FR2313933A1 - Tetrahydrofuranyl uracil derivs prepn. - by reacting 2,3-dihydrofuran with dry hydrogen chloride and then 2,4-bis(trimethylsilyl-oxy) pyrimidine deriv - Google Patents

Tetrahydrofuranyl uracil derivs prepn. - by reacting 2,3-dihydrofuran with dry hydrogen chloride and then 2,4-bis(trimethylsilyl-oxy) pyrimidine deriv

Info

Publication number
FR2313933A1
FR2313933A1 FR7518273A FR7518273A FR2313933A1 FR 2313933 A1 FR2313933 A1 FR 2313933A1 FR 7518273 A FR7518273 A FR 7518273A FR 7518273 A FR7518273 A FR 7518273A FR 2313933 A1 FR2313933 A1 FR 2313933A1
Authority
FR
France
Prior art keywords
dihydrofuran
bis
reacting
tetrahydrofuranyl
trimethylsilyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7518273A
Other languages
French (fr)
Other versions
FR2313933B1 (en
Inventor
S A Giller
A A Lazdinsh
A Veinberg
A B Sidorov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST ORGANICHESKOGO SINTEZA AK
Original Assignee
INST ORGANICHESKOGO SINTEZA AK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST ORGANICHESKOGO SINTEZA AK filed Critical INST ORGANICHESKOGO SINTEZA AK
Priority to FR7518273A priority Critical patent/FR2313933A1/en
Publication of FR2313933A1 publication Critical patent/FR2313933A1/en
Application granted granted Critical
Publication of FR2313933B1 publication Critical patent/FR2313933B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

The prepn. of N1-(2'-furanidyl)-5 substd. -uracil derivs. of formula (I) (where R is H, halogen or alkyl) comprises treating 2,3-dihydrofuran with dry HCl in an organic solvent, esp. a chlorinated aliphatic hydrocarbon, and reacting the prod. with 5-substd. -2,4-bis-(trimethylsilyloxy)-pyrimidines at is not >10 degrees C. The prods. of the reaction are also claimed. The prods. are esp. useful as antimetabolites of nucleic metabolism; N1-(2'-furanidyl)-5-fluorouracil is the active principle of an antitumour preparation. The present process gives improved yields c.f. prior art prepns. and the starting materials are more stable.
FR7518273A 1975-06-11 1975-06-11 Tetrahydrofuranyl uracil derivs prepn. - by reacting 2,3-dihydrofuran with dry hydrogen chloride and then 2,4-bis(trimethylsilyl-oxy) pyrimidine deriv Granted FR2313933A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7518273A FR2313933A1 (en) 1975-06-11 1975-06-11 Tetrahydrofuranyl uracil derivs prepn. - by reacting 2,3-dihydrofuran with dry hydrogen chloride and then 2,4-bis(trimethylsilyl-oxy) pyrimidine deriv

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7518273A FR2313933A1 (en) 1975-06-11 1975-06-11 Tetrahydrofuranyl uracil derivs prepn. - by reacting 2,3-dihydrofuran with dry hydrogen chloride and then 2,4-bis(trimethylsilyl-oxy) pyrimidine deriv

Publications (2)

Publication Number Publication Date
FR2313933A1 true FR2313933A1 (en) 1977-01-07
FR2313933B1 FR2313933B1 (en) 1978-12-15

Family

ID=9156368

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7518273A Granted FR2313933A1 (en) 1975-06-11 1975-06-11 Tetrahydrofuranyl uracil derivs prepn. - by reacting 2,3-dihydrofuran with dry hydrogen chloride and then 2,4-bis(trimethylsilyl-oxy) pyrimidine deriv

Country Status (1)

Country Link
FR (1) FR2313933A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31382E (en) * 1977-03-10 1983-09-13 E. I. Du Pont De Nemours And Company Static charge neutralizer and process

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. HET. CHEM. 1972, VOL. 9 5 , PAGES 1141-3 *
SOVIET INVENTIONS ILLUSTRATED, SEPTEMBRE 1971, 3, PHARMAC, PAGE 5.) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31382E (en) * 1977-03-10 1983-09-13 E. I. Du Pont De Nemours And Company Static charge neutralizer and process

Also Published As

Publication number Publication date
FR2313933B1 (en) 1978-12-15

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