GB1021217A - Isovaleric acid ester sedative and a process for its isolation - Google Patents
Isovaleric acid ester sedative and a process for its isolationInfo
- Publication number
- GB1021217A GB1021217A GB30730/64A GB3073064A GB1021217A GB 1021217 A GB1021217 A GB 1021217A GB 30730/64 A GB30730/64 A GB 30730/64A GB 3073064 A GB3073064 A GB 3073064A GB 1021217 A GB1021217 A GB 1021217A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid ester
- isovaleric acid
- aluminium oxide
- sedative
- isolation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 title abstract 8
- -1 Isovaleric acid ester Chemical class 0.000 title abstract 8
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 title abstract 8
- 239000000932 sedative agent Substances 0.000 title abstract 5
- 230000001624 sedative effect Effects 0.000 title abstract 5
- 238000002955 isolation Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 19
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- 239000012736 aqueous medium Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 101100129500 Caenorhabditis elegans max-2 gene Proteins 0.000 abstract 2
- 101100083446 Danio rerio plekhh1 gene Proteins 0.000 abstract 2
- 239000003125 aqueous solvent Substances 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001735 carboxylic acids Chemical class 0.000 abstract 2
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- 235000020767 valerian extract Nutrition 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 abstract 1
- 241001342522 Vampyrum spectrum Species 0.000 abstract 1
- 229940072049 amyl acetate Drugs 0.000 abstract 1
- PGMYKACGEOXYJE-UHFFFAOYSA-N anhydrous amyl acetate Natural products CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000002211 ultraviolet spectrum Methods 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/06—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
- B01J20/08—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04 comprising aluminium oxide or hydroxide; comprising bauxite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEK50367A DE1223993B (de) | 1963-07-27 | 1963-07-27 | Verfahren zur Isolierung eines zentral sedativ wirkenden Isovaleriansaeureesters aus nicht waessrigen Baldrian-Extrakten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1021217A true GB1021217A (en) | 1966-03-02 |
Family
ID=7225590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB30730/64A Expired GB1021217A (en) | 1963-07-27 | 1964-08-04 | Isovaleric acid ester sedative and a process for its isolation |
Country Status (12)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2654709C3 (de) * | 1976-12-02 | 1987-07-09 | A. H. Robins Co. Inc., Richmond, Va. | Verfahren zum Stabilisieren von Baldrianextraktpräparaten |
-
0
- NL NL129967D patent/NL129967C/xx active
-
1963
- 1963-07-27 DE DEK50367A patent/DE1223993B/de active Pending
-
1964
- 1964-06-29 CH CH850764A patent/CH462124A/de unknown
- 1964-07-23 FI FI157664A patent/FI42601B/fi active
- 1964-07-23 IL IL2175664A patent/IL21756A/en unknown
- 1964-07-24 NL NL6408498A patent/NL6408498A/xx unknown
- 1964-07-25 DK DK372264A patent/DK109934C/da active
- 1964-07-25 FR FR983075A patent/FR4112M/fr not_active Expired
- 1964-07-27 SE SE9126/64A patent/SE323472B/xx unknown
- 1964-07-27 BR BR16116864A patent/BR6461168D0/pt unknown
- 1964-07-27 BE BE651027A patent/BE651027A/xx unknown
- 1964-08-04 GB GB30730/64A patent/GB1021217A/en not_active Expired
-
1968
- 1968-12-31 MY MY6800079A patent/MY6800079A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE651027A (enrdf_load_stackoverflow) | 1965-01-27 |
| DK109934C (da) | 1968-08-05 |
| FI42601B (enrdf_load_stackoverflow) | 1970-06-01 |
| CH462124A (de) | 1968-09-15 |
| DE1223993B (de) | 1966-09-01 |
| BR6461168D0 (pt) | 1973-08-02 |
| NL6408498A (enrdf_load_stackoverflow) | 1965-01-28 |
| NL129967C (enrdf_load_stackoverflow) | |
| FR4112M (enrdf_load_stackoverflow) | 1966-04-25 |
| IL21756A (en) | 1968-01-25 |
| SE323472B (enrdf_load_stackoverflow) | 1970-05-04 |
| MY6800079A (en) | 1968-12-31 |
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