GB1077089A - 1-substituted-3,4-dihydroisoquinolines - Google Patents

1-substituted-3,4-dihydroisoquinolines

Info

Publication number
GB1077089A
GB1077089A GB5154564A GB5154564A GB1077089A GB 1077089 A GB1077089 A GB 1077089A GB 5154564 A GB5154564 A GB 5154564A GB 5154564 A GB5154564 A GB 5154564A GB 1077089 A GB1077089 A GB 1077089A
Authority
GB
United Kingdom
Prior art keywords
formula
halogen
prepared
pharmaceutically acceptable
chlorophenoxyacetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5154564A
Inventor
David Roy Gildersleve
Michael Shilton Tute
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Priority to GB5154564A priority Critical patent/GB1077089A/en
Priority to NL6516328A priority patent/NL6516328A/xx
Priority to DE19651620122 priority patent/DE1620122A1/en
Priority to CH1738465A priority patent/CH493520A/en
Priority to ES0320801A priority patent/ES320801A1/en
Priority to FI301865A priority patent/FI45757C/en
Priority to AT650867A priority patent/AT271478B/en
Priority to BE673952D priority patent/BE673952A/xx
Priority to DK648165A priority patent/DK114694B/en
Priority to SE1642265A priority patent/SE342623B/xx
Priority to AT1136665A priority patent/AT264525B/en
Priority to FR42726A priority patent/FR4911M/fr
Publication of GB1077089A publication Critical patent/GB1077089A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel compounds of the formula <FORM:1077089/C2/1> wherein R1, R2 and R3 are H or CH3, and X is H, C- 5 alkyl, C- 5 alkoxy or halogen, and the pharmaceutically acceptable acid addition salts thereof are prepared by cyclodehydration of an amide of formula <FORM:1077089/C2/2> wherein R1, R2, R3 and X are as defined, or by reaction of a phenoxyacetonitrile X.C6H4.O. CHR3.CN with a phenethyl chloride or bromide C6H5.CHR1.CHR2. Halogen, in the presence of SnCl4 as catalyst. The compounds have anti-viral activity. N - (p - chlorophenoxyacetyl) - b - phenyl ethylamine is prepared by reacting p-chlorophenoxyacetyl chloride and b - phenylethylamine. Pharmaceutical compositions comprise at least one compound of the first formula above, together with a pharmaceutically acceptable carrier.
GB5154564A 1964-12-18 1964-12-18 1-substituted-3,4-dihydroisoquinolines Expired GB1077089A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB5154564A GB1077089A (en) 1964-12-18 1964-12-18 1-substituted-3,4-dihydroisoquinolines
NL6516328A NL6516328A (en) 1964-12-18 1965-12-15
DE19651620122 DE1620122A1 (en) 1964-12-18 1965-12-15 Process for the preparation of 1-phenoxymethyl-3,4-dihydroisoquinolines and their acid addition salts
CH1738465A CH493520A (en) 1964-12-18 1965-12-16 Antiviral isoquinoline derivs esp 1-phenoxymethyl-3 4
ES0320801A ES320801A1 (en) 1964-12-18 1965-12-16 A procedure for the preparation of new 1-phenoximethyl-3,4-dihidroisoquinoleinas. (Machine-translation by Google Translate, not legally binding)
FI301865A FI45757C (en) 1964-12-18 1965-12-16 Process for the preparation of antiviral 1-phenoxymethyl-3,4-dihydroisoquinolines.
AT650867A AT271478B (en) 1964-12-18 1965-12-17 Process for the preparation of new 1-phenoxymethyl-3,4-dihydroisoquinolines and their acid addition salts
BE673952D BE673952A (en) 1964-12-18 1965-12-17
DK648165A DK114694B (en) 1964-12-18 1965-12-17 Analogous process for the preparation of 1-phenoxymethyl-3,4-dihydroisoquinolines or acid addition salts thereof.
SE1642265A SE342623B (en) 1964-12-18 1965-12-17
AT1136665A AT264525B (en) 1964-12-18 1965-12-17 Process for the preparation of new 1-phenoxymethyl-3,4-dihydroisoquinolines and their acid addition salts
FR42726A FR4911M (en) 1964-12-18 1965-12-17

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5154564A GB1077089A (en) 1964-12-18 1964-12-18 1-substituted-3,4-dihydroisoquinolines

Publications (1)

Publication Number Publication Date
GB1077089A true GB1077089A (en) 1967-07-26

Family

ID=10460432

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5154564A Expired GB1077089A (en) 1964-12-18 1964-12-18 1-substituted-3,4-dihydroisoquinolines

Country Status (11)

Country Link
AT (2) AT271478B (en)
BE (1) BE673952A (en)
CH (1) CH493520A (en)
DE (1) DE1620122A1 (en)
DK (1) DK114694B (en)
ES (1) ES320801A1 (en)
FI (1) FI45757C (en)
FR (1) FR4911M (en)
GB (1) GB1077089A (en)
NL (1) NL6516328A (en)
SE (1) SE342623B (en)

Also Published As

Publication number Publication date
DE1620122A1 (en) 1970-04-09
DK114694B (en) 1969-07-28
NL6516328A (en) 1966-06-20
FI45757B (en) 1972-05-31
BE673952A (en) 1966-04-15
AT264525B (en) 1968-09-10
SE342623B (en) 1972-02-14
CH493520A (en) 1970-07-15
ES320801A1 (en) 1967-03-01
FI45757C (en) 1972-09-11
FR4911M (en) 1967-03-13
AT271478B (en) 1969-06-10

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