FR3084999A1 - Tris (hydroxymethyl) aminomethane or salts thereof as active substance (s) for reducing the secretion of sweat - Google Patents

Abstract

The present invention relates to an antiperspirant composition for the local treatment of the skin, comprising tris (hydroxymethyl) aminomethane or salts thereof in an aqueous or hydroalcoholic support, the antiperspirant composition having a pH ranging from 3 to less than 7. The invention further relates to the use of tris (hydroxymethyl) aminomethane or salts thereof as an antiperspirant active substance (s) in an antiperspirant composition for the local treatment of the skin.

Description

Description

Title of the invention: Tris (hydroxymethyl) aminomethane or salts thereof as active substance (s) for reducing the secretion of sweat The present invention relates to an antiperspirant composition for the local treatment of skin, comprising tris (hydroxymethyl) aminomethane or salts thereof in an aqueous or hydroalcoholic support. The present invention further relates to the use of tris (hydroxymethyl) aminomethane or salts thereof as an antiperspirant active substance (s) in an antiperspirant composition for the local treatment of the skin.

Body odors come largely from the bacterial decomposition of the various constituents of perspiration on the skin. Essentially, in terms of body deodorization, a distinction can be made between, on the one hand, active substances which absorb (activated carbon, zinc ricinoleate, cyclodextrins, ion exchangers) or mask (aromatic substances, perfumes ) the smelly substances already formed, and, on the other hand, the active substances which prevent, or at least slow down, the breakdown of perspiration and the formation of smelly substances (active substances inhibiting germs, constituents with prebiotic effect and inhibitors of enzymes). Depending on the mechanism chosen to prevent body odor, it is possible to use, as cosmetic deodorant active substances, odor absorbers, aromatic substances, deodorizing ion exchangers, germ inhibitors, constituents with a prebiotic effect. , enzyme inhibitors and other active substances. The active substances must be included in the compositions, and it should be ensured that the compositions can be easily supplied in a desired presentation form and that the compositions do not cause an unpleasant sensation on the skin.

Moisture under the armpits is caused by liquid and aqueous sweat and often results in unwanted wet spots on clothing.

[0004] The cosmetic antiperspirants used in the prior art contain, as antiperspirant active substances, aluminum and / or zirconium compounds. These antiperspirant compounds on the one hand reduce the secretion of sweat by the body by temporarily shrinking and / or obstructing the excretory ducts of the sweat glands, so that the amount of sweat can be reduced by about 20 to 60%. On the other hand, due to their antimicrobial effect, they exhibit an additional deodorant effect. However, the aluminum and / or zirconium compounds used to inhibit sweating can cause unpleasant skin reactions in some users. Aluminum compounds, in particular, are critical to consumers. In addition, the use of the above-mentioned antiperspirant compounds may cause the appearance of stains on clothing, linked to the products used.

It is therefore necessary to use, instead of the commonly used aluminum and / or zirconium compounds, other antiperspirant cosmetic active substances, or at least to significantly reduce the amount of these compounds. The antiperspirant active substances must have a good antiperspirant effect, good compatibility with the skin and ease of formulation. In addition, these antiperspirant active substances must have no negative impact on the storage stability of the cosmetic agents used to inhibit perspiration.

The present invention aimed to develop active antiperspirant substances whose use avoids, or at least mitigates, the drawbacks of the prior art, and whose use results in a high skin tolerance while reliably reducing underarm humidity.

The problem underlying the invention is resolved by the subject of claim 1. A first subject of the invention is therefore an antiperspirant composition for the local treatment of the skin comprising tris (hydroxymethyl) aminomethane or salts thereof in an aqueous or hydroalcoholic support, the antiperspirant composition having a pH in the range of 2.5 to less than 7.

[0008] Tris (hydroxymethyl) aminomethane is also abbreviated THAM or

HO.

OH nh ₂ called tromethamine or trometamol (INN). Chemically, it is a primary amine with three alcoholic hydroxyl groups. The amino group can be protonated with acids to form the corresponding salts (hydrochlorides, hydrogen sulfates, lactates, citrates, etc.).

It has been found, surprisingly, that tris (hydroxymethyl) aminomethane in aqueous solution in an acidic pH range has an effect of reducing perspiration. In particular, tris (hydroxymethyl) aminomethane in the form of the hydrochloride has proved to be particularly advantageous. When the aqueous solution is adjusted to an acidic pH with hydrochloric acid, the antiperspirant composition is particularly effective. According to a preferred embodiment of the present invention, the antiperspirant composition has a pH in the range of 3.2 to less than 6, preferably 3.5 to 5.8, more preferably 4.0 at 5.5.

According to a preferred embodiment of the present invention, the antiperspirant composition contains tris (hydroxymethyl) aminomethane and / or salts thereof in a total amount ranging from 0.1 to 30% by weight, preferably from 1 to 15% by weight, more preferably from 5 to 10% by weight, relative to the total weight of the antiperspirant composition. In this area, tris (hydroxymethyl) aminomethane has been found to be particularly advantageous.

In summary, we prefer the antiperspirant compositions according to the invention which contain tris (hydroxymethyl) aminomethane and / or salts thereof in a total amount ranging from 0.1 to 30% by weight , preferably from 1 to 15% by weight, more preferably from 5 to 10% by weight, relative to the total weight of the antiperspirant composition, and / or are characterized in that the antiperspirant composition has a pH situated in the range from 3.2 to less than 6, preferably from 3.5 to 5.8, more preferably from 4.0 to 5.5.

The expression "tris (hydroxymethyl) aminomethane and / or salts thereof in a total amount ranging from 0.1 to 30% by weight" means that the compositions according to the invention may contain - only tris (hydroxymethyl) aminomethane in a total amount in the range from 0.1 to 30% by weight, or - only salts of tris (hydroxymethyl) aminomethane in a total amount located in the range from 0.1 to 30% by weight, or [0015] - tris (hydroxymethyl) aminomethane and tris (hydroxymethyl) aminomethane salts in a total amount lying in the range from 0.1 to 30% by weight.

For salts with heavy anions, the amount of active tris (hydroxymethyl) aminomethane or the protonated compound is reduced compared to the pure compound, which explains why the use of acids containing anions of low weight s' has been found to be particularly useful for adjusting the pH of the compositions according to the invention. Hydrochloric acid, which leads to the formation of tris (hydroxymethyl) aminomethane hydrochloride, has been found to be particularly effective.

In another embodiment of the invention, at least one other anion can be included to replace or in addition to the chloride ions. Inorganic anions, such as sulfate ions and / or phosphate ions, or organic anions can be included as other anions. The organic anions can be, for example, phosphonates, citrate, lactate, tartrate and / or malate. The preferred antiperspirant cosmetic agents according to the invention are characterized in that they contain at least one other anion, preferably an organic anion, which is more preferably chosen from the group consisting of citrate, lactate, tartrate and malate and / or other anions of organic acids.

The use of tris (hydroxymethyl) aminomethane and / or salts thereof makes it possible to provide an antiperspirant composition in which one can dispense with including aluminum and / or zirconium compounds, or in which the content of aluminum and / or zirconium compounds can be reduced. Therefore, in a preferred embodiment of the present invention, the antiperspirant composition is substantially free of compounds containing aluminum and / or zirconium.

Since the tris (hydroxymethyl) aminomethane and / or the salts thereof must reduce the formation of sweat, without completely preventing it, the formation of odors under the armpits is delayed, but is not totally prevented. According to a preferred embodiment of the present invention, it is provided that the antiperspirant composition comprises an antiperspirant active substance which is preferably an inorganic or organic salt of aluminum, zirconium, zinc, or a mixture thereof. , the antiperspirant active substance being present in a reduced amount compared to the products currently available on the market.

The preferred antiperspirant compositions according to the invention are characterized in that the antiperspirant composition comprises an antiperspirant active substance which is preferably an inorganic or organic salt of aluminum, zirconium, zinc, or a mixture of these .

In a preferred embodiment, the antiperspirant active substance is chosen from aluminum chlorohydrates, and the antiperspirant active substance more preferably comprises activated aluminum hydrochloride, aluminum sesquichlorohydrate, hydrochloride of aluminum-propylene glycol (PG), aluminum chlorhydrex-polyethylene glycol (PEG), aluminum sequichlorhydrex-PG, aluminum sequichlorhydrex-PEG, aluminum dichlorhydrex-PG, aluminum dichlorhydrex- PEG or aluminum hydroxide; or chosen from aluminum-zirconium hydrochloride, preferably aluminum-zirconium trichlorohydrate, aluminum-zirconium tetrachloride, aluminum-zirconium pentachlorohydrate or aluminum-zirconium octachlorohydrate; or chosen from aluminum hydrochloride-zirconium-glycine complexes, preferably aluminum hydrochloride-zirconium-glycine, aluminum tetrachlorhydrex-zirconium-glycine, aluminum pentachlorhydrex-zirconium-glycine, octachlorhydrex d aluminum-zirconium-glycine, or is chosen from potassium aluminum sulphate (KA1 _{(SO4) 2.} 12 H ₂ O, alum), the chlorohydroxyacétate of sodiumaluminium, aluminum hydrobromide, aluminum chloride, aluminum sulfate, zinc chloride, zinc sulfocarbolate, zinc sulfate or zirconium hydrochloride, the antiperspirant active substance being present in the antiperspirant composition in an amount in the range from more than 0 to 15 % by weight, preferably from 0.01 to 5% by weight, more preferably from 0.1 to 1% by weight, relative to the total weight of the antiperspirant composition.

In summary, the antiperspirant compositions according to the invention are preferred in which the antiperspirant active substance is chosen from aluminum chlorohydrates, preferably activated aluminum hydrochloride, aluminum sesquichlorohydrate, aluminum hydrochloride -propylene glycol (PG), aluminum chlorhydrex-polyethylene glycol (PEG), aluminum sequichlorhydrex-PG, aluminum sequichlorhydrex-PEG, aluminum dichlorhydrex-PG, aluminum dichlorhydrex-PEG or aluminum hydroxide; or chosen from aluminum zirconium hydrochloride, preferably aluminum zirconium trichlorhydrate, aluminum zirconium tetrachlorhydrate, aluminum zirconium pentachlorhydrate or aluminum zirconium octachlorhydrate; or chosen from aluminum hydrochloride-zirconium-glycine complexes, preferably aluminum hydrochloride-zirconium-glycine, aluminum tetrachlorhydrex-zirconium-glycine, aluminum pentachlorhydrex-zirconium-glycine, octachlorhydrex d aluminum-zirconium-glycine, or is selected from sulfate potassiumaluminium (KA1 _{(SO4) 2.} 12 H ₂ O, alum), sodium aluminum chlorohydroxyacétate, aluminum hydrobromide, aluminum chloride, aluminum sulphate, zinc chloride, zinc sulphocarbolate, zinc sulphate or zirconium hydrochloride, and / or in which the active antiperspirant substance is present in the antiperspirant composition in an amount ranging from more than 0 to 15% by weight, preferably 0.01 to 5% by weight, more preferably 0.1 to 1% by weight, relative to the total weight of the antiperspirant composition.

The active substances containing aluminum and / or zirconium, preferably used, can be activated by modification of their molecular weight. Their effectiveness in terms of antiperspirant properties can thus be improved compared to that of non-activated active substances. Especially preferred antiperspirant active substances according to the invention are therefore chosen from the so-called “activated” aluminum salts which are also designated by the term of antiperspirant active substances “with increased effectiveness” (English term: enhanced activity). Active substances of this type are known in the state of the art and are also commercially available. Activated aluminum salts are generally obtained by heat treatment of a relatively dilute solution of the salt produced (for example around 10% by weight of salt) to increase the surface ratio of peak 4 to peak 3 in high performance liquid chromatography ( HPLC). The activated salt can then be dried in powder form, in particular spray-dried. Besides spray drying, drying on rolls, for example, is also suitable.

However, the use of antiperspirant salts can also be completely avoided. The corresponding antiperspirant compositions, which are substantially free of aluminum-containing salts, are preferred according to another embodiment of the present invention.

The term "substantially free (s)" here means free (s) of aluminum salts added voluntarily, preferably corresponding to an aluminum salt content of less than 0.1% by weight, relative to the antiperspirant composition, particularly preferably with an aluminum salt content of less than 0.01% by weight, even more preferably with an aluminum salt content of less than 0.001% by weight and in particular with an aluminum salt content of less than 0.0001% by weight.

According to a preferred embodiment, the antiperspirant composition contains an emulsifier which is preferably an oil-in-water (O / W) emulsifier, having a hydrophilic / lipophilic equilibrium value (HLB) located in the range from 7 to 20, the O / W emulsifier being more preferably a nonionic O / W emulsifier. Alternatively, the antiperspirant composition contains an emulsifier, which is preferably a water-in-oil (W / O) emulsifier having an HLB value in the range of 2 to 7. According to another embodiment preferred, the antiperspirant composition contains a W / O emulsifier in a total amount in the range of 0.05 to 25% by weight, more preferably 0.2 to 10% by weight, even more preferably of 0.8 to 6% by weight, relative to the total weight of the antiperspirant composition. Alternatively, the antiperspirant composition contains an O / W emulsifier in a total amount in the range of 0.01 to 15% by weight, preferably 0.1 to 8% by weight, more preferably 0, 5 to 2% by weight, relative to the total weight of the antiperspirant composition, the antiperspirant composition particularly preferably containing an O / W emulsifier and a W / O emulsifier, the amount of O / W emulsifier being very particularly preferred greater than the amount of W / O emulsifier.

The preferred emulsifiers used are the alkoxylated fatty acid alcohols, particularly preferably the C14 to C18 alcohols having from 2 to 22 ethoxy groups, in particular Steareth-2 or Steareth-21, or even PPG -15 Stearyl ether.

In summary, the antiperspirant compositions according to the invention are preferred in which the antiperspirant composition contains an emulsifier which is preferably an oil-in-water (O / W) emulsifier having a hydrophilic / lipophilic balance value (hydrophilic / lipophilic balance, HLB) situated in the range from 7 to 20, the O / W emulsifier being more preferably a nonionic O / W emulsifier, and / or the antiperspirant composition containing an emulsifier which is preferably a water-in-oil (W / O) emulsifier having an HLB value in the range of 2 to 7, and / or in which the antiperspirant composition contains an O / W emulsifier in an amount in the range of from 0.05 to 25% by weight, more preferably from 0.2 to 10% by weight, even more preferably from 0.8 to 6% by weight, relative to the total weight of the antiperspirant composition, and / or the anti composition perspirant containing a W / O emulsifier in an amount in the range of 0.01 to 15% by weight, preferably 0.1 to 8% by weight, more preferably 0.5 to 2% by weight relative to the total weight of the antiperspirant composition, the antiperspirant composition particularly preferably containing an O / W emulsifier and a W / O emulsifier, the amount of O / W emulsifier preferably being greater than the amount of E emulsifier / H.

In a preferred embodiment, the antiperspirant composition contains a cosmetic oil in an amount ranging from 1 to 15% by weight, preferably from 2 to 10% by weight, more preferably from 3 to 5% by weight, relative to the total weight of the antiperspirant composition. The oil forms the oily phase. According to a particularly preferred embodiment, the oil is chosen from the group consisting of linear silicone oils, cyclic silicone oils, in particular cyclopentasiloxane, paraffins, isoparaffins, polypropylene glycol ethers, polyethylene ethers glycol, organic esters - especially glycerol esters, ethers and carbonates of ethers.

In the embodiments including an oily phase, particulate substances can preferably be included. Pyrogenated silicon dioxide or phyllosilicates, which are even more preferably hydrophobically modified, are particularly suitable. Particulate substances serve as thickeners and stabilizers. In this embodiment, the antiperspirant composition particularly preferably contains hydrophobic modified bentonites and / or hydrophobic modified hectorites.

In summary, the antiperspirant compositions according to the invention are preferred in which the antiperspirant composition contains a cosmetic oil in an amount ranging from 1 to 15% by weight, preferably from 2 to 10% by weight, more preferably 3 to 5% by weight, relative to the total weight of the antiperspirant composition, and / or in which the antiperspirant composition contains a stabilizer.

However, preferred embodiments based on a support comprising water or a water / alcohol mixture. The aqueous or hydroalcoholic support is preferably water or a water / alcohol mixture, the alcohol being preferably chosen from a linear or branched C2 to C6 alcohol, more preferably ethanol, propanol, isopropanol, propanediol-1,3 or dipropylene glycol, propanediol1,2, in particular propanediol-1,2. The water or the water / alcohol mixture is preferably present in an amount ranging from 60% by weight to 99% by weight, more preferably from 80% by weight to 96% by weight, most preferably from 85% by weight to 90% by weight, relative to the total weight of the antiperspirant composition.

In summary, the antiperspirant compositions according to the invention are preferred in which the aqueous or hydroalcoholic support is water or a water / alcohol mixture, the alcohol preferably being chosen from a linear or branched C2 alcohol. C6, more preferably ethanol, propanol, isopropanol, 1,3-propanediol or dipropylene glycol, 1,2-propanediol, in particular 1,2-propanediol, and / or water or the water / alcohol mixture is preferably present in an amount ranging from 60% by weight to 99% by weight, more preferably from 80% by weight to 96% by weight, most preferably from 85% by weight to 92% by weight, relative to the total weight of the antiperspirant composition.

Preferably, the antiperspirant composition comprises one or more aromatic or odorous substances. The definition of an odorous substance, within the meaning of the present application, corresponds to that generally accepted by those skilled in the art, as found in the RÔMPP Chemie Lexikon (chemistry lexicon RÔMPP, J. Falbe, M. Regitz (ed.), 10th edition, published in Ed. Thieme). In the context of the present invention, the aromatic or odorous substances can only be considered as those which, relative to the total weight of the antiperspirant composition, are present in an amount of 10% by weight and less in the antiperspirant composition. Examples of compounds of aromatic and fragrant substances of the ester type are benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzyl-carbinyl acetate (DMBCA ), phenylethyl acetate, benzyl acetate, ethyl methylphenyl glycinate, allyl cyclohexyl propionate, styrallyl propionate, benzyl salicylate, cyclohexyl salicylate, floramate, melusate and jasmacyclate . Examples of compounds of aromatic and odorous substances of ethers type are benzylethyl ether and ambroxane; examples of compounds of aromatic and odorous substances of aldehyde type are the linear alkanals of 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacétaldehyde, cyclamenaldehyde, lilial and bud; examples of compounds of aromatic and odorous substances of ketone type are the ionones, alpha-isomethylionone and methylcedrylketone; examples of compounds of aromatic and odorous substances of alcohol type are anethole, citronellol, eugenol, geraniol, linalol, phenylethyl alcohol and terpineol; examples of compounds of aromatic and odorous substances of the terpene type are limonene and pinene. Examples of compounds of aromatic and fragrant substances are pine oil, citrus oil, jasmine oil, patchouli oil, rose oil, ylang-ylang oil, muscat sage oil, chamomile oil, clove oil, mint oil, cinnamon leaf oil, lime blossom oil, juniper berry oil , vetiver oil, olibanum oil, galbanum oil, labdanum oil, orange flower oil, neroli oil, orange zest oil, sandalwood oil, as well as essential oils such as angelica root oil, anise oil, arnica flower oil, basil oil, Bay St Thomas, bergamot oil, champaca flower oil, silver fir oil, silver fir apple oil, elemi oil, eucalyptus oil, fennel oil, pine needle oil, geranium oil, ginger leaf oil, bo oil is from guaiac, Gurjun balm oil, helichrysum oil, Ho oil, ginger oil, iris oil, cajeput oil, calamus oil, chamomile oil, camphor oil, kanaga oil, cardamom oil, cassia oil, pine needle oil, kopaïva balm oil, oil cilantro, fried mint oil, cumin oil, lavender oil, lemongrass oil, lime oil, tangerine oil, lemon balm oil, oil of musk seeds, myrrh oil, clove oil, niaouli oil, orange oil, oregano oil, palmarosa oil, patchouli oil , Peruvian balsam oil, petit grain oil, pepper oil, peppermint oil, chili oil, pine oil, rose oil, rosemary oil, sandalwood oil, celery oil, lavender aspic oil, star anise oil, turpentine oil, thuja oil, thyme oil , verbena oil, juniper berry oil, absinthe oil, wintergreen oil, Ysop oil, cinnamon oil, lemongrass oil, lemon and cypress oil. Other compounds of aromatic and fragrant active substances are ambrettolide, alpha-amylcinnamaldehyde, anethol, anisaldehyde, anisic alcohol, anisol, methyl ester of anthranilic acid, acetophenone , benzylacetone, benzaldehyde, benzolic acid ethyl ester, benzophenone, benzyl alcohol, benzyl acetate, benzyl benzoate, benzyl formate, benzyl valerianate, borneol, bornyl acetate, alpha-bromstyrol, n-decylaldehyde, ndodecylaldehyde, eugenol, eugenol methyl ether, eucalyptol, farnesol, fenchone, fenchyl acetate, acetate geranyl, geranyl formate, heliotropin, heptincarbonic acid methyl ester, heptaldehyde, hydroquinone dimethyl ether, hydroxycinnamaldehyde, hydroxycinnamic alcohol, indole, irone, l iso-eugenol, iso-eugenol methyl ether, isosafrole, jasmone, camphor, coach vacrol, carvone, p-cresol methyl ether, coumarin, pmethoxyacetophenone, methyl-n-amylketone, methylanthranilic acid methyl ester, p-methylacetophenone, methylchavicol, p-methylquinoline, methyl-E-naphthyl ketone, methyl-n-nonylacetaldehyde, methyl-n-nonyl ketone, muscone, E-naphtholethyl ether, e-naphtholmethyl ether, nerole, nitrobenzole, n-nonylaldehyde, nonyl alcohol, n-octylaldehyde, p oxyacetophenone, pentadecanolide, e-phenylethyl alcohol, phenylacetaldehyde-dimethyl acetal, phenylacetic acid, pulegone, safrole, isoamyl ester of salicylic acid, ester salicylic acid methyl, salicylic acid hexyl ester, cyclohexylic ester of salicylic acid, santalol, scatol, terpineol, thymene, thymol, γ-undecalactone, vanillin, veratrumaldehyde, cinnamaldehyde, cinnamic alcohol, acid cinnamic, the ethyl ester of cinnamic acid and the benzyl ester of cinnamic acid. Other aromatic substances (more volatile) are alkyl isothiocyanates (alkyl mustard oils), butanedione, limonene, linalool, linayl acetate and propionate, menthol, menthone, methyl-n -heptenone, phellandrene, phenylacetaldehyde, terpinyl acetate, citral and citronellal. Particularly preferably, the perfumes or perfume oils are present in the antiperspirant composition in an amount ranging from 0.05 to 10% by weight, more preferably from 0.1 to 5% by weight, most preferably from 0.5 to 4% by weight, relative to the total weight of the antiperspirant composition.

In addition, the compositions according to the invention may contain additional deodorant active substances. Antimicrobial, antibacterial or germ-inhibiting substances, antioxidants, odor adsorbents or enzyme inhibitors can be used as deodorant active substances. The preferred antimicrobial, antibacterial or germ-inhibiting substances according to the invention are in particular halides and organohalogenated compounds, quaternary ammonium compounds and a certain number of plant extracts. Preferred are halogenated phenol derivatives such as, for example, hexachlorophene or Irgasan DP 300 (triclosan, 2,4,4'-trichloro-2'-hydroxydiphenylether), 3,4,4'-trichlorocarbanilide, chlorhexidine (1, hexamethylene-bis- [5- (4-chlorophenyl)] - biguanide), chlorhexidine gluconate, benzalkonium halides and cetylpyridinium chloride. In addition, sodium bicarbonate and sodium phenolsulfonate, and e.g. the constituents of linden flower oil can be used. Less effective antimicrobial substances, but which act specifically against Gram-positive germs responsible for the breakdown of sweat, can also be used as deodorant active substances. Benzyl alcohol can also be used as an active deodorant. Other deodorant substances with antibacterial effect are lantibiotics, glycoglycerolipids, sphingolipids (ceramides), sterols and other active substances which inhibit the adhesion of bacteria to the skin, e.g. glycosidases, lipases, proteases, carbohydrates, di- and oligosaccharide fatty acid esters and alkylated mono- and oligosaccharides. The preferred deodorant active substances are long chain diols, e.g. the

C5 to C18 1,2-alkanediols, C8 to C18 fatty acid glycerolmonoesters or, more preferably, C6 to C16 alkyl glycerolmonoethers, in particular 2-ethylhexylglycerol ethers, which are very well tolerated by the skin and mucous membranes and are effective against bacteria of the genus Corynebacterium, as well as phenoxyethanol, phenoxyisopropanol (3-phenoxy-propan-2-ol), anisic alcohol, 2-methyl-5-phenyl -pentan-l-ol, the

1.1- dimethyl-3-phenyl-propan-1-ol, benzyl alcohol, 2-phenylethan-1-ol, 3-phenylpropan-1-ol, 4-phenylbutan-1-ol, 5-phenylpentan -1-ol, 2-benzylheptan-1-ol, 2,2-dimethyl-3-phenylpropan-1-ol,

2.2- dimethyl-3- (3’-methylphenyl) -propan-l-ol, 2-ethyl-3-phenylpropan-l-ol,

2- ethyl-3- (3’-methylphenyl) -propan-l-ol, 3- (3’-chlorophenyl) -2-ethylpropan-l-ol,

3- (2'-chlorophenyl) -2-ethylpropan-l-ol, 3- (4'-chlorophenyl) -2-ethylpropan-l-ol, 3- (3 ', 4'-dichlorophenyl) -2- ethylpropan-1-ol, 2-ethyl-3- (2'-methylphenyl) -propan-1-ol, 2-ethyl-3- (4'-methylphenyl) -propan-1-ol, 3- ( 3 ', 4'-dimethylphenyl) -2-ethylpropan-1-ol, the

2- ethyl-3- (4’-methoxyphenyl) -propan-l-ol, the

3- (3 ’, 4’-dimethoxyphenyl) -2-ethylpropan-l-ol, 2-allyl-3-phenylpropan-l-ol and 2-n-pentyl-3-phenylpropan-ol.

In order to further improve the antiperspirant and anti-odor effect of the compositions according to the invention, these contain, in a preferred embodiment, at least one deodorant active substance in a total amount ranging from 0.001 to 15% by weight, relative to the total weight of the cosmetic agent. If ethanol is used in the agents according to the invention, in the context of the present invention, the latter is not considered as a deodorant active substance, but as a constituent of the support. Odor absorbers, ion exchangers with deodorizing action, germ-inhibiting agents, prebiotic active constituents as well as enzyme inhibitors or, in a particularly preferred manner, the combinations of the abovementioned active substances are deodorizing active substances preferred according to the invention. The silicates serve as odor absorbers, which can simultaneously advantageously support the rheological properties of the composition according to the invention. Among the particularly preferred silicates according to the invention are in particular the phyllosilicates, and among these in particular montmorillonite, caolinite, ilite, beidellite, nontronite, saponite, hectorite, bentonite, smectite , calcium silicate and talc.

Other preferred odor absorbers are, for example, zeolites, zinc ricinoleate, cyclodextrins, certain metal oxides, such as for example. alumina, as well as chlorophyll. Other preferred odor absorbers according to the invention are chosen from perlite. By active substances that inhibit germs or antimicrobials is meant, according to the invention, active substances which reduce the number of skin germs participating in the formation of odors or which inhibit their development. These germs include, among others, various species from the staphylococcus group, the corynebacteria group, anaerococci and micrococci.

The active germ-inhibiting or antimicrobial active substances preferred according to the invention are in particular organohalogenated compounds and halides, quaternary ammonium compounds, a certain number of plant extracts and zinc compounds. These include among others triclosan, chlorhexidine and chlorhexidine gluconate, 3,4,4'-trichlorocarbanilide, bromochlorophene, dichlorophene, chlorothymol, chloroxylenol, hexachlorophene, dichlorom-xylenol, chloride dequalinium, domiphenbromide, ammonium phenolsulfonate, benzalkonium halides, benzalkonium cetylphosphate, benzalkonium saccharinates, benzethonium chloride, cetylpyridinium chloride, laurylpyridinium chloride, laurylisoquin bromide methylbenzethonium. In addition, it is possible to use phenol, phenoxyethanol, disodium dihydroxyethylsulfosuccinylundecylenate, sodium bicarbonate, zinc lactate, sodium phenolsulfonate and zinc phenolsulfonate, ketoglutaric acid, terpenic alcohols such as by ex. farnesol, chlorophyllin-copper complexes, monoalkylglycerol ether with a branched or linear C6 to C22 alkyl radical, saturated or unsaturated, optionally hydroxylated, particularly preferably (2-ethylhexyl) glycerol ether, available in the trade under the brand Sensiva® SC 50 (from Schülke & Mayr), the carboxylic acid esters of mono-, di- and triglycerol (for example glycerol monolaurate, diglycerol monocaprinate), lantibiotics as well as extracts plants (for example green tea and the constituents of linden flower oil).

Other preferred deodorant active substances are chosen from the constituents known as having a prebiotic effect which, according to the invention, are understood as constituents which inhibit only or at least predominantly the odorous germs of the cutaneous microflora, but not the desired ones, that is to say the odorless germs which belong to the healthy microflora of the skin. Here are explicitly mentioned the active substances such as the extracts of conifers, in particular from the group Pinaceae, and the plant extracts from the group Sapindaceae, Araliaceae, Lamiaceae and Saxifragaceae, in particular the extracts of Picea spp., Paullinia sp. , Lamium album or Ribes nigrum and mixtures of these substances.

Other preferred deodorant active substances are chosen from scent oils that inhibit germs and Deosafe® scented oils, which are marketed by Symrise, formerly Haarmann and Reimer.

Other preferred deodorant active substances are chosen from silver salts, in particular silver citrate, silver dihydrogen citrate, silver lactate and silver sulphate, complex salts silver solubles, colloidal silver and silver zeolites.

Enzyme inhibitors include substances which inhibit the enzymes responsible for breaking down sweat, in particular arylsulfatase, Bglucuronidase, aminoacylase, cystathionin-B-lyase, esterases, lipases and / or lipoxigenase, e.g. the trialkyl ester of citric acid, in particular triethyl citrate, or zinc glycinate.

The preferred antiperspirant compositions according to the invention are characterized in that the deodorant active substance or substances are chosen from arylsulfatase inhibitors, β-glucuronidase inhibitors, aminoacylase inhibitors, inhibitors of cystathionin-B-lyase, esterase inhibitors, lipase inhibitors and lipoxygenase inhibitors, monoalkylglycerol ethers having a branched or linear C6 to C22 alkyl radical, saturated or unsaturated, optionally hydroxylated, in particular (2-ethylhexyl) glycerol ether, phenoxyethanol, benzylheptanol, cocamidopropyl PG-dimonium chloride phosphates and butyloctanoic acid, polyglycerol-3-caprylates, germ-inhibiting scented oils, scented oils Deosafe® (Deosafe® is a registered trademark of Symrise, formerly Haarmann & Reimer), prebiotic constituents, trialkyl esters of acid citric, in particular triethyl citrate, active substances reducing the number of skin germs involved in the formation of odors and originating from the group of staphylococci, corynebacteria, anaerococci and micrococci or inhibiting their development, zinc compounds in particular zinc phenolsulfonate and zinc ricinoleate, organohalogenated compounds, in particular triclosan, chlorhexidine, chlorhexidine gluconate and benzalkonium halides, quaternary ammonium compounds, in particular cetylpyridinium chloride, d absorbers odors, in particular silicates and zeolites, sodium bicarbonate, lantibiotics, as well as mixtures of the abovementioned substances.

Other preferred antiperspirant compositions according to the invention are characterized in that the at least one deodorant active substance is present in a total amount ranging from 0.0001 to 15% by weight, preferably 0.2 to 7% by weight, particularly preferably from 0.3 to 5% by weight and most preferably from 0.4 to 1.0% by weight, in each case relative to the total weight of the active substance of or active principle (s) deodorant (s) in the total composition.

In another particularly preferred embodiment, the compositions according to the invention contain both at least one deodorant active substance and at least one antiperspirant active substance.

Particularly preferably, triethyl citrate is present in the antiperspirant position. Most preferably, the amount of triethyl citrate is in the range of 0.0001 to 12% by weight, based on the total weight of the antiperspirant composition.

Chelating substances can also support the deodorizing effect by stably complexing heavy metal ions with an oxidative catalytic action (iron or copper, for example). Suitable chelating agents are e.g. the salts of ethylenediaminetetraacetic acid or of nitrilotriacetic acid and the salts of 1-hydroxyethane-1,1-diphosphonic acid.

It may be advantageous to add to the preparations according to the invention at least one chelating agent in a total amount ranging from 0.01 to 3.0% by weight, preferably from 0.02 to 1.0% by weight, in particular from 0.05 to 0.1% by weight, relative to the total weight of the antiperspirant agent according to the invention. In the context of the present invention, the preferred chelating agents are chosen from the group comprising βalaninediacetic acid, cyclodextrin, diethylenetriaminepentamethylenephosphonic acid, sodium, potassium, disodium calcium, ammonium and triethanolamine salts ethylenediaminetetraacetic acid (EDTA), etidronic acid, hydroxyethylethylenediaminetetraacetic acid (HEDTA) and their sodium salts.

For the thickening of the antiperspirant cosmetic agents according to the invention, it is preferable to use substances selected from cellulose ethers, xanthan gum, sclerotium gum, succinoglucans, polygalactomannans, pectins, l ' agar, Chondrus cripus (Carrageenan) algae extract, tragacanth, gum arabic, karaya gum, Tara gum, gellan gum, gelatin, propylene glycol alginate, alginic acids and their salts , polyvinylpyrrolidones, polyvinyl alcohols, polyacrylamides, physically modified starches (for example by pre-gelatinization) and / or chemically, acrylic acid-acrylate copolymers, acrylic acid-acrylamide copolymers, acrylic acid-vinylpyrrolidone copolymers, vinylformamide acrylic acid copolymers and polyacrylates. The particularly preferred thickeners are also chosen from carbomers. Carbomers are crosslinked thickening polymers based on acrylic acid, methacrylic acid and their salts. Crosslinking can be carried out using polyfunctional compounds such as polyalkylene ethers of polysaccharides or of polyalcohols, for example allyl ether of sucrose, allyl ether of pentaerythritol or allyl ether of propylene. Preferably used, in the context of the present invention, the homopolymers of acrylic acid or their salts which are crosslinked with an allyl ether of pentaerythritol, an allyl ether of sucrose or an allyl ether of propylene. A thickener which can be used in the context of the present invention is a copolymer of C10 to C30 alkyl acrylate, acrylic acid, methacrylic acid and their esters, crosslinked with a sucrose allyl ether or an allyl ether pentaerythritol. Carbomer thickeners are the products available under the trade name Carbopol® (BF Goodrich, Ohio, USA), such as Carbopol 934, Carbopol 940, Carbopol 941, Carbopol 971, Carbopol 974, Carbopol EZ2, Carbopol ETD 2001, Carbopol ETD 2020, Carbopol ETD 2050, Carbopol ultrez 10, Carbopol ultrez 20 or Carbopol ultrez 21.

The preferred compositions according to the invention also contain at least one water-soluble polyvalent C2 to C9 alkanol having from 2 to 6 hydroxyl groups and / or at least one water-soluble polyethylene glycol having from 3 to 50, preferably from 3 with 20 ethylene oxide units and mixtures thereof to further improve the stability of the compositions. Preferably, these constituents are chosen from 1,2-propylene glycol, 2-methyl-1,3-propanediol, glycerol,

1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, pentylene glycols such as 1,2-pentanediol and 1,5-pentanediol, hexanediols such as 1,6 -hexanediol, hexanetriols such as 1,2,6-hexanetriol, 1,2-octanediol, 1,8-octanediol, dipropylene glycol, tripropylene glycol, diglycerol, triglycerol, erythritol, sorbitol as well as mixtures of the above substances. Suitable water-soluble polyethylene glycols are chosen from PEG-3, PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18 and PEG20 as well as mixtures thereof, PEG-3 to PEG-8 being preferred. Propylene glycol, dipropylene glycol or a mixture thereof is preferably present, propylene glycol alone being more preferably present. Preferably, these are present in a total amount in the range of 0.1 to 50% by weight, more preferably 0.5 to 10 or 1 to 5% by weight.

According to another embodiment of the present invention, the antiperspirant cosmetic agents also contain at least one active substance with a cooling effect on the skin. The active substances with a cooling effect for the skin which are suitable according to the invention are, for example, menthol, isopulegol and menthol derivatives, for example. menthyl lactate, menthyl glycolate, menthyl ethyl oxamate, menthyl pyrrolidone-carboxylic acid, menthyl methyl ether, menthoxy propane diol, menthone glycerol acetal (9-methyl-6- (l- methylethyl) -1,4-dioxaspiro (4.5) decane-2-methanol), monomethylsuccinate, 2-hydroxymethyl-3,5,5-trimethylcyclohexanol and 5-methyl-2- (1-methylethyl) cyclohexyl-N- éthyloxamate. The preferred active substances with a cooling effect on the skin are the following: menthol, isopulegol, menthyl lactate, menthoxypropanediol, carboxylic acid of menthylpyrrolidone and 5-methyl-2- (1-methylethyl) cyclohexyl- N-ethyloxamate and mixtures of these substances, in particular mixtures of menthol and menthyl lactate; menthol, menthol glycolate and menthyl lactate; menthol and menthoxypropanediol or menthol and isopulegol. According to the invention, the antiperspirant cosmetic agent may preferably also contain at least one antioxidant agent, preferably in a total amount ranging from 0.01 to 5.0% by weight, relative to the total weight of l cosmetic agent. The antioxidant agent can be chosen from ascorbic acid, ascorbyl palmitate, BHT, substituted hydroxyhydrocinnamic acid esters, substituted benzotriazoles, dialkylthiodialkanoates, tocopherol and its esters (for example acetate), hydroxymethoxyphenyl decanones, paradol and their mixtures, in particular substituted hydroxyhydrocinnamic acid esters and mixtures thereof.

The propellants (propellants) preferred are propane, propene, nbutane, isobutane, isobutene, n-pentane, pentene, isopentane, isopentene, methane, ethane, dimethyl ether, nitrogen, air, oxygen, nitrous oxide, 1,1,1,3-tetrafluoroethane, heptafluoro-n-propane, perfluoroethane, monochlorodifluoromethane, 1 , 1-difluoroethane, tetrafluoropropene, both separately and as a mixture. Hydrophilic propellants, such as carbon dioxide, can also be advantageously used within the meaning of the present invention if the proportion of hydrophilic gases chosen is low and a lipophilic propellant (eg propane / butane) is present in excess. Particularly preferred are propane, n-butane, isobutane and mixtures of these propellants. It has been found that the use of n-butane as the sole propellant may be particularly preferred according to the invention.

The invention further sought to develop a substance having an antiperspirant effect and which can be used in an antiperspirant composition.

The problem underlying the invention is solved by the subject of claim 9. A second subject of the invention is therefore the use of tris (hydroxymethyl) aminomethane or salts thereof as as an active antiperspirant substance in an antiperspirant composition for the local treatment of the skin.

According to a preferred embodiment of the present invention, tris (hydroxymethyl) aminomethane or its salts are used as active substance (s) antiperspirant (s) in an antiperspirant composition according to the present invention, which means that tris (hydroxymethyl) aminomethane or its salts are used in a composition in accordance with the first subject of the invention.

The preferred uses are therefore characterized in that the antiperspirant composition is an antiperspirant composition according to the invention.

The characteristics relating to the preferred embodiments of the first object of the invention, which are described above only in this regard, of course apply to the second object as characteristics of the preferred embodiments. The cosmetic agents which are very particularly preferred according to the invention comprise at least one of the following embodiments A) to E):

A) Antiperspirant composition for the local treatment of the skin, comprising tris (hydroxymethyl) aminomethane in an aqueous or hydroalcoholic support, the antiperspirant composition having a pH in the range from 3 to less than 7 and the tris (hydroxymethyl) aminomethane being present in the antiperspirant composition in an amount ranging from 0.1 to 30% by weight, preferably from 1 to 15% by weight, more preferably from 5 to 10% by weight weight, relative to the total weight of the antiperspirant composition.

B) Antiperspirant composition for the local treatment of the skin, comprising tris (hydroxymethyl) aminomethane in an aqueous or hydroalcoholic support, the antiperspirant composition having a pH in the range from 3 to less than 7 and the tris (hydroxymethyl) aminomethane being present in the antiperspirant composition in an amount ranging from 0.1 to 30% by weight, preferably from 1 to 15% by weight, more preferably from 5 to 10% by weight weight, relative to the total weight of the antiperspirant composition, the aqueous or hydroalcoholic support being water or a water / alcohol mixture, the alcohol preferably being chosen from a linear or branched C2 to C6 alcohol, more preferred ethanol, propanol, isopropanol, propanediol-1,3, dipropylene glycol, propanediol-1,2, in particular propanediol-1,2, and / or water or water / alcohol preferably being pr present in an amount in the range from 60% by weight to 96% by weight, most preferably from 85% by weight to 92% by weight, relative to the total weight of the antiperspirant composition.

C) Use of tris (hydroxymethyl) aminomethane as an antiperspirant active substance in an antiperspirant composition for the local treatment of the skin, the antiperspirant composition comprising an aqueous or hydroalcoholic support and having a pH located in the range ranging from 3 to less than 7.

D) Use of tris (hydroxymethyl) aminomethane as an antiperspirant active substance in an antiperspirant composition for the local treatment of the skin, the antiperspirant composition comprising an aqueous or hydroalcoholic support and having a pH located in the range ranging from 3 to less than 7, and the tris (hydroxymethyl) aminomethane being present in the antiperspirant composition in an amount ranging from 0.1 to 30% by weight, preferably from 1 to% by weight, so more preferred from 5 to 10% by weight, relative to the total weight of the antiperspirant composition.

E) Use of tris (hydroxymethyl) aminomethane as an antiperspirant active substance in an antiperspirant composition for the local treatment of the skin, the antiperspirant composition comprising an aqueous or hydroalcoholic support and having a pH located in the range ranging from 3 to less than 7, and the tris (hydroxymethyl) aminomethane being present in the antiperspirant composition in an amount ranging from 0.1 to 30% by weight, preferably from 1 to 15% by weight, more preferably 5 to 10% by weight, relative to the total weight of the antiperspirant composition, and the aqueous or hydroalcoholic support being water or a water / alcohol mixture, the alcohol being preferably chosen from a linear alcohol or branched in C2 to C6, more preferably ethanol, propanol, isopropanol, propanediol-1,3, dipropylene glycol, propanediol-1,2, in particular propanediol- 1,2, and / or the water or water / alcohol mixture preferably being present in an amount in the range of 60% by weight to 99% by weight, more preferably from 80% by weight to 96 % by weight, most preferably from 85% by weight to 92% by weight, relative to the total weight of the antiperspirant composition.

Examples The following compositions can be produced by way of examples:

Example 1: Formulation of an antiperspirant composition for use in the form of a roll-on [Tables 1]

O / W emulsion Amounts in% by weight Tris (hydroxymethyl) ammométhane 8 Demineralized Water As necessary 20% hydrochloric acid ** As much as necessary to obtain a pH of 3.5 1,2-propanediol 0 PPG-15 Stearyl ether * 1 Steareth - 2 * 1 Steareth - 21 * 2.5 Perfume 0.8 phenoxyethanol 0.5 antioxidant 0.05

* INCI Designation ** The hydrochloric acid is added in sufficient quantity to reach the pH indicated in the table.

Example 2: Formulation of an antiperspirant composition to be used in the form of a roll-on [Tables!]

O / W emulsion Amounts in% by weight Tris (hydroxymethyl) aminomethane 10 Demineralized Water As necessary 20% hydrochloric acid ** As much as necessary to obtain a pH of 4.5 1,2-propanediol 2 PPG-15 Stearyl ether * 3 Steareth - 2 * 3 Steareth - 21 * 4 Perfume 1.5 phenoxyethanol 0.5 antioxidant 0.9

* INCI Designation ** The hydrochloric acid is added in sufficient quantity to reach the pH indicated in the table.

Example 3: Formulation of an antiperspirant composition to be used in the form of a roll-on [Tables 80]

O / W emulsion Amounts in% by weight Tris (hydroxymethyl) aminomethane 25 Demineralized Water As necessary 20% hydrochloric acid ** As much as necessary to obtain a pH of 4.5 1,2-propanediol 5 PPG-15 Stearyl ether * 5 Steareth - 2 * 5 Steareth - 21 * 5 Perfume 2.0 phenoxyethanol 1.0 antioxidant 2.0

* INCI name ** The hydrochloric acid is added in sufficient quantity to reach the pH indicated in the table.

Example 4: Formulation of an antiperspirant composition to be used in the form of a spray [Tables 84]

W / O emulsion Amounts in% by weight Tris (hydroxymethyl) aminomethane 8 Demineralized Water As necessary 20% hydrochloric acid ** As much as necessary to obtain a pH of 3.5 1,2-propanediol 5 cyclopentasiloxane 11.2 Isopropyl myristate 2 Formulation aid ES-5227 DM (Dow Corning) 3 Perfume 1 phenoxyethanol 1.0 antioxidant 0.05

** The hydrochloric acid is added in an amount sufficient to reach the pH indicated in the table.

Example 5: Formulation of an antiperspirant composition to be used in the form of a spray [Tables 87]

W / O emulsion Amounts in% by weight Tris (hydroxymethyl) aminomethane 10 Demineralized Water As necessary 20% hydrochloric acid ** As much as necessary to obtain a pH of 4.9 1,2-propanediol 25 cyclopentasiloxane 11.2 Isopropyl myristate 5 Formulation aid ES-5227 DM (Dow Corning) 4 Perfume 4 phenoxyethanol 0.1 antioxidant 0.05

** The hydrochloric acid is added in sufficient quantity to reach the pH indicated in the table.

Example 6: Formulation of an antiperspirant composition to be used in the form of a spray [Tables 90]

W / O emulsion Amounts in% by weight Tris (hydroxymethyl) ammométhane 15 Demineralized Water As necessary 20% hydrochloric acid ** As much as necessary to obtain a pH of 4.9 1,2-propanediol 20 cyclopentasiloxane 11.2 Isopropyl myristate 10 Formulation aid ES-5227 DM (Dow Corning) 7.5 Perfume 3 phenoxyethanol 1.0 antioxidant 1.2

** The hydrochloric acid is added in an amount sufficient to reach the pH indicated in the table.

The filling is carried out jointly with a propane gas based on propane and / or butane and / or isobutane in a filling ratio of 10.0 to 40.0% by weight of W / O emulsion for 60.0 to 90.0% by weight of propellant.

The spray compositions indicated by way of examples can be introduced into an aluminum aerosol can optionally covered with a layer of epoxy-phenolic lacquer in a weight ratio between the propellant (butane / propane / isobutane mixture) and the emulsion of 70:30, 75:25, 80:20 or 85:15 or 60:40 or 90:10.

Example 7: Formulation of an antiperspirant composition for use in the form of a roll-on [Tables?]

Roll-on mix Amounts in% by weight Tris (hydroxymethyl) aminomethane 15 Demineralized Water As necessary 20% hydrochloric acid ** As much as necessary to obtain a pH of 3.5 96% ethanol (cosmetic, denatured) 30 Ceteareth-12 2 Ceteareth-30 2 hydroxyethyl 0.5 Perfume 1.0 phenoxyethanol 1.0 antioxidant 0.2 Deodorant active substance 2.0

** The hydrochloric acid is added in an amount sufficient to reach the pH indicated in the table.

Example 8: Formulation of an antiperspirant composition to be used in the form of a spray [Tables 98]

Sprayer mixture Amounts in% by weight Tris (hydroxymethyl) aminomethane 10 Demineralized Water As necessary 20% hydrochloric acid ** As much as necessary to obtain a pH of 3.5 96% ethanol (cosmetic, denatured) 40 Ceteareth-12 2 Ceteareth-30 2 Refreshing agent 0.1 Perfume 1.0 phenoxyethanol 1.0 antioxidant 0.2 Deodorant active substance 2.0

The product is applied mechanically in the form of fine particles to the skin using a sprayer.

Example 9: Formulation of an antiperspirant composition to be used in the form of a spray [0101] [Tables9]

Sprayer mixture Amounts in% by weight Tris (hydroxymethyl) aminomethane 10 Demineralized Water As necessary 20% hydrochloric acid ** As much as necessary to obtain a pH of 3.5 Propanediol-1,2 (optional) 20.0 Ceteareth-12 2 Ceteareth-30 2 Refreshing agent 0.1 Perfume 1.0 phenoxyethanol 1.0 antioxidant 0.2 Deodorant active substance 2.0

The product is applied mechanically in the form of fine particles to the skin using a sprayer.

Example 10: Formulation of an antiperspirant composition to be used in the form of a roll-on [0104] [Tables 10]

Roll-on mix Amounts in% by weight Tris (hydroxymethyl) aminomethane 10 Demineralized Water As necessary 20% hydrochloric acid ** As much as necessary to obtain a pH of 3.5 Propanediol-1,2 (optional) 20.0 Ceteareth-12 2 Ceteareth-30 2 hydroxyethyl 0.5 Perfume 1.0 phenoxyethanol 1.0 antioxidant 0.2 Deodorant active substance 2.0

The product is applied mechanically in the form of fine particles to the skin using a sprayer.

In addition, tests were carried out to assess the antiperspirant effect. To evaluate the effect of tris (hydroxymethyl) aminomethane, the following compositions were tested:

[0107] - 10% aluminum hydrochloride, in aqueous solution, used as reference [0108] - 10% Tris (hydroxymethyl) aminomethane, dissolved in water, the pH of the sample is adjusted to 3, 5 with 20% hydrochloric acid.

To determine the antiperspirant effect, a study was carried out on the back of 16 subjects. The following antiperspirants have been used for this purpose:

[Tables 110]

Antiperspirant No. Aqueous solution containing 10% aluminum hydrochloride (ACH) *, pH = 4 V-I Aqueous solution containing 10% tris (hydroxymethyl) aminomethane pH adjusted to 3.5 with 20% hydrochloric acid. E-I **

* Active substance [0112] ** Composition according to the invention [0113] 16 subjects were applied to the back, in each case on one side next to the spine, ~ 40 μl of the antiperspirant agent VI and, in each case, 75 μl of the cosmetic agent EI. After 5 minutes, the treated sites were covered with a non-adsorbent occlusive film. After 2 hours, these non-adsorbent buffers were removed. The compositions were each applied to the subjects' backs for four consecutive days, in each case as described above. 24 hours after the last application of the composition, absorbent pads were applied to the back of the subjects at the places where the compositions had been previously applied. In addition, on the other side of the spine, at the same height, witness pads were also applied. After the subjects perspired for about 15 minutes at 80 ° C in the sauna, the amount of sweat absorbed by the pads was determined by gravimetry, comparing each composition to the corresponding untreated site on the back. From the gravimetric determination of the amount of sweat, the reduction in sweat secretion was determined, all the determined values then being statistically significant.

The reduction in the secretion of sweat associated with the corresponding composition compared to an untreated skin site is indicated in the following table:

[Tables 115]

No. Reduction of sweat secretion V-I 56% * E-I 13% *

* Significant [0117] The use of cosmetic agents containing tris (hydroxymethyl) aminomethane, in particular in the form of hydrochlorides, causes, when these agents are applied to the skin, a reduction in perspiration and a reduction in body odor.

Claims (1)

claims [Claim 1] Antiperspirant composition for the local treatment of the skin comprising tris (hydroxymethyl) aminomethane or its salts in an aqueous or hydroalcoholic support, the antiperspirant composition having a pH in the range from 2.5 to less than 7. [Claim 2] Antiperspirant composition according to Claim 1, characterized in that the antiperspirant composition contains tris (hydroxymethyl) aminomethane and / or salts thereof in a total amount ranging from 0.1 to 30% by weight, preferably 1 to 15% by weight, more preferably 5 to 10% by weight, relative to the total weight of the antiperspirant composition, and / or characterized in that the antiperspirant composition has a pH in the range from 3.2 to less than 6, preferably 3.5 to 5.8, more preferably 4.0 to 5.5. [Claim 3] Antiperspirant composition according to claim 1 or claim 2, characterized in that the antiperspirant composition is substantially free of aluminum-containing salts. [Claim 4] Antiperspirant composition according to claim 1 or claim 2, characterized in that the antiperspirant composition comprises an antiperspirant active substance which is preferably an inorganic or organic salt of aluminum, zirconium, zinc, or a mixture thereof. [Claim 5] Antiperspirant composition according to Claim 4, characterized in that the antiperspirant active substance is chosen from aluminum chlorohydrates, preferably activated aluminum hydrochloride, aluminum sesquichlorohydrate, aluminum chlorhydrex-propylene glycol (PG) , aluminum chlorhydrex-polyethylene glycol (PEG), aluminum sequichlorhydrex-PG, aluminum sequichlorhydrex-PEG, aluminum dichlorhydrex-PG, aluminum dichlorhydrex-PEG or hydroxide aluminum; or chosen from aluminum-zirconium hydrochlorides, preferably aluminum-zirconium trichlorohydrate, aluminum-zirconium tetrachlorohydrate, aluminum-zirconium pentachlorohydrate or aluminum-zirconium octachohydrate; or chosen from aluminum hydrochloride-zirconium-glycine complexes, preferably hydrochloride [Claim 6] [Claim 7] aluminum-zirconium-glycine, aluminum tetrachlorhydrex-zirconium-glycine, aluminum pentachlorhydrex-zirconium-glycine, aluminum octachlorhydrex-zirconium-glycine, or is chosen among potassium aluminum sulphate (KA1 (SO ₄ ) _2. 12 H ₂ 0, alum), sodium aluminum chlorohydroxyacetate, aluminum hydrobromide, aluminum chloride, aluminum sulphate, chloride zinc, zinc sulfocarbolate, zinc sulfate or zirconium hydrochloride, and / or characterized in that the antiperspirant active substance is present in the antiperspirant composition in an amount ranging from more than 0 to 15% by weight, preferably from 0.01 to 5% by weight, more preferably from 0.1 to 1% by weight, relative to the total weight of the antiperspirant composition. Antiperspirant composition according to one of the preceding claims, characterized in that the antiperspirant composition contains an emulsifier which is preferably an oil-in-water (O / W) emulsifier having a hydrophilic / lipophilic balance value (hydrophilic / lipophilic balance, HLB) situated in the range from 7 to 20, the O / W emulsifier being more preferably a nonionic O / W emulsifier, and / or the antiperspirant composition containing an emulsifier which is preferably a water emulsifier in oil (W / O) having an HLB value situated in the range from 2 to 7, and / or characterized in that the antiperspirant composition contains an O / W emulsifier in an amount lying in the range ranging from 0.05 to 25% by weight, more preferably 0.2 to 10% by weight, even more preferably 0.8 to 6% by weight, relative to the total weight of the antiperspirant composition, and / or compose it antiperspirant ion containing a W / O emulsifier in an amount in the range of 0.01 to 15% by weight, preferably 0.1 to 8% by weight, more preferably 0.5 to 2% by weight weight, relative to the total weight of the antiperspirant composition, the antiperspirant composition particularly preferably containing an O / W emulsifier and a W / O emulsifier, the amount of O / W emulsifier preferably being greater than the amount of emulsifier E / H. Antiperspirant composition according to one of the preceding claims, characterized in that the antiperspirant composition contains a cosmetic oil in an amount ranging from 1 to 15% by weight, preferably 2 to 10% by weight, more [Claim 8] [Claim 9] [Claim 10] preferred from 3 to 5% by weight, relative to the total weight of the antiperspirant composition, and / or characterized in that the antiperspirant composition contains a stabilizer. Antiperspirant composition according to one of the preceding claims, characterized in that the aqueous or hydroalcoholic support is water or a water / alcohol mixture, the alcohol preferably being chosen from a linear or branched C2 to C6 alcohol, more preferably ethanol, propanol, isopropanol, propanediol-1,3 or dipropylene glycol, propanediol-1,2, in particular propanediol-1,2, and / or water or the mixture water / alcohol is preferably present in an amount in the range of 60% by weight to 99% by weight, more preferably from 80% by weight to 96% by weight, most preferably from 85% by weight to 92% by weight, relative to the total weight of the antiperspirant composition. Use of tris (hydroxymethyl) aminomethane or salts thereof as an antiperspirant active substance in an antiperspirant composition for the local treatment of the skin. Use according to claim 9, characterized in that the antiperspirant composition is an antiperspirant composition according to one of claims 1 to 8.