FR3116273B1 - Tétrapeptides, compositions les comprenant et leur utilisation cosmétique - Google Patents
Tétrapeptides, compositions les comprenant et leur utilisation cosmétique Download PDFInfo
- Publication number
- FR3116273B1 FR3116273B1 FR2011742A FR2011742A FR3116273B1 FR 3116273 B1 FR3116273 B1 FR 3116273B1 FR 2011742 A FR2011742 A FR 2011742A FR 2011742 A FR2011742 A FR 2011742A FR 3116273 B1 FR3116273 B1 FR 3116273B1
- Authority
- FR
- France
- Prior art keywords
- chosen
- xaa
- tetrapeptides
- skin
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002537 cosmetic Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 1
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 206010040925 Skin striae Diseases 0.000 abstract 1
- 208000031439 Striae Distensae Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000003712 anti-aging effect Effects 0.000 abstract 1
- 230000001153 anti-wrinkle effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004057 biotinyl group Chemical group [H]N1C(=O)N([H])[C@]2([H])[C@@]([H])(SC([H])([H])[C@]12[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000002744 extracellular matrix Anatomy 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 101150009274 nhr-1 gene Proteins 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000007665 sagging Methods 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Tétrapeptides, compositions les comprenant et leur utilisation cosmétique Tétrapeptide de formule X-(Xaa)nPG(Xaa)m-Z dans laquelle Xaa est un acide aminé choisi parmi A et V, les Xaa étant choisis indépendamment les uns des autres, soit n=2 et m=0, soit n=1 et m=1, avec en extrémité N-terminale X choisi parmi H, -CO-R1, -SO2-R1 ou un groupe biotinoyle ; en extrémité C-terminale Z choisi parmi OH, OR1, NH2, NHR1 ou NR1R2 ; et R1 et R2 étant, indépendamment l’un de l’autre, choisis parmi un groupe alkyle, aryle, aralkyle, alkylaryl, alkoxy, saccharide et aryloxy, pouvant être linéaire, ramifié, cyclique, polycyclique, insaturé, hydroxylé, carbonylé, phosphorylé et/ou soufré, ledit groupe ayant de 1 à 24 atomes de carbone et pouvant posséder dans son squelette un ou plusieurs hétéroatomes O, S et/ou N. Les séquences peptidiques préférées sont X-AVPG-Z et X-VPGA-Z.Ces tétrapeptides stimulent la synthèse des molécules constituant la matrice extracellulaire dermique, notamment le collagène 1 et 4 et la fibronectine, et peuvent être utilisés pour un traitement cosmétique notamment anti-âge, anti-rides et ridules, pour améliorer les propriétés mécaniques de la peau, fermeté/tonicité/élasticité/souplesse, pour augmenter la densité et le volume de la peau, pour un effet restructurant et/ou pour lutter contre les vergétures, et/ou pour lutter contre l’affaissement cutané.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR2011742A FR3116273B1 (fr) | 2020-11-17 | 2020-11-17 | Tétrapeptides, compositions les comprenant et leur utilisation cosmétique |
CN202180077315.4A CN116615176A (zh) | 2020-11-17 | 2021-11-15 | 四肽、包含其的组合物及其美容用途 |
EP21810355.4A EP4247835A1 (fr) | 2020-11-17 | 2021-11-15 | Tétrapeptides, compositions les comprenant, et leur utilisation cosmétique |
PCT/EP2021/081723 WO2022106365A1 (fr) | 2020-11-17 | 2021-11-15 | Tétrapeptides, compositions les comprenant, et leur utilisation cosmétique |
KR1020237020301A KR20230110549A (ko) | 2020-11-17 | 2021-11-15 | 테트라펩타이드, 이를 포함하는 조성물, 및 이의 화장품 용도 |
US18/035,860 US20230399359A1 (en) | 2020-11-17 | 2021-11-15 | Tetrapeptides, compositions comprising them, and their cosmetic use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR2011742 | 2020-11-17 | ||
FR2011742A FR3116273B1 (fr) | 2020-11-17 | 2020-11-17 | Tétrapeptides, compositions les comprenant et leur utilisation cosmétique |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3116273A1 FR3116273A1 (fr) | 2022-05-20 |
FR3116273B1 true FR3116273B1 (fr) | 2023-10-27 |
Family
ID=74045915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR2011742A Active FR3116273B1 (fr) | 2020-11-17 | 2020-11-17 | Tétrapeptides, compositions les comprenant et leur utilisation cosmétique |
Country Status (6)
Country | Link |
---|---|
US (1) | US20230399359A1 (fr) |
EP (1) | EP4247835A1 (fr) |
KR (1) | KR20230110549A (fr) |
CN (1) | CN116615176A (fr) |
FR (1) | FR3116273B1 (fr) |
WO (1) | WO2022106365A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3136172A1 (fr) * | 2022-06-07 | 2023-12-08 | L V M H Recherche | Composition anti-âge avec extraits de rose et peptides |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6069129A (en) * | 1998-03-13 | 2000-05-30 | Mrs, Llc | Elastin derived composition and method of using same |
AU2001275018B2 (en) * | 2000-05-30 | 2008-04-03 | Connective Tissue Imagineering Llc | Composition and method for enhancing elasticity of tissue |
US6794362B1 (en) * | 2000-05-30 | 2004-09-21 | Connective Tissue Imagineering Llc | Asparagine containing elastin peptide analogs |
US8318678B2 (en) * | 2008-05-30 | 2012-11-27 | Jan Marini Skin Research | Cosmetic compositions |
EP2623097B1 (fr) * | 2012-02-01 | 2015-07-15 | Samsung Electronics Co., Ltd | Nanoparticules lipidiques solides comprenant des polypeptides semblables à de l'élastine et son utilisation |
FR2998570B1 (fr) | 2012-11-26 | 2016-12-02 | Sederma Sa | Peptides, compositions les comprenant et utilisations notamment cosmetiques propigmentantes |
FR3021319B1 (fr) | 2014-05-22 | 2018-08-31 | Sederma | Peptides, compositions les comprenant et utilisations notamment cosmetiques |
FR3029782B1 (fr) | 2014-12-16 | 2019-06-07 | Sederma | Composes peptidiques, compositions les comprenant et utilisations notamment cosmetiques |
FR3052453B1 (fr) | 2016-06-14 | 2018-05-18 | Sederma | Peptide, composition le comprenant et utilisations notamment cosmetiques |
-
2020
- 2020-11-17 FR FR2011742A patent/FR3116273B1/fr active Active
-
2021
- 2021-11-15 WO PCT/EP2021/081723 patent/WO2022106365A1/fr active Application Filing
- 2021-11-15 CN CN202180077315.4A patent/CN116615176A/zh active Pending
- 2021-11-15 KR KR1020237020301A patent/KR20230110549A/ko unknown
- 2021-11-15 US US18/035,860 patent/US20230399359A1/en active Pending
- 2021-11-15 EP EP21810355.4A patent/EP4247835A1/fr active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4247835A1 (fr) | 2023-09-27 |
WO2022106365A1 (fr) | 2022-05-27 |
US20230399359A1 (en) | 2023-12-14 |
KR20230110549A (ko) | 2023-07-24 |
CN116615176A (zh) | 2023-08-18 |
FR3116273A1 (fr) | 2022-05-20 |
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