GB1036282A - Pregnane-aldehyde and derivatives thereof - Google Patents

Pregnane-aldehyde and derivatives thereof

Info

Publication number
GB1036282A
GB1036282A GB3568963A GB3568963A GB1036282A GB 1036282 A GB1036282 A GB 1036282A GB 3568963 A GB3568963 A GB 3568963A GB 3568963 A GB3568963 A GB 3568963A GB 1036282 A GB1036282 A GB 1036282A
Authority
GB
United Kingdom
Prior art keywords
dien
acetonide
trihydroxy
pregnane
aldehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3568963A
Inventor
Robert Rothes Goodall
John Goldman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB3568963A priority Critical patent/GB1036282A/en
Publication of GB1036282A publication Critical patent/GB1036282A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises 6a ,9a -difluoro-11b , 16a ,17a - trihydroxy - 3,20 - dioxo - pregna - 1,4-dien - 21 - al - 16a ,17a - acetonide, and its hydrates, and its preparation by oxidation of the corresponding 21-ol with a reducible metal salt or selenious acid.ALSO:Pharmaceutical compositions having anti-inflammatory activity comprise 6a , 9a -difluoro11b , 16a , 17a -trihydroxy-3, 20-dioxopregno-1, 4 dien-21-al-16a , 17a -acetonide or a hydrate thereof in combination with a carrier, for example in forms suitable for oral parenteral or topical administration, such as tablets, capsules, solutions, suspensions, ointments, creams and lotions. One or more known anti-inflammatory steroids may also be present.
GB3568963A 1963-09-10 1963-09-10 Pregnane-aldehyde and derivatives thereof Expired GB1036282A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3568963A GB1036282A (en) 1963-09-10 1963-09-10 Pregnane-aldehyde and derivatives thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3568963A GB1036282A (en) 1963-09-10 1963-09-10 Pregnane-aldehyde and derivatives thereof

Publications (1)

Publication Number Publication Date
GB1036282A true GB1036282A (en) 1966-07-20

Family

ID=10380484

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3568963A Expired GB1036282A (en) 1963-09-10 1963-09-10 Pregnane-aldehyde and derivatives thereof

Country Status (1)

Country Link
GB (1) GB1036282A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2316959A1 (en) * 1975-07-07 1977-02-04 Syntex Inc 21-ACETALS AND MIXED ACETALS OF STEROIDS OF THE CORTICOID SERIES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2316959A1 (en) * 1975-07-07 1977-02-04 Syntex Inc 21-ACETALS AND MIXED ACETALS OF STEROIDS OF THE CORTICOID SERIES

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