GB1014889A - Maleamic acid derivatives - Google Patents
Maleamic acid derivativesInfo
- Publication number
- GB1014889A GB1014889A GB467363A GB467363A GB1014889A GB 1014889 A GB1014889 A GB 1014889A GB 467363 A GB467363 A GB 467363A GB 467363 A GB467363 A GB 467363A GB 1014889 A GB1014889 A GB 1014889A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reaction
- naphthyl
- compounds
- cycloalkyl
- methylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention comprises compounds of formula <FORM:1014889/C2/1> wherein R is a methylene, ethylene or propylene radical optionally substituted by C1- 10 alkyl, cycloalkyl or aryl groups, and their preparation by reaction of the appropriate naphthyl-alkylamine with maleic anhydride. The compounds of the invention have pharmaceutical activity (see Division A5). Naphthylalkylamine starting materials are prepared by reaction of a carbonyl compound with formamide and formic acid. 1 - (1 - Naphthyl) - 1 - hexanone or pentanone are prepared by reaction of 1-naphthyl cyanide with amyl or butyl magnesium bromide to form the corresponding ketimine, which is then hydrolysed.ALSO:Pharmaceutical compositions for administration in conjunction with penicillin and having uric acid-excretion enhancing and blood-cholesterol-lowering activity comprise compounds of formula <FORM:1014889/A5-A6/1> wherein R is a methylene, ethylene or propylene radical optionally substituted by C1-10 alkyl, cycloalkyl or aryl groups, in dosage form, optionally in combination with a carrier, for example in forms suitable for oral or parenteral administration, such as tablets, capsules, pills or solutions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17282962A | 1962-02-08 | 1962-02-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1014889A true GB1014889A (en) | 1965-12-31 |
Family
ID=22629404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB467363A Expired GB1014889A (en) | 1962-02-08 | 1963-02-05 | Maleamic acid derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1014889A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988005040A1 (en) * | 1985-04-25 | 1988-07-14 | The Dow Chemical Company | Arylcyclobutenyl amido alkenoic acids and salts thereof |
| EP0611749A1 (en) * | 1993-02-12 | 1994-08-24 | Banyu Pharmaceutical Co., Ltd. | Substituted amic acid derivatives useful for treatment of arteriosclerosis |
-
1963
- 1963-02-05 GB GB467363A patent/GB1014889A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988005040A1 (en) * | 1985-04-25 | 1988-07-14 | The Dow Chemical Company | Arylcyclobutenyl amido alkenoic acids and salts thereof |
| EP0611749A1 (en) * | 1993-02-12 | 1994-08-24 | Banyu Pharmaceutical Co., Ltd. | Substituted amic acid derivatives useful for treatment of arteriosclerosis |
| US5488149A (en) * | 1993-02-12 | 1996-01-30 | Banyu Pharmaceutical Co., Ltd. | Substituted amic acid derivatives |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL38972A (en) | Substituted phenyl alkanol derivatives,their preparation and compositions containing them | |
| GB1014889A (en) | Maleamic acid derivatives | |
| GB1297386A (en) | ||
| GB1104145A (en) | Pyrazolo-pyridine derivatives | |
| GB915804A (en) | Process for the production of basically substituted carboxylic acid amides | |
| GB1059174A (en) | Diazacycloalkane derivatives | |
| GB1041787A (en) | Novel medicament having as a base thiazolidine carboxylic acid for treatment of illnesses caused by disturbances of the liver | |
| GB1035448A (en) | Iminodibenzyl derivatives and a process for the manufacture thereof | |
| GB978088A (en) | N-acyl-ª-amino acid amides | |
| GB1069717A (en) | Improvements in or relating to pyrido[3,4-b]indole derivatives | |
| US3649632A (en) | 3 4-dihydroacridin-2-(1h)-one derivatives | |
| GB1151095A (en) | 1,3-Dioxan-2-yl-Alkanoic Acids and derivatives thereof | |
| GB1173809A (en) | N-Substituted Nor-Morphines | |
| ES346192A1 (en) | 6-chloro-2-(5-nitro-2-furyl) cinchoninic acid | |
| GB1106609A (en) | New butyne-2 derivatives, their process of preparation and therapeutical compositioncontaining same | |
| GB1217689A (en) | Ethyl esters of fluro-acetic acids | |
| US3373184A (en) | Sulfamide derivatives | |
| ES348490A1 (en) | N-substituted phthalimidines | |
| GB1089013A (en) | Improvements in or relating to the production of derivatives of nitrofuran | |
| ES339128A1 (en) | Azabicycloalkane derivatives | |
| ES363742A1 (en) | N-Substituted 2-Hydroxymorphinanes and Pharmaceutical Compositions containing them | |
| GB1015407A (en) | Anorexogenic compositions | |
| GB1015030A (en) | Anorexagenic compositions | |
| GB1385610A (en) | Process for the manufacture of benzodiazepine derivatives | |
| GB1034874A (en) | Penicillins |