GB1046303A - Polypeptides - Google Patents
PolypeptidesInfo
- Publication number
- GB1046303A GB1046303A GB9743/65A GB974365A GB1046303A GB 1046303 A GB1046303 A GB 1046303A GB 9743/65 A GB9743/65 A GB 9743/65A GB 974365 A GB974365 A GB 974365A GB 1046303 A GB1046303 A GB 1046303A
- Authority
- GB
- United Kingdom
- Prior art keywords
- homocys
- boc
- leu
- ileu
- oet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Peptides of the formula <FORM:1046303/C2/1> wherein X is H or an acyl residue derived from an a -amino acid or a polypeptide containing from 2 to 6 such amino acids and Y is an ethyl, propyl, isopropyl, allyl, butyl, isobutyl or benzyl group, protected derivatives thereof having the amino and carboxyl groups not involved in the formation of peptide linkages blocked by protecting groups capable of being removed by acidolysis or hydrogenolysis, and non-toxic pharmaceutically acceptable acid addition salts thereof, are prepared by methods in themselves known in the peptide art. The following intermediates were prepared:- H - Leu - (S - Et) - Homocys - NH2 and its BOC - derivative; BOC - Ala - Phe - Ileu-GlyOH and its ethyl ester; BOC - Ileu - Gly- OEt; BOC - Phe - Ileu - Gly - OEt; H - (S - Pr)- Homocys - OMe; H - (S - Pr) - Homocys - NH2; BOC - Leu - (S - Pr) - Homocys - NH2; H - Leu-(S - Pr) - Homocys - NH2;H - (S - Bz) - Homocys-OMe; H - (S - Bz) - Homocys - NH2; BOC - Leu-(S - Bz) - Homocys - NH2; and H - Leu - (S-Bz) -Homocys-NH2. Pharmaceutical compositions which contain compounds of the above general formula are anti-hypertensive agents. The agents may be administered parenterally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT553364 | 1964-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1046303A true GB1046303A (en) | 1966-10-19 |
Family
ID=11120271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9743/65A Expired GB1046303A (en) | 1964-03-13 | 1965-03-08 | Polypeptides |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE661020A (en) |
| DE (1) | DE1518302A1 (en) |
| FR (1) | FR4181M (en) |
| GB (1) | GB1046303A (en) |
-
1965
- 1965-03-08 DE DE19651518302 patent/DE1518302A1/en active Pending
- 1965-03-08 FR FR8282A patent/FR4181M/fr not_active Expired
- 1965-03-08 GB GB9743/65A patent/GB1046303A/en not_active Expired
- 1965-03-12 BE BE661020D patent/BE661020A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1518302A1 (en) | 1969-06-12 |
| FR4181M (en) | 1966-05-23 |
| BE661020A (en) | 1965-07-01 |
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