GB1018990A - Method of preparing barbituric acid derivatives - Google Patents

Method of preparing barbituric acid derivatives

Info

Publication number
GB1018990A
GB1018990A GB2929365A GB2929365A GB1018990A GB 1018990 A GB1018990 A GB 1018990A GB 2929365 A GB2929365 A GB 2929365A GB 2929365 A GB2929365 A GB 2929365A GB 1018990 A GB1018990 A GB 1018990A
Authority
GB
United Kingdom
Prior art keywords
alkyl
methyl
barbituric acid
hydrogen
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2929365A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aspro Nicholas Ltd
Original Assignee
Aspro Nicholas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspro Nicholas Ltd filed Critical Aspro Nicholas Ltd
Publication of GB1018990A publication Critical patent/GB1018990A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/66—Thiobarbituric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method of preparing a barbituric acid derivative, comprising the step of condensing thiourea with a malonic ester in an inert material solvent and in the presence of a condensing agent at a temperature not exceeding 30 DEG C. until a thiobarbituric acid results, the said malonic ester having the formula <FORM:1018990/C2/1> wherein R is (a) R1.R2.N.A-, wherein R1 is alkyl and R2 is alkyl and A is an unsubstituted or methyl substituted alkylene radical having 2 or 3 chain members; or (b) <FORM:1018990/C2/2> wherein <FORM:1018990/C2/3> is a heterocyclic group containing at least 5 ring atoms and A is as above, or (c) R3-(CH2)n, where n is 1 or 2 and R3 is 2-pyridyl or N-methyl -2-piperidinyl; X is hydrogen or at least one halogen alkyl or alkoxy substituent provided that when R is a dimethylamino group free from substitution by methyl in the alpha position of the alkyl group X is not hydrogen; and alkoxy and alkyl groups contain from 1 to 4 carbon atoms.
GB2929365A 1963-09-25 1963-09-25 Method of preparing barbituric acid derivatives Expired GB1018990A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2929363 1963-09-25

Publications (1)

Publication Number Publication Date
GB1018990A true GB1018990A (en) 1966-02-02

Family

ID=10289242

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2929365A Expired GB1018990A (en) 1963-09-25 1963-09-25 Method of preparing barbituric acid derivatives
GB3782563A Expired GB1015029A (en) 1963-09-25 1963-09-25 Pharmaceutical compositions containing barbituric acid derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB3782563A Expired GB1015029A (en) 1963-09-25 1963-09-25 Pharmaceutical compositions containing barbituric acid derivatives

Country Status (1)

Country Link
GB (2) GB1018990A (en)

Also Published As

Publication number Publication date
GB1015029A (en) 1965-12-31

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