GB1021526A - New isquinolines and process for preparing them - Google Patents
New isquinolines and process for preparing themInfo
- Publication number
- GB1021526A GB1021526A GB720564A GB720564A GB1021526A GB 1021526 A GB1021526 A GB 1021526A GB 720564 A GB720564 A GB 720564A GB 720564 A GB720564 A GB 720564A GB 1021526 A GB1021526 A GB 1021526A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- nitro
- chloromethyl
- halo
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 150000002537 isoquinolines Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- SFJHFGNNFPEFGX-UHFFFAOYSA-N 1,7-dichloro-3-(chloromethyl)-4-methylisoquinoline Chemical compound ClC1=NC(=C(C2=CC=C(C=C12)Cl)C)CCl SFJHFGNNFPEFGX-UHFFFAOYSA-N 0.000 abstract 1
- UBDLQXBAHOOYAF-UHFFFAOYSA-N 1-chloro-3-(chloromethyl)-4-methyl-5-nitroisoquinoline Chemical compound ClC1=NC(=C(C2=C(C=CC=C12)[N+](=O)[O-])C)CCl UBDLQXBAHOOYAF-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- 230000000954 anitussive effect Effects 0.000 abstract 1
- 239000003434 antitussive agent Substances 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH220563A CH449013A (de) | 1963-02-21 | 1963-02-21 | Verfahren zur Herstellung neuer Isochinolinverbindungen |
| CH67264 | 1964-01-21 | ||
| CH67164 | 1964-01-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1021526A true GB1021526A (en) | 1966-03-02 |
Family
ID=27172297
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB720564A Expired GB1021526A (en) | 1963-02-21 | 1964-02-20 | New isquinolines and process for preparing them |
| GB720464A Expired GB1021525A (en) | 1963-02-21 | 1964-02-20 | New isoquinolines and process for preparing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB720464A Expired GB1021525A (en) | 1963-02-21 | 1964-02-20 | New isoquinolines and process for preparing them |
Country Status (4)
| Country | Link |
|---|---|
| BE (2) | BE644126A (enrdf_load_stackoverflow) |
| FR (2) | FR3534M (enrdf_load_stackoverflow) |
| GB (2) | GB1021526A (enrdf_load_stackoverflow) |
| NL (2) | NL6401593A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1718342A4 (en) * | 2004-02-12 | 2009-07-22 | Molecular Insight Pharm Inc | TECHNETIUM AND RHENIUM-BIS (HETEROARYL) COMPLEXES AND APPLICATION METHODS |
| US7824661B2 (en) | 2002-03-11 | 2010-11-02 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof |
| US7875258B2 (en) | 2002-03-11 | 2011-01-25 | Molecular Insight Pharmaceuticals, Inc. | Technetium-dipyridine complexes, and methods of use thereof |
-
1964
- 1964-02-20 BE BE644126A patent/BE644126A/xx unknown
- 1964-02-20 BE BE644127A patent/BE644127A/xx unknown
- 1964-02-20 GB GB720564A patent/GB1021526A/en not_active Expired
- 1964-02-20 NL NL6401593A patent/NL6401593A/xx unknown
- 1964-02-20 NL NL6401592A patent/NL6401592A/xx unknown
- 1964-02-20 GB GB720464A patent/GB1021525A/en not_active Expired
- 1964-05-20 FR FR975038A patent/FR3534M/fr not_active Expired
- 1964-05-20 FR FR975039A patent/FR3782M/fr not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7824661B2 (en) | 2002-03-11 | 2010-11-02 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof |
| US7875258B2 (en) | 2002-03-11 | 2011-01-25 | Molecular Insight Pharmaceuticals, Inc. | Technetium-dipyridine complexes, and methods of use thereof |
| EP1718342A4 (en) * | 2004-02-12 | 2009-07-22 | Molecular Insight Pharm Inc | TECHNETIUM AND RHENIUM-BIS (HETEROARYL) COMPLEXES AND APPLICATION METHODS |
| US8685369B2 (en) | 2004-02-12 | 2014-04-01 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis (heteroaryl) complexes, and methods of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6401593A (enrdf_load_stackoverflow) | 1964-08-24 |
| BE644126A (enrdf_load_stackoverflow) | 1964-08-20 |
| NL6401592A (enrdf_load_stackoverflow) | 1964-08-24 |
| GB1021525A (en) | 1966-03-02 |
| FR3782M (fr) | 1965-12-27 |
| FR3534M (fr) | 1965-09-13 |
| BE644127A (enrdf_load_stackoverflow) | 1964-08-20 |
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