GB1037143A - Polypeptides - Google Patents
PolypeptidesInfo
- Publication number
- GB1037143A GB1037143A GB47570/64A GB4757064A GB1037143A GB 1037143 A GB1037143 A GB 1037143A GB 47570/64 A GB47570/64 A GB 47570/64A GB 4757064 A GB4757064 A GB 4757064A GB 1037143 A GB1037143 A GB 1037143A
- Authority
- GB
- United Kingdom
- Prior art keywords
- boc
- amino
- acid
- groups
- onp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Peptides of the formula X-phe-ile-gly-leu-met-NH2 where X is H or the acyl residue of an a -amino acid excepting L-lysine and L-alanine, or the acyl residue of a dipeptide with the exception of H-asp(OH)-ala-, its protected derivatives having the amino groups and the carboxyl groups not involved in the formation of peptide links blocked by protecting groups capable of being removed by acidolysis or hydrogenolysis and their non-toxic, pharmaceutically acceptable acid addition salts are prepared by reacting an a -amino-acid or a polypeptide with another polypeptide whose amino acid sequences are part of the above sequence, the amino and carboxylic acid groups not involved in the condensation being suitably protected and, if desired, removed from the final product. Intermediates prepared include: BOC-phe-ile-gly OEt and the free acid; BOC - pro - ONP; BOC - met - ONP and BOC - asp (NH2) - BOC - lys OMe (where BOC = t-butyloxy carbonyl and NP = p-nitrophenyl). Pharmaceutical compositions comprise the compounds of the invention together with a pharmaceutically acceptable carrier. The compositions, which are hypotensive agents, may be in a form suitable for parenteral administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2422463 | 1963-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1037143A true GB1037143A (en) | 1966-07-27 |
Family
ID=11212639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB47570/64A Expired GB1037143A (en) | 1963-11-28 | 1964-11-23 | Polypeptides |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE656369A (en) |
| DE (1) | DE1518288A1 (en) |
| GB (1) | GB1037143A (en) |
-
1964
- 1964-11-23 GB GB47570/64A patent/GB1037143A/en not_active Expired
- 1964-11-23 DE DE19641518288 patent/DE1518288A1/en active Pending
- 1964-11-27 BE BE656369D patent/BE656369A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1518288A1 (en) | 1969-07-24 |
| BE656369A (en) | 1965-03-16 |
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