GB1003092A - Novel antibacterial substances - Google Patents

Novel antibacterial substances

Info

Publication number
GB1003092A
GB1003092A GB41330/62A GB4133062A GB1003092A GB 1003092 A GB1003092 A GB 1003092A GB 41330/62 A GB41330/62 A GB 41330/62A GB 4133062 A GB4133062 A GB 4133062A GB 1003092 A GB1003092 A GB 1003092A
Authority
GB
United Kingdom
Prior art keywords
anhydro
apo
group
och3
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB41330/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US200632A external-priority patent/US3140293A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB1003092A publication Critical patent/GB1003092A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention comprises antibiotics of formula <FORM:1003092/C2/1> wherein R is an alkyl group having 1 to 6 carbon atoms, R1 is a methoxy or amino group and R2 is a hydrogen atom or a methyl group, and their preparation by catalytic hydrogenation in a polar solvent of a compound of formula <FORM:1003092/C2/2> or its methyl ether or in the presence of a catalyst comprising gold or a metal of Periods 5 and 6 of Group VIII of the Periodic Table or an oxide thereof until 1 mole of hydrogen is absorbed and reoxidizing the product, and, if desired, reacting the compound obtained with liquid ammonia. Certain of the products are designated anhydro apo mitomycin A (R = -CH3, R1 = -OCH3, R2 = -H), anhydro apo mitimycin B (R = -CH3, R1 = -OCH3, R2 = -CH3), and anhydro apo porfiromycin (R = -CH3, R1 = -NH2, R2 = -CH3).
GB41330/62A 1961-11-09 1962-11-01 Novel antibacterial substances Expired GB1003092A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15115561A 1961-11-09 1961-11-09
US200632A US3140293A (en) 1962-06-07 1962-06-07 Anhydro apo mitomycin compounds

Publications (1)

Publication Number Publication Date
GB1003092A true GB1003092A (en) 1965-09-02

Family

ID=26848378

Family Applications (1)

Application Number Title Priority Date Filing Date
GB41330/62A Expired GB1003092A (en) 1961-11-09 1962-11-01 Novel antibacterial substances

Country Status (2)

Country Link
FR (1) FR2980M (en)
GB (1) GB1003092A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256685A (en) * 1991-03-26 1993-10-26 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256685A (en) * 1991-03-26 1993-10-26 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives
US5334611A (en) * 1991-03-26 1994-08-02 Kyowa Hakko Kogyo Co., Ltd. 6-ethyl mitomycin derivatives

Also Published As

Publication number Publication date
FR2980M (en) 1964-12-07

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