GB1070308A - Pyridyl dihydroisoquinolines - Google Patents
Pyridyl dihydroisoquinolinesInfo
- Publication number
- GB1070308A GB1070308A GB12886/66A GB1288666A GB1070308A GB 1070308 A GB1070308 A GB 1070308A GB 12886/66 A GB12886/66 A GB 12886/66A GB 1288666 A GB1288666 A GB 1288666A GB 1070308 A GB1070308 A GB 1070308A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- alkyl
- compound
- cyanopyridine
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004076 pyridyl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- GPHQHTOMRSGBNZ-UHFFFAOYSA-N pyridine-4-carbonitrile Chemical compound N#CC1=CC=NC=C1 GPHQHTOMRSGBNZ-UHFFFAOYSA-N 0.000 abstract 3
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 2
- 238000007363 ring formation reaction Methods 0.000 abstract 2
- YMKBSXVBAHEQHF-UHFFFAOYSA-N (2-chloro-2-methylpropyl)benzene Chemical compound CC(C)(Cl)CC1=CC=CC=C1 YMKBSXVBAHEQHF-UHFFFAOYSA-N 0.000 abstract 1
- RIWRBSMFKVOJMN-UHFFFAOYSA-N 2-methyl-1-phenylpropan-2-ol Chemical compound CC(C)(O)CC1=CC=CC=C1 RIWRBSMFKVOJMN-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical group 0.000 abstract 1
- -1 analgesic Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000005660 chlorination reaction Methods 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 229910001507 metal halide Inorganic materials 0.000 abstract 1
- 150000005309 metal halides Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DET0028238 | 1965-03-24 | ||
| DET0029988 | 1965-12-10 | ||
| DET0030096 | 1965-12-22 | ||
| DET0031921 | 1966-08-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1070308A true GB1070308A (en) | 1967-06-01 |
Family
ID=38089161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB12886/66A Expired GB1070308A (en) | 1965-03-24 | 1966-03-23 | Pyridyl dihydroisoquinolines |
Country Status (11)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5118690A (en) * | 1989-09-20 | 1992-06-02 | John Wyeth & Brother Limited | Pharmaceutical tetrahydroisoquinolines |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1620549A1 (de) * | 1966-06-16 | 1970-08-20 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen Pyridyl-tetrahydroisochinolinen |
| US3517015A (en) * | 1969-03-10 | 1970-06-23 | Sandoz Ag | Tetrahydro-isoquino(2,1-d)(1,4)benzodiazepines |
| DE2811361A1 (de) * | 1978-03-16 | 1979-09-27 | Hoechst Ag | Neue isochinolinaldehyde und verfahren zu ihrer herstellung |
| DE3143876A1 (de) * | 1981-11-05 | 1983-05-11 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue1-furyl-3,4-dihydroisochinoline diese enthaltende arzneimittel sowie verfahren zu deren herstellung und deren verwendung |
| DE3244594A1 (de) * | 1982-12-02 | 1984-06-07 | Hoechst Ag, 6230 Frankfurt | 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133926A (en) * | 1961-05-23 | 1964-05-19 | Ciba Geigy Corp | 1-(pyridyl-lower alkyl)-1, 2, 3, 4-tetrahydro-isoquinolines |
| GB973911A (en) * | 1962-06-04 | 1964-11-04 | Ici Ltd | Dihydroisoquinoline derivatives |
| US3301857A (en) * | 1963-08-26 | 1967-01-31 | Hoffmann La Roche | Spiro |
-
1965
- 1965-03-24 DE DE19651620496 patent/DE1620496A1/de active Pending
-
1966
- 1966-03-02 US US531042A patent/US3457265A/en not_active Expired - Lifetime
- 1966-03-17 CH CH385166A patent/CH471787A/de not_active IP Right Cessation
- 1966-03-22 SE SE3793/66A patent/SE311359B/xx unknown
- 1966-03-23 GB GB12886/66A patent/GB1070308A/en not_active Expired
- 1966-03-23 DK DK150866AA patent/DK116587B/da unknown
- 1966-03-24 FR FR54887A patent/FR5269M/fr not_active Expired
- 1966-10-16 IL IL26700A patent/IL26700A/xx unknown
- 1966-10-24 BE BE688799D patent/BE688799A/xx unknown
- 1966-10-28 NL NL6615253A patent/NL6615253A/xx unknown
-
1967
- 1967-07-14 CH CH1007867A patent/CH536309A/de not_active IP Right Cessation
- 1967-08-23 ES ES344387A patent/ES344387A1/es not_active Expired
- 1967-08-24 SE SE11862/67A patent/SE328885B/xx unknown
- 1967-08-25 DK DK431267AA patent/DK123413B/da unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5118690A (en) * | 1989-09-20 | 1992-06-02 | John Wyeth & Brother Limited | Pharmaceutical tetrahydroisoquinolines |
Also Published As
| Publication number | Publication date |
|---|---|
| BE688799A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1967-03-31 |
| ES344387A1 (es) | 1968-12-01 |
| DK116587B (da) | 1970-01-26 |
| US3457265A (en) | 1969-07-22 |
| FR5269M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1967-07-31 |
| IL26700A (en) | 1970-11-30 |
| CH471787A (de) | 1969-04-30 |
| SE328885B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1970-09-28 |
| SE311359B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1969-06-09 |
| DK123413B (da) | 1972-06-19 |
| NL6615253A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1967-06-12 |
| CH536309A (de) | 1973-04-30 |
| DE1620496A1 (de) | 1970-01-02 |
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