GB1035180A - Process for the preparation of ninhydrin - Google Patents
Process for the preparation of ninhydrinInfo
- Publication number
- GB1035180A GB1035180A GB24588/65A GB2458865A GB1035180A GB 1035180 A GB1035180 A GB 1035180A GB 24588/65 A GB24588/65 A GB 24588/65A GB 2458865 A GB2458865 A GB 2458865A GB 1035180 A GB1035180 A GB 1035180A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methylmercaptoindan
- dione
- ninhydrin
- bromine
- chlorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Ninhydrin is prepared by oxidizing 2-hydroxy 2 - methylmercaptoindan - 1,3 - dione of the formula <FORM:1035180/C2/1> with chlorine or bromine, preferably in aqueous suspension. Examples of the use of both chlorine and bromine are given. 2 - Hydroxy - 2 - methylmercaptoindan - 1,3-dione, used as starting material, is obtainable (1) by aqueous hydrolysis of 2-chloro-2-methylmercaptoindan-1,3-dione or (2) by condensing a phthalic acid diester with dimethyl sulphoxide in the presence of an alkali metal alcoholate, and rearranging the product with sulphuric acid. Examples of both these processes are given.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DER38122A DE1229080B (en) | 1964-06-12 | 1964-06-12 | Process for the preparation of 2-methylmercapto-indandione (1, 3) derivatives |
DER38123A DE1207381B (en) | 1964-06-12 | 1964-06-12 | Process for the preparation of 2-hydroxy-2-methylmercapto-indandione- (1, 3) |
DEP1270A DE1270040B (en) | 1964-06-12 | 1964-06-19 | Process for the production of ninhydrin |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1035180A true GB1035180A (en) | 1966-07-06 |
Family
ID=27212157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB24588/65A Expired GB1035180A (en) | 1964-06-12 | 1965-06-10 | Process for the preparation of ninhydrin |
Country Status (4)
Country | Link |
---|---|
CH (1) | CH461472A (en) |
DE (3) | DE1229080B (en) |
FR (1) | FR1437103A (en) |
GB (1) | GB1035180A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3385894A (en) * | 1965-06-30 | 1968-05-28 | Shulton Inc | Oxidation of activated methylene group containing compounds to the corresponding carbonyl compounds |
CN108047018A (en) * | 2017-12-12 | 2018-05-18 | 上海三爱思试剂有限公司 | A kind of synthetic method of ninhydrin |
-
1964
- 1964-06-12 DE DER38122A patent/DE1229080B/en active Pending
- 1964-06-12 DE DER38123A patent/DE1207381B/en active Pending
- 1964-06-19 DE DEP1270A patent/DE1270040B/en active Pending
-
1965
- 1965-05-14 CH CH681365A patent/CH461472A/en unknown
- 1965-06-10 GB GB24588/65A patent/GB1035180A/en not_active Expired
- 1965-06-11 FR FR20546A patent/FR1437103A/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3385894A (en) * | 1965-06-30 | 1968-05-28 | Shulton Inc | Oxidation of activated methylene group containing compounds to the corresponding carbonyl compounds |
CN108047018A (en) * | 2017-12-12 | 2018-05-18 | 上海三爱思试剂有限公司 | A kind of synthetic method of ninhydrin |
CN108047018B (en) * | 2017-12-12 | 2022-07-22 | 上海三爱思试剂有限公司 | Synthetic method of ninhydrin |
Also Published As
Publication number | Publication date |
---|---|
DE1270040B (en) | 1968-06-12 |
FR1437103A (en) | 1966-04-29 |
DE1207381B (en) | 1965-12-23 |
DE1229080B (en) | 1966-11-24 |
CH461472A (en) | 1968-08-31 |
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