GB1006724A - Antifungal compound and the production thereof - Google Patents
Antifungal compound and the production thereofInfo
- Publication number
- GB1006724A GB1006724A GB7992/62A GB799262A GB1006724A GB 1006724 A GB1006724 A GB 1006724A GB 7992/62 A GB7992/62 A GB 7992/62A GB 799262 A GB799262 A GB 799262A GB 1006724 A GB1006724 A GB 1006724A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radicicolin
- volume
- parts
- culture
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
Abstract
An antifungal substance radicicolin having an optical rotation <FORM:1006724/C2/1> - 193.5 DEG at a concentration of 1.4g. in 100g. methanol and yielding on acid hydrolysis amino acids with Rf values 0.3, 0.4, 0.54, and 0.7 in a paper chromatographic system comprising n-butanol (120 parts by volume) acetic acid (30 parts by volume) and water (50 parts by volume), the amino acids being identified as DL-alamine, L-a -amino-n-butyric acid, L-valine and L-N-methyl-leucine respectively, may be prepared by a process comprising the cultivation of Cylindrocarpon radicicola Wollenweber in an aqueous nutrient medium containing assimilable carbon and nitrogen under aerobic conditions until the culture has developed substantial antifungal activity, and then recovering radicicolin from the culture by solvent extraction, the radicicolin being isolated from the extract or extracts by adsorption or partition chromatography, liquid-liquid phase separation or precipitation. Pharmaceutical compositions for the treatment of a fungal infection comprise radicicolin together with a carrier therefor in forms such as a powder, a solution or suspension in non-aqueous or emulsified liquid, or a spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7992/62A GB1006724A (en) | 1962-03-01 | 1962-03-01 | Antifungal compound and the production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7992/62A GB1006724A (en) | 1962-03-01 | 1962-03-01 | Antifungal compound and the production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1006724A true GB1006724A (en) | 1965-10-06 |
Family
ID=9843692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7992/62A Expired GB1006724A (en) | 1962-03-01 | 1962-03-01 | Antifungal compound and the production thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1006724A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4215199A (en) | 1978-06-05 | 1980-07-29 | Sandoz Ltd. | Antibiotic production |
-
1962
- 1962-03-01 GB GB7992/62A patent/GB1006724A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4215199A (en) | 1978-06-05 | 1980-07-29 | Sandoz Ltd. | Antibiotic production |
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