GB1035180A - Process for the preparation of ninhydrin - Google Patents

Process for the preparation of ninhydrin

Info

Publication number
GB1035180A
GB1035180A GB24588/65A GB2458865A GB1035180A GB 1035180 A GB1035180 A GB 1035180A GB 24588/65 A GB24588/65 A GB 24588/65A GB 2458865 A GB2458865 A GB 2458865A GB 1035180 A GB1035180 A GB 1035180A
Authority
GB
United Kingdom
Prior art keywords
methylmercaptoindan
dione
ninhydrin
bromine
chlorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24588/65A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Honeywell Riedel de Haen AG
Original Assignee
Riedel de Haen AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riedel de Haen AG filed Critical Riedel de Haen AG
Publication of GB1035180A publication Critical patent/GB1035180A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ninhydrin is prepared by oxidizing 2-hydroxy 2 - methylmercaptoindan - 1,3 - dione of the formula <FORM:1035180/C2/1> with chlorine or bromine, preferably in aqueous suspension. Examples of the use of both chlorine and bromine are given. 2 - Hydroxy - 2 - methylmercaptoindan - 1,3-dione, used as starting material, is obtainable (1) by aqueous hydrolysis of 2-chloro-2-methylmercaptoindan-1,3-dione or (2) by condensing a phthalic acid diester with dimethyl sulphoxide in the presence of an alkali metal alcoholate, and rearranging the product with sulphuric acid. Examples of both these processes are given.
GB24588/65A 1964-06-12 1965-06-10 Process for the preparation of ninhydrin Expired GB1035180A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DER38122A DE1229080B (en) 1964-06-12 1964-06-12 Process for the preparation of 2-methylmercapto-indandione (1, 3) derivatives
DER38123A DE1207381B (en) 1964-06-12 1964-06-12 Process for the preparation of 2-hydroxy-2-methylmercapto-indandione- (1, 3)
DEP1270A DE1270040B (en) 1964-06-12 1964-06-19 Process for the production of ninhydrin

Publications (1)

Publication Number Publication Date
GB1035180A true GB1035180A (en) 1966-07-06

Family

ID=27212157

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24588/65A Expired GB1035180A (en) 1964-06-12 1965-06-10 Process for the preparation of ninhydrin

Country Status (4)

Country Link
CH (1) CH461472A (en)
DE (3) DE1229080B (en)
FR (1) FR1437103A (en)
GB (1) GB1035180A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3385894A (en) * 1965-06-30 1968-05-28 Shulton Inc Oxidation of activated methylene group containing compounds to the corresponding carbonyl compounds
CN108047018A (en) * 2017-12-12 2018-05-18 上海三爱思试剂有限公司 A kind of synthetic method of ninhydrin

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3385894A (en) * 1965-06-30 1968-05-28 Shulton Inc Oxidation of activated methylene group containing compounds to the corresponding carbonyl compounds
CN108047018A (en) * 2017-12-12 2018-05-18 上海三爱思试剂有限公司 A kind of synthetic method of ninhydrin
CN108047018B (en) * 2017-12-12 2022-07-22 上海三爱思试剂有限公司 Synthetic method of ninhydrin

Also Published As

Publication number Publication date
DE1270040B (en) 1968-06-12
FR1437103A (en) 1966-04-29
DE1207381B (en) 1965-12-23
DE1229080B (en) 1966-11-24
CH461472A (en) 1968-08-31

Similar Documents

Publication Publication Date Title
GB1228606A (en)
GB1238960A (en)
GB1067472A (en) 2-sulphamylthioxanthene-9-one compounds and the preparation thereof
GB1042632A (en) New indane derivatives and processes for the preparation thereof
GB1035180A (en) Process for the preparation of ninhydrin
GB1016356A (en) Preparation of organic peroxycarboxylic acids
GB1107515A (en) New anthraquinone dyestuffs and processes for their manufacture and use
GB1500839A (en) Preparation of 4-acylamino-anthrones
ES416909A1 (en) Keto-esters
GB1019569A (en) Esters of 1ª‡,2ª‡-methylene-í¸-androstene-3,17ª‰-diol and a process for their manufacture
GB1066811A (en) 1-hydroxy-2,2,6,6,-tetrachlorocyclohexane-carbonamide-1
GB1046849A (en) A new dicarboxylic acid derived from glycyrrhetinic acid
GB1090222A (en) Process for the preparation of 1,2-dichlorotetrafluoro-cyclopentenone-3
GB924648A (en) Production of ª -oxo-ª -fluoro-ª -carbethoxy-ª -butyrolactone and ª -fluoroacrylic ethyl ester
GB1005472A (en) Process for the preparation of hydroxy-alkenoic acids
GB957220A (en) A novel steroid compound and processes for its preparation
GB935610A (en) 3ªá-amino-pregnane compounds
GB985471A (en) Androstanes
GB1093908A (en) New derivatives of glycyrrhetinic acid
GB1017602A (en) Beta-dialkylaminoxyethyl esters of substituted benzoic acids
GB1084446A (en) Improvements in or relating to a benzocycloheptathiophenone
GB936366A (en) Methylsulphonyl-phenyl compounds
GB1179109A (en) New 5-Chloro-10-Dioxo-11-Alkyl-Dibenzo (c,f) Thiazepine (1,2) Derivatives and process for preparing them
JPS51118717A (en) Process for preparation of methacryic acid
GB914734A (en) New cyclopentano-naphthalene derivatives and their formation