GB1017613A - Piperidine derivatives and processes for their production - Google Patents
Piperidine derivatives and processes for their productionInfo
- Publication number
- GB1017613A GB1017613A GB11376/63A GB1137663A GB1017613A GB 1017613 A GB1017613 A GB 1017613A GB 11376/63 A GB11376/63 A GB 11376/63A GB 1137663 A GB1137663 A GB 1137663A GB 1017613 A GB1017613 A GB 1017613A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- formula
- radical
- alkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003053 piperidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 230000003301 hydrolyzing effect Effects 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 3
- 239000007795 chemical reaction product Substances 0.000 abstract 3
- -1 1-ethenyl-2-ylidene Chemical group 0.000 abstract 2
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004442 acylamino group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001118 alkylidene group Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- YNJSNEKCXVFDKW-UHFFFAOYSA-N 3-(5-amino-1h-indol-3-yl)-2-azaniumylpropanoate Chemical compound C1=C(N)C=C2C(CC(N)C(O)=O)=CNC2=C1 YNJSNEKCXVFDKW-UHFFFAOYSA-N 0.000 abstract 1
- REAKCDAYGJOJIY-UHFFFAOYSA-N 3-methyl-1a,2,7,7a-tetrahydronaphtho[2,3-b]oxirene Chemical compound CC1=C2CC3C(CC2=CC=C1)O3 REAKCDAYGJOJIY-UHFFFAOYSA-N 0.000 abstract 1
- MRLBDJHIJZHYMK-UHFFFAOYSA-N 5,6,8,9-tetrahydrobenzo[7]annulen-7-one Chemical compound C1CC(=O)CCC2=CC=CC=C21 MRLBDJHIJZHYMK-UHFFFAOYSA-N 0.000 abstract 1
- SZSULKQHNHYFKF-UHFFFAOYSA-N 5-methyl-1,4-dihydronaphthalene Chemical compound C1C=CCC2=C1C=CC=C2C SZSULKQHNHYFKF-UHFFFAOYSA-N 0.000 abstract 1
- ORNNOOXHHWMNHW-UHFFFAOYSA-N 6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl 4-methylbenzenesulfonate Chemical compound C1(=CC=C(C=C1)S(=O)(=O)OC1CCC2=C(CC1)C=CC=C2)C ORNNOOXHHWMNHW-UHFFFAOYSA-N 0.000 abstract 1
- DWGQGUVDDJHLQF-UHFFFAOYSA-N 7-bromo-6,7,8,9-tetrahydro-5h-benzo[7]annulene Chemical compound C1CC(Br)CCC2=CC=CC=C21 DWGQGUVDDJHLQF-UHFFFAOYSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000000954 anitussive effect Effects 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 150000001555 benzenes Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH386262A CH407121A (de) | 1962-03-30 | 1962-03-30 | Verfahren zur Herstellung von neuen Piperidinderivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1017613A true GB1017613A (en) | 1966-01-19 |
Family
ID=4265061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB11376/63A Expired GB1017613A (en) | 1962-03-30 | 1963-03-22 | Piperidine derivatives and processes for their production |
Country Status (10)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7273857B2 (en) | 2001-10-02 | 2007-09-25 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
| US7291611B2 (en) * | 2001-10-02 | 2007-11-06 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2982783A (en) * | 1961-05-02 | Amevoevdanes |
-
1962
- 1962-03-30 CH CH386262A patent/CH407121A/de unknown
-
1963
- 1963-03-22 GB GB11376/63A patent/GB1017613A/en not_active Expired
- 1963-03-29 ES ES286564A patent/ES286564A1/es not_active Expired
- 1963-03-29 SE SE6269/65A patent/SE308107B/xx unknown
- 1963-03-29 AT AT257063A patent/AT246139B/de active
- 1963-03-29 BR BR148044/63A patent/BR6348044D0/pt unknown
- 1963-03-29 DK DK145463AA patent/DK118819B/da unknown
- 1963-03-29 ES ES286563A patent/ES286563A1/es not_active Expired
- 1963-03-29 AT AT811164A patent/AT250360B/de active
- 1963-03-29 SE SE3489/63A patent/SE307947B/xx unknown
- 1963-03-29 AT AT811364A patent/AT249678B/de active
- 1963-03-29 DE DE19631545918 patent/DE1545918A1/de active Pending
- 1963-03-29 ES ES286565A patent/ES286565A1/es not_active Expired
- 1963-03-29 FI FI0576/63A patent/FI40629B/fi active
- 1963-03-29 DE DE19631545917 patent/DE1545917A1/de active Pending
-
1964
- 1964-12-12 DK DK612164AA patent/DK111567B/da unknown
- 1964-12-12 DK DK612064AA patent/DK112312B/da unknown
-
1965
- 1965-05-13 SE SE626865A patent/SE314371B/xx unknown
-
1967
- 1967-05-19 US US663905A patent/US3479363A/en not_active Expired - Lifetime
- 1967-05-19 US US639912A patent/US3479361A/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7273857B2 (en) | 2001-10-02 | 2007-09-25 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
| US7291611B2 (en) * | 2001-10-02 | 2007-11-06 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
| US7300928B2 (en) | 2001-10-02 | 2007-11-27 | Acadia Pharmaceuticals, Inc. | Benzimidazolidinone derivatives as muscarinic agents |
Also Published As
| Publication number | Publication date |
|---|---|
| SE314371B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1969-09-08 |
| AT246139B (de) | 1966-04-12 |
| DE1545918A1 (de) | 1970-01-22 |
| FI40629B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-12-31 |
| SE308107B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1969-02-03 |
| DK111567B (da) | 1968-09-16 |
| DK118819B (da) | 1970-10-12 |
| ES286563A1 (es) | 1963-11-16 |
| CH407121A (de) | 1966-02-15 |
| ES286564A1 (es) | 1963-11-16 |
| BR6348044D0 (pt) | 1973-07-03 |
| ES286565A1 (es) | 1963-11-16 |
| SE307947B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1969-01-27 |
| US3479363A (en) | 1969-11-18 |
| US3479361A (en) | 1969-11-18 |
| AT249678B (de) | 1966-10-25 |
| DK112312B (da) | 1968-12-02 |
| AT250360B (de) | 1966-11-10 |
| DE1545917A1 (de) | 1970-01-22 |
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