GB1039536A - Manufacture of highly active isomers of hypertensin ó and of its analogues - Google Patents
Manufacture of highly active isomers of hypertensin ó and of its analoguesInfo
- Publication number
- GB1039536A GB1039536A GB23241/63A GB2324163A GB1039536A GB 1039536 A GB1039536 A GB 1039536A GB 23241/63 A GB23241/63 A GB 23241/63A GB 2324163 A GB2324163 A GB 2324163A GB 1039536 A GB1039536 A GB 1039536A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- lower alkyl
- amino acids
- acetyl
- acetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
L-b -, D-a - and D-b -Asparagyl-L-a -amino-(amino lower alkyl)-acetyl-L-a -amino lower alkyl - acetyl - L - tyrosyl - L - a - amino - lower alkyl - acetyl - L - histidyl - L - prolyl - L - phenylalanine and its physiologically tolerable acid addition salts are prepared by linking an appropriately substituted L- or D-aspartic acid in the given order of succession with the amino acids: L-a -amino-(amino-lower alkyl)-acetic acid, L-a -amino-lower alkyl acetic acid, L-tyresine, L-a -amino-lower alkyl acetic acid, L-histidine, L-proline, L-phenylalanine by a series of reactions selected from condensations of amino acids with further amino acids, condensations of amino acids with smaller peptide chains and condensation of smaller peptide chains with further smaller peptide chains in which amino groups or carboxylic groups not taking part in the reactions are protected and removing the protecting groups at the end of the synthesis. "Lower alkyl" is defined as a C1- 4 alkyl group. Nitro - arg - val - tyr - val - bis - pro - phe - OMe is prepared from its carbobenzoxy derivative. Pharmaceutical compositions having hypertensive action comprise the compounds of the invention and a carrier therefore. The compositions are in forms suitable for enteral or parenteral administration.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH741762A CH437338A (en) | 1962-06-20 | 1962-06-20 | Process for the preparation of highly active isomers of Hypertensin II and its analogues |
| CH268263 | 1963-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1039536A true GB1039536A (en) | 1966-08-17 |
Family
ID=25691133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23241/63A Expired GB1039536A (en) | 1962-06-20 | 1963-06-11 | Manufacture of highly active isomers of hypertensin ó and of its analogues |
Country Status (4)
| Country | Link |
|---|---|
| AT (1) | AT250587B (en) |
| ES (1) | ES289189A1 (en) |
| FR (1) | FR2950M (en) |
| GB (1) | GB1039536A (en) |
-
1963
- 1963-06-11 GB GB23241/63A patent/GB1039536A/en not_active Expired
- 1963-06-19 ES ES289189A patent/ES289189A1/en not_active Expired
- 1963-06-19 AT AT491563A patent/AT250587B/en active
- 1963-09-19 FR FR948012A patent/FR2950M/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES289189A1 (en) | 1963-12-16 |
| FR2950M (en) | 1964-11-23 |
| AT250587B (en) | 1966-11-25 |
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