family

ID=10265327

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0314976A Expired ES314976A1 (en) 1964-07-06 1965-07-05 Amine salts of nopinic acid

Country Status (9)

Country Link
US (1) US3520920A (en)
BE (1) BE666352A (en)
CY (1) CY616A (en)
DE (1) DE1235310B (en)
ES (1) ES314976A1 (en)
FR (2) FR4687M (en)
GB (1) GB1117782A (en)
MY (1) MY7100219A (en)
NL (1) NL6508625A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1319931C (en) * 2005-08-05 2007-06-06 中国科学院广州化学研究所 Method for preparing 4-isopropyl-naphthenic acid
CN1331837C (en) * 2005-09-01 2007-08-15 中国科学院广州化学研究所 Nopinic acid preparing process
CN100436396C (en) * 2006-09-11 2008-11-26 浙江树人大学 New method for synthesizing p-isopropyl benzoic acid

Also Published As

Publication number Publication date
NL6508625A (en) 1966-01-07
US3520920A (en) 1970-07-21
DE1235310B (en) 1967-03-02
CY616A (en) 1971-10-20
BE666352A (en) 1966-01-03
FR4687M (en) 1966-12-19
FR1439597A (en) 1966-05-20
GB1117782A (en) 1968-06-26
MY7100219A (en) 1971-12-31

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