GB1046404A - Salts of basically substituted dibenzocycloheptenes - Google Patents
Salts of basically substituted dibenzocycloheptenesInfo
- Publication number
- GB1046404A GB1046404A GB33706/63A GB3370663A GB1046404A GB 1046404 A GB1046404 A GB 1046404A GB 33706/63 A GB33706/63 A GB 33706/63A GB 3370663 A GB3370663 A GB 3370663A GB 1046404 A GB1046404 A GB 1046404A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- alkenyl
- compound
- ch2nr3r4
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A pamoate, tannate or C12-18 fatty acid salt of a compound of the formula <FORM:1046404/C2/1> wherein the dotted line indicates that the compound may be saturated or unsaturated at the indicated position, each of X and X1 is H or halogen, or a C1-6-alkyl, C1-6-alkoxy, trifluoromethyl, C1-4-alkylsulphonyl or C2-8-dialkylsulphamoyl group, X and X1 being the same or different and more than one such radical may be present on each benzene ring and R is - (1) <FORM:1046404/C2/2> where R1 is H, C1-5-alkyl, C2-5-alkenyl or phenyl-C1-5-alkyl; (2) <FORM:1046404/C2/3> where R2 is H, C1-5-alkyl, C2-5-alkenyl, C1-5-hydroxyalkyl, methanesulphonyloxy-C1-5-alkyl or di-(C1-5-alkyl)amino-C1-5-alkyl; (3) =CH-CH2-CH2NR3R4 where each of R3 and R4 represents a C1-5-alkyl group or R3 and R4 are linked to form a 1-piperidyl, 1-pyrrolidyl, 4-morpholinyl or 1-(C1-5-alkyl)-4-piperazinyl residue; (4) -CH2-CH2-CH2NR3R4; (5) =CH-CH2-CH2NHR5 where R5 is H, C1-5-alkyl, C2-5-alkenyl, cycloalkyl or benzyl; or (6) -CH2CH2CH2NHR5 is prepared by contacting the dibenzocycloheptene, in the form of its free base or soluble salt, with the corresponding acid, or a soluble salt thereof, in an inert solvent.ALSO:Pharmaceutical compositions comprise a pamoate, tannate or C12-18 fatty acid salt of a compound of the formula <FORM:1046404/A5-A6/1> wherein the dotted line indicates that the compound may be saturated or unsaturated at the position indicated, each of X and X1 is H or halogen or a C1-6 alkyl, C1-6 alkoxy, trifluoromethyl, C1-4 alkylsulphonyl, or C2-8 dialkylsulphamoyl group, each of X and X1 being the same or different and more than one such radical may be present in each benzene ring and R is <FORM:1046404/A5-A6/2> where R1 is H, C1-5 alkyl, C2-5 alkenyl or phenyl C1-5 alkyl; <FORM:1046404/A5-A6/3> where R2 is H, C1-5 alkyl, C2-5 alkenyl C1-5 hydroxyalkyl, methanesulphonyloxy -C1-5-alkyl or di-(C1-5 alkyl) amino-C1-5-alkyl; = CH-CH2-CH2NR3R4 where each of R3 and R4 represents a C1-5 alkyl group or R3 and R4 are linked to forma a 1-piperidyl, 1-pyroldidyl, 4-morpholinyl or 1-(C1-5 alkyl)-4-piperazinyl residue; -CH2-CH2-CH2-NR3R4 = CH-CH2CH2NHR5, where R5 is H, C1-5 -alkyl, C2-5 -alkenyl, cycloalkyl, or benzyl; or -CH2-CH2-CH2NHR5, and an inert carrier and optionally, other therapeutic constituents such as analgesics, antitussives and expectorants. The formulation may be administered either orally or parenterally. Added therapeutic constituents comprise, for example, aluminium aspirin, noscapine base and acetaminophen.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22266862A | 1962-09-10 | 1962-09-10 | |
US22266962A | 1962-09-10 | 1962-09-10 | |
US22266762A | 1962-09-10 | 1962-09-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1046404A true GB1046404A (en) | 1966-10-26 |
Family
ID=27397125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB33706/63A Expired GB1046404A (en) | 1962-09-10 | 1963-08-26 | Salts of basically substituted dibenzocycloheptenes |
Country Status (3)
Country | Link |
---|---|
BE (1) | BE637154A (en) |
FR (1) | FR3558M (en) |
GB (1) | GB1046404A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4060622A (en) | 1974-07-10 | 1977-11-29 | Merck & Co., Inc. | (+) AND (-) 1-Methyl-4-(3-cyano-5H-dibenzo(a,d)-cyclohepten-5-ylidene)piperidine containing compositions and methods for using same |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5508280A (en) * | 1990-05-18 | 1996-04-16 | Merrell Pharmaceuticals, Inc. | 5H-Dibenzo (A,D) cycloheptenes as muscarinic receptor antagonists |
-
0
- BE BE637154D patent/BE637154A/xx unknown
-
1963
- 1963-08-26 GB GB33706/63A patent/GB1046404A/en not_active Expired
- 1963-12-09 FR FR946957A patent/FR3558M/en active Active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4060622A (en) | 1974-07-10 | 1977-11-29 | Merck & Co., Inc. | (+) AND (-) 1-Methyl-4-(3-cyano-5H-dibenzo(a,d)-cyclohepten-5-ylidene)piperidine containing compositions and methods for using same |
Also Published As
Publication number | Publication date |
---|---|
BE637154A (en) | |
FR3558M (en) | 1965-09-20 |
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