GB1078426A - Novel 9ª‰,10ª‡-steroids and a process for the manufacture thereof - Google Patents
Novel 9ª‰,10ª‡-steroids and a process for the manufacture thereofInfo
- Publication number
- GB1078426A GB1078426A GB3054565A GB3054565A GB1078426A GB 1078426 A GB1078426 A GB 1078426A GB 3054565 A GB3054565 A GB 3054565A GB 3054565 A GB3054565 A GB 3054565A GB 1078426 A GB1078426 A GB 1078426A
- Authority
- GB
- United Kingdom
- Prior art keywords
- keto
- steroid
- compounds
- reaction
- trisdehydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
- G01F23/30—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by floats
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
- B22D18/00—Pressure casting; Vacuum casting
- B22D18/04—Low pressure casting, i.e. making use of pressures up to a few bars to fill the mould
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
- B22D2/00—Arrangement of indicating or measuring devices, e.g. for temperature or viscosity of the fused mass
- B22D2/003—Arrangement of indicating or measuring devices, e.g. for temperature or viscosity of the fused mass for the level of the molten metal
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
- B22D37/00—Controlling or regulating the pouring of molten metal from a casting melt-holding vessel
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
- B22D7/00—Casting ingots, e.g. from ferrous metals
- B22D7/06—Ingot moulds or their manufacture
- B22D7/10—Hot tops therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- General Physics & Mathematics (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 3-keto-4-dehydro-, 3 - keto - 4,6 - bisdehydro-, 3 - keto - 1,4,6 - trisdehydro-, 3 - acyloxy - 3,5 - bisdehydro- and 3-acyloxy-2,4,6-trisdehydro-derivatives of compounds of formula <FORM:1078426/C2/1> and 3-keto-5-dehydro-derivatives of compounds of formula <FORM:1078426/C2/2> wherein -OR1 is a free, esterified or etherified hydroxy group, R2 is a hydrogen atom or a C1- 5 alkyl group, and R is a C1- 5 alkyl group or an aralkyl group, and their preparation by (a) reaction of a 3-keto-D 4-steroid with a cyclic secondary amine to form a 3-enamino-D 3,5-steroid and treating this with an alkylating or aralkylating agent, followed by hydrolysis, (b) reaction of a 3-keto-D 4-steroid with formaldehyde and a thiol to form a 4-thiomethyl ether and subjecting this to reductive desulphurization, or (c) reaction of a 3-keto-D 4-steroid with an alkylating or aralkylating agent in the presence of a proton acceptor, using excess reagent if a 4,4-disubstituted product is desired, followed, if desired, by (d) reduction of a 17-keto-compound to a 17b -hydroxy compound, with partial reoxidation of any 3,17-diol formed, (e) enol acylation or enol ester hydrolysis, or (f) 17-etherification or esterification or ether or ester hydrolysis. The compounds of the invention have anabolic and differential antigonadotrophic activity and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for oral, parenteral or rectal administration.
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1402467A CH473796A (en) | 1964-10-28 | 1964-10-28 | Process for making new 9B, 10a steroids |
CH1402567A CH473787A (en) | 1964-10-28 | 1964-10-28 | Process for making new 9B, 10a steroids |
CH1402367A CH473795A (en) | 1964-10-28 | 1964-10-28 | Process for making new 9B, 10a steroids |
CH1397964A CH464908A (en) | 1964-10-28 | 1964-10-28 | Process for making new 9B, 10a steroids |
BE705455 | 1967-10-20 | ||
CH1476467A CH472255A (en) | 1964-10-28 | 1967-10-23 | Method and device for controlling the height of a liquid metal level |
NL6714413A NL6714413A (en) | 1964-10-28 | 1967-10-24 | |
LU54730A LU54730A1 (en) | 1964-10-28 | 1967-10-24 | |
GB48328/67A GB1203070A (en) | 1964-10-28 | 1967-10-24 | Mold riser height control |
DEA0057162 | 1967-10-24 | ||
AU28875/67A AU425465B2 (en) | 1964-10-28 | 1967-10-24 | Mold riser height control |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1078426A true GB1078426A (en) | 1967-08-09 |
Family
ID=27581354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3054565A Expired GB1078426A (en) | 1964-10-28 | 1965-07-19 | Novel 9ª‰,10ª‡-steroids and a process for the manufacture thereof |
Country Status (3)
Country | Link |
---|---|
CH (1) | CH473796A (en) |
GB (1) | GB1078426A (en) |
NL (1) | NL6509355A (en) |
-
1964
- 1964-10-28 CH CH1402467A patent/CH473796A/en not_active IP Right Cessation
-
1965
- 1965-07-19 GB GB3054565A patent/GB1078426A/en not_active Expired
- 1965-07-20 NL NL6509355A patent/NL6509355A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NL6509355A (en) | 1966-04-29 |
CH473796A (en) | 1969-06-15 |
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