GB1072415A - Closure of columns, particularly chromatographic columns - Google Patents

Closure of columns, particularly chromatographic columns

Info

Publication number
GB1072415A
GB1072415A GB40220/64A GB4022064A GB1072415A GB 1072415 A GB1072415 A GB 1072415A GB 40220/64 A GB40220/64 A GB 40220/64A GB 4022064 A GB4022064 A GB 4022064A GB 1072415 A GB1072415 A GB 1072415A
Authority
GB
United Kingdom
Prior art keywords
porous body
capillary
closure
columns
screwed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB40220/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Czech Academy of Sciences CAS
Original Assignee
Czech Academy of Sciences CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Czech Academy of Sciences CAS filed Critical Czech Academy of Sciences CAS
Publication of GB1072415A publication Critical patent/GB1072415A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6026—Fluid seals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6017—Fluid distributors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6021—Adjustable pistons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6034—Construction of the column joining multiple columns

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

1,072,415. Closures for upper ends of chromatography columns. CESKOSLOVENSKA AKADEMIE VED. Oct. 2, 1964 [Oct. 2, 1963], No. 40220/64. Heading B1X. A closure for the upper ends of chromatography columns comprises a porous body, a capillary duct for admitting a liquid to one surface of the porous body and a packing means, fitting within the column and through which the capillary duct passes, for locating and retaining the porous body in a position which prevents the formation of a liquidfilled space above the charge in the column. In Fig. 3 (not shown), capillary (1) passes through closure (4) and terminates above porous body (5) which is made from layers of filter paper. In Fig. 4 (not shown) the duct through closure (4) (for example a rubber bung) leads to a conical recess (6) within the closure, the recess being filled with a porous body, the interface between the porous body and the column charge being convex to the charge. In Fig. 5, the centre portion of the porous filling is made less permeable by application of a plastics material 13. Packing device 4<SP>1</SP> is held between tubular nut 8 and plate 10; packing sleeve 14 is compressed between plates 10 and 15. In Fig. 6, plate 10 has upward and downward extensions, bottom nut 20 being screwed on its lower end and tube 11 to its upper end. Thread 19 may be truncated or may have a longitudinal groove (Fig. 9) to allow liquid fed in by capillary 1 to flow upwards to porous body 22, which may be of polyetetrafluorethylene or sintered glass. Fig. 7 is a version of the apparatus of Fig. 6 permitting its use in columns of varying diameters. Fig. 8 illustrates a clamping device for capillary (1) for use in narrow columns, for example 1.5 to 3 mm. i.d. In Fig. 10, sleeve 14 or I4<SP>1</SP> has circumferental grooves arranged so that they tend to open under the pressure below the closure. Capillary needle 1 is screwed into plate 10 and axial cut 35 serves to admit the liquid to porous body 22. In Fig. 15 (not shown), bottom nut (20) is screwed on to the lower end of capillary needle 1. Figs. 16 and 17 (not shown) relate to fittings for the top of the capillary needle assembly which enable the needle to be tightened or loosened in nut (20), so increasing or releasing the pressure on the porous body.
GB40220/64A 1963-10-02 1964-10-02 Closure of columns, particularly chromatographic columns Expired GB1072415A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CS1278401X 1963-10-02
CS538463 1963-10-02

Publications (1)

Publication Number Publication Date
GB1072415A true GB1072415A (en) 1967-06-14

Family

ID=34276336

Family Applications (1)

Application Number Title Priority Date Filing Date
GB40220/64A Expired GB1072415A (en) 1963-10-02 1964-10-02 Closure of columns, particularly chromatographic columns

Country Status (4)

Country Link
US (1) US3511377A (en)
CH (1) CH465271A (en)
DE (1) DE1278401B (en)
GB (1) GB1072415A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011106642A1 (en) * 2010-02-26 2011-09-01 Perkin Elmer Health Sciences, Inc. Fluid chromatography injectors and injector inserts
US8951471B2 (en) 2010-02-26 2015-02-10 Perkinelmer Health Sciences, Inc. Jet assembly for use in detectors and other devices

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3771659A (en) * 1971-06-07 1973-11-13 Cenco Medical Health Supply Co Bottom connector and filter holder for chromotographic column
BE785686A (en) * 1971-07-01 1973-01-02 Merck Patent Gmbh COLUMNS PREPARED FOR CHROMATOGRAPHY
US3814253A (en) * 1971-10-01 1974-06-04 K Forsberg Liquid control apparatus for chromatography columns
AU476229B2 (en) * 1971-10-01 1976-09-16 Suomen Sokeri Osakeyhtio Liquid control apparatus for chromatography columns
FR2219797B1 (en) * 1973-03-01 1978-03-03 Roussel Uclaf
US3878099A (en) * 1974-04-08 1975-04-15 Beckman Instruments Inc Mounting for liquid chromatograph column
EP0008921A1 (en) * 1978-09-08 1980-03-19 Wright Scientific Limited Column chromatography and like processes and apparatus for the practice thereof
JPS5570738A (en) * 1978-11-22 1980-05-28 Kusano Kagaku Kikai Seisakusho:Kk High pressure glass column for high speed liquid chromatograph
DE3021366A1 (en) * 1980-06-06 1981-12-17 Merck Patent Gmbh, 6100 Darmstadt SEPARATION COLUMN FOR THE LIQUID CHROMATOR GRAPHI
US4399032A (en) * 1982-09-22 1983-08-16 Mott Lambert H Chromatographic column terminator element and assembly
FR2533836B1 (en) * 1982-10-05 1988-01-22 Elf Aquitaine METHOD AND DEVICE FOR FILLING CHROMATOGRAPHIC COLUMNS
US4597866A (en) * 1983-12-02 1986-07-01 Groupe Industriel De Realisations Et Applications Chromatography apparatus
US4861473A (en) * 1984-02-29 1989-08-29 Rainin Instrument Co., Inc. Apparatus for facilitating compression of packing material in a liquid chromatography column
GB8413121D0 (en) * 1984-05-23 1984-06-27 Weaver V C Preparative columns for chromatography
US4793920A (en) * 1985-12-11 1988-12-27 Lee Scientific, Inc. Chromatography columns with cast porous plugs and methods of fabricating same
DE3606474A1 (en) * 1986-02-28 1987-09-17 Merck Patent Gmbh CHROMATOGRAPHY PRE-COLUMN
US4737292A (en) * 1986-06-05 1988-04-12 Separations Technology, Inc. HPLC column and a column packing method
DE3636490A1 (en) * 1986-10-27 1988-04-28 Labomatic Ag CLOSING DEVICE FOR A COLUMN FOR CHROMATOGRAPHY
DE3637916A1 (en) * 1986-11-06 1988-05-19 Labomatic Gmbh CHROMATOGRAPHIC COLUMN
DE4014605A1 (en) * 1990-05-07 1991-11-14 Kronwald Separationstechnik Gm MULTI-PIECE CHROMATOGRAPHIC COLUMN CONNECTION
GB2248097A (en) * 1990-09-19 1992-03-25 Amicon Ltd Piston for chromatography column
US5338448A (en) * 1992-10-16 1994-08-16 Sarasep, Inc. Method of preventing contamination of a chromatography column
US5582723A (en) * 1993-11-26 1996-12-10 Keystone Scientific, Inc. Chromatography cartridge
US6001253A (en) * 1995-05-16 1999-12-14 Dyax Corporation Liquid chromatography column
US6177008B1 (en) * 1996-08-01 2001-01-23 Merck & Co., Inc. Dual compartment solid phase extraction cartridge
CA2309936A1 (en) 1997-11-14 1999-05-27 Biotage, Inc. Liquid chromatography column
US6117329A (en) 1999-03-25 2000-09-12 Dyax Corporation Chromatography cartridge end cap fixation
US6783673B2 (en) * 2002-08-23 2004-08-31 Biotage, Inc. Composite chromatography column
DE102005019703A1 (en) * 2005-04-21 2006-11-30 Atoll Gmbh chromatography column
WO2012063238A1 (en) * 2010-11-08 2012-05-18 Yeda Research And Development Co.Ltd A closure for capillary columns
US11389747B2 (en) 2013-06-07 2022-07-19 Waters Technologies Corporation Chromatographic filter
CN107389834B (en) * 2017-07-12 2022-11-01 中国地质大学（武汉） Visual low pressure isotope separation chromatographic column
CN116002789B (en) * 2023-03-20 2023-06-06 山东省地质矿产勘查开发局八〇一水文地质工程地质大队(山东省地矿工程勘察院) Groundwater normal position restoration treatment device

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US454340A (en) * 1891-06-16 Filter
US3077103A (en) * 1958-02-10 1963-02-12 Gen Motors Corp Chromatographic method and apparatus
DE1109145B (en) * 1958-10-23 1961-06-22 Forsch Inst Professor Ing Chem Method and device for filtering
US3032953A (en) * 1959-09-30 1962-05-08 Standard Oil Co Process and apparatus for gas chromatography
US3103807A (en) * 1960-07-08 1963-09-17 Phillips Petroleum Co Liquid sample injection in a chromatographic apparatus
DE1181449B (en) * 1962-10-20 1964-11-12 Bodenseewerk Perkin Elmer Co Flow divider for gas chromatograph
US3354619A (en) * 1963-08-23 1967-11-28 Continental Oil Co Vapor phase chromatography system
US3315736A (en) * 1964-09-17 1967-04-25 Continental Oil Co Condenser in sample fractionating system

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011106642A1 (en) * 2010-02-26 2011-09-01 Perkin Elmer Health Sciences, Inc. Fluid chromatography injectors and injector inserts
US8951471B2 (en) 2010-02-26 2015-02-10 Perkinelmer Health Sciences, Inc. Jet assembly for use in detectors and other devices
AU2011220544B2 (en) * 2010-02-26 2015-11-12 Perkinelmer U.S. Llc Fluid chromatography injectors and injector inserts

Also Published As

Publication number Publication date
US3511377A (en) 1970-05-12
CH465271A (en) 1968-11-15
DE1278401B (en) 1968-09-26

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