GB1001996A - Method and apparatus for filling hypodermic syringes, ampules, etc - Google Patents
Method and apparatus for filling hypodermic syringes, ampules, etcInfo
- Publication number
- GB1001996A GB1001996A GB2832063A GB2832063A GB1001996A GB 1001996 A GB1001996 A GB 1001996A GB 2832063 A GB2832063 A GB 2832063A GB 2832063 A GB2832063 A GB 2832063A GB 1001996 A GB1001996 A GB 1001996A
- Authority
- GB
- United Kingdom
- Prior art keywords
- syringes
- liquid
- stoppers
- driven
- filling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B7/00—Closing containers or receptacles after filling
- B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
- B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
- B65B7/2821—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers applying plugs or threadless stoppers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2055—Connecting means having gripping means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2058—Connecting means having multiple connecting ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2068—Venting means
- A61J1/2075—Venting means for external venting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2079—Filtering means
- A61J1/2082—Filtering means for gas filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/008—Racks for supporting syringes or needles
Abstract
1,001,996. Filling and sealing containers. B-D LABORATORIES Ltd. July 17, 1963 [July 31, 1962], No. 28320/63. Heading B8T. In a method of and apparatus for filling and sealing a syringe or like container, the latter is initially charged with a predetermined quantity of liquid, a stopper is placed above its open top, the liquid surface is subjected to a vacuum and the stopper is then moved into the open top and into contact with the whole of the upper surface of the liquid in the container. The various operations take place within a sealed cabinet 20, Fig. 1, with windows 22, 24 and ports 23 spaced therearound, the latter leading into gloves for the hands and forearms of attendants to manipulate the parts within the cabinet. Liquid supply tubes lead from an auxiliary cabinet 27 to the main one whereby liquid is pumped to the syringes to be filled. The syringes are first placed in racks 35, Fig. 16, and introduced to the main cabinet at one end through doors 29. The racks also receive rubber or like stoppers 38, Figs. 7, 13, with peripheral grooves, aligned with and located above the stoppers. A conveyer may transfer the racks to a liquid filling station where each rack is supported between two hollow columns 55. An array of filling nozzles 69 is supported above the rack, one nozzle aligned with each syringe, by posts 53 extending through the columns. The lower ends of the posts engage cams on a shaft 63 which is driven via a one revolution clutch, whereby the posts and nozzle array are moved downwardly to bring the nozzles into the syringes and are then returned to their upper positions. During this stage the stoppers in the rack are moved out of alignment with the syringes. This drive automatically brings into operation a set of liquid dispensing units within the auxiliary cabinet 27, one unit per syringe, each unit comprising a piston or plunger 45, Fig. 8, within a cylinder 43 pivoted at 44. Each plunger is driven by an adjustable eccentric pin 46 on a motor-driven rotatable member 47, whereby a predetermined quantity of liquid is pumped via a line 49 to each filling nozzle 69 when the member 47 is driven through one revolution. The operation of the pistons and cylinders is such that an aspirating action occurs on the filling nozzles as they are withdrawn from the syringes, whereby dripping is prevented. Cylinders 43 of various sizes may be accommodated. Each rack with the filled syringes is then transferred to an evacuation station where the stoppers are applied. At this station a rack of filled syringes with overlying stoppers is mounted within a housing 80, and a vertically slidable closure panel 82 with a window 84 is then moved upwardly via a guideway 87, and then laterally against a seal 81 and against the action of spring-urged balls 89 by upwardly driven wedge members 90. The panel and wedges are driven via crank rods. A horizontal member 98 extends above the syringes and between rods 95<SP>1</SP>, and carries a series of push rods 110, one for each syringe. When the housing has been sealed and suction applied thereto through a tube 101<SP>1</SP>, the member 98 and rods 95<SP>1</SP> are driven downwardly by a crank rod whereby the rods 110 move pusher pins 112 into engagement with the stoppers and force them into the tops of the syringes and into contact with the liquid therein. The pusher pin assemblies are carried at the top of the housing, and each includes a secured bushing 104<SP>1</SP> with sealing rings, and through which a rod 110 extends. The lower end of each rod carries a sleeve 111 with a spring-urged pin 112 which, in operation, extends into a recess of a stopper. Pneumatic and electrical components which are switch operated control the operations of the various parts of the apparatus. The housing 80 may additionally be filled with one or more floodings of inert gases with intervening vacuum whereby to flush out harmful gases.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21374862 US3245194A (en) | 1962-07-31 | 1962-07-31 | Method and apparatus for filling hypodermic syringes, ampules, etc. |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1001996A true GB1001996A (en) | 1965-08-18 |
Family
ID=22796344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2832063A Expired GB1001996A (en) | 1962-07-31 | 1963-07-17 | Method and apparatus for filling hypodermic syringes, ampules, etc |
Country Status (4)
Country | Link |
---|---|
US (1) | US3245194A (en) |
DE (1) | DE1276871B (en) |
FR (1) | FR1367759A (en) |
GB (1) | GB1001996A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2476288A (en) * | 2009-12-18 | 2011-06-22 | Univet Res Ltd | Bucket conveyor and syringe filler |
CN111977593A (en) * | 2020-08-28 | 2020-11-24 | 任汉友 | Liquid cosmetic canning system and method |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3511022A (en) * | 1969-05-29 | 1970-05-12 | Pet Inc | Aseptic filling apparatus |
US3662517A (en) * | 1970-04-08 | 1972-05-16 | Sherwood Medical Ind Inc | Syringe filling apparatus |
US3708945A (en) * | 1971-01-06 | 1973-01-09 | Upjohn Co | Syringe assembling method and machine |
US3744209A (en) * | 1971-01-13 | 1973-07-10 | Dean Foods Co | Sterilized packaging system |
US4118914A (en) * | 1977-10-25 | 1978-10-10 | Shields Walter A | Vial assembler |
US4240242A (en) * | 1979-06-18 | 1980-12-23 | Grey Charles M | Sterile capping method for a plurality of I.V. bottles |
FR2556214B1 (en) * | 1983-12-08 | 1986-08-14 | Merieux Inst | PROCESS FOR THE SERIAL PREPARATION OF SELF-INJECTION SYRINGES CONTAINING A LYOPHILIZED MEDICAMENT AND DEVICE FOR CARRYING OUT SAID METHOD |
FR2583979B1 (en) * | 1985-07-01 | 1987-08-21 | Merieux Inst | PROCESS FOR THE SERIAL PREPARATION OF SELF-INJECTION SYRINGES IN A SEALED CONTAINER, FOR LYOPHILIZED MEDICINAL PRODUCT, AND DEVICE FOR CARRYING OUT SAID METHOD |
DE3613489A1 (en) * | 1986-04-22 | 1987-11-05 | Helmut Vetter | DEVICE FOR HANDLING PRE-FILLED SYRINGES |
DE3819095A1 (en) * | 1988-06-04 | 1989-12-07 | Ruchozki Manfred Dipl Ing Fh | FILLING AND SEALING MACHINE FOR DISPOSABLE SPRAYING |
US5884457A (en) * | 1997-02-05 | 1999-03-23 | Smithkline Beecham Corporation | Method and apparatus for automatically producing a plurality of sterile liquid filled delivery devices |
IT1291845B1 (en) * | 1997-04-30 | 1999-01-21 | Co Ri Ma S R L | DEVICE FOR CENTERING DISPOSABLE SYRINGE CYLINDERS IN AUTOMATIC FILLING AND PACKAGING MACHINES |
JP2005218899A (en) * | 2004-02-03 | 2005-08-18 | Toshiba Corp | Coating device and display device manufacturing apparatus provided with this |
US8141330B2 (en) * | 2004-05-20 | 2012-03-27 | KNAPP Logistics Automation, Inc. | Systems and methods of automated tablet dispensing, prescription filling, and packaging |
US20070169434A1 (en) * | 2006-01-26 | 2007-07-26 | Shawn Kinney | Process for aseptic vacuum filling and stoppering of low viscosity liquids in syringes |
WO2007089295A2 (en) * | 2006-01-26 | 2007-08-09 | Hyaluron, Inc. | Process for aseptic vacuum filling and stoppering of low viscosity liquids in containers |
DE102006039120B4 (en) * | 2006-08-21 | 2017-11-23 | Robert Bosch Gmbh | Filling machine with improved feed |
US8069582B2 (en) * | 2007-12-27 | 2011-12-06 | Daewoo Electronics Corporation | Dryer |
CN102574123B (en) * | 2009-08-10 | 2015-02-11 | 西部制药服务公司 | Apparatus and method for filling flangeless containers |
US10723497B2 (en) | 2014-11-03 | 2020-07-28 | Vanrx Pharmasystems Inc. | Apparatus and method for monitoring and controlling the filling of a container with a pharmaceutical fluid in an aseptic environment |
ES2718093T3 (en) * | 2013-08-16 | 2019-06-27 | Vanrx Pharmasystems Inc | Method to fill pharmaceutical containers |
FR3035331B1 (en) * | 2015-04-24 | 2017-04-07 | Nemera La Verpilliere | METHOD FOR CONTROLLING THE QUANTITY OF LIQUID DISTRIBUTED BY A NEEDLE INJECTION DEVICE |
USD797823S1 (en) * | 2015-06-01 | 2017-09-19 | Bobst Mex Sa | Bracket for a packaging machine |
USD844036S1 (en) * | 2015-09-14 | 2019-03-26 | Gorby LLC | Packaging machine |
US10926025B2 (en) * | 2016-09-15 | 2021-02-23 | Tandem Diabetes Care, Inc. | Vial supporter for medicament pump |
US20210362893A1 (en) * | 2020-05-22 | 2021-11-25 | Protocol Lab, LLC | Systems and methods for oxygen free packaging |
USD995589S1 (en) * | 2021-08-06 | 2023-08-15 | Robopac S.P.A. | Packaging machine |
CN116767554B (en) * | 2023-08-22 | 2023-10-20 | 成都中核高通同位素股份有限公司 | Serial multi-container equal-quantity split charging system and method for pertechnetate sodium |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE640979C (en) * | 1934-11-06 | 1937-01-16 | Felix Meyer | Procedure for opening and filling ampoules |
US2174745A (en) * | 1935-10-15 | 1939-10-03 | Liquid Carbonic Corp | Method and machine for filling containers |
US2130761A (en) * | 1938-04-04 | 1938-09-20 | Frederick E Bickford | Package treating machine |
US2353985A (en) * | 1938-11-07 | 1944-07-18 | Sharp & Dohme Inc | Preservation of biologically active substances |
US2517569A (en) * | 1945-11-23 | 1950-08-08 | Huzenlaub Erich Gustav | Process of extracting and preserving the original flavors and food value of fruit juices |
US2896381A (en) * | 1954-05-27 | 1959-07-28 | Hodes Lange Corp | Method and apparatus for treating and filling ampoules |
DE965156C (en) * | 1955-09-20 | 1957-06-06 | Espe Fabrik Pharm Praeparate G | Filling device for ampoules or the like. |
US2998686A (en) * | 1957-01-10 | 1961-09-05 | Pirro Raffaele | Apparatus for the closure under high vacuum of glass bottles and small bottles |
FR1248582A (en) * | 1959-01-23 | 1960-12-16 | Sandoz Ag | Device for cleaning, filling and sealing containers such as ampoules, for example |
US3110309A (en) * | 1960-08-15 | 1963-11-12 | Brunswick Corp | Plastic cartridge needle assembly |
-
1962
- 1962-07-31 US US21374862 patent/US3245194A/en not_active Expired - Lifetime
-
1963
- 1963-06-28 FR FR939804A patent/FR1367759A/en not_active Expired
- 1963-07-17 GB GB2832063A patent/GB1001996A/en not_active Expired
- 1963-07-30 DE DEB72911A patent/DE1276871B/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2476288A (en) * | 2009-12-18 | 2011-06-22 | Univet Res Ltd | Bucket conveyor and syringe filler |
GB2476288B (en) * | 2009-12-18 | 2014-05-14 | Univet Res Ltd | A method of manufacturing a medicinal product |
CN111977593A (en) * | 2020-08-28 | 2020-11-24 | 任汉友 | Liquid cosmetic canning system and method |
CN111977593B (en) * | 2020-08-28 | 2022-03-11 | 广州华狮化妆品科技有限公司 | Liquid cosmetic canning system and method |
Also Published As
Publication number | Publication date |
---|---|
DE1276871B (en) | 1968-09-05 |
FR1367759A (en) | 1964-07-24 |
US3245194A (en) | 1966-04-12 |
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