GB1552100A - Cephalospin analogues - Google Patents

Cephalospin analogues

Info

Publication number
GB1552100A
GB1552100A GB32622/77A GB3262277A GB1552100A GB 1552100 A GB1552100 A GB 1552100A GB 32622/77 A GB32622/77 A GB 32622/77A GB 3262277 A GB3262277 A GB 3262277A GB 1552100 A GB1552100 A GB 1552100A
Authority
GB
United Kingdom
Prior art keywords
cephalospin
analogues
formula
acylation
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32622/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB1552100A publication Critical patent/GB1552100A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

The 1-oxacephalosporin derivatives of the formula I in which the substituents X, Y, Z and R have the definition given in Patent Claim 1 are prepared by acylation of a compound of the formula II. The compounds of the formula I exhibit a potent antimicrobial action. <IMAGE>
GB32622/77A 1976-08-09 1977-08-03 Cephalospin analogues Expired GB1552100A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP51095146A JPS609515B2 (en) 1976-08-09 1976-08-09 3'-Noroxacephalosporins
CH974077A CH644382A5 (en) 1976-08-09 1978-01-01 1-Oxacephalosporin derivatives and a process for their preparation

Publications (1)

Publication Number Publication Date
GB1552100A true GB1552100A (en) 1979-09-05

Family

ID=25705254

Family Applications (1)

Application Number Title Priority Date Filing Date
GB32622/77A Expired GB1552100A (en) 1976-08-09 1977-08-03 Cephalospin analogues

Country Status (8)

Country Link
JP (1) JPS609515B2 (en)
BE (1) BE857621A (en)
CA (1) CA1078380A (en)
CH (1) CH644382A5 (en)
DE (1) DE2735888A1 (en)
FR (1) FR2361399A1 (en)
GB (1) GB1552100A (en)
NL (1) NL7708793A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0098615A1 (en) * 1982-07-09 1984-01-18 Meiji Seika Kaisha Ltd. 1-Oxadethiacephalosporin compound and antibacterial agent containing the same
EP0111421A1 (en) * 1982-12-06 1984-06-20 Shionogi & Co., Ltd. Oxacephalosporin derivatives, their preparation and use

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197402A (en) * 1976-08-09 1980-04-08 Shionogi & Co., Ltd. Cephalosporin analogues
JPS5331690A (en) * 1976-09-01 1978-03-25 Shionogi & Co Ltd Oxadithiacephalosporins
IT1102408B (en) * 1977-12-23 1985-10-07 Fujisawa Pharmaceutical Co ANALOGUE COMPOUNDS OF CEPHALOSPHORINE AND PROCEDURES FOR THEIR PREPARATION
JPS5616491A (en) * 1979-07-19 1981-02-17 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
JPS5768922A (en) * 1980-10-17 1982-04-27 Matsushita Electric Ind Co Ltd Thickness slip quarts oscillator
FR2494279A1 (en) * 1980-11-20 1982-05-21 Rhone Poulenc Ind NEW OXACEPHALOSPORINS, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
FR2505338A1 (en) * 1981-05-11 1982-11-12 Rhone Poulenc Sante 3-Substd. thio-vinyl 1-oxa-ceph-3-em-4-carboxylic acid antibacterials - esp. having 7-2-2-amino-4-thiazolyl-2-methoxy:imino-acetamido Gp., 3-thio substits. include thiadiazolyl and triazinyl Gps.
FR2505339A1 (en) * 1981-05-11 1982-11-12 Rhone Poulenc Sante 3-Substd. thio-vinyl 1-oxa-ceph-3-em-4-carboxylic acid antibacterials - esp. having 7-2-2-amino-4-thiazolyl-2-methoxy:imino-acetamido Gp., 3-thio substits. include thiadiazolyl and triazinyl Gps.
US5688786A (en) * 1994-04-01 1997-11-18 Microcide Pharmaceuticals, Inc. β-lactam antibiotics
WO1996038450A1 (en) * 1995-05-31 1996-12-05 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL178005C (en) * 1972-11-06 1986-01-02 Merck & Co Inc METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION WITH ANTIBACTERIAL ACTION, AND METHOD FOR PREPARING A CEPHALOSPORINE ANTIBIOTIC.
GB1510794A (en) * 1974-08-06 1978-05-17 Univ Kingston 1-oxacephems and intermediates therefor

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0098615A1 (en) * 1982-07-09 1984-01-18 Meiji Seika Kaisha Ltd. 1-Oxadethiacephalosporin compound and antibacterial agent containing the same
EP0111421A1 (en) * 1982-12-06 1984-06-20 Shionogi & Co., Ltd. Oxacephalosporin derivatives, their preparation and use

Also Published As

Publication number Publication date
CA1078380A (en) 1980-05-27
CH644382A5 (en) 1984-07-31
FR2361399B1 (en) 1981-02-06
FR2361399A1 (en) 1978-03-10
JPS609515B2 (en) 1985-03-11
JPS5321188A (en) 1978-02-27
NL7708793A (en) 1978-02-13
DE2735888A1 (en) 1978-02-16
BE857621A (en) 1978-02-09

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee