GB1073137A - Purine n-oxide derivatives - Google Patents
Purine n-oxide derivativesInfo
- Publication number
- GB1073137A GB1073137A GB44259/64A GB4425964A GB1073137A GB 1073137 A GB1073137 A GB 1073137A GB 44259/64 A GB44259/64 A GB 44259/64A GB 4425964 A GB4425964 A GB 4425964A GB 1073137 A GB1073137 A GB 1073137A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oxide
- purine
- nitrite
- oxide derivatives
- adenosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- TUUQUSLFBYMDFB-UHFFFAOYSA-N 1-hydroxypurine Chemical class ON1C=NC2=NC=NC2=C1 TUUQUSLFBYMDFB-UHFFFAOYSA-N 0.000 title 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 3
- 239000002126 C01EB10 - Adenosine Substances 0.000 abstract 2
- HCNYQMUPJHKYCI-UHFFFAOYSA-N [O-][N+]1=CN=C2N=CNC2=C1 Chemical class [O-][N+]1=CN=C2N=CNC2=C1 HCNYQMUPJHKYCI-UHFFFAOYSA-N 0.000 abstract 2
- 229960005305 adenosine Drugs 0.000 abstract 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 abstract 2
- 229930024421 Adenine Natural products 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- QQZWEECEMNQSTG-UHFFFAOYSA-N Ethyl nitrite Chemical compound CCON=O QQZWEECEMNQSTG-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- GJTDJAPHKDIQIQ-UHFFFAOYSA-L barium(2+);dinitrite Chemical compound [Ba+2].[O-]N=O.[O-]N=O GJTDJAPHKDIQIQ-UHFFFAOYSA-L 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- -1 nitrite ions Chemical class 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5799563 | 1963-10-29 | ||
| JP6564363 | 1963-12-06 | ||
| JP862764 | 1964-02-19 | ||
| JP2923164 | 1964-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1073137A true GB1073137A (en) | 1967-06-21 |
Family
ID=27454988
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB44259/64A Expired GB1073137A (en) | 1963-10-29 | 1964-10-29 | Purine n-oxide derivatives |
| GB44258/64A Expired GB1073136A (en) | 1963-10-29 | 1964-10-29 | Production of purine derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB44258/64A Expired GB1073136A (en) | 1963-10-29 | 1964-10-29 | Production of purine derivatives |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US3317511A (enExample) |
| CH (1) | CH443312A (enExample) |
| GB (2) | GB1073137A (enExample) |
| NL (1) | NL6412520A (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3915958A (en) * | 1972-05-22 | 1975-10-28 | Icn Pharmaceuticals | 6-Substituted purine nucleotides |
| US3928582A (en) * | 1972-10-03 | 1975-12-23 | Abbott Lab | N{HU 1{B -oxides of adenosine-5{40 -carboxylates for treating angina |
| US4093714A (en) * | 1974-03-15 | 1978-06-06 | Icn Pharmaceuticals, Inc. | 9β-D-Arabinofuranosylpurine nucleotides and method of use |
| US4221910A (en) * | 1978-09-15 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | 9-(Hydroxy alkyl)purines |
| US4405781A (en) * | 1981-03-02 | 1983-09-20 | Polaroid Corporation | Method for preparing salts of 6-chloropurine |
| US4760137A (en) * | 1984-08-06 | 1988-07-26 | Brigham Young University | Method for the production of 2'-deoxyadenosine compounds |
| US5602246A (en) * | 1992-11-25 | 1997-02-11 | Schering Aktiengesellschaft | Process for the preparation of fludarabine or fludarabine phosphate from guanosine |
| JP2002193967A (ja) * | 2000-07-10 | 2002-07-10 | Sumika Fine Chemicals Co Ltd | ２，６−ジクロロプリンの製造方法 |
| JP4222837B2 (ja) * | 2001-04-05 | 2009-02-12 | 住友化学株式会社 | ２，６−ジハロゲノプリンの製法 |
| CN1161357C (zh) * | 2001-09-07 | 2004-08-11 | 浙江诚意药业有限公司 | 一种制备2,6-二氯嘌呤的方法 |
| WO2003084958A1 (en) * | 2002-04-04 | 2003-10-16 | Sumitomo Chemical Company, Limited | Production method of 2,6-dihalopurine |
| MX2013005454A (es) * | 2010-11-15 | 2013-06-24 | Abbvie Inc | Inhibidores de nampt y rock. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2482069A (en) * | 1944-11-06 | 1949-09-13 | Frances R Ruskin | Preparation of adenylic and thio-adenylic acid |
| US2719843A (en) * | 1951-10-24 | 1955-10-04 | Davoll John | Method of synthesizing nucleosides and analogous compounds and compounds prepared thereby |
| US3074929A (en) * | 1955-08-11 | 1963-01-22 | Burroughs Wellcome Co | Glycosides of 6-mercaptopurine |
| US3180859A (en) * | 1962-12-05 | 1965-04-27 | Upjohn Co | Derivatives of decoyinine and process for preparing same |
| BE650411A (enExample) * | 1963-07-12 |
-
1964
- 1964-10-12 CH CH1322564A patent/CH443312A/fr unknown
- 1964-10-27 US US406881A patent/US3317511A/en not_active Expired - Lifetime
- 1964-10-28 NL NL6412520A patent/NL6412520A/xx unknown
- 1964-10-29 GB GB44259/64A patent/GB1073137A/en not_active Expired
- 1964-10-29 GB GB44258/64A patent/GB1073136A/en not_active Expired
- 1964-11-30 US US414853A patent/US3314938A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB1073136A (en) | 1967-06-21 |
| US3314938A (en) | 1967-04-18 |
| CH443312A (fr) | 1967-09-15 |
| US3317511A (en) | 1967-05-02 |
| NL6412520A (enExample) | 1965-05-03 |
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