GB1006137A - Alkyl xanthine derivatives - Google Patents

Alkyl xanthine derivatives

Info

Publication number
GB1006137A
GB1006137A GB9584/63A GB958463A GB1006137A GB 1006137 A GB1006137 A GB 1006137A GB 9584/63 A GB9584/63 A GB 9584/63A GB 958463 A GB958463 A GB 958463A GB 1006137 A GB1006137 A GB 1006137A
Authority
GB
United Kingdom
Prior art keywords
compounds
alk
groups
chr
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB9584/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt filed Critical Degussa GmbH
Publication of GB1006137A publication Critical patent/GB1006137A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Abstract

The invention comprises compounds of general formula T-Alk-NH-CHR-CH2-A wherein T is the 7-theophyllinyl or 1-theobrominyl group, Alk is a straight or branched alkylene chain (2-6 C), R is hydrogen or alkyl (1-3 C), and A is a phenyl radical which may be substituted with one, two or three hydroxyl groups, alkyl (1-3 C) groups, aralkyl groups, aryl alkoxy groups, alkoxy (1-3 C) groups, alkylene dioxy groups, chlorine and/or bromine atoms; and their salts; and their preparation by (1) reacting compounds T-Alk-Halo and H2N-CHR-CH2-A, (2) reacting compounds T-Alk-NH2 and Halo-CHR-CH2-A, (3) condensing by hydrogenation compounds T-Alk1-CHO (where Alk1 is Alk minus a CH2 group) and H2N-CHR-CH2-A, and (4) condensing by hydrogenation compounds T-Alk-NH2 and OCR-CH2-A, and (5) the optional further slip for compounds wherein the phenyl radical A is hydroxy-substituted of catalytic hydrogenation of corresponding benzyloxy compounds. Specification 927,288 is referred to.
GB9584/63A 1962-03-30 1963-03-11 Alkyl xanthine derivatives Expired GB1006137A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DED38531A DE1221641B (en) 1962-03-30 1962-03-30 Process for the preparation of basic substituted theophylline derivatives

Publications (1)

Publication Number Publication Date
GB1006137A true GB1006137A (en) 1965-09-29

Family

ID=7044170

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9584/63A Expired GB1006137A (en) 1962-03-30 1963-03-11 Alkyl xanthine derivatives

Country Status (5)

Country Link
BE (1) BE630294A (en)
BR (1) BR6347019D0 (en)
CH (1) CH429739A (en)
DE (1) DE1221641B (en)
GB (1) GB1006137A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1560389A (en) 1976-12-14 1980-02-06 Degussa Bascically substituted theophylline derivatives
DE3028272A1 (en) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe ALKYLAMINO-DESOXY-1.4; 3.6-DIANHYDRO-HEXIT-NITRATE SUBSTITUTED BY PURINE BASES, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATION

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1100642B (en) * 1956-09-25 1961-03-02 Chemiewerk Homburg Process for the preparation of basic substituted alkylxanthine derivatives
DE1123329B (en) * 1958-10-18 1962-02-08 Chemiewerk Homburg, Zweigniederlassung der Deutschen Gold- und Silber Scheideanstalt vormals Roessler, Frankfurt/M Process for the preparation of basic substituted alkylxanthine derivatives.
DE1124041B (en) * 1959-06-10 1962-02-22 Boehringer Sohn Ingelheim Process for the production of new xanthine derivatives

Also Published As

Publication number Publication date
CH429739A (en) 1967-02-15
DE1221641B (en) 1966-07-28
BE630294A (en) 1963-07-15
BR6347019D0 (en) 1973-07-19

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