FR3092991A1 - Device for administration and collection of liquid for nasal purposes. - Google Patents

Abstract

Device for administering and withdrawing liquid for nasal purposes comprising: an administration circuit 100 connected to a nostril of a patient, capable of containing a liquid 103 and of administering it into the nose under the effect of manual pressure, - a sampling circuit 200, connected on the one hand to the second nostril of the patient and on the other hand to a suction source, According to the invention, it also comprises a connection means 300 suitable to join the two circuits 100 and 200 together so that the user is able, with one hand to administer the liquid 103 in one nostril, and withdraw it by the other, the administration of liquid taking place separately or from simultaneously with the suction. Figure for the abstract: Fig. 5

Description

Device for administering and withdrawing liquid for nasal purposes.

The present invention relates to a device designed to administer and withdraw a liquid, whether or not loaded with substances, in the ENT sphere.

It is intended for hygiene, irrigation, treatment and care of the nasal cavities, and more particularly for clearing those of a young child or a disabled person by acting as a baby fly-irrigator.

The accumulation of phlegm in the nasal passages of a child is problematic because it prevents him from breathing normally (this is especially true for babies under one year old who cannot breathe through their mouth). In addition, their stagnation promotes bacterial proliferation with the risk of contamination extended to the entire ENT sphere (otitis for example).

The evacuation of phlegm in young children up to three years old, when they have generally acquired autonomy in the gesture of blowing their nose, can be carried out with a baby nasal aspirator. The treatment consists in generating a depression in a nostril in order to extract the mucus which hinders the respiratory flow.

There are different types of baby fly:

- the oral suction baby nasal aspirator, comprising a pipe connected to the mouth of the user, a nosepiece and a reservoir intended to collect the mucus extracted from the nostril under the effect of the user's suction. It may also include a filter to prevent the passage of mucus into the suction tube.

- the deformable bulb baby nasal aspirator. After deformation by the user, the return to position of an elastic element generates suction in order to extract mucus and collect it in a reservoir.

- the electric baby nasal aspirator which, by means of an electric pump, generates a vacuum to collect mucus in a reservoir.

These devices are widely used, however it must be recognized that in the event of severe obstruction or dry phlegm, the result is not always there. In addition, too frequent use of a suction device without moistening the nasal cavities leads to their irritation.

For this reason, aspiration into the nostril is often preceded by a spraying or instillation of physiological serum, which however requires successively introducing the tip of the bottle into each nostril, then the suction tip. , operations that take time and contribute to the nervousness of the child.

Many devices, such as the one described in document EP 1584 340 A1, allow the liquid to be sprayed and then sucked up through the same nozzle, but the operation must however be repeated on the second nostril. In addition, as the liquid is aspirated through the same nostril, it does not penetrate deeply into the nasal cavities, thereby reducing its impact on the evacuation of mucus.

Another method consists of first administering an appropriate liquid (physiological serum, sea water, etc.) into one nostril in order to soften the phlegm and, secondly, letting the liquid flow out the other nostril, or It is good to suck it in with a baby nasal aspirator, the child's head being kept tilted to the side to facilitate its evacuation and limit the penetration of liquid into the back of the throat. The treatment is repeated for the other nostril. However, if the care is badly done, the liquid can flow into the child's throat, which he does not really appreciate and makes the operation very difficult to repeat.

A much more effective variant consists of instilling liquid into a nostril and closing the child's mouth to force him to expel the air contained in the lungs through his nose and thus evacuate the liquid and mucus. Alas, this care is a little tricky to implement and it is therefore little practiced.

The administration of a liquid in one nostril and its aspiration by the other is a therapy recognized for its effectiveness.

This treatment is known as the "Proetz displacement method" and consists of administering the liquid into a first nostril with a pipette held in one hand and then withdrawing it into the second nostril through a source of electric suction held in the other hand and generally slaved to a foot control. The treatment requires a lot of precautions on the part of the user because it is essential, under penalty of serious trauma, to control the value of the depression applied in the ENT sphere of the patient. In addition, for the depression to be established, it is necessary for the patient to keep the soft palate sealed (for example by pronouncing the phoneme "KéKéKé"), thus isolating the nasopharynx from the throat. In fact, this method is not applicable to children under 4 years old, or to disabled people, unable to voluntarily seal their soft palate.

Various documents describe devices for irrigating both nostrils simultaneously.

Document GB 178630 describes an administration device comprising, connected to a common reservoir:

-An administration circuit, connectable in a sealed manner to a nostril of the user and capable of containing a liquid and,

-A sampling circuit, connectable in a sealed manner to the user's second nostril,

-An input circuit connected to the mouth of the user.

With this device, the liquid solution is administered in one nostril by the action of the pressure delivered by the breath of the user, and its excess reaching the other nostril returns to the reservoir via the sampling circuit. Blowing automatically closes the soft palate, so the liquid does not pass into the throat. The device therefore operates in a closed circuit, which leads to obtaining a sampling rate identical to the administration rate and, moreover, subordinate to the latter.

However, it is impossible to apply such a device to a child or a disabled person, since they are unable to blow voluntarily or close the soft palate.

The device needs to be in a vertical position to work well, a position that is difficult to reconcile with pediatric care.

Document US 1,502,163 A describes a device comprising:

-An administration circuit, connectable in a sealed manner to a nostril of the user and capable of containing a liquid and,

- A sampling circuit, connectable in a sealed manner to the user's second nostril and to a suction bulb, circuit capable of collecting liquid from the nasal cavities.

It also includes a shutter manipulated by the user and able to vent the administration circuit. By activating the bulb, the user generates a depression in the sampling circuit which allows the liquid present in the administration circuit to be sucked up. The device therefore operates in a closed circuit, which leads to obtaining an administration flow rate identical to the suction flow rate and, moreover, subordinate to the latter.

In addition, the device needs to be in a vertical position to function properly, a position that is difficult to reconcile with pediatric care.

The document EP 2389918 filed in the name of the applicant describes a device administering a liquid in a first nostril while withdrawing it through the other thanks to the mobilization of a separation means which can be constituted by the piston of a syringe or by a deformable membrane. This device works in a closed circuit, without an external source of suction, which makes it possible, by a phenomenon of surface tension, to limit the penetration of liquid into the throat, in particular in children, on the condition, however, of having a seal. perfect at the level of the nostrils, which is not always easy to obtain if the child struggles. In addition, the administration of liquid is subordinated to a transfer of fluid in the sampling circuit, which deprives the user of the possibility of administering the liquid and then of suspending the operation during the aspiration phase.

The applicant's approach was therefore to reconsider the traditional methods of nasal unblocking and to find out whether it would be possible to obtain a device making it possible to irrigate and extract mucus from both nasal cavities at the same time, in complete safety, the two operations occurring simultaneously or offset in time, avoiding the penetration of liquid into the back of the throat regardless of the position of the head of the recipient of the treatment, device in addition operating with one hand, in particular to be able to be used by a single operator, who must at the same time ensure the maintenance of the beneficiary of the treatment.

This is what the invention proposes, using known means, namely:

- an administration circuit, intended to be connected to a nostril of the recipient of the treatment by means of a nasal administration nozzle, and capable of containing a liquid and of administering it into the nose under the effect of manual pressure,

- a sampling circuit, intended to be connected, on the one hand, to the second nostril of the recipient of the treatment by means of a sampling nosepiece, and on the other hand, by means of a connection means , to a source of suction with a flow controlled by the operator or the recipient of the treatment, a sampling circuit also able to collect the liquid coming from the ENT sphere of the recipient of the treatment.

The device according to the invention further comprises a connecting means, capable of bringing the two circuits together so that the recipient of the care or the operator is able, with one hand, both to hold the device, to position it in the nose, independently of any other external support, and by manual pressure, to administer the liquid in one nostril, whatever the position of the head of the recipient of the care, and to withdraw it by the other, possibly responsible for bodily elements, the administration of liquid taking place separately or simultaneously with the aspiration, the flow of administration of the liquid, adjustable by the operator or the beneficiary of the treatment, being independent of that of the aspiration.

Thus, the user can, with one hand, carry out complete care of the patient's nasal cavities by simultaneously evacuating the mucus located in the two nasal cavities, in complete safety, by suction capable of generating a depression, without however reach dangerous values for the recipient of the care. With his free hand, he can, during the treatment, hold the patient, which often proves to be an essential condition in the case of a young child, because he does not appreciate the operation, and he shows by crying and gesticulating. One of the solutions used by practitioners consists in keeping the child's head on the side with the hand while the forearm immobilizes the body. It is almost impossible to carry out this type of treatment without firm support for the child. It is also interesting to be able to use the device regardless of the position of the patient's head, the treatment can thus be carried out indifferently in a lying or sitting position. The device, through simultaneous aspiration, prevents the penetration of liquid into the throat and therefore makes the operation less traumatic for the patient, thus facilitating its reiteration.

In an alternative embodiment, the device comprises a pipe and a mouthpiece so that the operator or the recipient of the treatment can generate oral suction. The device thus does not require any energy source other than that supplied by the user. In addition, oral suction is particularly well suited here because it makes it possible to generate a flow of air controlled by the operator, without manual action, with a high peak flow rate, while remaining within depression values that are not dangerous for the patient.

In another configuration, suction is provided by an electric pump. Thus the user is exempted from sucking into the device, the operation can sometimes be inconvenient. This configuration also makes it possible to carry out, in adults, operations to evacuate bodily elements, such as scabs, particularly in the case of post-surgical care.

In an alternative embodiment, the connecting means is capable of modifying and maintaining the position of the administration and sampling circuits between them. Thus, the device is able to allow the adjustment of the position of the nasal prongs to adapt to the nasal morphology of the patient and also to provide ergonomics such that it can be manipulated by a right-handed or left-handed user.

In a preferred embodiment of the invention, the device comprises at least one single-dose type pipette initially filled with liquid. Thus, the liquid contained in the pipette is administered directly into the nostril, and a previously used pipette acts as a disposable collection reservoir.

In an alternative embodiment, the administration circuit consists of a means capable of delivering the liquid in the form of droplets, fine jets, aerosols or fine particles, such as a spray, mechanical or under pressure. This configuration allows the use of an accessory already present on the market and capable of carrying out numerous liquid administrations without replacement intervention.

Other characteristics and advantages of the invention will emerge from the following description with reference to the appended drawing, schematically representing several embodiments, and in which:

illustrates the schematic representation of the ENT sphere.

illustrates the circulation of liquid in the ENT sphere during irrigation with the soft palate closed.

illustrates the case of administration of liquid into one nostril when the soft palate is open and suction is applied to the second nostril.

illustrates an embodiment with the use of a reserve of deformable liquid associated with oral aspiration.

represents a preferred embodiment of the invention using two pipettes of the single-dose type.

shows an embodiment in which the transfer of liquid in the administration circuit is ensured by a piston.

illustrates an alternative embodiment using a spray with a mechanical action, with a connecting means offering the possibility of obtaining a variable position between the two ducts intended for the nostrils.

illustrates an alternative embodiment with a spray of the pressurized type.

illustrates a configuration in which suction is provided by an electric pump.

In the description, the terms patient or beneficiary of the care designate the person to whom the care is provided. The terms operator or user designate the person providing the care, who can also perform the care for themselves.

The nasopharynx, from a fluidic point of view, can be schematized by a Y as illustrated in figure 1. The nostrils 1 and 2 serve as entrances to the nasal fossae 3 and 4, the latter joining in the cavum 5. The nasopharynx can be isolated from the mouth by closing the soft palate 6, which communicates with the back of the throat. The retrovelar space 7 corresponds to the diameter of the larynx.

Figure 2 illustrates the flow of fluid when administered through one nostril and withdrawn through the second, with the patient's soft palate sealed, usually by asking the patient to pronounce the phoneme “KéKéKé”. The liquid then passes through the two nasal fossae and because the connection to the nose is tight, it is necessary to control the flow rates applied to each nostril to prevent a pressure differential detrimental to the patient from being established in the ENT sphere.

Figure 3 illustrates fluid circulation when the soft palate is open. In order to prevent it from entering the throat, it is then necessary to apply suction with a flow rate greater than or equal to that of the liquid administered and such that it can generate a flow of air capable of entraining the said liquid and any phlegm outside the nasal cavities. This sampling rate is mainly a function of that of the administered liquid, of the passage diameter corresponding to the retrovelar space and of the air inlet present at the level of the administration nostril or that of the sampling in the event of absence of sealing. In the event of nasal obstruction, aspiration also makes it possible to generate a depression capable of freeing the congested passage. When liquid is administered in the form of fine droplets, the air flow entrains them according to the same principle. It is of course possible to collect the liquid outside the administration phase.

Figure 4 shows the device consisting of an administration circuit 100, a sampling circuit 200 and a connection means 300.

The administration circuit 100 consists of an administration reserve 101, deformable by manual pressure and capable of containing a liquid 103 charged or not with treatment substances, connected in its upper part to a first nostril of the beneficiary of the treatment by a administration duct 102, inclined relative to the vertical at an angle of between 0° and 60°, and provided at its end with an administration nose piece 110, preferably flexible and deformable. The administration reserve 101, advantageously made of viscoelastic material, comprises lateral bellows to facilitate its axial deformation.

The sampling circuit 200 comprises a collection reservoir 201 connected to the second nostril of the patient via a sampling conduit 202 inclined with respect to the vertical by an angle comprised between 0° and 60° and fitted at its end of a sampling nosepiece 210, preferably flexible and deformable and capable of being connected in a sealed manner. The collection tank 201 accommodates in its lower part a shutter 203 intended to provide a tight closure, the said shutter 203 comprising a suction conduit 204 capable of containing a filtration means 205, for example a cellular foam. A connection means 220 allows the connection with the mouth of the operator or that of the beneficiary of the treatment. It consists of a connector 221 sealed at one end with the lower part of the suction duct 204, for example by clamping, and connected at the second end to a suction pipe 222 fitted with a mouthpiece 223.

The connecting means 300 provides a solid assembly of the administration circuit 100 and the sampling circuit 200, advantageously by a form resulting from molding uniting and immobilizing by adjustment the two conduits 102 and 202. The connecting means 300 makes it possible to ensure the position of the two fingers (index and middle fingers) while the thumb is positioned on the bottom of the administration reserve 101.

After filling the administration reserve 101 with the appropriate liquid 103 and keeping the patient in a favorable position with his arm or his free hand in the case of pediatric use, the operator positions his other hand on the device, thumb on the bottom of the administration reserve 101, index and middle fingers on the connecting means 300, similar to the positioning of the fingers on a syringe. The mouthpiece 223 held between the lips, it then simultaneously introduces the two nosepieces 110 and 210 into the nostrils of the recipient of the treatment, without any other external support. By exerting a push on the administration reserve 101, the operator administers the liquid 103 in the corresponding nostril and, simultaneously or after having suspended its delivery, he draws in the sampling circuit 200 to collect it in the collection reservoir 201 , possibly loaded with phlegm from the nasal cavities, without having to change the position of his fingers on the device. He can start the treatment again at his leisure without changing his position. He also has the possibility of precisely metering the flow rate and the quantity of liquid 103 administered by modulating the pressure exerted on the administration reserve 101, separately or simultaneously with aspiration, the liquid administration flow being independent from that of aspiration.

If the sampling flow is sufficient, the treatment is effective regardless of the position of the patient's head because by opposing the gravity of the liquid 103, it prevents it from entering the throat. Sustaining the suction after the administration phase makes it possible to evacuate the residual liquid corresponding to the volume of the nasal cavities.

A preferred embodiment is illustrated by FIG. 5 in which the administration circuit 100 is a pipette of the single-dose type, of a design that is otherwise well known, forming both the administration reserve 101 and the nasal tip. administration 110, pipette deformable by manual pressure and pre-filled in a sterile manner with the liquid 103 to be administered. The collection reservoir 201 also consists of a single-dose pipette, previously used and whose orifice has been enlarged, for example by cutting or by introducing a rod of greater diameter, in order to facilitate the passage of mucus. The suction duct 204 comprises a sealing means 208 able to perforate the bottom of the collection reservoir 201 (the single-dose pipette), like a trocar, and able to provide a sealed connection with the latter. The filtration means 205 is positioned in the suction duct 204, the latter being closed off by the shutter 203. The latter is a part resulting from plastic injection also comprising the connector 221 itself connected in a sealed manner to the pipe. suction 222 and the mouthpiece 223.

The connecting means 300, advantageously one-piece and made of viscoelastic material, comprises two holding elements 305, such as molded clamps or clips, capable of providing a removable connection with each circuit 100, 200 in order to be able to put them in place or get out while keeping them attached to said connecting means 300 during the treatment. The latter also comprises two stop elements 306 capable of blocking the translation of the circuits 100 and 200 so that they do not slide down the device during its use.

The operator uncaps the single-dose pipette constituting the administration reserve 101, inserts it into the connecting means 300, after having taken care to place a single-dose pipette, empty, on the suction conduit 204 by pressing it downwards so that its lower part is pierced by the sealing means 208. By controlled manual pressure on the administration reserve 101, he is able to administer the liquid 103 and to proceed with the care as described above.

FIG. 6 illustrates a configuration in which the administration reserve 101, such as a syringe body, allows movement of a mobilization means 150 capable of generating the transfer of the liquid 103 into the administration circuit 100. The means of mobilization 150 consists of a piston 155 integrally connected to a rod 152 sliding in a bearing 151 provided in the lower part of the administration reserve 101 for guiding purposes, said mobilization means 150 having, to be actuated, a manipulation element 153 intended to allow the support of the thumb.

A nozzle 104, such as a nozzle, capable of administering the liquid 103 in the form of a spray, droplets or fine jets, is positioned in the administration duct 102, advantageously close to the nasal administration nozzle 110.

It will be noted that several nozzles 104 can be arranged in the administration duct 102.

The administration circuit 100 is therefore in the form of a syringe, advantageously pre-filled with the liquid 103.

The operator exerts manual pressure on the manipulation element 153 to administer the liquid 103 in the form of fine droplets and collect them, possibly in association with mucus.

Depending on the diameter of the nozzle 104, the mobilization means 150, identical to a syringe, makes it possible to aspirate the liquid 103 through the nasal administration nozzle 110, from an additional container, for then deliver it to the patient. It thus makes it possible to establish the transfer of the liquid 103 into the administration circuit 100, either by aspiration or by administration.

FIG. 7 illustrates an embodiment in which the administration circuit 100 consists of a device capable of delivering the liquid 103 in the form of a spray, droplets, fine particles, aerosols or fine jets, such as a nasal spray. This can be of the mechanical type, as illustrated, i.e. comprising a pump actuated by manual pressure, or else be in the form of a pressurized container provided with a valve actuated by manual pressure. These devices are of a design known elsewhere and in widespread use.

These therefore comprise an administration nosepiece 110, a nozzle 104 and an administration reserve 101 filled with liquid 103.

Note that once initiated, the spray can deliver at least one puff, regardless of its orientation.

The connecting element 300 comprises an orifice 307 capable of allowing the passage and optionally capable of holding the nasal administration nozzle 110 by adjustment. The orifice 307 also allows the rotation of the connecting means 300 around the nasal nozzle of administration 110 in order to be used indifferently by a right-handed or left-handed operator.

The connecting means 300 is capable of taking a shape and keeping it in order to modify and maintain the position of the two circuits 100 and 200, and consequently of the two nosepieces 110 and 210, relative to each other. To achieve this, it consists of a strip comprising two metal wires embedded in a viscoelastic material, the whole thus giving it shape memory. It has mechanical characteristics allowing it to be deformed by the user without the aid of tools while maintaining the position thus obtained throughout the treatment.

After having deformed the connecting means 300 to his liking, the user positions the two circuits 100 and 200 and more particularly the two nosepieces 110 and 210 so that they adapt well to the nostrils of the patient, and then he delivers a liquid dose 103 in the form of droplets or fine jets by exerting pressure on the lower part of the nasal spray.

FIG. 8 illustrates a configuration in which the administration circuit 100 is a nasal spray of the pressurized type, therefore capable of containing a volume of pressurized gas. The connecting means 300 consists of two holding elements 305, two clip-type clamps, assembled head to tail and intended to removably hold the administration circuit 100 through the nasal tip 110 and the sampling circuit 200 through the collection reservoir 201. The two holding elements 305 advantageously form a single and same part resulting from molding. Depending on whether he is right-handed or left-handed, the operator will position the sampling circuit 200 to the left or to the right of the administration circuit 100. By simple pressure on the administration nosepiece 110, the operator proceeds to liquid administration 103.

It will be noted that the connecting means 300 could in the same way be secured to the sampling nasal tip 210 and include a clamp for holding the administration circuit 100 or vice versa.

The connecting means 300 can also take the form of a single piece resulting from plastic injection including the two nosepieces 110 and 210.

FIG. 9 illustrates an alternative embodiment in which the suction is generated by a suction means 400 consisting of a body 401 housing an electric pump 404 powered by an energy source 403, such as batteries. The electric pump 404 comprises in its upper part a suction channel 405 intended to be connected to the connector 221, the latter comprising an O-ring 224, to reinforce the seal. The electric pump 404 also comprises a discharge channel 406, lateral, emerging in the open air. A control element 402 allows the operator to start or stop the electric pump 404 by establishing or interrupting the electrical connection with the energy source 403. The suction means 400 is of a well-designed design. known, advantageously, it corresponds to an electric baby fly pump able to generate a pneumatic depression, limited to -500 mb in order to avoid possible barotraumas.

The connecting means 300 is assembled integrally by any suitable fastening element on the upper part of the suction means 400. Advantageously, it forms an integral part of the body 401. It is also able to hold the circuit integrally administration 100 through the base of the administration reserve 101 and the sampling circuit 200 through the obturator 203, the assembly thus formed constituting a device held in one hand. The control element 402 is positioned so that it can be actuated by at least one finger of the user, for example the index or middle finger, while the thumb exerts pressure on the administration reserve 101. Thus, the user can establish a suction flow in the sampling circuit 200 at any time during the treatment, simultaneously or separately from the administration of liquid, the suction flow being independent of that of administration and vice versa.

It emerges from the foregoing that the device according to the invention is intended to facilitate the treatment, and more particularly the irrigation and extraction of mucus in a patient, by offering a single operator the possibility of providing complete care of the nasal cavities. It is particularly suitable when the soft palate cannot be closed voluntarily, for example for very young children or people who are not independent, as well as in the case of velopharyngeal insufficiency.

It also finds its place in the treatment of post-surgical care in adults by allowing the drainage of body elements, such as crusts resulting from the healing of wounds.

Claims (12)

Device for administering and withdrawing liquid for nasal purposes comprising:
- an administration circuit (100), intended to be connected to a nostril of the care recipient by means of an administration nosepiece (110), and suitable for containing a liquid (103) and for administering it in the nose under the effect of manual pressure,
- a sampling circuit (200), intended to be connected on the one hand, to the second nostril of the recipient of the care by means of a sampling nosepiece (210) and on the other hand, by means of a means of connection (220), to a source of aspiration with a flow controlled by the operator or the beneficiary of the care, sampling circuit (200) further able to collect the liquid (103) coming from the ENT sphere of the care recipient,
characterized in that it also comprises a connecting means (300), configured to join the two circuits (100) and (200) together so that the beneficiary of the care or the operator is able, with a single hand, to the time of holding the device, positioning it in the nose, independently of any other external support, and by manual pressure, of administering the liquid (103) into a nostril, regardless of the position of the head of the recipient of the treatment, and withdraw it by the other, possibly loaded with body elements, the administration of liquid taking place separately or simultaneously with the aspiration, the flow of administration of the liquid (103), adjustable by the operator or the beneficiary of the care, being independent of that of the aspiration. Administration device according to Claim 1, characterized in that the connection means (220) comprises a suction pipe (222) and a mouthpiece (223). Administration device according to Claim 1, characterized in that it comprises an electric suction means (400), connected to the connection means (220) and configured to generate suction in the sampling circuit (200). Administration device according to Claim 1, 2 or 3, characterized in that the connecting means (300) is configured to modify and maintain the position of the two circuits (100) and (200) relative to each other. . Administration device according to any one of the preceding claims, characterized in that the connecting means (300) comprises at least one holding element (305) configured to provide a removable connection with one of the two circuits (100,200). Administration device according to any one of the preceding claims, characterized in that it comprises an administration reserve (101) configured to be deformed by manual pressure. Administration device according to any one of the preceding claims, characterized in that it comprises at least one pipette of the single-dose type. Administration device according to the preceding claim, characterized in that the sampling circuit (200) comprises a sealing means (208) configured to provide a sealed connection with a pipette of the single-dose type. Administration device according to any one of the preceding claims, characterized in that the administration circuit (100) comprises at least one nozzle (104) configured to administer the liquid (103) in the form of a spray, droplets or jets purposes. Administration device according to one of Claims 1 to 5 in combination with Claim 9, characterized in that the administration circuit (100) consists of a device configured to deliver a liquid in the form of aerosols or particles thin, like a nasal spray. Administration device according to one of Claims 1 to 5 in combination with Claim 9, characterized in that it comprises mobilization means (150) configured to establish the transfer of the liquid (103) into the administration circuit ( 100). Administration device according to any one of the preceding claims, characterized in that the connection means (300) comprises at least one element (305, 307) configured to ensure the mechanical connection with the administration nosepiece (110) .