GB1069345A - New alkanolamine derivatives - Google Patents
New alkanolamine derivativesInfo
- Publication number
- GB1069345A GB1069345A GB4716066A GB4716066A GB1069345A GB 1069345 A GB1069345 A GB 1069345A GB 4716066 A GB4716066 A GB 4716066A GB 4716066 A GB4716066 A GB 4716066A GB 1069345 A GB1069345 A GB 1069345A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- alkyl
- substituent
- bears
- radicals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 2,5-dichlorophenyl Chemical group 0.000 abstract 32
- 125000001424 substituent group Chemical group 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 150000003254 radicals Chemical class 0.000 abstract 5
- 125000005248 alkyl aryloxy group Chemical group 0.000 abstract 4
- 125000003435 aroyl group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000001769 aryl amino group Chemical group 0.000 abstract 4
- 125000005110 aryl thio group Chemical group 0.000 abstract 4
- 125000004104 aryloxy group Chemical group 0.000 abstract 4
- 125000001589 carboacyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001412 amines Chemical class 0.000 abstract 3
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical compound [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 2
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 2
- BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical compound O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000002346 iodo group Chemical group I* 0.000 abstract 2
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- 229920005990 polystyrene resin Polymers 0.000 abstract 2
- 229920003002 synthetic resin Polymers 0.000 abstract 2
- 239000000057 synthetic resin Substances 0.000 abstract 2
- YDNBUDLNDAAOEH-UHFFFAOYSA-N 1-(2,3-dimethylphenoxy)-3-(propan-2-ylamino)propan-2-ol Chemical compound CC(C)NCC(O)COC1=CC=CC(C)=C1C YDNBUDLNDAAOEH-UHFFFAOYSA-N 0.000 abstract 1
- OQXUPNVDHOSPGN-UHFFFAOYSA-N 1-(3-ethoxyphenoxy)-3-(propan-2-ylamino)propan-2-ol oxalic acid Chemical compound C(C(=O)O)(=O)O.C(C)OC=1C=C(OCC(CNC(C)C)O)C=CC1 OQXUPNVDHOSPGN-UHFFFAOYSA-N 0.000 abstract 1
- UFLVPYQUIGXQNW-UHFFFAOYSA-N 1-(3-methylphenoxy)-3-(propan-2-ylamino)propan-2-ol;hydrochloride Chemical compound Cl.CC(C)NCC(O)COC1=CC=CC(C)=C1 UFLVPYQUIGXQNW-UHFFFAOYSA-N 0.000 abstract 1
- YUFPERPQVJMWEN-UHFFFAOYSA-N 1-(4-phenylmethoxyphenoxy)-3-(propan-2-ylamino)propan-2-ol Chemical compound C1=CC(OCC(O)CNC(C)C)=CC=C1OCC1=CC=CC=C1 YUFPERPQVJMWEN-UHFFFAOYSA-N 0.000 abstract 1
- ALKYHXVLJMQRLQ-UHFFFAOYSA-N 3-Hydroxy-2-naphthoate Chemical class C1=CC=C2C=C(O)C(C(=O)O)=CC2=C1 ALKYHXVLJMQRLQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 235000021314 Palmitic acid Nutrition 0.000 abstract 1
- 239000004793 Polystyrene Substances 0.000 abstract 1
- 235000021355 Stearic acid Nutrition 0.000 abstract 1
- 235000011054 acetic acid Nutrition 0.000 abstract 1
- 150000001242 acetic acid derivatives Chemical class 0.000 abstract 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical class OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 abstract 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001860 citric acid derivatives Chemical class 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000003840 hydrochlorides Chemical class 0.000 abstract 1
- 150000003903 lactic acid esters Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 235000021313 oleic acid Nutrition 0.000 abstract 1
- 150000002889 oleic acids Chemical class 0.000 abstract 1
- 150000003901 oxalic acid esters Chemical class 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 229920002223 polystyrene Polymers 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003902 salicylic acid esters Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 150000003899 tartaric acid esters Chemical class 0.000 abstract 1
- NXQMNKUGGYNLBY-UHFFFAOYSA-N toliprolol Chemical compound CC(C)NCC(O)COC1=CC=CC(C)=C1 NXQMNKUGGYNLBY-UHFFFAOYSA-N 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2871763 | 1963-07-19 | ||
| GB4674063 | 1963-11-13 | ||
| GB3934465A GB1123258A (en) | 1965-09-15 | 1965-09-15 | Alkanolamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1069345A true GB1069345A (en) | 1967-05-17 |
Family
ID=27258745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4716066A Expired GB1069345A (en) | 1963-07-19 | 1962-12-11 | New alkanolamine derivatives |
Country Status (5)
| Country | Link |
|---|---|
| DK (6) | DK117710B (enrdf_load_stackoverflow) |
| FR (1) | FR1394771A (enrdf_load_stackoverflow) |
| GB (1) | GB1069345A (enrdf_load_stackoverflow) |
| MY (1) | MY7400144A (enrdf_load_stackoverflow) |
| SE (5) | SE313575B (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4080471A (en) * | 1976-06-25 | 1978-03-21 | Aktiebolaget Hassle | Use of substituted isopropylaminopropanols for inducing inotropic effects of the human heart |
| US4244969A (en) * | 1974-02-14 | 1981-01-13 | Aktiebolaget Hassle | Heart active compounds |
| WO1989005794A1 (en) * | 1987-12-23 | 1989-06-29 | Aktiebolaget Hässle | Novel antiarrhythmic agents i |
| US5504087A (en) * | 1993-02-15 | 1996-04-02 | Senju Pharmaceutical Co., Ltd. | 1-phenoxy-2-propanol derivatives useful in treating hypertension and glaucoma |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3466325A (en) * | 1965-04-30 | 1969-09-09 | Haessle Ab | 1-(ortho-alkenyl phenoxy) - 2-hydroxy-3-isopropylaminopropanes and the salts thereof |
| US4117128A (en) | 1976-08-03 | 1978-09-26 | Smithkline Corporation | Sulfonyl benzofurans and benzothiophenes having coronary vasodilator activity |
| SE8401907L (sv) * | 1984-04-05 | 1985-10-06 | Haessle Ab | Nya fenoxipropanolaminsalter och farmaceutiska beredningar derav |
-
1962
- 1962-12-11 GB GB4716066A patent/GB1069345A/en not_active Expired
-
1963
- 1963-12-11 FR FR956847A patent/FR1394771A/fr not_active Expired
-
1965
- 1965-09-09 DK DK463565A patent/DK117710B/da unknown
- 1965-09-09 DK DK463365A patent/DK117963B/da unknown
- 1965-09-09 DK DK463465A patent/DK118772B/da unknown
- 1965-09-09 DK DK463665A patent/DK119063B/da unknown
- 1965-09-09 DK DK463765A patent/DK117640B/da unknown
- 1965-12-21 SE SE1657565A patent/SE313575B/xx unknown
- 1965-12-21 SE SE16572/65A patent/SE338569B/xx unknown
- 1965-12-21 SE SE16573/65A patent/SE338570B/xx unknown
- 1965-12-21 SE SE16574/65A patent/SE338571B/xx unknown
- 1965-12-21 SE SE1657665A patent/SE314991B/xx unknown
-
1966
- 1966-07-06 DK DK349566A patent/DK113370B/da unknown
-
1974
- 1974-12-31 MY MY7400144A patent/MY7400144A/xx unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4244969A (en) * | 1974-02-14 | 1981-01-13 | Aktiebolaget Hassle | Heart active compounds |
| US4080471A (en) * | 1976-06-25 | 1978-03-21 | Aktiebolaget Hassle | Use of substituted isopropylaminopropanols for inducing inotropic effects of the human heart |
| WO1989005794A1 (en) * | 1987-12-23 | 1989-06-29 | Aktiebolaget Hässle | Novel antiarrhythmic agents i |
| US5155133A (en) * | 1987-12-23 | 1992-10-13 | Aktiebolaget Hassle | Antiarrhythmic compounds and pharmaceutical compositions and methods thereof |
| US5504087A (en) * | 1993-02-15 | 1996-04-02 | Senju Pharmaceutical Co., Ltd. | 1-phenoxy-2-propanol derivatives useful in treating hypertension and glaucoma |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1394771A (fr) | 1965-04-09 |
| DK117963B (da) | 1970-06-22 |
| SE314991B (enrdf_load_stackoverflow) | 1969-09-22 |
| DK113370B (da) | 1969-03-17 |
| SE338571B (enrdf_load_stackoverflow) | 1971-09-13 |
| DK117640B (da) | 1970-05-19 |
| SE338569B (enrdf_load_stackoverflow) | 1971-09-13 |
| DK119063B (da) | 1970-11-09 |
| DK118772B (da) | 1970-10-05 |
| SE313575B (enrdf_load_stackoverflow) | 1969-08-18 |
| SE338570B (enrdf_load_stackoverflow) | 1971-09-13 |
| MY7400144A (en) | 1974-12-31 |
| DK117710B (da) | 1970-05-25 |
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