GB1033520A - 3-amino steroids - Google Patents

3-amino steroids

Info

Publication number
GB1033520A
GB1033520A GB693465A GB693465A GB1033520A GB 1033520 A GB1033520 A GB 1033520A GB 693465 A GB693465 A GB 693465A GB 693465 A GB693465 A GB 693465A GB 1033520 A GB1033520 A GB 1033520A
Authority
GB
United Kingdom
Prior art keywords
group
reaction
formula
tertiary amino
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB693465A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of GB1033520A publication Critical patent/GB1033520A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of formula <F\1> wherein B = N is a tertiary amino- or tertiary amino-N-oxide group, R is an alkylidene group having 1 to 6 carbon atoms, or a monocyclic aromatic-methylene group, X is H2 or an oxygen atom, and Z is a carbonyl or BETA-hydroxymethylene group, acid addition and quaternary ammonium salts thereof, and their preparation by reaction of a compound of formula <F\1> with a carbonyl compound R = O at 50-150 DEG C. in an organic solvent in the presence of a strong base, followed if desired by (a) reduction of the 17-keto group to a hydroxy group by an alkali metal borohydride, (b) formation of an amine oxide by reaction with hydrogen peroxide, or (c) salt formation.
GB693465A 1962-03-30 1963-03-28 3-amino steroids Expired GB1033520A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18373762A 1962-03-30 1962-03-30

Publications (1)

Publication Number Publication Date
GB1033520A true GB1033520A (en) 1966-06-22

Family

ID=22674092

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1229263A Expired GB1000410A (en) 1962-03-30 1963-03-28 Amino-androstanes
GB693465A Expired GB1033520A (en) 1962-03-30 1963-03-28 3-amino steroids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB1229263A Expired GB1000410A (en) 1962-03-30 1963-03-28 Amino-androstanes

Country Status (1)

Country Link
GB (2) GB1000410A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085457A2 (en) * 2003-03-24 2004-10-07 Sterix Limited 17beta-hydroxysteroid dehydrogenase inhibitors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011127465A2 (en) * 2010-04-09 2011-10-13 The Research Foundation Of The State University Of New York Ship inhibitors and uses thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085457A2 (en) * 2003-03-24 2004-10-07 Sterix Limited 17beta-hydroxysteroid dehydrogenase inhibitors
WO2004085457A3 (en) * 2003-03-24 2005-02-03 Sterix Ltd 17beta-hydroxysteroid dehydrogenase inhibitors
EP2336146A1 (en) * 2003-03-24 2011-06-22 Sterix Limited 17beta-hydroxysteroid dehydrogenase inhibitors
US8003783B2 (en) 2003-03-24 2011-08-23 Sterix Limited 17B-hydroxysteroid dehydrogenase inhibitors

Also Published As

Publication number Publication date
GB1000410A (en) 1965-08-04

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