FR3084998A1 - Tetrahydroxypropyl ethylenediamine or its salts as an active ingredient intended to reduce the secretion of sweat - Google Patents

Abstract

The present invention relates to an antiperspirant composition intended for topical treatment of the skin, comprising tetrahydroxypropyl ethylenediamine or its salts in an aqueous or hydroalcoholic support, the antiperspirant composition having a pH ranging from 3 to less than 7. In addition , the invention relates to the use of tetrahydroxypropyl ethylenediamine or its salts as an antiperspirant active ingredient in an antiperspirant composition intended for topical treatment of the skin.

Description

Description

Title of the invention: Tetrahydroxypropyl ethylenediamine or its salts as an active ingredient intended to reduce the secretion of sweat The present invention relates to an antiperspirant composition intended for topical treatment of the skin, comprising tetrahydroxypropyl ethylenediamine or its salts in an aqueous or hydroalcoholic support. In addition, the present invention relates to the use of tetrahydroxypropyl ethylenediamine or its salts as an antiperspirant active ingredient in an antiperspirant composition intended for topical treatment of the skin.

Body odors come mainly from the bacterial breakdown of certain components of sweat on the skin. In terms of deodorization of the body, one can globally make a distinction between the active principles which absorb the substances with an unpleasant odor which are already secreted (activated carbon, zinc ricinoleate, cyclodextrin, ion exchangers) or cover them (substances fragrances, perfumes), and active ingredients that prevent or at least slow down the breakdown of sweat and the appearance of unpleasant-smelling substances (antibacterial active ingredients, components with prebiotic effect as well as enzyme inhibitors). Depending on the mechanism chosen to prevent the appearance of body odors, it is possible to use, as cosmetic deodorant active principles, odor absorbers, perfumed substances, ion exchangers with deodorant effect, agents antimicrobials, prebiotic components, enzyme inhibitors and other active substances. The active ingredients must be present in the compositions to ensure that the latter can be prepared without difficulty in a desired dosage form and that they do not cause an unpleasant sensation on the skin.

Humidity in the armpits is caused by aqueous sweat, eccrine, and often causes unwanted wet spots.

Cosmetic antiperspirants used to inhibit sweat known in the prior art contain aluminum and / or zirconium compounds as active antiperspirant ingredients. On the one hand, antiperspirant compounds reduce the secretion of sweat by the body by means of a narrowing and / or temporary obstruction of the excretory ducts of the sweat glands, so that the amount of sweat can be reduced by about 20 to 60 percent. On the other hand, they have an additional deodorant effect due to their antimicrobial action. The aluminum and / or zirconium compounds used to reduce sweat can, however, cause unpleasant skin reactions in some people. Consumers are currently expressing criticism of aluminum compounds. In addition, the use of the above-mentioned antiperspirant compounds can cause stains (caused by the products used) on clothing.

There is therefore a demand to use other cosmetic antiperspirant active ingredients in place of traditional aluminum and / or zirconium compounds, or at least to significantly reduce the amount of these compounds. The antiperspirant active ingredients must have a good antiperspirant action, have good skin compatibility and the formulation of which must be simple. In addition, these antiperspirant active ingredients must not have a negative influence on the storage stability of the cosmetic agents used in order to inhibit sweat.

The object of the present invention was to provide antiperspirant active principles, the use of which reduces the drawbacks of the prior art or at least alleviates them, and the use of which results in high skin compatibility as well as , simultaneously, in a proven reduction of humidity in the armpits.

The mission inherent in the invention is achieved by the object described below. A first object of the invention is therefore an antiperspirant composition for the topical treatment of the skin, comprising tetrahydroxypropyl ethylenediamine or its salts in an aqueous or hydroalcoholic support, the antiperspirant composition having a pH ranging from 2.5 to less of 7.

[0008] Tetrahydroxypropyl ethylenediamine [Chem. 1] OH is

OH

H _s C.,. _v .J OH

OH also called N, N, N ', N'-tetrakis (2-hydroxypropyl) ethylenediamine. From a chemical point of view, it is a tertiary diamine with four alcoholic hydroxy groups. The amino groups can be protonized with acids in order to obtain the corresponding salts (hydrochlorides, hydrogen sulfates, lactates, citrates, etc.).

Surprisingly, it has been discovered that tetrahydroxypropyl ethylenediamine, in an aqueous solution in an acidic pH range, has an action reducing sweat. In particular, tetrahydroxypropyl ethylenediamine in the form of its hydrochloride has been found to be particularly advantageous. When the aqueous solution comprising hydrochloric acid is adjusted to an acidic pH value, the antiperspirant composition is particularly effective. According to a preferred embodiment of the present invention, the antiperspirant composition has a pH ranging from 3.2 to less than 6, preferably from 3.5 to 5.8, more preferably from 4.0 to 5.5.

According to a preferred embodiment of the present invention, the antiperspirant composition contains tetrahydroxypropyl ethylenediamine and / or its salts in a total amount ranging from 0.1 to 30% by weight, preferably from 1 to 15% by weight, more preferably from 5 to 10% by weight, relative to the total weight of the antiperspirant composition. In these ranges, tetrahydroxypropyl ethylenediamine has been found to be particularly advantageous.

In summary, the antiperspirant compositions according to the invention are preferred, which contain tetrahydroxypropyl ethylenediamine and / or its salts in a total amount ranging from 0.1 to 30% by weight, preferably from 1 to 15 % by weight, more preferably 5 to 10% by weight, relative to the total weight of the antiperspirant composition, and / or characterized in that the antiperspirant composition has a pH ranging from 3.2 to less from 6, preferably from 3.5 to 5.8, more preferably from 4.0 to 5.5.

The formula "tetrahydroxypropyl ethylenediamine and / or its salts in a total amount ranging from 0.1 to 30% by weight" means that the compositions according to the invention can only contain [...] tetrahydroxypropyl ethylenediamine in one total amount ranging from 0.1 to% by weight, or [...] that one or more tetrahydroxypropyl ethylenediamine salt (s) in a total amount ranging from 0.1 to 30% by weight, or [0015] - as many tetrahydroxypropyl ethylenediamine that one or more salt (s) of tetrahydroxypropyl ethylenediamine in a total amount ranging from 0.1 to 30% by weight.

In heavy anion salts, the amount of active tetrahydroxypropyl ethylenediamine or of the protonated compound is reduced compared to the pure compound, this is why the use of acids with light anions has proved to be particularly effective in adjusting the pH of the agent according to the invention. The hydrochloric acid leading to the formation of tetrahydroxypropyl ethylenediamine hydrochloride has been found to be particularly effective.

In another embodiment of the invention, at least one other anion may be present as a replacement for or in addition to the chloride ion. Other anions may be present, either inorganic anions, for example sulfate ions and / or phosphate ions, or organic anions. The organic anions can for example be phosphonates, citrate, lactate, tartrate and / or malate.

The preferred antiperspirant cosmetic agents according to the invention are, as such, characterized in that they contain at least one other anion, preferably an organic anion, which is chosen more preferably from the group including citrate, lactate, tartrate and malate and / or other anions of organic acids.

The use of tetrahydroxypropyl ethylenediamine and / or its salts makes it possible to provide an antiperspirant composition in which it is possible to dispense with aluminum and / or zirconium compounds, or in which the content of compounds d aluminum and / or zirconium can be reduced. Thus, in a preferred embodiment of the present invention, the antiperspirant composition is substantially free of compounds containing aluminum and / or zirconium.

Since tetrahydroxypropyl ethylenediamine and / or its salts must reduce the secretion of sweat, without however completely preventing it, the appearance of odors under the armpits is slowed down and does not disappear completely. According to a preferred embodiment of the present invention, it is intended that the antiperspirant composition comprises an antiperspirant active principle, which is preferably an organic or inorganic salt of aluminum, zirconium, zinc or a mixture of these, the amount of the antiperspirant active principle being reduced compared to the traditional products that are found on the market.

The preferred antiperspirant compositions according to the invention of this embodiment are characterized in that the antiperspirant composition comprises an antiperspirant active principle, which is preferably an inorganic or organic salt of aluminum , zirconium, zinc or a mixture thereof.

In a preferred embodiment, the antiperspirant active ingredient is chosen from an aluminum hydrochloride, more preferably the antiperspirant active ingredient comprises aluminum hydrochloride, aluminum sesquichlorhydrate, hydrochloride aluminum-propylene glycol (PG), aluminum hydrochloride-polyethylene glycol (PEG), aluminum sesquichlorhydrex-PG, aluminum sesquichlorhydrex-PEG, aluminum dichlorhydrex-PG, aluminum dichlorhydrex-PEG or activated aluminum hydroxide; or is chosen from an aluminum zirconium hydrochloride, preferably aluminum zirconium trichlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate or aluminum zirconium octachlorohydrate; or is chosen from a glycine-aluminum zirconium hydrochloride complex, preferably aluminum-zirconium glycine-trichlorhydrex, aluminum-zirconium glycine-tetrachlorhydrex, glycine-aluminum zirconium pentachlorhydrex, aluminum glycine-octachlorhydrex-zirconium, or is chosen from potassium-aluminum sulphate (KAI (SO4) 2 - 12 H2O, alum), sodium-aluminum hydrochloroacetate, aluminum hydrobromide, aluminum chloride , aluminum sulfate, zinc chloride, zinc sulfocarbolate, zinc sulfate or zirconium hydrochloride, the antiperspirant active ingredient being present in the antiperspirant composition in an amount ranging from more than 0 to 15% by weight, preferably from 0.01 to 5% by weight, more preferably from 0.1 to 1% by weight, relative to the total weight of the antiperspirant composition.

In summary, the preferred antiperspirant compositions according to the invention are those in which the antiperspirant active principle is chosen from an aluminum hydrochloride, preferably aluminum hydrochloride, aluminum sesquichlorohydrate, aluminum hydrochloride-propylene glycol (PG), aluminum chlorhydrex-polyethylene glycol (PEG), aluminum sesquichlorhydrex-PG, aluminum sesquichlorhydrex-PEG, aluminum dichlorhydrex-PG, dichlorhydrex-PEG aluminum or aluminum hydroxide; or is chosen from an aluminum zirconium hydrochloride, preferably aluminum zirconium trichlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate or aluminum zirconium octachlorohydrate; or is chosen from a glycine-aluminum zirconium hydrochloride complex, preferably aluminum-zirconium glycine-trichlorhydrex, aluminum-zirconium glycine-tetrachlorhydrex, glycine-aluminum zirconium pentachlorhydrex, aluminum glycine-octachlorhydrex-zirconium, or is chosen from potassium-aluminum sulphate (KAI (SO4) 2 - 12 H2O, alum), sodium-aluminum hydrochloroacetate, aluminum hydrobromide, aluminum chloride , aluminum sulfate, zinc chloride, zinc sulfocarbolate, zinc sulfate or zirconium hydrochloride, and / or in which the active antiperspirant ingredient is present in the antiperspirant composition in an amount ranging from more than 0 to 15% by weight, preferably from 0.01 to 5% by weight, more preferably from 0.1 to 1% by weight, relative to the total weight of the antiperspirant composition.

The active ingredients used in a preferred manner, containing aluminum and / or zirconium, can be activated by modifying their molecular weight. Thus, their antiperspirant properties can be made more effective compared to the non-activated active ingredients. Active antiperspirant active principles which are particularly preferred according to the invention are therefore selected from the so-called “activated” aluminum salts which are also designated by the term of antiperspirant active principles “with increased effectiveness” (English term: enhanced activity). Active ingredients of this type are known in the art and are also available on the market. Activated aluminum salts are generally produced by heat treatment of a relatively dilute solution of the salt (for example about 10% by weight of the salt) in order to increase its surface ratio HPLC-peak 4-over-peak 3. The activated salt can then be dried into a powder, in particular can be dried by spraying. Besides spray drying, drum drying is also suitable, for example.

But it is also possible to do without antiperspirant salts completely. The corresponding antiperspirant compositions, which are substantially free of aluminum-containing salts, are preferred according to another embodiment of the present invention.

"Substantially free" means as such free of aluminum salts intentionally added, preferably an aluminum salt content of <0.1% by weight, relative to the antiperspirant composition, particularly preferred an aluminum salt content of <0.01% by weight, more preferably an aluminum salt content of <0.001% by weight and in particular an aluminum salt content of <0.0001% in weight.

According to a preferred embodiment, the antiperspirant composition contains an emulsifier which is preferably an oil-in-water emulsifier (O / W) with an HLB value ranging from 7 to 20, the emulsifier H / E being more preferably a nonionic O / W emulsifier. Otherwise, the antiperspirant composition contains an emulsifier which is preferably a water-in-oil (W / O) emulsifier with an HLB value ranging from 2 to 7. According to another preferred embodiment, the antiperspirant composition contains an O / W emulsifier in an amount ranging from 0.05 to 25% by weight, more preferably from 0.2 to 10% by weight, even more preferably from 0.8 to 6% by weight, per relative to the total weight of the antiperspirant composition. Otherwise, the antiperspirant composition contains a W / O emulsifier in an amount ranging from 0.01 to 15% by weight, preferably from 0.1 to 8% by weight, more preferably from 0.5 to 2 % by weight, relative to the total weight of the antiperspirant composition, the antiperspirant composition containing in a particularly preferred manner an O / W emulsifier and a W / O emulsifier, the amount of O / W emulsifier being generally particularly preferred more important than the amount of W / O emulsifier.

As preferred emulsifiers, alkoxylated fatty acid alcohols are used, particularly preferably alcohols C14 to C18 having 2 to 22 ethoxy groups, in particular steareth-2 or steareth-21, or stearyl ether PPG-15.

In summary, the preferred antiperspirant compositions according to the invention are those in which the antiperspirant composition contains an emulsifier which is preferably an oil-in-water (O / W) emulsifier having an HLB value ranging from 7 to 20, the O / W emulsifier being more preferably a nonionic O / W emulsifier, and / or the antiperspirant composition containing an emulsifier which is preferably a water-in-oil emulsifier (E / H) having a value ranging from 2 to 7, and / or in which the antiperspirant composition contains an O / W emulsifier in an amount ranging from 0.05 to 25% by weight, more preferably from 0.2 to 10% by weight, even more preferably from 0.8 to 6% by weight, relative to the total weight of the antiperspirant composition, and / or the antiperspirant composition containing a W / O emulsifier in an amount ranging from 0 , 01 to 15% by weight, so preferred from 0.1 to 8% by weight, more preferably from 0.5 to 2% by weight, relative to the total weight of the antiperspirant composition, the antiperspirant composition particularly preferably containing an emulsifier H / E and a W / O emulsifier, the amount of O / W emulsifier being greater than the amount of W / O emulsifier.

In a preferred embodiment, the antiperspirant composition may contain a cosmetic oil in an amount ranging from 1 to 15% by weight, preferably from 2 to 10% by weight, more preferably from 3 to 5% by weight, relative to the total weight of the antiperspirant composition. The oil forms the oily phase. According to a particularly preferred embodiment, the oil is chosen from the group comprising linear silicone oils, cyclic silicone oils, in particular cyclopentasiloxane, paraffins, isoparaffins, polypropylene glycol ether, ether of polyethylene glycol, organic esters - in particular glycerol esters, ethers and ethercarbonates.

The embodiments comprising an oily phase may, preferably, contain particulate substances. Pyrogenic silicon dioxide or phyllosilicates, more preferably those hydrophobically modified, are particularly suitable. Particulate substances act as thickeners and stabilizers. In a particularly preferred manner in this embodiment, the antiperspirant composition contains hydrophobically modified bentonites and / or hydrophobically modified hectorites.

In summary, preferred are antiperspirant compositions in which the antiperspirant composition contains a cosmetic oil in an amount ranging from 1 to 15% by weight, preferably from 2 to 10% by weight, more preferred 3 to 5% by weight, relative to the total weight of the antiperspirant composition, and / or in which the antiperspirant composition contains a stabilizer.

However, preferred are the embodiments based on a support which comprises water or a water-alcohol mixture. Preferably, the aqueous or hydroalcoholic support is water or a water-alcohol mixture, the alcohol being preferably chosen from a linear or branched C2 to C6 alcohol, more preferably ethanol, propanol , isopropanol, 1,3-propanediol, dipropylene glycol, 1,2-propanediol, in particular 1,2-propanediol. Preferably, the amount of water or of water-alcohol mixture ranges from 60% by weight to 99% by weight, more preferably from 80% by weight to 96% by weight, most preferably from 85% by weight. weight 90% by weight, relative to the total weight of the antiperspirant composition.

In summary, the antiperspirant compositions according to the invention are preferred in which the aqueous or hydroalcoholic support is water or a water / alcohol mixture, the alcohol preferably being chosen from an alcohol in C2 to C6 linear or branched, more preferably ethanol, propanol, isopropanol, 1,3-propanediol or dipropylene glycol, 1,2-propanediol, in particular 1,2-propanediol, and / or the water or the water / alcohol mixture preferably representing an amount ranging from 60% by weight to 99% by weight, more preferably from 80% by weight to 96% by weight, most preferably from 85 % by weight to 92% by weight, relative to the total weight of the antiperspirant composition.

Preferably, the antiperspirant composition comprises one or more perfumes or odorous substances. Within the meaning of the present application, the definition of an odorous substance corresponds to the usual definition for those skilled in the art, as given in the Lexicon of chemistry RÔMPP ("Rômpp Lexikon Chemie", J. Falbe, M. Regitz (Hrsg.), 10th edition, Thieme editions). In the context of the present invention, perfumes or odorous substances are considered as such only if - relative to the total weight of the antiperspirant composition - they are present in the antiperspirant composition in an amount less than or equal to 10% by weight. As examples of compounds of perfumes and odorous substances of the ester type, there may be mentioned benzyl acetate, phenoxyethyl isobutyrate, p-tert.-butylcyclohexyl acetate, linalyl acetate, acetate dimethyl benzyl carbinyl (DMBCA), phenylethyl acetate, benzyl acetate, ethylmethylphenyl glycinate, allylcyclohexyl propionate, styrallyl propionate, benzyl salicylate, cyclohexyl salicylate, floramate, melusate and jasmacyclate.

As examples of compounds of perfumes and odorous substances of the ethers type, mention may be made of benzylethyl ether and ambroxane; as examples of compounds of perfumes and odorous substances of the aldehyde type, mention may be made of linear alkanals having from 8 to 18 carbon atoms, citral, citronellal, citronellyl oxyacetaldehyde, cyclamine aldehyde, lilial and the bud; as examples of compounds of perfumes and odorous substances of the ketone type, mention may be made of ionones, alpha-isomethylionone and methylcedrylketone; as examples of compounds of perfumes and odorous substances of the alcohol type, there may be mentioned anethole, citronellol, eugenol, geraniol, linalol, phenylethyl alcohol and terpineol, as examples of compounds of perfumes and odorous substances such as terpenes; include limonene and pinene. As examples of compounds of perfumes and odorous substances, mention may be made of pine, citrus, jasmine, patchouly, rose, ylang-ylang oil, clary sage oil, chamomile oil , clove oil, mint oil, cinnamon leaf oil, lime blossom oil, juniper berry oil, vetiver oil, frankincense, galbanum oil, labdanum oil, orange blossom oil, neroli oil, orange zest and sandalwood oil, as well as essential oils such as angelica root oil, anise oil, arnica flower oil, basil oil, Pimenta racemosa oil, bergamot oil, flower oil champaca, white fir oil, white pine cone oil, elemi oil, eucalyptus oil, fennel oil, pine needle oil, oil geranium oil palmarosa, guaiacum wood oil, gurjun balm oil, helichrysum oil, ho wood oil, ginger oil, iris oil, cageput, sweet-smelling oil, chamomile oil, camphor oil, kanaga oil, cardamom oil, cassia oil, pine needle oil, l kopaïva balm oil, coriander oil, spearmint oil, caraway oil, cumin oil, lavender oil, lemongrass oil, lime oil, tangerine oil, lemon balm oil, musk grain oil, myrrh oil, clove oil, niaouli oil, orange oil, oil oregano, palmarosa oil, patchouli oil, peruvian balsam oil, petitgrain oil, pepper oil, peppermint oil, chili oil , pine oil, rose oil, rosemary oil, sandalwood, celery oil, Lavandula latifolia oil, Chinese badian tree oil, turpentine oil, thuja oil, thyme oil, verbena oil, l juniper berry oil, wormwood oil, wintergreen oil, hyssop oil, cinnamon oil, lemongrass oil, lemon oil and cypress oil . As other perfume compounds and odorous compounds, there may be mentioned ambrettolide, alphaamylcinnamic aldehyde, anethol, anisaldehyde, anise alcohol, anisol, methyl ester of anthranilic acid, l acetophenone, benzyl acetone, benzyl aldehyde, ethyl ester of benzoic acid, benzophenone, benzyl alcohol, benzyl acetate, benzyl benzoate, benzyl formate, benzyl valeranate, borneol, bomyl acetate, alpha bromostyrene, n-decylaldehyde, ndodecylaldehyde, eugenol, eugenol methyl ether, eucalyptol, farnesol, fenchone, fenchyl acetate, geranyl acetate , geranyl formate, heliotropin, heptynecarboxylic acid methyl ester, heptanal, dimethyl ether hydroquinone, hydroxycinnamic aldehyde, hydroxycinnamic alcohol, indol, irone, isoeugenol, methyl ether d isoeugenol, isosafrol, jasmone, camphor, carvacrol, carvone, methyl ether p-cresol, coumarin, pmethoxyacetophenone, methyl-n-amyl ketone, methylanthranilic acid methyl ester, p- methylacetophenone, methylchavicol, p-methylquinoline, methyl-e-naphthylketone, methyl-n-nonylacetaldehyde, methyl-n-nonylketone, muscone, e-naphtholethyl ether, e-naphtholmethyl ether, nitrol n-nonylaldehyde, nonyl alcohol, n-octylaldehyde, p-oxy-acetophenone, pentadecanolide, e-phenylethyl alcohol, phenylacetaldehyde-dimethylacetal, phenylacetic acid, pulegone, safrol, isoamyl ester of salicylic acid, methyl ester of salicylic acid, hexyl ester of salicylic acid, cyclohexyl ester of salicylic acid, santalol, scatol, terpineol, thymene, thymol, J-undecalactone, vanilin e, veratraldehyde, cinnamic aldehyde, cinnamic alcohol, cinnamic acid, cinnamic acid ethyl ester and cinnamic acid benzyl ester. The other odorous substances (very volatile) are alkyl isothiocyanates (alkyl mustard oils), butanediol, limonene, linalol, acetate and linayl propionate, menthol, menthone, methyln-heptenone , phellandrene, phenylacetaldehyde, terpinyl acetate, citral and citronellal. The perfumes or perfumed oils are present in the antiperspirant composition preferably in an amount ranging from 0.05 to 10% by weight, more preferably from 0.1 to 5% by weight, most preferably from 0, 5 to 4% by weight, relative to the total weight of the antiperspirant composition.

In addition, the compositions according to the invention may contain additional deodorant active ingredients. Antimicrobial, antibacterial or germ-inhibiting substances, antioxidants, odor adsorbents or enzyme inhibitors can be used as deodorant active ingredients. Suitable antimicrobial, antibacterial or germ-inhibiting substances include organohalogenated compounds and halides, quaternary ammonium compounds and a series of plant extracts. The preferred halogenated phenol derivatives are for example hexachlorophene or Irgasan DP 300 (triclosan, ether

2,4,4'-trichloro-2'-hydroxydiphenyl), 3,4,4'-trichlorocarbanilide, chlorhexidine (1,1'- hexamethylene-bis- [5- (4-chlorphenyl)] - biguanide), chlorhexidine gluconate, benzalkonium halides and cetylpyridinium chloride. In addition, sodium bicarbonate and sodium phenolsulfonate as well as components of linden oil, for example, can be used. Antimicrobial substances with a weaker effect, but which have a specific effect against the gram-positive germs responsible for the breakdown of sweat, can also be used as deodorant active ingredients. Benzyl alcohol can also be used as a deodorant active ingredient. Lantibiotics, glyco-glycerolipids, sphingolipids (ceramides), sterols and other active ingredients that inhibit bacterial adhesion to the skin, such as glycosidases, lipases, proteases, carbohydrates, acid esters di- and oligosaccharide fats as well as alkylated mono- and oligosaccharides are other deodorants with antibacterial effect. The preferred deodorant active ingredients are long chain diols, for example

1.2- alkana- (C5-C18) -diols, the fatty acid monoester (C8-C18) of glycerol or, in a particularly preferred manner, the monoalkylether (C6-C16) of glycerol, in particular glycerol ether 2 -ethylhexylic which are very well compatible with the skin and mucous membranes and act against corynebacteria, as well as phenoxyethanol, phenoxyisopropanol (3-phenoxy-propane-2-ol), anise alcohol, 2 -methyl-5-phenyl-pentane-l-ol, l, l-dimethyl-3-phenyl-propane-l-ol, benzyl alcohol, 2-phenylethane-l-ol, 3-phenylpropane-l -ol, 4-phenylbutane-l-ol, 5-phenylpentane-l-ol, 2-benzylheptane-l-ol,

2.2- dimethyl-3-phenylpropane-1-ol, the

2.2- dimethyl-3- (3'-methylphenyl) -propane-l-ol, 2-ethyl-3-phenylpropane-l-ol, 2-ethyl-3- (3'-methylphenyl) -propane-l- ol, 3- (3'-chlorphenyl) -2-ethylpropane-1-ol, 3- (2'-chlorphenyl) -2-ethylpropane-1-ol, 3- (4'-chlorphenyl) -2- ethylpropane-1-ol, 3- (3 ', 4'-dichlorphenyl) -2-ethylpropane-1-ol, 2-ethyl-3- (2'-methylphenyl) -propane-1-ol,

2- ethyl-3- (4’-methylphenyl) -propane-l-ol, the

3- (3 ’, 4’-dimethylphenyl) -2-ethylpropane-l-ol, the

2- ethyl-3- (4’-methoxyphenyl) -propane-l-ol, the

3- (3 ’, 4’-dimethoxyphenyl) -2-ethylpropane-l-ol, 2-allyl-3-phenylpropane-l-ol and 2-n-pentyl-3-phenylpropane-l-ol.

In order to further improve the antiperspirant and odor reduction effect of the compositions according to the invention, they contain, according to a preferred embodiment, at least one deodorant active principle in a total amount ranging from 0.001 to 15% by weight, relative to the total weight of the cosmetic agent. If ethanol is used in the agents according to the invention, it is not considered as a deodorant active principle in the context of the present invention, but as a component of the support. The preferred deodorant active principles according to the invention are odor absorbers, ion exchangers with deodorant effect, germ-inhibiting agents, prebiotically active components as well as enzymatic inhibitors or, in a particularly preferred manner, combinations of the active ingredients mentioned. The silicates serve as odor absorbers which at the same time also advantageously contribute to the rheological properties of the composition according to the invention. The particularly preferred silicates according to the invention are mainly phyllosilicates, and among these, in particular montmorillonite, kaolinite, ilite, beidellite, nontronite, saponite, hectorite, bentonite, smectite, calcium silicate and talc.

Other preferred odor absorbers are, for example, zeolites, zinc rinoleate, cyclodextrins, certain metal oxides, such as for example aluminum oxide, as well as chlorophyll. Other preferred odor absorbers according to the invention are chosen from perlite. By active ingredients that inhibit germs or antimicrobials, according to the invention means the active ingredients which reduce the number of skin germs involved in the secretion of odors or which inhibit their growth. These germs include among others various species from the group of staphylococci, corynebacteria, anaerococci and micrococci.

In particular, organohalogen compounds and organohalides, quaternary ammonium compounds, a number of plant extracts and zinc compounds are preferred according to the invention as active ingredients that inhibit germs or antimicrobials. These include triclosan, chlorhexidine and chlorhexidine gluconate, 3,4,4'-trichlorocarbanilide, bromochlorophene, dichlorophene, chlorothymol, chloroxylenol, hexachlorophene, dichlorom-xylenol, dequalinium chloride, domiphenyl bromide, ammonium phenolsulfonate, benzalkonium halides, benzalkonium cetyl phosphate, benzalkonium saccharinates, benzethonium chloride, cetylpyridinium chloride, laurylpyridinium chloride, laurylisoquin bromide , methyl benzethonium chloride. It is also possible to use phenol, phenoxyethanol, dihydroxyethyl sulfosuccinylundecylenate disodium, sodium bicarbonate, zinc lactate, sodium phenolsulfonate and zinc phenolsulfonate, ketoglutaric acid, terpene alcohols example farnesol, copper-chlorophyllin complexes, glycerol 1-monoalkylether having a branched or linear, saturated or unsaturated alkyl radical, optionally hydroxylated at C6-C22, particularly preferably ether l- (2 -ethylhexyl) glycerol, available on the market under the name Sensiva® SC 50 (ex Schülke & Mayr), the carboxylic acid ester of mono-, di- and triglycerol (for example glycerol monolaurate, monocaprinate diglycerol), lantibiotics and plant extracts (e.g. green tea and components of linden flower oil).

Other preferred deodorant active principles are chosen from the so-called prebiotically active components which, according to the invention, must be understood as the components which inhibit only or at least mainly the odor-generating germs of the cutaneous microflora, but not those which are desired, that is to say the non-odor generating germs which belong to a healthy cutaneous microflora. We will explicitly cite here the active principles such as the extracts of conifers, in particular from the Pinaceae group, and the plant extracts from the Sapindaceae group,

Araliaceae, Lamiaceae and Saxifragaceae, in particular extracts from Picea spp., Paullinia sp., Panax sp., Lamium album or Ribes nigrum, as well as mixtures of these substances.

Other preferred deodorant active ingredients are chosen from scented oils with antibacterial action and Deosafe® scented oils, produced by the company Symrise, ex-Haarmann und Reimer.

Other preferred deodorant active principles are chosen from silver salts, in particular silver citrate, silver hydrogen hydrogen citrate, silver lactate and silver sulphate, soluble complex salts silver, colloidal silver and silver zeolites.

Among the enzyme inhibitors are substances which inhibit the enzymes responsible for the breakdown of sweat, in particular arylsulfatases, ùglucuronidase, aminoacylase, cystathionine-B-lyase, esterases, lipases and / or lipoxigenase, for example the ester of trialkylcitric acid, in particular triethyl citrate or zinc glycinate.

The preferred antiperspirant compositions according to the invention are characterized in that at least one deodorant active principle is chosen from arylsulfatase inhibitors, beta-glucuronidase inhibitors, aminoacylase inhibitors, inhibitors of cystathionine-B-lyases, esterase inhibitors, lipase inhibitors and lipoxygenase inhibitors, monoalkylglycerol ethers having a branched or linear C6 to C22 alkyl radical, saturated or unsaturated, optionally hydroxylated, in particular l (2-ethylhexyl) glycerol ether, phenoxyethanol, benzylheptanol, Cocamidopropyl PG-dimonium chloride phosphate and butyloctanoic acid, Polyglycerin-3-Caprylate, fragrant oils with antibacterial effect, Deosafe® fragrant oils (Deosafe ® is a registered trademark of the company Symrise, formerly Haarmann & Reimer), components with a prebiotic effect, esters of trialkylcit acid risk, in particular triethyl citrate, the active principles reducing the number of skin germs involved in the appearance of odors (from the group of staphylococci, corynebacteria, anaerococci and micrococci) or inhibiting their growth, zinc compounds, in particular the zinc phenolsulfonate and zinc ricinoleate, organic halogenated compounds, in particular triclosan, chlorhexidine and benzalkonium halides, quaternary ammonium compounds, in particular cetylpyridinium chloride, odor absorbers, in particular silicates and zeolites, sodium bicarbonate, lantibiotics, as well as mixtures of the above-mentioned substances.

Other preferred antiperspirant compositions according to the invention are characterized in that at least one deodorant active principle is present in the total composition in a total amount ranging from 0.0001 to 15% by weight, preferably 0.2 to 7% by weight, particularly preferably 0.3 to 5% by weight and most preferably 0.4 to 1.0% by weight, respectively relative to the total weight of the active substance deodorant active ingredient or deodorant active ingredient.

In another particularly preferred embodiment, the compositions according to the invention contain both at least one deodorant active principle as well as at least one antiperspirant active principle.

In a particularly preferred manner, the antiperspirant composition contains triethyl citrate. Most preferably, the amount of triethyl citrate is in a range from 0.0001 to 12% by weight, relative to the total weight of the antiperspirant composition.

Chelating substances can also contribute to the deodorant action in that they stably complexify the heavy metal ions with an oxidizing catalytic action (for example iron or copper). Suitable complexing agents are, for example, the salts of ethylenediamine-tetraacetic acid or of nitrilotriacetic acid as well as the salts of l-hydroxyethane-1,1-diphosphonic acid.

It may be advantageous to add to the preparations according to the invention at least one chelating agent in a total amount ranging from 0.01 to 3.0% by weight, preferably from 0.02 to 1.0% by weight. weight, in particular from 0.05 to 0.1% by weight, relative to the total weight of the antiperspirant agent according to the invention. In the context of the present invention, the preferred chelating agents are chosen from the group comprising β-alaninediacetic acid, cyclodextrin, diethylenetriaminepentamethylenephosphonic acid, sodium, potassium, disodium calcium, ammonium and ethylene diaminetetraacetic acid (EDTA) triethanolamine, etidronic acid, hydroxyethylenediaminetetraacetic acid (HEDTA) and their sodium salts.

To thicken the perspiration-inhibiting cosmetic agents according to the invention, substances chosen from cellulose ethers, xanthan gum, sclerotum gum, succinoglycans, polygalactomannans, pectins, agar are preferably used. , carragheen (carrageenan), tragacanth, gum arabic, gum arabic, karaya gum, tara gum, gellan, gelatin, propylene glycol alginate, alginic acids and their salts, polyvinylpyrrolidones, alcohols polyvinyls, polyacrylamides, physically modified starches (eg pregelatinization) and / or chemically, acrylic acid / acrylate copolymers, acrylic acid / acrylamide copolymers, acrylic acid / vinylpyrrolidone copolymers, acid copolymers acrylic / vinyl form amide and polyacrylates. The particularly preferred thickening agents are also chosen from carbomers. Carbomers are crosslinked thickening polymers derived from acrylic acid, methacrylic acid and their salts. Crosslinking can be carried out using polyfunctional compounds such as polyalkylenic ethers of polysaccharides or polyalcohols such as the allyl ether of sucrose, the allyl ether of pentaerythritol and the allyl ether of propylene. Homopolymers of acrylic acid or its salts, which are crosslinked with a pentaerythritolallyl ether, a saccharoseallyl ether or a propyleneallyl ether, are preferred in the context of the present invention. A thickening agent which can be used in the context of the present invention is a copolymer of C10 to C30 alkyl acrylate, acrylic acid, methacrylic acid and their esters, which is crosslinked with an allyl ether of sucrose or an allyl ether of pentaerythritol. Carbomer-based thickening agents are the products sold under the Carbopol® brand (BF Goodrich, Ohio, USA), such as for example Carbopol 934, Carbopol 940, Carbopol 941, Carbopol 971, Carbopol 974, Carbopol EZ2, Carbopol ETD 2001 , Carbopol ETD 2020, Carbopol ETD 2050, Carbopol ultrez 10, Carbopol ultrez 20, or Carbopol ultrez 21.

The preferred compositions according to the invention also contain at least one water-soluble polyvalent C2 to C9 alkanol containing from 2 to 6 hydroxyl groups and / or at least one water-soluble polyethylene glycol containing from 3 to 50, preferably 3 to 20 ethylene oxide units and mixtures thereof to further improve the stability of the compositions. Preferably, these components are chosen from 1,2-propylene glycol, 2-methyl-1,3-propanediol, glycerol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol , pentylene glycols such as 1,2-pentanediol and 1,5-pentanediol, hexanediols such as 1,6-hexanediol, hexantriols such as 1,2,6-hexanetriol, 1,2-octanediol, 1,8-octanediol, dipropylene glycol, tripropylene glycol, diglycerol, triglycerol, erythritol, sorbitol as well as mixtures of the abovementioned substances. Suitable water-soluble polyethylene glycols are selected from PEG-3, PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16 , PEG-18 and PEG20 as well as mixtures thereof, the substances PEG-3 to PEG-8 being preferred. Preferably propylene glycol, dipropylene glycol or a mixture thereof is present, more preferably only propylene glycol is present. Preferably, these are present in a total amount ranging from 0.1 to 50% by weight, more preferably from 0.5 to 10% by weight or from 1 to 5% by weight.

According to another embodiment of the present invention, the antiperspirant cosmetic agents also contain at least one active principle that cools the skin. The cooling active principles suitable for the skin according to the invention are for example menthol, isopulegol as well as menthol derivatives, for example menthyl lactate, menthyl glycolate, menthyl ethyloxamate, menthylpyrrolidone acid carbonic acid, methyl methyl ether, menthoxypropanediol, Menthone Glycerin Acetal (9-methyl-6- (1-methylethyl) -l, 4-dioxaspiro (4.5) decane-2-methanol), monomenthyl succinate, 2- hydroxymethyl-3,5,5-trimethylcyclohexanol and 5-methyl-2- (1-methylethyl) cyclohexyl-nethyloxamate. The active refrigerants for the skin are preferably menthol, isopulegol, menthyl lactate, menthoxypropanediol, menthylpyrrolidone carbonic acid and 5-methyl-2- (1-methylethyl) cyclohexyl-nethyloxamate as well as mixtures of these substances, in particular mixtures of menthol and menthyl lactate, menthol, menthol glycolate and menthyl lactate, menthol and menthoxypropanediol or menthol and isopulegol. Preferably according to the invention, the antiperspirant cosmetic agent may also contain an antioxidant agent, preferably in an amount ranging from 0.01 to 5.0% by weight, relative to the total weight of the cosmetic agent. The antioxidant agent can be chosen from ascorbic acid, ascorbyl palmitate, BHT, substituted esters of hydroxyhydrocinnamic acid, substituted benzotriazoles, dialkylthiodialkanoates, tocopherol and its esters (e.g. acetate) , hydroxymethoxyphenyldecanones, paradol and their mixtures, in particular substituted esters of hydroxyhydrocinnamic acid and mixtures of these.

The propellants (propellants) preferred are propane, propene, nbutane, isobutane, isobutene, n-pentane, pentene, isopentane, isopentene, methane, ethane, dimethyl ether, nitrogen, air, oxygen, nitrous oxide, 1,1,1,3-tetrafluoroethane, heptafluoro-n-propane, perfluoroethane, monochlorodifluoromethane, 1 , 1-difluoroethane, tetrafluoropropene, either singly or in mixtures. Hydrophilic propellants, such as carbon dioxide, can also be used advantageously within the meaning of the present invention if the proportion of hydrophilic gases is low and if the lipophilic propellant (eg propane / butane) is present in excess. Propane, n-butane, isobutane and mixtures of these propellants are particularly preferred. It has been found that the use of n-butane as the sole propellant may be particularly preferred according to the invention.

In addition, the mission inherent in the invention was to provide a substance having an antiperspirant action and which can be used in an antiperspirant composition. The mission inherent in the invention is achieved by the object described below. A second object of the invention is therefore the use of tetrahydroxypropyl ethylenediamine or its salts as an antiperspirant active ingredient in an antiperspirant composition intended for topical treatment of the skin.

According to a preferred embodiment of the present invention, tetrahydroxypropyl ethylenediamine or its salts are used as an antiperspirant active ingredient in an antiperspirant composition according to the present invention, ie. that tetrahydroxypropyl ethylenediamine or its salts are used in a composition according to the first subject of the invention.

The preferred uses are therefore characterized in that the antiperspirant composition is an antiperspirant composition according to the invention.

The characteristics relating to the preferred embodiments of the first object of the invention, which are only described above as such, obviously apply in the same way to the second object, as characteristics of modes of more preferred achievement.

The cosmetic agents very particularly preferred according to the invention comprise at least one of embodiments A) to E) [0062] A) Antiperspirant composition for topical treatment of the skin, comprising tetrahydroxypropyl ethylenediamine in an aqueous or hydroalcoholic support, the antiperspirant composition having a pH value ranging from 3 to less than 7 and the tetrahydroxypropyl ethylenediamine being present in the antiperspirant composition in an amount ranging from 0.1 to 30% by weight, preferably from 1 to 15% by weight, more preferably from 5 to 10% by weight, relative to the total weight of the antiperspirant composition.

B) Antiperspirant composition for the topical treatment of the skin, comprising tetrahydroxypropyl ethylenediamine in an aqueous or hydroalcoholic support, the antiperspirant composition having a pH value ranging from 3 to less than 7 and the tetrahydroxypropyl ethylenediamine being present in the antiperspirant composition in an amount ranging from 0.1 to 30% by weight, preferably from 1 to 15% by weight, more preferably from 5 to 10% by weight, relative to the total weight of the antiperspirant composition, the aqueous or hydroalcoholic support being water or a water / alcohol mixture, the alcohol being preferably chosen from a linear or branched C2 to C6 alcohol, more preferably from ethanol, propanol, isopropanol, 1.3-propanediol, dipropylene glycol, 1.2-propanediol, in particular 1,2-propanediol, and / or preferably water or the water / mixture alcohol is present in an amount ranging from 60% by weight to 96% by weight, most preferably from 85% by weight to 92% by weight, relative to the total weight of the antiperspirant composition.

C) Use of tetrahydroxypropyl ethylenediamine as an antiperspirant active ingredient in an antiperspirant composition intended for topical treatment of the skin, the antiperspirant composition having an aqueous or hydroalcoholic support and having a pH ranging from 3 unless 7.

D) Use of tetrahydroxypropyl ethylenediamine as an antiperspirant active ingredient in an antiperspirant composition intended for topical treatment of the skin, the antiperspirant composition having an aqueous or hydroalcoholic support and having a pH value ranging from 3 to less than 7 and the tetrahydroxypropyl ethylenediamine being present in the antiperspirant composition in an amount ranging from 0.1 to 30% by weight, preferably from 1 to 15% by weight, more preferably from 5 to 10 % by weight, relative to the total weight of the antiperspirant composition.

E) Use of tetrahydroxypropyl ethylenediamine as an antiperspirant active ingredient in an antiperspirant composition intended for topical treatment of the skin, the antiperspirant composition having an aqueous or hydroalcoholic support and having a pH value ranging from 3 to less than 7 and the tetrahydroxypropyl ethylenediamine being present in the antiperspirant composition in an amount ranging from 0.1 to 30% by weight, preferably from 1 to 15% by weight, more preferably from 5 to 10 % by weight, relative to the total weight of the antiperspirant composition, and the aqueous or hydroalcoholic support being water or a water / alcohol mixture, the alcohol being preferably chosen from a linear C2 to C6 alcohol or branched, more preferably ethanol, propanol, isopropanol, 1,3-propanediol, dipropylene glycol, 1,2-propanediol, in particular 1,2-pro panediol, and / or preferably the water or the water / alcohol mixture is present in an amount ranging from 60% by weight to 99% by weight, particularly preferably from 80 to 96% by weight, preferably between all from 85% by weight to 92% by weight, relative to the total weight of the antiperspirant composition.

Examples The following composition can for example be produced as follows:

Example 1: Manufacture of an antiperspirant composition for use in a ball applicator [Tables 74]

O / W emulsion Quantities expressed in% by weight Tetrahydroxypropyl ethylenediamine 8 Demineralized Water qs Hydrochloric acid 20% ** qs pH 3.5 1,2-propanediol 0 PPG-15 Stearylether * 1 Steareth - 2 * 1 Steareth - 21 * 2.5 Perfume 0.8 phenoxyethanol 0.5 antioxidant 0.05

* INCI name [**] The amount of hydrochloric acid necessary to reach the pH indicated in the table is added.

Example 2: Manufacture of an antiperspirant composition for use as a ball applicator [Tables!]

O / W emulsion Quantities expressed in% by weight Tetrahydroxypropyl ethylenediamine 10 Demineralized Water qs Hydrochloric acid 20% ** qs pH 4.5 1,2-propanediol 2 PPG-15 Stearylether * 3 Steareth - 2 * 3 Steareth - 21 * 4 Perfume 1.5 phenoxyethanol 0.5 antioxidant 0.9

* INCI name [**] The quantity of hydrochloric acid necessary to reach the pH indicated in the table is added.

Example 3: Manufacture of an antiperspirant composition for use as a ball applicator [Tables 82]

O / W emulsion Quantities expressed in% by weight Tetrahydroxypropyl ethylenediamine 25 Demineralized Water qs Hydrochloric acid 20% ** qs pH 4.5 1,2-propanediol 5 PPG-15 Stearylether * 5 Steareth - 2 * 5 Steareth - 21 * 5 Perfume 2.0 phenoxyethanol 1.0 antioxidant 2.0

* INCI name [**] The quantity of hydrochloric acid necessary to reach the pH indicated in the table is added.

Example 4: Manufacture of an antiperspirant composition for use as a spray [Tables 86]

O / W emulsion Quantities expressed in% by weight Tetrahydroxypropyl ethylenediamine 8 Demineralized Water qs Hydrochloric acid 20% ** qs pH 3.5 1,2-propanediol 5 cyclopentasiloxane 11.2 Isopropyl myristate 2 Dow Corning Formula Adjuvant ES-5227 DM 3 Perfume 1 phenoxyethanol 1.0 antioxidant 0.05

** The quantity of hydrochloric acid necessary to reach the pH indicated in the table is added.

Example 5: Manufacture of an antiperspirant composition for use in a spray [0089] [Tables5]

O / W emulsion Quantities expressed in% by weight Tetrahydroxypropyl ethylenediamine 10 Demineralized Water qs Hydrochloric acid 20% ** qs pH 4.9 1,2-propanediol 25 cyclopentasiloxane 11.2 Isopropyl myristate 5 Dow Corning Formula Adjuvant ES-5227 DM 4 Perfume 4 phenoxyethanol 0.1 antioxidant 0.05

** The quantity of hydrochloric acid necessary to reach the pH indicated in the table is added.

Example 6: Manufacture of an antiperspirant composition for use as a spray [Tables 92]

O / W emulsion Quantities expressed in% by weight Tetrahydroxypropyl ethylenediamine 15 Demineralized Water qs Hydrochloric acid 20% ** qs pH 4.9 1,2-propanediol 20 cyclopentasiloxane 11.2 Isopropyl myristate 10 Dow Corning Formula Adjuvant ES-5227 DM 7.5 Perfume 3 phenoxyethanol 1.0 antioxidant 1.2

** The quantity of hydrochloric acid necessary to reach the pH indicated in the table is added.

The filling is carried out jointly with a propane and / or butane and / or isobutane propellant in a filling proportion of 10.0 to 40.0% by weight of W / O and 60 emulsion. 0.0 to 90.0% by weight of propellant.

The exemplary compositions for the sprays can be packaged in an aluminum spray cartridge, optionally covered with epoxy-phenol lacquer in a proportion by weight of propellant (butane / propane / isobutane mixture) on emulsion from 70:30, 75:25, 80:20 or 85:15 or 60:40 or 90:10 Example 7: Manufacture of an antiperspirant composition for use in a ball applicator [Tables] ?]

Mixture for ball applicator Quantities expressed in% by weight Tetrahydroxypropyl ethylenediamine 15 Demineralized Water qs Hydrochloric acid 20% ** qs pH 3.5 96% ethanol (cosmetic, denatured) 30 Ceteareth-12 2 Ceteareth-30 2 hydroxyethyl 0.5 Perfume 1.0 phenoxyethanol 1.0 antioxidant 0.2 Deodorant active ingredient 2.0

** The quantity of hydrochloric acid necessary to reach the pH indicated in the table is added.

Example 8: Manufacture of an antiperspirant composition for use as a spray [0100] [Tables8]

Pump spray mixture Quantities expressed in% by weight Tetrahydroxypropyl ethylenediamine 10 Demineralized Water qs Hydrochloric acid 20% ** qs pH 3.5 96% ethanol (cosmetic, denatured) 40 Ceteareth-12 2 Ceteareth-30 2 Refrigerant 0.1 Perfume 1.0 phenoxyethanol 1.0 antioxidant 0.2 Deodorant active ingredient 2.0

The product is applied mechanically to the skin, using a sprayer, in the form of fine particles.

Example 9: Manufacture of an antiperspirant composition for use as a spray [0103] [Tables 9]

Pump spray mixture Quantities expressed in% by weight Tetrahydroxypropyl ethylenediamine 10 Demineralized Water qs Hydrochloric acid 20% ** qs pH 3.5 1,2-propanediol, optional 20.0 Ceteareth-12 2 Ceteareth-30 2 Refrigerant 0.1 Perfume 1.0 phenoxyethanol 1.0 antioxidant 0.2 Deodorant active ingredient 2.0

The product is applied mechanically to the skin, using a sprayer, in the form of fine particles.

Example 10: Manufacture of an antiperspirant composition for use in a ball applicator [0106] [Tables 10]

Mixture for ball applicator Quantities expressed in% by weight Tetrahydroxypropyl ethylenediamine 10 Demineralized Water qs Hydrochloric acid 20% ** qs pH 3.5 1,2-propanediol, optional 20.0 Ceteareth-12 2 Ceteareth-30 2 hydroxyethyl 0.5 Perfume 1.0 phenoxyethanol 1.0 antioxidant 0.2 Deodorant active ingredient 2.0

The product is applied mechanically to the skin, using a sprayer, in the form of fine particles.

In addition, the antiperspirant effect was tested. To test the effect of tetrahydroxypropyl ethylenediamine, the following compositions were tested:

- 10% aluminum chlorohydrates, aqueous solution as reference [0110] - 10% tetrahydroxypropyl ethylenediamine dissolved in water, the sample is adjusted to a pH of 3.5 with hydrochloric acid 20% In order to determine the antiperspirant effect, a study relating to this property was carried out on the backs of 16 subjects. To do this, the following antiperspirant agents were used:

[T118]

Antiperspirant agent No. Aqueous solution with 10% aluminum hydrochloride "ACH", pH 4 V-I 10% aqueous solution of tetrahydroxypropyl ethylenediamine adjusted to a pH of 3.5 with 20% hydrochloric acid E-I **

* Active substance [0114] ** Composition according to the invention [0115] On the back of 16 subjects, 40 μΐ of the antiperspirant agent VI and 75 μΐ of the antiperspirant agent EI cosmetic were applied to one side near the spine. After 5 minutes, the treated areas were covered with a non-absorbent occlusive film. 2 hours later, these non-absorbent pads were removed. The compositions were applied to the back of the test subjects for four consecutive days as described above.

24 hours after the last application of the composition, absorbent pads were applied to the back of the subjects in the place where the compositions had been applied before. In addition, pads were applied to the other side of the spine at the same height, which served as a control. After the subjects perspired for about 15 minutes at 80 ° C in the sauna, the amount of sweat absorbed by the pads was determined by gravimetry, comparing each composition with the corresponding untreated area on the back. The reduction in perspiration was determined from the gravimetric determination of the amount of perspiration, all the determined values being statistically significant.

The reduction in perspiration of the respective composition relative to an untreated area of the skin is indicated in the following table:

[0118] [Tablesl2]

No. Reduction of perspiration V-I 56% * E-I 17% *

* Significant [0120] The use of cosmetic agents containing tetrahydroxypropyl ethylenediamine, in particular in the form of hydrochlorides, causes a reduction in perspiration and body odors when they are applied to the skin.

Claims (1)

claims [Claim 1] Antiperspirant composition for topical treatment of the skin, comprising tetrahydroxypropyl ethylenediamine or its salts in an aqueous or hydroalcoholic support, the antiperspirant composition having a pH ranging from 2.5 to less than 7. [Claim 2] Antiperspirant composition according to Claim 1, characterized in that the antiperspirant composition contains tetrahydroxypropyl ethylenediamine and / or its salts in a total amount ranging from 0.1 to 30% by weight, preferably from 1 to 15 % by weight, more preferably 5 to 10% by weight, relative to the total weight of the antiperspirant composition, and / or characterized in that the antiperspirant composition has a pH ranging from 3.2 to less from 6, preferably from 3.5 to 5.8, more preferably from 4.0 to 5.5. [Claim 3] Antiperspirant composition according to claim 1 or claim 2, characterized in that the antiperspirant composition contains substantially no salts containing aluminum. [Claim 4] Antiperspirant composition according to claim 1 or claim 2, characterized in that the antiperspirant composition comprises an antiperspirant active principle, which is preferably an inorganic or organic salt of aluminum, zirconium, zinc or a mixture of these. [Claim 5] Antiperspirant composition according to Claim 4, characterized in that the antiperspirant active principle is chosen from an aluminum hydrochloride, preferably aluminum hydrochloride, aluminum sesquichlorohydrate, aluminum hydrochloride-propylene glycol (PG), aluminum hydrochloride-polyethylene glycol (PEG), aluminum sesquichlorhydrex-PG, aluminum sesquichlorhydrex-PEG, aluminum dichlorhydrex-PG, aluminum dichlorhydrex-PEG or aluminum hydroxide; or is chosen from an aluminum zirconium hydrochloride, preferably aluminum zirconium trichlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate or aluminum zirconium octachlorohydrate; or is chosen from an aluminum-zirconium glycine hydrochloride complex, preferably aluminum-zirconium glycinetrichlorhydrex, aluminum-zirconium glycine-tetrachlorhydrex, glycine-pentachlorhydrex [Claim 6] [Claim 7] aluminum-zirconium, glycine-octachlorhydrex aluminum-zirconium, or is chosen from potassium aluminum sulphate (KAI (SO4) 2 - 12 H2O, alum), sodium hydrochloroacetate- aluminum, aluminum hydrobromide, aluminum chloride, aluminum sulfate, zinc chloride, zinc sulfocarbolate, zinc sulfate or zirconium hydrochloride, and / or characterized in that the active principle antiperspirant is present in the antiperspirant composition in an amount ranging from more than 0 to 15% by weight, preferably from 0.01 to 5% by weight, more preferably from 0.1 to 1% by weight weight, relative to the total weight of the antiperspirant composition. Antiperspirant composition according to one of the preceding claims, characterized in that the antiperspirant composition contains an emulsifier which is preferably an oil-in-water (O / W) emulsifier having an HLB value ranging from 7 to 20.1 the O / W emulsifier being more preferably a nonionic O / W emulsifier, and / or the antiperspirant composition containing an emulsifier which is preferably a water-in-oil (W / O) emulsifier having a value ranging from 2 to 7, and / or characterized in that the antiperspirant composition contains an O / W emulsifier in an amount ranging from 0.05 to 25% by weight, more preferably from 0.2 to 10% by weight, even more preferably from 0.8 to 6% by weight, relative to the total weight of the antiperspirant composition, and / or the antiperspirant composition containing a W / O emulsifier in an amount ranging from 0.01 to 15 % by weight, preferably e from 0.1 to 8% by weight, more preferably from 0.5 to 2% by weight, relative to the total weight of the antiperspirant composition, the antiperspirant composition particularly preferably containing an O / W emulsifier and a W / O emulsifier, the amount of O / W emulsifier being greater than the amount of W / O emulsifier. Antiperspirant composition according to one of the preceding claims, characterized in that the antiperspirant composition contains a cosmetic oil in an amount ranging from 1 to 15% by weight, preferably from 2 to 10% by weight, so more preferred from 3 to 5% by weight, relative to the total weight of the antiperspirant composition, and / or characterized in that the antiperspirant composition contains a stabilizer chosen from particulate substances, preferably pyrogenic silicon dioxide or phyllo [ Claim 8] [Claim 9] [Claim 10] silicates, more preferably those hydrophobically modified, in particular hydrophobically modified bentonites and / or hydrophobically modified hectorites. Antiperspirant composition according to one of the preceding claims, characterized in that the aqueous or hydroalcoholic support is water or a water / alcohol mixture, the alcohol being preferably chosen from a C2 to C6 alcohol linear or branched, more preferably ethanol, propanol, isopropanol, 1,3-propanediol or dipropylene glycol, 1,2-propanediol, in particular 1,2-propanediol, and / or so preferred water or water / alcohol mixture representing an amount ranging from 60% by weight to 99% by weight, more preferably from 80% by weight to 96% by weight, most preferably from 85% by weight 92% by weight, relative to the total weight of the antiperspirant composition. Use of tetrahydroxypropyl ethylenediamine or its salts as an antiperspirant active ingredient in an antiperspirant composition intended for topical treatment of the skin. Use according to claim 9, characterized in that the antiperspirant composition is an antiperspirant composition according to one of claims 1 to 8.