GB1114870A - Process for the preparation of pyrimidine nucleosides - Google Patents

Process for the preparation of pyrimidine nucleosides

Info

Publication number
GB1114870A
GB1114870A GB49968/65A GB4996865A GB1114870A GB 1114870 A GB1114870 A GB 1114870A GB 49968/65 A GB49968/65 A GB 49968/65A GB 4996865 A GB4996865 A GB 4996865A GB 1114870 A GB1114870 A GB 1114870A
Authority
GB
United Kingdom
Prior art keywords
preparation
ketopyrimidine
pyrimidine nucleosides
nucleosides
anhydrolyxofuranosyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB49968/65A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1114870A publication Critical patent/GB1114870A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1 - (21, 31 - Anhydrolyxofuranosyl) - 2 - ketopyrimidine nucleosides are prepared by reacting the corresponding 51-O-benzoyl derivatives with a nitrogenous base having a dissociation constant in water, Kb, of 1.0 x 10-3 to 1.0 x 10-9 in the presence of an inert solvent at - 20 DEG to 25 DEG C. The 2-ketopyrimidine group may be derived from uracil, 5-fluorouracil, thymine, cytosine or azauracil. Suitable nitrogenous bases include primary and secondary amines, ammonia and hydrazine and suitable solvents include alkanols.
GB49968/65A 1964-12-18 1965-11-24 Process for the preparation of pyrimidine nucleosides Expired GB1114870A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US419552A US3288781A (en) 1964-12-18 1964-12-18 Process for deacylating anhydro-lyxofuranosyl with nitrogen base

Publications (1)

Publication Number Publication Date
GB1114870A true GB1114870A (en) 1968-05-22

Family

ID=23662742

Family Applications (1)

Application Number Title Priority Date Filing Date
GB49968/65A Expired GB1114870A (en) 1964-12-18 1965-11-24 Process for the preparation of pyrimidine nucleosides

Country Status (7)

Country Link
US (1) US3288781A (en)
CH (1) CH460788A (en)
DE (1) DE1620617A1 (en)
FR (1) FR1460359A (en)
GB (1) GB1114870A (en)
IL (1) IL24689A (en)
NL (1) NL6516393A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8800502D0 (en) * 1988-01-11 1988-02-10 Cerestar Holding Bv Method of adding borax/boric acid to mixing/reaction-zone
GB0202563D0 (en) * 2002-02-04 2002-03-20 Glaxo Group Ltd Process

Also Published As

Publication number Publication date
DE1620617A1 (en) 1970-05-14
IL24689A (en) 1969-05-28
NL6516393A (en) 1966-06-20
US3288781A (en) 1966-11-29
CH460788A (en) 1968-08-15
FR1460359A (en) 1966-11-25

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