GB2577178A

GB2577178A - Tetrahydroxypropyl ethylene diamine or its salts as an active substance for reducing sweat secretion

Info

Publication number: GB2577178A
Application number: GB1911322.4A
Authority: GB
Inventors: Banowski Bernhard; Claas Marcus
Original assignee: Henkel AG and Co KGaA
Current assignee: Henkel AG and Co KGaA
Priority date: 2018-08-16
Filing date: 2019-08-07
Publication date: 2020-03-18
Anticipated expiration: 2039-08-07
Also published as: DE102018213830A1; FR3084998A1; GB201911322D0; GB2577178B

Abstract

An antiperspirant (deoodrant) composition comprising tetrahydroxypropyl ethylene diamine (THPE, tetrahydroxypropyl ethylendiamine) and/or salt forms, preferably 0.1 to 30 wt%, in an aqueous (water) or alcohol-aqueous carrier (1,2-propanediol), with a pH between 2.5 and 7. The pH is controlled by the addition of 20% HCl (hydrochloric acid), preferably from pH 3.5 to 4.9. The antiperspirant preferably contains no aluminium; however, it may include inorganic or organic salts of aluminium (aluminum), zirconium, zinc or a mixture. Oil-in-water (O/W) and water-in-oil (W/O) emulsifiers are also present (steareth, ceteareth), as well as cosmetic oils (cyclopentasiloxane, polypropylene glycol ether, PEG), thickening agents (fumed silica), perfumes or fragrances, a deodorant active substance (antimicrobial, antibacterial, germ-inhibitor, odour adsorbent, enzyme inhibitor, silicates, silver salts, triethyl citrate), chelating agents (EDTA), thickening agents (hydroxyethyl cellulose, carbomers), cooling agents (menthol), antioxidants (hydroxy(hydro)cinnamic acid) and propellants (n-butane). The composition can be formulated as a roll-on or a spray and is used as a topical treatment on skin.

Description

(56) Documents Cited:

US 20150118173

US 20060188459

US 20040096409

A1

US 20070031361 A1

US 20060104940 A1 (71) Applicant(s):

Henkel AG & Co. KGaA (Incorporated in the Federal Republic of Germany) HenkelstraBe 67, Henkel, Duesseldorf, 40589, Germany (72) Inventor(s):

Bernhard Banowski

Marcus Claas (74) Agent and/or Address for Service:

LKGlobal UK LTD

Cambridge House, Henry Street, Bath, BA1 1BT, United Kingdom (58) Field of Search:

INT CLA61K, A61Q

Other: WPI, EPODOC, Patent Fulltext (54) Title of the Invention: Tetrahydroxy propyl ethylene diamine or its salts as an active substance for reducing sweat secretion Abstract Title: An antiperspirant composition comprising tetrahydroxypropyl ethylene diamine (57) An antiperspirant (deoodrant) composition comprising tetrahydroxypropyl ethylene diamine (THPE, tetrahydroxypropyl ethylendiamine) and/or salt forms, preferably 0.1 to 30 wt%, in an aqueous (water) or alcoholaqueous carrier (1,2-propanediol), with a pH between 2.5 and 7. The pH is controlled by the addition of 20% HCI (hydrochloric acid), preferably from pH 3.5 to 4.9. The antiperspirant preferably contains no aluminium; however, it may include inorganic or organic salts of aluminium (aluminum), zirconium, zinc or a mixture. Oil-in-water (O/W) and water-in-oil (W/O) emulsifiers are also present (steareth, ceteareth), as well as cosmetic oils (cyclopentasiloxane, polypropylene glycol ether, PEG), thickening agents (fumed silica), perfumes or fragrances, a deodorant active substance (antimicrobial, antibacterial, germ-inhibitor, odour adsorbent, enzyme inhibitor, silicates, silver salts, triethyl citrate), chelating agents (EDTA), thickening agents (hydroxyethyl cellulose, carbomers), cooling agents (menthol), antioxidants (hydroxy(hydro)cinnamic acid) and propellants (n-butane). The composition can be formulated as a roll-on or a spray and is used as a topical treatment on skin.

SPECIFICATION

TETRAHYDROXYPROPYL ETHYLENE DIAMINE OR ITS SALTS AS AN ACTIVE SUBSTANCE FOR REDUCING SWEAT SECRETION

TECHNICAL FIELD [0001] The present invention relates to an antiperspirant composition for the topical treatment of the skin comprising tetrahydroxypropyl ethylene diamine or its salts in an aqueous or aqueous-alcoholic carrier. Further, the present invention relates to the use of tetrahydroxypropyl ethylene diamine or its salts as an antiperspirant active substance in an antiperspirant composition for the topical treatment of the skin.

BACKGROUND [0002] Body odor arises to a large extent from the bacterial decomposition of individual components of sweat on the skin. In body deodorization, one can roughly differentiate between active substances which absorb unpleasant-smelling substances already formed (activated carbon, zinc ricinoleate, cyclodextrins, ion exchangers) or cover (fragrances, perfumes) them, and active substances which prevent the decomposition of perspiration and the formation of unpleasant-smelling substances or at least slow them down (germ-inhibiting active substances, prebiotic components and enzyme inhibitors). Depending on the chosen mechanism by which body odor is to be prevented, odor absorbers, fragrances, deodorizing ion exchangers, germ-inhibiting agents, prebiotic active components, enzyme inhibitors and other active substances can be used as cosmetic deodorizing active substances. The active substances must be included in the compositions, ensuring that the compositions can be conveniently provided in a desired dosage form and that the compositions do not cause an unpleasant sensation on the skin.

[0003] Underarm wetness is caused by eccrine, watery sweat and often results in unwanted wet spots on clothing.

[0004] The antiperspirant cosmetic antiperspirants used in the prior art contain aluminum and/or zirconium compounds as antiperspirant active substances. These antiperspirant compounds reduce sweat secretion of the body by temporarily narrowing and/or obstructing the excretory ducts of the sweat glands, so that the amount of sweat can be reduced by from about 20 to about 60 percent. On the other hand, they have an additional deodorizing effect due to their antimicrobial effect. However, the aluminum and/or zirconium compounds used to inhibit sweat can lead to unpleasant skin reactions in some users. Aluminum compounds are especially considered critical by consumers. In addition, the use of the aforementioned antiperspirant compounds can lead to staining by the products being applied on the clothing.

[0005] There is therefore a need, instead of the commonly used aluminum and/or zirconium compounds, to use other antiperspirant cosmetic active substances or at least to significantly reduce the amount of these compounds. The antiperspirant active substances should have a good antiperspirant effect, good skin compatibility and be easy to formulate. In addition, these antiperspirant active substances should have no negative impact on the storage stability of the cosmetic agents used for sweat inhibition.

BRIEF SUMMARY [0006] In a first respect, the present invention relates to an antiperspirant composition for the topical treatment of the skin comprising tetrahydroxypropyl ethylene diamine or its salts in an aqueous or aqueous-alcoholic carrier, wherein the antiperspirant composition has a pH value from about 2.5 to less than about 7.

[0007] Preferably, the antiperspirant composition contains tetrahydroxypropyl ethylene diamine and/or its salts in a total amount of from about 0.1 to about 30% by weight, preferably from about 1 to about 15% by weight, more preferably from about 5 to about 10% by weight, based on the total weight of the antiperspirant composition, and/or characterized in that the antiperspirant composition has a pH value of from about 3.2 to less than about 6, preferably from about 3.5 to about 5.8, more preferably from about 4.0 to about 5.5.

[0008] The antiperspirant composition may be essentially free of salts containing aluminum, or the antiperspirant composition may comprise an antiperspirant active substance which is preferably an inorganic or organic salt of aluminum, zirconium, zinc or a mixture thereof.

[0009] Preferably, the antiperspirant active substance is selected from an aluminum chlorohydrate, preferably activated aluminum chlorohydrate, aluminum sesquichlorohydrate, aluminum chlorohydrex propylene glycol (PG), aluminum chlorohydrex polyethylene glycol (PEG), aluminum sesquichlorohydrex PG, aluminum sesquichlorohydrex PEG, aluminum PG-dichiorhydrex, aluminum PEG-dichlorhydrex or aluminum hydroxide; or is selected from an aluminum zirconium chlorohydrate, preferably aluminum zirconium tri chlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate or aluminum zirconium octachlorohydrate; or is selected from an aluminum-zirconiumchlorohydrate-glycine complex, preferably aluminum zirconium trichlorohydrexglycine, aluminum zirconium tetrachlorohydrex glycine, aluminum zirconium pentachlorohydrex glycine, aluminum zirconium octachlorohydrex glycine, or is selected from potassium aluminum sulfate (KA1(SO4)2 - 12 H20, alum), sodium aluminum chlorine hydroxyacetate, aluminum bromohydrate, aluminum chloride, aluminum sulfate, zinc chloride, zinc sulfocarbolate, zinc sulfate or zirconium chlorohydrate. Preferably, the antiperspirant active substance is present in the antiperspirant composition in an amount of more than 0 to about 15% by weight, preferably from about 0.01 to about 5% by weight, more preferably from about 0.1 to about 1% by weight, based on the total weight of the antiperspirant composition.

[0010] Preferably, the antiperspirant composition contains an emulsifier which is preferably an oil-in-water (O/W) emulsifier having an HLB value from about 7 to about 20, wherein the O/W emulsifier is more preferably a nonionic O/W emulsifier, and/or wherein the antiperspirant composition has an emulsifier, which is preferably a water-in-oil (W/O) emulsifier having an HLB value of from about 2 to about 7. Preferably, the antiperspirant composition contains an O/W emulsifier in an amount from about 0.05 to about 25% by weight, more preferably from about 0.2 to about 10% by weight, more preferably from about 0.8 to about 6% by weight, based on the total weight of the antiperspirant composition, and/or contains a W/O emulsifier in an amount of from about 0.01 to about 15% by weight, preferably from about 0.1 to about 8% by weight, more preferably from about 0.5 to about 2% by weight, based on the total weight of the antiperspirant composition. The antiperspirant composition particularly preferably contains an O/W emulsifier and a W/O emulsifier, wherein preferably the amount of O/W emulsifier is greater than the amount of W/O emulsifier.

[0011] The antiperspirant composition may contain a cosmetic oil in an amount of from about 1 to about 15% by weight, preferably from about 2 to about 10% by weight, more preferably from about 3 to about 5% by weight, based on the total weight of the antiperspirant composition.

[0012] The antiperspirant composition may contain a stabilizer.

[0013] The aqueous or aqueous-alcoholic carrier is preferably water or a water/alcohol mixture, wherein the alcohol preferably is selected from a linear or branched C2 to C6 alcohol, more preferably ethanol, propanol, isopropanol, 1,3-propandiol, or dipropylene glycol, 1,2-propanediol, in particular 1,2-propanediol. Preferably, the water or the water/alcohol mixture is present in an amount of from about 60% by weight to about 99% by weight, more preferably from about 80% by weight to about 96% by weight, most preferably from about 85% by weight to about 92% by weight, based on the total weight of the antiperspirant composition.

[0014] In a second respect, the present invention relates to the use of tetrahydroxypropyl ethylene diamine or its salts as an antiperspirant active substance in an antiperspirant composition for the topical treatment of the skin. The antiperspirant composition is preferably an antiperspirant composition as described supra.

DETAILED DESCRIPTION [0015] The following detailed description is merely exemplary in nature and is not intended to limit the disclosure or the application and uses of the subject matter as described herein. Furthermore, there is no intention to be bound by any theory presented in the preceding background or the following detailed description.

[0016] It is an object of the present invention to provide antiperspirant active substances, the use of which avoids or at least mitigates the disadvantages of the prior art and use of which results in a high skin compatibility with simultaneous reliable reduction of underarm wetness.

[0017] This has now been achieved by providing an antiperspirant composition for the topical treatment of the skin comprising tetrahydroxypropyl ethylene diamine or its salts in an aqueous or aqueous-alcoholic carrier, wherein the antiperspirant composition has a pH from about 2.5 to less than about 7.

[0018] Tetrahydroxypropyl ethylene diamine

OH

OH h₃c_x^J oh

QH is also referred to as 7V,7V,7V',7V'-tetrakis (2-hydroxypropyl) ethylene diamine. Chemically, it is a tertiary amine having having alcoholic hydroxy groups. The amino group can be protonated with acids to form the corresponding salts (hydrochlorides, hydrogensulfates, lactates, citrates, etc.).

[0019] It has surprisingly been found that tetrahydroxypropyl ethylene diamine exhibits a sweat-reducing effect in aqueous solution in an acidic pH range. In particular, tetrahydroxypropyl ethylene diamine in the form of its hydrochloride has proven to be particularly advantageous. When the aqueous solution is adjusted to an acidic pH with hydrochloric acid, the antiperspirant composition is particularly effective. According to a preferred embodiment of the present invention, the antiperspirant composition has a pH value from about 3.2 to less than about 6, preferably from about 3.5 to about 5.8, more preferably from about 4.0 to about 5.5.

[0020] According to a preferred embodiment of the present invention, the antiperspirant composition contains tetrahydroxypropyl ethylene diamine and/or its salts in a total amount of from about 0.1 to about 30% by weight, preferably from about 1 to about 15% by weight, more preferably from about 5 to about 10% by weight, based on the total weight of the antiperspirant composition. Tetrahydroxypropyl ethylene diamine has been found to be particularly advantageous in this range.

[0021] In summary, antiperspirant compositions according to the invention are preferred which contain tetrahydroxypropyl ethylene diamine and/or its salts in a total amount of from about 0.1 to about 30% by weight, preferably from about 1 to about 15% by weight, more preferably from about 5 to about 10% by weight, based on the total weight of the antiperspirant composition, and/or are characterized in that the antiperspirant composition has a pH value from about 3.2 to less than about 6, preferably from about 3.5 to about 5.8, more preferably from about 4.0 to about 5.5.

[0022] The formulation tetrahydroxypropyl ethylene diamine and/or its salts in a total amount of from about 0.1 to about 30% by weight means that the compositions according to the invention can contain

- only tetrahydroxypropyl ethylene diamine in a total amount of from about 0.1 to about 30% by weight or

- only tetrahydroxypropyl ethylene diamine salt(s) in a total amount of from about 0.1 to about 30% by weight or

- both tetrahydroxypropyl ethylene diamine and tetrahydroxypropyl ethylene diamine salt(s) in a total amount of from about 0.1 to about 30% by weight.

[0023] The amount of active tetrahydroxypropyl ethylene diamine or the protonated compound compared to the pure compound is reduced for salts with heavy anions, which is why the use of acids with low-weight anions has proven particularly useful for pH adjustment of the agents according to the invention. Hydrochloric acid has been found to be particularly effective leading to the formation of tetrahydroxypropyl ethylene diamine hydrochloride.

[0024] In another embodiment of the invention, at least one further anion can be present as a substitute or in addition to chloride ions. Inorganic anions, for example, sulfate ions and/or phosphate ions or organic anions can be included as further ions. The organic anions can be, for example, phosphonates, citrate, lactate, tartrate and/or malate. Preferred antiperspirant cosmetic agents according to the invention are characterized in that they contain at least one further anion, preferably an organic anion which is more preferably selected from the group consisting of citrate, lactate, tartrate and malate and/or other anions of organic acids.

[0025] The use of tetrahydroxypropyl ethylene diamine and/or its salts makes it possible to provide an antiperspirant composition which can dispense with aluminum and/or zirconium compounds or in which the content of aluminum and/or zirconium compounds can be reduced. Therefore, in a preferred embodiment of the present invention, the antiperspirant composition is essentially free of compounds containing aluminum and/or zirconium.

[0026] Since tetrahydroxypropyl ethylene diamine and/or its salts are to reduce but not completely prevent the formation of sweat, the underarm odor formation is retarded and is not completely prevented. It is provided according to a preferred embodiment of the present invention that the antiperspirant composition comprises an antiperspirant active substance, which is preferably an inorganic or organic salt of aluminum, zirconium, zinc or a mixture thereof, wherein the amount of antiperspirant active substance is present in a reduced amount compared to conventional commercial products.

[0027] Preferred antiperspirant compositions of this embodiment according to the invention are characterized in that the antiperspirant composition comprises an antiperspirant active substance which is preferably an inorganic or organic salt of aluminum, zirconium, zinc or a mixture thereof.

[0028] In a preferred embodiment, the antiperspirant active substance is selected from an aluminum chlorohydrate, more preferably the antiperspirant active substance comprises activated aluminum chlorohydrate, aluminum sesquichlorohydrate, aluminum chlorhydric propylene glycol (PG), aluminum chlorohydrex-polyethylene glycol (PEG), aluminum sesquichlorohydrex PG, aluminum sesquichlorohydrex PEG, aluminum PG dichlorohydrex, aluminum PEG dichlorohydrex or aluminum hydroxide; or is selected from an aluminum zirconium chlorohydrate, preferably aluminum zirconium tri chlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate or aluminum zirconium octachlorohydrate; or is selected from an aluminum-zirconium chlorohydrateglycine complex, preferably aluminum zirconium trichlorohydrex glycine, aluminum zirconium tetrachlorohydrex glycine, aluminum zirconium pentachlorohydrex glycine, aluminum zirconium octachlorohydrex glycine, or selected from potassium aluminum sulphate (KAI(SO4)2 - 12 H2O, alum), sodium aluminum chlorohydroxy acetate, aluminum bromohydrate, aluminum chloride, aluminum sulphate, zinc chloride, zinc sulfocarbolate, zinc sulfate or zirconium chlorohydrate, wherein the antiperspirant active substance is present in the antiperspirant composition in an amount of more than 0 to about 15% by weight, preferably from about 0.01 to about 5% by weight, more preferably from about 0.1 to about

1% by weight, based on the total weight of the antiperspirant composition.

[0029] In summary, antiperspirant compositions according to the invention are preferred in which the antiperspirant active substance is selected from an aluminum chlorohydrate, preferably activated aluminum chlorohydrate, aluminum sesquichlorohydrate, aluminum chlorohydrex propylene glycol (PG), aluminum chlorohydrex polyethylene glycol (PEG), aluminum sesquichlorohydrex PG, aluminum sesquichlorohydrex PEG, aluminum PGdichiorhydrex, aluminum PEG-dichlorhydrex or aluminum hydroxide; or is selected from an aluminum zirconium chlorohydrate, preferably aluminum zirconium tri chlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate or aluminum zirconium octachlorohydrate; or is selected from an aluminum-zirconiumchlorohydrate-glycine complex, preferably aluminum zirconium trichlorohydrexglycine, aluminum zirconium tetrachlorohydrex glycine, aluminum zirconium pentachlorohydrex glycine, aluminum zirconium octachlorohydrex glycine, or selected from potassium aluminum sulfate (KAI(SO4)2 - 12 H2O, alum), sodium aluminum chlorine hydroxyacetate, aluminum bromohydrate, aluminum chloride, aluminum sulfate, zinc chloride, zinc sulfocarbolate, zinc sulfate or zirconium chlorohydrate, and/or in which the antiperspirant active substance is present in the antiperspirant composition in an amount of more than 0 to about 15% by weight, preferably from about 0.01 to about 5% by weight, more preferably from about 0.1 to about 1% by weight, based on the total weight of the antiperspirant composition.

[0030] The preferably used aluminum and/or zirconium-containing active substances can be activated by modifying them in molecular weight. They can thus be made more effective in terms of the sweat-reducing properties compared to non-activated active substances. Antiperspirant active substances which are particularly preferred according to the invention are therefore selected from so-called activated aluminum salts, which are also referred to as antiperspirant active substances having enhanced activity. Such active substances are known in the art and are also commercially available. Activated aluminum salts are typically produced by heat treating a relatively dilute solution of the salt (for example, about 10% by weight salt) to increase its HPLC peak 4-to-peak 3 area ratio. The activated salt can then be dried to a powder, in particular spray-dried. In addition to spray drying, for example, roller drying is also suitable.

[0031] However, the use of antiperspirant salts can also be completely dispensed with. Corresponding antiperspirant compositions that are essentially free of salts containing aluminum are preferred according to a further embodiment of the present invention.

[0032] Essentially free here means free of intentionally added aluminum salts, preferably a content of aluminum salts of < 0.1% by weight, based on the antiperspirant composition, particularly preferably a content of aluminum salts of < 0.01% by weight, still further preferred a content of aluminum salts of < 0.001% by weight and in particular a content of aluminum salts of < 0.0001% by weight.

[0033] According to a preferred embodiment, the antiperspirant composition contains an emulsifier which is preferably an oil-in-water (O/W) emulsifier having an HLB value of from about 7 to about 20, wherein the O/W emulsifier is more preferably a nonionic O/W emulsifier. Alternatively, the antiperspirant composition contains an emulsifier, which is preferably a water-in-oil (W/O) emulsifier having an HLB value of from about 2 to about 7. According to a further preferred embodiment, the antiperspirant composition contains an O/W emulsifier in an amount of from about 0.05 to about 25% by weight, more preferably from about 0.2 to about 10% by weight, more preferably from about 0.8 to about 6% by weight, based on the total weight of the antiperspirant composition. Alternatively, the antiperspirant composition contains a W/O emulsifier in an amount from about 0.01 to about 15% by weight, preferably from about 0.1 to about 8% by weight, more preferably from about 0.5 to about 2% by weight, based on the total weight of the antiperspirant composition, wherein more preferably the antiperspirant composition contains an O/W emulsifier and a W/O emulsifier, wherein most preferably the amount of O/W emulsifier is greater than the amount of W/O emulsifier.

[0034] Alkoxylated fatty acid alcohols, more preferably C14 -C18 alcohols having from two to 22 ethoxy groups, in particular steareth-2 or steareth-21, or else PPG-15 stearyl ethers are used as preferred emulsifiers.

[0035] In summary, antiperspirant compositions according to the present invention are preferred in which the antiperspirant composition contains an emulsifier which is preferably an oil-in-water (O/W) emulsifier having an HLB value from about 7 to about 20, wherein the O/W emulsifier is more preferably a nonionic O/W emulsifier, and/or wherein the antiperspirant composition has an emulsifier, which is preferably a water-in-oil (W/O) emulsifier having an HLB value of from about 2 to about 7, and/or in which the antiperspirant composition contains an O/W emulsifier in an amount from about 0.05 to about 25% by weight, more preferably from about 0.2 to about 10% by weight, more preferably from about 0.8 to about 6% by weight, based on the total weight of the antiperspirant composition, and/or wherein the antiperspirant composition contains a W/O emulsifier in an amount of from about 0.01 to about 15% by weight, preferably from about 0.1 to about 8% by weight, more preferably from about 0.5 to about 2% by weight, based on the total weight of the antiperspirant composition, wherein the antiperspirant composition particularly preferably contains an O/W emulsifier and a W/O emulsifier, wherein preferably the amount of O/W emulsifier is greater than the amount of W/O emulsifier.

[0036] In a preferred embodiment, the antiperspirant composition can contain a cosmetic oil in an amount of from about 1 to about 15% by weight, preferably from about 2 to about 10% by weight, more preferably from about 3 to about 5% by weight, based on the total weight of the antiperspirant composition. The oil forms the oil phase. According to a particularly preferred embodiment, the oil is selected from the group consisting of linear silicone oils, cyclic silicone oils, in particular cyclopentasiloxane, paraffins, isoparaffins, polypropylene glycol ethers, polyethylene glycol ethers, organic esters - especially esters of glycerol, ethers and ether carbonates.

[0037] Particulate substances can preferably be included in the embodiments which have an oil phase. Particularly suitable are fumed silica or phyllosilicates, which are more preferably hydrophobically modified. The particulate substances serve as thickening agents and stabilizers. In this embodiment, hydrophobically modified bentonites and/or hydrophobically modified hectorites are particularly preferably present in the antiperspirant composition.

[0038] In summary, antiperspirant compositions according to the invention are preferred in which the antiperspirant composition contains a cosmetic oil in an amount of from about 1 to about 15% by weight, preferably from about 2 to about 10% by weight, more preferably from about 3 to about 5% by weight, based on the total weight of the antiperspirant composition, and/or in which the antiperspirant composition contains a stabilizer.

[0039] However, embodiments based on a carrier comprising water or a water/alcohol mixture are preferred. Preferably, the aqueous or aqueous-alcoholic carrier is water or a water/alcohol mixture, wherein the alcohol is preferably selected from a linear or branched C2 to C6 alcohol, more preferably ethanol, propanol, isopropanol, 1,3-propanediol, dipropylene glycol, 1,2-propanediol, in particular 1,2-propanediol. Preferably, water or the water/alcohol mixture is present in an amount from about 60% to about 99%, more preferably from about 80% to about 96%, most preferably from about 85% to about 90% by weight, based on the total weight of the antiperspirant composition.

[0040] In summary, antiperspirant compositions according to the invention are preferred in which the aqueous or aqueous-alcoholic carrier is water or a water/alcohol mixture, wherein the alcohol preferably is selected from a linear or branched C2 to C6 alcohol, more preferably ethanol, propanol, isopropanol, 1,3-propandiol, or dipropylene glycol, 1,2propanediol, in particular 1,2-propanediol, and/or wherein preferably water or the water/alcohol mixture is present in an amount of from about 60% by weight to about 99% by weight, more preferably from about 80% by weight to about 96% by weight, most preferably from about 85?^zo by weight to about 92% by weight, based on the total weight of the antiperspirant composition.

[0041] Preferably, the antiperspirant composition comprises one or more perfumes or fragrances. The definition of a fragrance in the context of the present application corresponds to the definition customary in the art, as can be taken from the ROMPP Chemie Lexikon (Rompp Lexikon Chemie, J. Falbe, M. Regitz (ed.), 10th edition, Thieme Verlag). In the context of the present invention, perfumes or fragrances can only be considered as those which, based on the total weight of the antiperspirant composition, are present in an amount of about 10% by weight and less in the antiperspirant composition. Examples of ester-type perfume and fragrance compounds are benzyl acetate, phenoxy ethyl isobutyrate, p-tertbutylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinylacetate (DMBCA), phenyl ethyl acetate, benzyl acetate, ethylmethylphenylglycinate, allylcyclohexylpropionate, styrallylpropionate, benzylsalicylate, cyclohexylsalicylate, floramate, melusate and jasmecy elate.

[0042] Examples of fragrance and scent compounds of the ether type are benzyl ethyl ether and ambroxane, examples of fragrance and scent compounds of the aldehyde type are the linear alkanals having from about 8-18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, lilial and bourgeonal, examples of fragrance and scent compounds of the ketone type are the ionones, alpha-isomethylionone and methyl cedryl ketone, examples of fragrance and scent compounds of the alcohol type are anethole, citronellol, eugenol, geraniol, linalool, phenylethyl alcohol and terpineol, examples of fragrance and scent compounds of the terpene type are limonene and pinene. Examples of perfume and fragrance compounds are pine oil, citrus oil,jasmine oil, patchouly oil, rose oil, ylang-ylang oil, muscat sage oil, chamomile oil, clove oil, mint oil, cinnamon leaf oil, lime blossom oil, juniper berry oil, vetiver oil, olibanum oil, galbanum oil, labdanum oil, orange blossom oil, neroli oil, orange peel oil and sandalwood oil, further the essential oils such as angelica root oil, aniseed oil, arnica blossom oil, basil oil, bay oil, bergamot oil, champacilla blossom oil, fir pine oil, pinecone oil, elemi oil, eucalyptus oil, fennel oil, spruce needle oil, geranium oil, ginger grass oil, guaiac wood oil, gurdy balm oil, helichrysum oil, Ho oil, ginger oil, iris oil, cajeput oil, calamus oil, chamomile oil, camphor oil, kanga oil, cardamom oil, cassia oil, pine needle oil, copaiba balsam, coriander oil, spearmint oil, caraway oil, cumin oil, lavender oil, lemongrass oil, lime oil, tangerine oil, melissa oil, musk kernel oil, myrrh oil, clove oil, niaouli oil, orange oil, origanum oil, palmarosa oil, patchouli oil, pearl balsam oil, petitgrain oil, pepper oil, peppermint oil, pimento oil, pine oil, rose oil, rosemary oil, sandalwood oil, celery oil, spike oil, star aniseed oil, turpentine oil, thuja oil, thyme oil, verbena oil, juniper berry oil, wormwood oil, wintergreen oil, hyssop oil, cinnamon oil, citron oil, lemon oil and cypress oil. Further perfume and fragrance compounds are ambrettolide, alpha-amylcinnamaldehyde, anethole, anisaldehyde, anisalcohol, anisole, anthranilic acid methyl ester, acetophenone, benzylacetone, benzaldehyde, benzoic acid ethyl ester, benzophenone, benzyl alcohol, benzyl acetate, benzyl benzoate, benzyl formate, benzyl valerate, borneol, bornyl acetate, alpha-bromostyrene, n-decyl aldehyde, n-dodecyl aldehyde, eugenol, eugenol methyl ether, eucalyptol, farnesol, fenchone, fenchyl acetate, geranyl acetate, geranyl formate, heliotropin, heptincarboxylic acid methyl ester, heptaldehyde, hydroquinone dimethyl ether, hydroxycinnamaldehyde, hydroxycinnamyl alcohol, indole, iron, isoeugenol, isoeugenol methyl ether, isosafrolejasmone, camphor, carvacrol, carvon, p-cresol methyl ether, coumarin, p-methoxyacetophenone, methyl-n-amyl ketone, methyl anthranilic acid methyl ester, p-methylacetophenone, methylchavicol, p-methylquinoline, methyl β-naphthyl ketone, methyl n-nonyl acetaldehyde, methyl n-nonyl ketone, muscone, β-naphthol ethyl ether, β-naphthol methyl ether, nerol, nitrobenzene, n-nonylaldehyde, nonyl alcohol, n-octylaldehyde, p-oxyacetophenone, pentadecanolide, β-phenylethyl alcohol, phenyl acetaldehyde dimethyacetal, phenylacetic acid, pulegone, safrole, salicylic acid isoamyl ester, salicylic acid methyl ester, salicylic acid hexyl ester, salicylic acid cyclohexyl ester, santalol, skatole, terpineol, thymene, thymol, γ-undecalactone, vanillin, veratrum aldehyde, cinnamaldehyde, cinnamyl alcohol, cinnamic acid, cinnamic acid ethyl ester and cinnamic acid benzyl ester. Further (more volatile) fragrances are alkyl isothiocyanates (alkyl mustard oils), butanedione, limonene, linalool, linayl acetate and propionate, menthol, menthone, methyl-n-heptenone, phellandrene, phenyl acetaldehyde, terpinyl acetate, citral and citronellal. Particularly preferred, perfumes or perfume oils are present in the antiperspirant composition in an amount from about 0.05 to about 10% by weight, more preferably from about 0.1 to about 5% by weight, most preferably from about 0.5 to about 4% by weight, based on the total weight the antiperspirant composition.

[0043] Furthermore, the compositions of the invention can contain additional deodorant active substances. Antimicrobial, antibacterial or germ-inhibiting substances, antioxidants, odor adsorbents or enzyme inhibitors can be used as deodorant active substances. Suitable antimicrobial, antibacterial or antimicrobial substances are in particular organohalogen compounds and halides, quaternary ammonium compounds and a number of plant extracts. Preference is given to halogenated phenol derivatives such as hexachlorophene or Irgasan DP 300 (triclosan, 2,4,4'-trichloro-2'-hydroxydiphenyl ether), 3,4,4'-trichlorocarbanilide, chlorhexidine (1, l'-hexamethylene-bis-[5-(4-chlorophenyl)]-biguanide), chlorhexidine gluconate, benzalkonium halides and cetylpyridinium chloride. Furthermore, sodium bicarbonate and sodium phenol sulfonate and, for example, the components of lime blossom oil can be used. Even less effective antimicrobial substances, which still have a specific effect against the gram-positive bacteria responsible for the sweat decomposition, can be used as deodorant active substances. Benzyl alcohol can also be used as a deodorant active substance. Further antibacterial deodorants are lantibiotics, glyco-glycerolipids, sphingolipids (ceramides), sterols and other active substances that inhibit bacterial adhesion to the skin, for example, glycosidases, lipases, proteases, carbohydrates, di- and oligosaccharide fatty acid esters and alkylated monosaccharides and oligosaccharides. Preferred deodorant active substances are long chain diols, for example, 1,2-alkane (C5-C18) diols, glycerol mono (C8C18) fatty acid esters or, more preferably, glycerol mono (C6-C16) alkyl ethers, in particular

2- ethylhexyl glycerol ethers, which are very well tolerated by skin and mucous membranes and are active against corynebacteria, and further phenoxyethanol, phenoxyisopropanol (3phenoxy-propan-2-ol), anisalcohol, 2-methyl-5-phenyl-pentan-l-ol, l,l-dimethyl-3-phenyl propan-l-ol, benzyl alcohol, 2-phenylethan-l-ol, 3-phenylpropan-l-ol, 4-phenylbutan-l-ol, 5-phenylpentan-l-ol, 2-benzylheptan-l-ol, 2,2- dimethyl 3-phenylpropan-l-ol, 2,2-dimethyl-

3- (3'-methylphenyl)-propan-l-ol, 2-ethyl-3-phenylpropan-l-ol, 2-ethyl-3-(3'- methylphenyl)-propan-l-ol, 3-(3'-chlorophenyl)-2-ethyl-propan-l-ol, 3-(2'-chlorophenyl)-2ethyl-propan-l-ol, 3-(4'-dichlorophenyl) -2-ethyl-propan-1-ol, 2-ethyl-3-(2'-methylphenyl)propan-1 -ol, 2-ethyl-3 -(4'-methylphenyl)-propan-1 -ol, 3 -(3 ',4'-dimethylphenyl)-2ethylpropan-1 -ol, 2-ethyl-3-(4'-methoxyphenyl)-propan-1 -ol, 3-(3 ',4'-dimethoxyphenyl)-2ethyl-propan-l-ol, 2-allyl-3-phenylpropan-l-ol and 2-n-pentyl-3-phenylpropan-l-ol.

[0044] In order to further improve the antiperspirant and odor-reducing effect of the compositions according to the invention, in a preferred embodiment, they contain at least one deodorant active substance in a total amount from about 0.001 to about 15% by weight, based on the total weight of the cosmetic agent. If ethanol is used in the compositions according to the invention, this does not apply in the context of the present invention as a deodorant active substance, but rather as a constituent of the carrier. Deodorant active substances which are preferred according to the invention are odor absorbers, deodorizing ion exchangers, germinhibiting agents, prebiotic active components and also enzyme inhibitors or, with particular preference, combinations of said active substances. Silicates serve as odor absorbers, which simultaneously advantageously support the rheological properties of the composition according to the invention. The silicates which are particularly preferred according to the invention include, primarily, phyllosilicates and, among these, in particular montmorillonite, kaolinite, illite, beidellite, nontronite, saponite, hectorite, bentonite, smectite, calcium silicate and talc.

[0045] Further preferred odor absorbers are, for example, zeolites, zinc ricinoleate, cyclodextrins, certain metal oxides, such as alumina, and chlorophyll. Further preferred odor absorbers according to the invention are selected from perlite. According to the invention, germ-inhibiting or antimicrobial active substances are understood to mean those active substances which reduce the number of skin germs participating in the formation of the odor or inhibit their growth. These organisms include, among others, various species from the group of staphylococci, the group of corynebacteria, anaerococci and micrococci.

[0046] Preferred antimicrobial or antimicrobial active substances according to the invention are in particular organohalogen compounds and halides, quaternary ammonium compounds, a number of plant extracts and zinc compounds. These include, among other things, triclosan, chlorhexidine and chlorhexidine gluconate, 3,4,4'-trichlorocarbanilide, bromochlorophene, di chlorophene, chlorothymol, chloroxylenol, hexachlorophene, dichlorom-xylenol, dequalinium chloride, domiphenbromide, ammonium phenol sulfonate, benzalkonium halides, benzalkonium cetyl phosphate, benzalkonium saccharinates, benzethonium chloride, cetylpyridinium chloride, laurylpyridinium chloride, laurylisoquinolinium bromide, methylbenzethonium chloride. Furthermore, phenol, phenoxyethanol, disodium dihydroxy ethyl sulfosuccinyl undecylenate, sodium bicarbonate, zinc lactate, sodium phenol sulfonate and zinc phenol sulfonate, ketoglutaric acid, terpene alcohols such as farnesol, chlorophyllin copper complexes, 1-monoalkyl glycerol ethers having a branched or linear saturated or unsaturated, optionally hydroxylated C6-C22 alkyl radical, particularly preferably l-(2-ethylhexyl) glycerol ether, commercially available as Sensiva® SC 50 (ex Schiilke & Mayr), carboxylic esters of mono-, di- and triglycerols (for example, glycerol monolaurate, diglycerol monocaprinate), lantibiotics and plant extracts (for example, green tea and constituents of lime blossom oil).

[0047] Further preferred deodorant active substances are selected from so-called probiotically active components, which according to the invention are to be understood to mean those components which inhibit only or at least predominantly inhibit the odor-causing germs of the skin microflora, but not the desired ones, that is, the non-odor-forming germs that belong to healthy skin microflora. Explicit are here active substances such as conifer extracts, in particular from the group of Pinaceae, and plant extracts from the group of Sapindaceae, Araliaceae, Lamiaceae and Saxifragaceae, in particular extracts of Picea spp., Paullinia sp., Panax sp., Lamium album or Ribes nigrum and mixtures to name these substances.

[0048] Further preferred deodorant active substances are selected from the germinhibiting perfume oils and the Deosafe® perfume oils, which are available from the company Symrise, formerly Haarmann and Reimer.

[0049] Further preferred deodorant active substances are selected from silver salts, in particular silver citrate, dihydrogen silver citrate, silver lactate and silver sulfate, soluble complex salts of silver, colloidal silver and silver zeolites.

[0050] The enzyme inhibitors include substances which inhibit the enzymes responsible for the sweat decomposition, in particular aryl sulfatase, β-glucuronidase, aminoacylase, cystathionine β-lyase, esterases, lipases and/or lipoxygenase, for example, trialkylcitric acid ester, in particular triethyl citrate, or zinc glycinate.

[0051] Preferred antiperspirant compositions according to the invention are characterized in that the at least one deodorant active substance is selected from arylsulfatase inhibitors, beta-glucuronidase inhibitors, aminoacylase inhibitors, cysthionin β-lyase inhibitors, esterase inhibitors, lipase inhibitors and lipoxigenase inhibitors, monoalkyl glycerol ethers having a branched or linear saturated or unsaturated, optionally hydroxylated C6-C22 alkyl radical, in particular (2-ethylhexyl) glycerol ether, phenoxyethanol, benzylheptanol, Cocamidopropyl PG-Dimonium Chloride Phosphate and butyloctanoic acid, polyglycerol-3-caprylate, germinhibiting perfume oils, Deosafe® perfume oils (Deosafe® is a registered trademark of the company Symrise, formerly Haarmann & Reimer), prebiotic components, trialkyl citric acid esters, in particular triethyl citrate, active substances which reduce the number of skin germs from the group of staphylococci, corynebacteria, anaerococci and micrococci involved in the formation of odors or inhibit their growth, zinc compounds, in particular zinc phenol sulfonate and zinc ricinoleate, organohalogen compounds, in particular triclosan, chlorhexidine, chlorhexidine gluconate and benzalkonium halides, quaternary ammonium compounds, in particular cetylpyridinium chloride, odor absorbers, especially silicates and zeolites, sodium bicarbonate, lantibiotics, and mixtures of the aforementioned substances.

[0052] Further preferred antiperspirant compositions according to the invention are characterized in that the at least one deodorant active substance is present in a total amount from about 0.0001 - 15% by weight, preferably from about 0.2-7% by weight, particularly preferably from about 0.3-5% by weight and most preferably from about 0.4-1.0% by weight, each based on the total weight of the active substance of the deodorant active substance or the deodorant active substances in the overall composition.

[0053] In a further particularly preferred embodiment, the compositions according to the invention contain both at least one deodorant and at least one antiperspirant active substance.

[0054] Triethyl citrate is particularly preferably present in the antiperspirant composition. Most preferably, the amount of tri ethyl citrate lies in the range from about 0.0001 to about 12% by weight, based on the total weight of the antiperspirant composition.

[0055] Complex-forming substances can also support the deodorizing effect by stably complexing the oxidative catalytically active heavy metal ions (for example, iron or copper). Suitable complexing agents are, for example, the salts of ethylenediaminetetraacetic acid or nitrilotriacetic acid and the salts of 1-hydroxyethane-1,1-diphosphonic acid.

[0056] It can be advantageous for the preparations according to the invention to add at least one chelating agent in a total amount from about 0.01 to about 3.0% by weight, preferably from about 0.02 to about 1.0% by weight, in particular from about 0.05 to about 0.1% by weight, based on the total weight of the antiperspirant agent according to the invention. In the context of the present invention, preferred chelating agents are selected from the group of β-alaninediacetic acid, cyclodextrin, diethylenetriaminepentamethylenephosphonic acid, sodium, potassium, calcium disodium, ammonium and triethanolamine salts of ethylenediaminetetraacetic acid (EDTA), etidronic acid, hydroxyethylethylenediaminetetraacetic acid (HEDTA) and their sodium salts.

[0057] Substances which are selected from cellulose ethers, xanthan gum, sclerotium gum, succinoglucans, polygalactomannans, pectins, agar, carrageenan, tragacanth, gum arabic, karaya gum, tara gum, gellan, gelatin, propylene glycol alginate, alginic acids and salts thereof, polyvinylpyrrolidones, polyvinyl alcohols, polyacrylamides, physically (for example, by pre-gelatinization) and/or chemically modified starches, acrylic acid-acrylate copolymers, acrylic acid-acrylamide copolymers, acrylic acid-vinylpyrrolidone copolymers, acrylic acid vinyl formamide copolymers and polyacrylates are preferably used to thicken the antiperspirant cosmetic agents according to the invention. Particularly preferred thickening agents are furthermore selected from carbomers. Carbomers are thickening crosslinked polymers of acrylic acid, methacrylic acid and salts thereof. The crosslinking can be carried out by means of polyfunctional compounds such as polyalkylene ethers of polysaccharides or polyalcohols, for example, sucrose allyl ether, pentaerythritol allyl ether, propylene allyl ether. Preferred in the context of the present invention are homopolymers of acrylic acid or salts thereof, which are crosslinked with a pentaerythritol allyl ether, a sucroseallyl ether or a propylene allyl ether. A thickening agent which can be used in the context of the present invention is a copolymer of C10-30 alkyl acrylate, acrylic acid, methacrylic acid and esters thereof, which is crosslinked with a sucrose allyl ether or a pentaerythritol allyl ether. Thickening agents based on carbomer are the products available under the trade name Carbopol® (BF Goodrich, Ohio, USA) such as Carbopol 934, Carbopol 940, Carbopol 941, Carbopol 971, Carbopol 974, Carbopol EZ2, Carbopol ETD 2001, Carbopol ETD 2020, Carbopol ETD 2050, Carbopol ultrez 10, Carbopol ultrez 20, or Carbopol ultrez 21.

[0058] Preferred compositions according to the invention further contain at least one water-soluble polyvalent C2 -C9 alkanol having from about 2-6 hydroxyl groups and/or at least one water-soluble polyethylene glycol having from about 3-50, preferably from about 3-20 ethylene oxide units and mixtures thereof in order to further improve the stability of the compositions. Preferably, these components are selected from 1,2-propylene glycol, 2methyl-1,3-propanediol, glycerol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, pentylene glycols such as 1,2-pentanediol and 1,5-pentanediol, hexanediols such as 1,6-hexanediol, hexanetriols such as 1,2,6-hexanetrioloctanediol, 1,2-octanediol, 1,8octanediol, dipropylene glycol, tripropylene glycol, diglycerol, triglycerol, erythritol, sorbitol and mixtures of aforementioned substances. Suitable water-soluble polyethylene glycols are selected from PEG-3, PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18 and PEG-20 and mixtures thereof, wherein PEG-3 to PEG-8 are preferred. Preference is given to propylene glycol, dipropylene glycol or a mixture thereof, more preferably only propylene glycol. Preferably, these are present in a total amount of from about 0.1 to about 50% by weight, more preferably from about 0.5 to about 10 or from about 1 to about 5% by weight.

[0059] According to another embodiment of the present invention, the antiperspirant cosmetic agents further contain at least one skin-cooling active substance. Skin-cooling active substances suitable according to the invention are, for example, menthol, isopulegol and menthol derivatives, for example, menthyl lactate, menthyl glycolate, menthyl ethyl oxamate, menthyl pyrrolidone carboxylic acid, menthyl methyl ether, menthoxy propane diol, menthone glycerol acetal (9-methyl-6-(l-methylethyl)- 1,4-dioxaspiro (4.5) decane-2methanol), monomethyl succinate, 2-hydroxymethyl -3,5,5-trimethylcyclohexanol and 5methyl-2-(l -methyl ethyl) cyclohexyl-nethyl oxamate. Preferred skin-cooling active substances are menthol, isopulegol, menthyl lactate, menthoxypropanediol, menthylpyrrolidonecarboxylic acid and 5-methyl-2-(l -methyl ethyl) cyclohexyl methyloxamate, and mixtures of these substances, in particular mixtures of menthol and menthyl lactate, menthol, menthol glycolate and menthyl lactate, menthol and menthoxypropanediol or menthol and isopulegol. In the present invention, the antiperspirant cosmetic agent can preferably further contain at least one antioxidant, preferably in a total amount of from about 0.01 to about 5.0% by weight, based on the total weight of the cosmetic agent. The antioxidation agent can be selected from ascorbic acid, ascorbyl palmitate, BHT, substituted hydroxyhydrocinnamic acid esters, substituted benzotriazoles, dialkyl thiodialkanoates, tocopherol and its esters (for example, acetate), hydroxymethoxyphenyl decanones, paradol and mixtures thereof, in particular substituted hydroxyhydro cinnamic acid esters and mixtures thereof.

[0060] Preferred propellants (propellant gases) are propane, propene, n-butane, isobutane, isobutene, n-pentane, pentene, isopentane, isopentene, methane, ethane, dimethyl ether, nitrogen, air, oxygen, nitrous oxide, 1,1,1,3-tetrafluoroethane, heptafluoro-n-propane, perfluoroethane, monochiorodifluoromethane, 1,1-difluoroethane, tetrafluoropropenes, both individually and in mixtures thereof. Hydrophilic propellant gases, such as carbon dioxide, can also be used advantageously in the context of the present invention, when the proportion of hydrophilic gases is selected low and lipophilic propellant gas (for example, propane/butane) is present in excess. Particularly preferred are propane, n-butane, isobutane and mixtures of these propellant gases. It has been found that the use of n-butane as the only propellant gas according to the invention can be particularly preferred.

[0061] A further object of the invention is to provide a substance which has an antiperspirant effect and can be used in an antiperspirant composition.

[0062] A second aspect of the present invention relates to the use of tetrahydroxypropyl ethylene diamine or its salts as an antiperspirant active substance in an antiperspirant composition for the topical treatment of the skin.

[0063] According to a preferred embodiment of the present invention, tetrahydroxypropyl ethylene diamine or its salts are used as an antiperspirant active substance in an antiperspirant composition according to the present invention, that is, tetrahydroxypropyl ethylene diamine or its salts are used in a composition according to the first subject of the invention.

[0064] Preferred uses are therefore characterized in that the antiperspirant composition is an antiperspirant composition according to the invention.

[0065] Features concerning preferred embodiments of the first subject of the invention, which are described above only in this regard, of course, apply correspondingly to the second subject as features of preferred embodiments.

[0066] Very particularly preferred cosmetic agents according to the invention comprise at least one of the following embodiments A) to E)

A)

Antiperspirant composition for the topical treatment of the skin comprising tetrahydroxypropyl ethylene diamine in an aqueous or aqueous-alcoholic carrier, wherein the antiperspirant composition has a pH value from about 3 to less than about 7 and wherein the tetrahydroxypropyl ethylene diamine is present in the antiperspirant composition in an amount of from about 0.1 to about 30% by weight, preferably from about 1 to about 15% by weight, more preferably from about 5 to about 10% by weight, based on the total weight of the antiperspirant composition.

B)

Antiperspirant composition for the topical treatment of the skin comprising tetrahydroxypropyl ethylene diamine in an aqueous or aqueous-alcoholic carrier, wherein the antiperspirant composition has a pH value from about 3 to less than about 7, and wherein the tetrahydroxypropyl ethylene diamine is present in the antiperspirant composition in an amount from about 0.1 to about 30% by weight, preferably from about 1 to about 15% by weight, more preferably from about 5 to about 10% by weight, based on the total weight of the antiperspirant composition, wherein the aqueous or aqueous-alcoholic carrier is water or a water/alcohol mixture, wherein the alcohol is preferably selected from a linear or branched C2 to C6 alcohol, more preferably ethanol, propanol, isopropanol, 1,3-propanediol, dipropylene glycol, 1,2propanediol, in particular 1,2-propanediol, and/or wherein preferably water or the water/alcohol mixture is present in an amount of from about 60% by weight to about 96% by weight, most preferably from about 85% by weight to about 92% by weight, based on the total weight of the antiperspirant composition.

C)

Use of tetrahydroxypropyl ethylene diamine as an antiperspirant active substance in an antiperspirant composition for the topical treatment of the skin, wherein the antiperspirant composition has an aqueous or aqueous-alcoholic carrier and a pH value from about 3 to less than about 7.

D)

Use of tetrahydroxypropyl ethylene diamine as an antiperspirant active substance in an antiperspirant composition for the topical treatment of the skin, wherein the antiperspirant composition has an aqueous or aqueous-alcoholic carrier and a pH from about 3 to less than about 7, and wherein the tetrahydroxypropyl ethylene diamine is present in the antiperspirant composition in an amount from about 0.1 to about 30% by weight, preferably from about 1 to about 15% by weight, more preferably from about 5 to about 10% by weight, based on the total weight of the antiperspirant composition.

E)

Use of tetrahydroxypropyl ethylene diamine as antiperspirant active in an antiperspirant composition for the topical treatment of the skin, wherein the antiperspirant composition has an aqueous or aqueous-alcoholic carrier and a pH from about 3 to less than about 7, and wherein the tetrahydroxypropyl ethylene diamine is present in the antiperspirant composition in an amount of from about 0.1 to about 30% by weight, preferably from about 1 to about 15% by weight, more preferably from about 5 to about 10% by weight, based on the total weight of the antiperspirant composition, and the aqueous or aqueous-alcoholic carrier is water or a water/alcohol mixture, wherein the alcohol is preferably selected from a linear or branched C2 to C6 alcohol, more preferably ethanol, propanol, isopropanol, 1,3-propanediol, dipropylene glycol, 1,2-propanediol, in particular 1,2-propanediol, and/or wherein preferably water or the water/alcohol mixture is present in an amount of from about 60% by weight to about 99% by weight, more preferably from about 80% by weight to about 96% by weight, most preferably from about 85% by weight to about 92% by weight, based on the total weight of the antiperspirant composition.

Examples [0067] The following composition can be produced by way of example:

[0068] Example 1: Preparation of an antiperspirant composition for use as roll-on

[O/W emulsion	[Quantities in % b
[Tetrahydroxypropyl ethylene diamine______ pemineralized water____________________ Hydrochloricacid20°o** 1,2-propanediol____________________________ PPG-15stearylether* [Steareth-2* pteareth^Tl* Perfume phenoxyethanol________________________ Antioxidant	8 _______ q.s._________________ pTpiilil j 1 1 Z5 —— 0 5______________

* INCI name ** The hydrochloric acid is added in an amount to reach the pH value stated in the table [0069] Example 2: Preparation of an antiperspirant composition for use as roll-on

P/W emulsion________________________	Quantities in % by
Tetrahydroxypropyl ethylene diamine	10______________
[Demineralized water	.............. 9...S......................................
[Hydrochloric acid 20% **	q.s. pH 4,5____________
[1,2-propanediol	2

* INCI name

PG-15 stearyl ether *

Steareth -2*

Steareth -21* erfume henoxyethanol

Antioxidant

1.5

0.5

0.9 ** The hydrochloric acid is added in an amount to reach the pH value stated in the table.

[0070] Example 3: Preparation of an antiperspirant composition for use as roll-on

p/W emulsion	Quantities in % b
Tetrahydroxypropyl ethylene diamine pemineralized water____________________ jl,2-propanediol____________________________ pPG-nTirt^ Steareth - 2* ______________________________ Steareth-21* perfume_____________________________ phenoxyethanol________________________ Antioxidant	___ _______ q.s._________________ p?pH41 Γ 5 ___ 5_________________ 5 2Ό TO 2Ό

* INCI name ** The hydrochloric acid is added in an amount to reach the pH value stated in the table.

[0071] Example 4: Preparation of an antiperspirant composition for use as a spray

W/O emulsion___________________________	Quantities in % b
jTetrahydroxypropyl ethylene diamine__________ pemineralized water________________________ Hydrochloricacicl20%** jl,2-propanediol________________________________ pyclopentasiloxane__________________________ [Isopropyl myristate pow Coming ES-5227 DM Formulation Aid Perfume phenoxyethanol____________________________ \|Anti oxidant	j 8 q.s._________________ psTpHll j 5^ j LL2 1 2ZI 3_________________ 1 ΓΖΖ 1,0_______________ j 5^5

** The hydrochloric acid is added in an amount to reach the pH value stated in the table.

[0072] Example 5: Preparation of an antiperspirant composition for use as a spray

W/O emulsion___________________________	Quantities in % b~
(Tetrahydroxypropyl ethylene diamine__________ (Demineralized water pTydrochloric acid 20% **____________________ (1,2-propanediol (Cyclopentasiloxane___________________________ (Isopropyl myristate_____________________________ powCorningES-5227DMForrnuiationAid perfume_________________________________ (Phenoxyethanol_______________________________ (Antioxidant	10______________ ..................................................... q.s. pH 4,9____________ 1 25ZZ 11,2_____________ j Γ \| 4 j 4 \| ol j 0.05

[0073] Example 6: Preparation of an antiperspirant composition for use as a spray

W/O emulsion	Quantities in % by
(Tetrahydroxypropyl ethylene diamine	1 i?ZZ
(Demineralized water	1 q.s. (
Hydrochloric acid 20% **	q.s. pH 4.9
(1,2-propanediol	20_____________
(Cyclopentasiloxane	11.2
(Isopropyl myristate	10______________
Dow Coming ES-5227 DM Formulation Aid	j 7,5 _______________
(Perfume	3__________________
(Phenoxyethanol	1,0________________
(Antioxidant	1 1.2

[0074] The filling takes place together with a propellant gas of propane and/or butane and/or isobutane in the filling ratio 10.0 to 40.0% by weight W/O emulsion and propellant gas 60.0 to 90.0% by weight.

[0075] The example compositions for sprays can be filled in an aluminum spray optionally coated with epoxy-phenolic lacquer in a weight ratio of propellant (butane / propane / isobutane mixture) to emulsion of 70: 30, 75: 25, 80:20 or 85:15 or 60:40 or 90:10.

[0076] Example 7: Preparation of an antiperspirant composition for use as roll-on

Roll-on mixture_________________________	_____Quantities in % b
jTetrahydroxypropyl ethylene diamine______ pemineralized water pydrochloric acid 20% **_______________ Ethanol 96% (cosmetic, denatured) Ceteareth-12___________________________ petearethrSO Hydroxyethyl cellulose____________________ perfume______________________________ phenoxyethanol________________________ j Anti oxidant________________________________ Deodorant active substance	15______________ .............................g.-.s...................................... q.s. pH 3,5____________ 2_____________ 2 ol EQ L0 02 ................r___........

[0077] Example 8: Preparation of an antiperspirant composition for use as a spray

Pump atomizer mixture	Quantities in % b
Tetrahydroxypropyl ethylene diamine_____ pemineralized water____________________ Hydrochloricacid20⁰o** Ethanol 96% (cosmetic, denatured)________ Ceteareth-12 jCeteareth-30 jCooling agent____________________________ Perfume phenoxyethanol________________________ 1 Anti oxidant Deodorant active substance	TO _______ q.s._________________ pTpHll Γ 4ΪΓ 2 2 Ori 1,0_______________ 2.0

[0078] The product is mechanically applied to the skin in fine particles with an atomizer.

[0079] Example 9: Preparation of an antiperspirant composition for use as a spray

pump atomizer mixture__________________	Quantities in % b
jTetrahydroxypropyl ethylene diamine______ pemineralized water____________________ pydjOcMoric^id^0%3EZZIIZZZZZZZZ jPropanediol 1,2 optional Ceteareth-12	10 q.s._________________ p?pH3~5 2

[0080] The product is mechanically applied to the skin in fine particles with an atomizer.

[0081] Example 9: Preparation of an antiperspirant composition for use as roll-on

Roll-on mixture__________________________	Quantities in % b
Tetrahydroxypropyl ethylene diamine______ ^Demineralized water pTydrochloric acid 20% **_________________ ^Propanediol 1,2 optional Ceteareth-12 _________________________ peteareth20 jHydroxyethyl cellulose_____________________ perfume phenoxyethanol_________________________ j Anti oxidant_________________________________ Deodorant active substance	10_______________ .............. CL.S......................................... q.s. pH 3,5____________ 2_______________ 0,5________________ —__ 10___________ 02 .........

[0082] The product is mechanically applied to the skin in fine particles with an atomizer.

[0083] Furthermore, tests for antiperspirant activity were performed. To test the effect of tetrahydroxypropyl ethylene diamine, the following compositions were tested:

10% aluminum chlorohydrate, aqueous solution as benchmark

10% tetrahydroxypropyl ethylene diamine dissolved in water, the sample is adjusted to pH 3.5 using 20% hydrochloric acid [0084] To determine the antiperspirant effect, an antiperspirant study was performed on the backs of 16 test persons. The following antiperspirant agent was used for this:

Aqueous solution with 10% aluminum chlorohydrate ACH *, pH 4

Aqueous solution 10% tetrahydroxypropyl ethylene diamine

V-I * Active substance ** Composition according to the invention [0085] On the back of 16 subjects each on one side next to the spine were applied 40 pl of the antiperspirant agent V-I and in each case 75 pl of the cosmetic agent E-I. After 5 minutes, the treated sites were covered with occlusive non-adsorbent film. After 2 hours, these nonadsorbent pads were removed. The compositions were each applied to the backs of the subjects for four consecutive days in the manner previously described.

[0086] 24 h after the last application of the composition, absorbent pads were applied to the backs of the subjects at the sites where the compositions were previously applied. Furthermore, pads, which served as a control, were also applied on the other side of the spine at the same height. After the subjects had sweat for about 15 minutes at 80°C in the sauna, the amount of perspiration absorbed by the pads was determined gravimetrically, wherein each composition was compared with the corresponding untreated site on the back. The sweat reduction was determined from the gravimetric determination of the amount of sweat, wherein all determined values were statistically significant.

[0087] The sweat reduction of the respective composition compared to an untreated skin site is shown in the following table:

No.	Sweat reduction
V-f'	56% *
fa	_______

* significant [0088] The use of cosmetic agents containing tetrahydroxypropyl ethylenediamine, in particular as hydrochlorides, leads to a reduction in transpiration and a reduced body odor when these agents are applied to the skin.

[0089] While at least one exemplary embodiment has been presented in the foregoing detailed description, it should be appreciated that a vast number of variations exist. It should also be appreciated that the exemplary embodiment or exemplary embodiments are only examples, and are not intended to limit the scope, applicability, or configuration of the various embodiments in any way. Rather, the foregoing detailed description will provide those skilled in the art with a convenient road map for implementing an exemplary embodiment as contemplated herein. It being understood that various changes may be made in the function and arrangement of elements described in an exemplary embodiment without departing from the scope of the various embodiments as set forth in the appended claims.

Claims

Patent claims

1. An antiperspirant composition for the topical treatment of the skin comprising tetrahydroxypropyl ethylene diamine or its salts in an aqueous or aqueous-alcoholic carrier, wherein the antiperspirant composition has a pH value from about 2.5 to less than about 7.

2. The antiperspirant composition according to claim 1, characterized in that the antiperspirant composition contains tetrahydroxypropyl ethylene diamine and/or its salts in a total amount of from about 0.1 to about 30% by weight based on the total weight of the antiperspirant composition.

3. The antiperspirant composition according to claim 1 or 2, wherein the antiperspirant composition has a pH value of from about 3.2 to less than about 6.

4. The antiperspirant composition according to any one of claims 1 to 3, wherein the antiperspirant composition is essentially free of salts containing aluminum.

5. The antiperspirant composition according to any one of claims 1 to 3, wherein the antiperspirant composition comprises an antiperspirant active substance selected from an inorganic or organic salt of aluminum, zirconium, zinc or a mixture thereof.

6. The antiperspirant composition according to claim 4, wherein the antiperspirant active substance is selected from an aluminum chlorohydrate, an aluminum zirconium chlorohydrate, an aluminum-zirconium-chlorohydrate-glycine complex, potassium aluminum sulfate (KA1(SO4)2 - 12 H2O, alum), sodium aluminum chlorine hydroxyacetate, aluminum bromohydrate, aluminum chloride, aluminum sulfate, zinc chloride, zinc sulfocarbolate, zinc sulfate or zirconium chlorohydrate.

7. The antiperspirant composition according to claim 6, wherein the aluminum chlorohydrate is selected from activated aluminum chlorohydrate, aluminum sesquichlorohydrate, aluminum chlorohydrex propylene glycol (PG), aluminum chlorohydrex polyethylene glycol (PEG), aluminum sesquichlorohydrex PG, aluminum sesquichlorohydrex PEG, aluminum PG-dichiorhydrex, aluminum PEG-dichlorhydrex or aluminum hydroxide.

8. The antiperspirant composition according to claim 6, wherein the aluminum zirconium chlorohydrate is selected from aluminum zirconium tri chlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate or aluminum zirconium octachlorohydrate.

9. The antiperspirant composition according to claim 6, wherein the aluminumzirconium-chlorohydrate-glycine complex is selected from aluminum zirconium trichlorohydrexglycine, aluminum zirconium tetrachlorohydrex glycine, aluminum zirconium pentachlorohydrex glycine, or aluminum zirconium octachlorohydrex glycine.

10. The antiperspirant composition according to any one of claims 6 to 9, wherein the antiperspirant active substance is present in the antiperspirant composition in an amount of more than 0 to about 15% by weight based on the total weight of the antiperspirant composition.

11. The antiperspirant composition as claimed in any one of the preceding claims, wherein the sweat-inhibiting composition contains an emulsifier.

12. The antiperspirant composition as claimed in claim 11, wherein the emulsifier is an oil-in-water (O/W) emulsifier with an HLB value of from about 7 to about 20, and/or wherein the emulsifier is a water-in-oil (W/O) emulsifier with an HLB value of from about 2 to about 7.

13. The antiperspirant composition as claimed in claim 11 or 12, wherein the sweat-inhibiting composition contains an O/W emulsifier in a quantity of from about 0.05 to about 25% by weight with respect to the total weight of the sweat-inhibiting composition, and/or wherein the sweat-inhibiting composition contains a W/O emulsifier in a quantity of from about 0.01 to about 15% by weight with respect to the total weight of the sweatinhibiting composition.

14. The antiperspirant composition as claimed in any one of claims 11 to 13, wherein the sweat-inhibiting composition contains an O/W emulsifier and a W/O emulsifier

15. The antiperspirant composition as claimed in claim 14, wherein the quantity of

0/W emulsifier is larger than the quantity of W/0 emulsifier.

16. The antiperspirant composition as claimed in one of the preceding claims, wherein the sweat-inhibiting composition contains a cosmetic oil in a quantity of from about 1 to about 15% by weight with respect to the total weight of the sweat-inhibiting composition.

17. The antiperspirant composition as claimed in any one of the preceding claims, wherein the sweat-inhibiting composition contains a stabilizer.

18. The antiperspirant composition as claimed in any one of the preceding claims, wherein the aqueous or hydroalcoholic support is water or a water/alcohol mixture.

19. The antiperspirant composition as claimed in claim 18, wherein the alcohol is selected from a linear or branched C2 to C6 alcohol.

20. The antiperspirant composition as claimed in claim 19, wherein the alcohol is selected from ethanol, propanol, isopropanol, 1,3-propanediol, or dipropylene glycol, 1,2propanediol.

21. The antiperspirant composition as claimed in claims 18 to 20, wherein the composition contains water or the water/alcohol mixture in a quantity of from about 60% by weight to about 99% by weight with respect to the total weight of the sweat-inhibiting composition.

22. A use of tetrahydroxypropyl ethylene diamine or its salts as an antiperspirant active substance in an antiperspirant composition for the topical treatment of the skin.

23. The use according to claim 22, characterized in that the antiperspirant composition is an antiperspirant composition according to one of claims 1 to 21.

Intellectual

Property

Office

Application No: GB1911322.4