GB1055615A - Oleandomycin acyl ester n-oxides - Google Patents
Oleandomycin acyl ester n-oxidesInfo
- Publication number
- GB1055615A GB1055615A GB4096364A GB4096364A GB1055615A GB 1055615 A GB1055615 A GB 1055615A GB 4096364 A GB4096364 A GB 4096364A GB 4096364 A GB4096364 A GB 4096364A GB 1055615 A GB1055615 A GB 1055615A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oleandomycin
- oxide
- sulphonic
- acyl
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
N-Oxides of oleandomycin acyl esters of formula <FORM:1055615/C2/1> wherein R1, R2 and R3 are hydrogen, acetyl or propionyl and at least one of R1, R2 and R3 is said acyl, are prepared by reacting the corresponding oleandomycin acyl ester with hydrogen peroxide or a peroxy acid such as peracetic, perbenzoic, monoperphthalic or persulphuric acid. Water or an inert organic solvent may be used as reaction medium. Stable acid addition salts may be formed with mineral and organic acids, e.g. oxalic, maleic, fumaric, tartaric, citric, benzoic, phthalic, salicylic, dichloracetic, benzene-sulphonic, p-toluene sulphonic, a - or beta-naphthalene sulphonic or ethane sulphonic acid. With weak acids such as acetic and lactic, the salts hydrolyse in the presence of water. Typical compounds are 1,2,3-triacetyloleandomycin N-oxide, 1-monopropionyloleandomycin N-oxide and 1-monoacetyloleandomycin N-oxide. Pharmaceutical compositions contain an oleandomycin acyl ester N-oxide and a carrier. Formulations include tablets, capsules, lozenges, powders, sprays, aqueous suspensions, elixirs, syrups and injections.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4096364A GB1055615A (en) | 1964-10-07 | 1964-10-07 | Oleandomycin acyl ester n-oxides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4096364A GB1055615A (en) | 1964-10-07 | 1964-10-07 | Oleandomycin acyl ester n-oxides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1055615A true GB1055615A (en) | 1967-01-18 |
Family
ID=10417471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4096364A Expired GB1055615A (en) | 1964-10-07 | 1964-10-07 | Oleandomycin acyl ester n-oxides |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1055615A (en) |
-
1964
- 1964-10-07 GB GB4096364A patent/GB1055615A/en not_active Expired
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