GB1091096A - Acylated mitosenes - Google Patents
Acylated mitosenesInfo
- Publication number
- GB1091096A GB1091096A GB46763/65A GB4676365A GB1091096A GB 1091096 A GB1091096 A GB 1091096A GB 46763/65 A GB46763/65 A GB 46763/65A GB 4676365 A GB4676365 A GB 4676365A GB 1091096 A GB1091096 A GB 1091096A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acylated
- mitosenes
- mitosene
- alkyl
- raw fish
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 4
- CWDCKPDZWAUGCG-UHFFFAOYSA-N (7-methyl-5,8-dioxo-2,3-dihydro-1h-pyrrolo[1,2-a]indol-4-yl)methyl carbamate Chemical compound O=C1C(C)=CC(=O)C2=C1N1CCCC1=C2COC(N)=O CWDCKPDZWAUGCG-UHFFFAOYSA-N 0.000 abstract 3
- 241000251468 Actinopterygii Species 0.000 abstract 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000003755 preservative agent Substances 0.000 abstract 2
- 230000002335 preservative effect Effects 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 229930192392 Mitomycin Natural products 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000000645 desinfectant Substances 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229960004857 mitomycin Drugs 0.000 abstract 1
- -1 mitomycin compound Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 230000002829 reductive effect Effects 0.000 abstract 1
- JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Acylated mitosenes of formula <FORM:1091096/C2/1> wherein X11 is -OCH3, -NHCOR or -OCOR, R is H or C1- 4 alkyl and Z is H or CH3, are prepared by the reductive acylation with (RCO)2O or RCO hal, wherein R is H or C1- 4 alkyl and hal is halogen, of mitomycin compound I <FORM:1091096/C2/2> mitosene compound II <FORM:1091096/C2/3> mitosene compound III <FORM:1091096/C2/4> wherein X is CH3O or NH2; X1 is CH3O, NH2 or OH; Y is OH or OCH3; and Z is H or CH3. The reducing agent may be sodium hydrosulphite, zinc dust or palladium-on-carbon. The acylated mitosenes are non-toxic anti-tumour, anti-bacterial agents and may be used topically, e.g. in ointments, or orally. They may be used as disinfectants and as a preservative for raw fish (Division A2).ALSO:A preservative for raw fish consists of an acylated mitosene of formula:- <FORM:1091096/A1-A3/1> wherein X11 is -O CH3, -NH CO R or -O CO R, R is H or C1- alkyl, Z is H or CH3. The antibiotic in the form of a powder is scattered uniformly over the raw fish (Example 5).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6280664 | 1964-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1091096A true GB1091096A (en) | 1967-11-15 |
Family
ID=13210932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB46763/65A Expired GB1091096A (en) | 1964-11-07 | 1965-11-04 | Acylated mitosenes |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | USRE27384E (en) |
| BE (1) | BE671904A (en) |
| BR (1) | BR6574623D0 (en) |
| CH (1) | CH465613A (en) |
| DE (1) | DE1570046A1 (en) |
| DK (1) | DK115115B (en) |
| FR (2) | FR1550958A (en) |
| GB (1) | GB1091096A (en) |
| NL (1) | NL6514382A (en) |
| NO (1) | NO119275B (en) |
| SE (1) | SE305217B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523411A (en) * | 1994-03-14 | 1996-06-04 | Rutgers University | Synthesis of mitomycin and its analogs |
-
1965
- 1965-11-03 CH CH1516065A patent/CH465613A/en unknown
- 1965-11-03 NO NO160317A patent/NO119275B/no unknown
- 1965-11-04 GB GB46763/65A patent/GB1091096A/en not_active Expired
- 1965-11-05 BE BE671904D patent/BE671904A/xx unknown
- 1965-11-05 NL NL6514382A patent/NL6514382A/xx unknown
- 1965-11-05 SE SE14322/65A patent/SE305217B/xx unknown
- 1965-11-05 BR BR174623/65A patent/BR6574623D0/en unknown
- 1965-11-06 DK DK571765AA patent/DK115115B/en unknown
- 1965-11-06 DE DE19651570046 patent/DE1570046A1/en active Pending
- 1965-11-08 FR FR1550958D patent/FR1550958A/fr not_active Expired
-
1966
- 1966-02-05 FR FR48578A patent/FR5204M/fr not_active Expired
-
1969
- 1969-12-31 US US27384D patent/USRE27384E/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE305217B (en) | 1968-10-21 |
| BR6574623D0 (en) | 1973-08-07 |
| CH465613A (en) | 1968-11-30 |
| NL6514382A (en) | 1966-05-09 |
| BE671904A (en) | 1966-03-01 |
| DE1570046A1 (en) | 1970-02-12 |
| DK115115B (en) | 1969-09-08 |
| NO119275B (en) | 1970-04-27 |
| FR1550958A (en) | 1968-12-27 |
| USRE27384E (en) | 1972-06-13 |
| FR5204M (en) | 1967-06-26 |
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