FR3066386B1 - Procede de preparation d'un gel aqueux d'acide hyaluronique - Google Patents

Procede de preparation d'un gel aqueux d'acide hyaluronique Download PDF

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Publication number
FR3066386B1
FR3066386B1 FR1754397A FR1754397A FR3066386B1 FR 3066386 B1 FR3066386 B1 FR 3066386B1 FR 1754397 A FR1754397 A FR 1754397A FR 1754397 A FR1754397 A FR 1754397A FR 3066386 B1 FR3066386 B1 FR 3066386B1
Authority
FR
France
Prior art keywords
aqueous gel
hyaluronic acid
preparing
acid gel
aqueous hyaluronic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1754397A
Other languages
English (en)
Other versions
FR3066386A1 (fr
Inventor
Frederic Bertaina
Alexandre Guerry
Caroline Ceccaldi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioxis Pharmaceuticals
Original Assignee
Bioxis Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1754397A priority Critical patent/FR3066386B1/fr
Application filed by Bioxis Pharmaceuticals filed Critical Bioxis Pharmaceuticals
Priority to EP18724248.2A priority patent/EP3624764A1/fr
Priority to US16/609,283 priority patent/US20200060959A1/en
Priority to CA3060431A priority patent/CA3060431A1/fr
Priority to CN201880031113.4A priority patent/CN110621294A/zh
Priority to KR1020197033720A priority patent/KR20200008560A/ko
Priority to BR112019024106-0A priority patent/BR112019024106A2/pt
Priority to PCT/EP2018/062871 priority patent/WO2018210999A1/fr
Publication of FR3066386A1 publication Critical patent/FR3066386A1/fr
Application granted granted Critical
Publication of FR3066386B1 publication Critical patent/FR3066386B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

La présente invention a pour objet, selon un premier aspect, un procédé de préparation d'un gel aqueux d'acide hyaluronique comprenant les étapes suivantes: a) la préparation d'un gel aqueux d'acide hyaluronique réticulé, b) l'homogénéisation du gel aqueux formé à l'étape (a) par laminage, c) la récupération du gel aqueux homogénéisé à l'étape (b). L'invention a également pour objet, selon un second aspect, un gel aqueux d'acide hyaluronique susceptible d'être obtenu par un tel procédé. L'invention a encore pour objet, selon un troisième aspect, l'utilisation cosmétique d'un tel gel aqueux dans la réparation ou la reconstruction des tissus, en particulier pour le comblement des rides et ridules, ou ledit gel aqueux pour son utilisation médicale pour la réparation ou la reconstruction des tissus.
FR1754397A 2017-05-18 2017-05-18 Procede de preparation d'un gel aqueux d'acide hyaluronique Active FR3066386B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR1754397A FR3066386B1 (fr) 2017-05-18 2017-05-18 Procede de preparation d'un gel aqueux d'acide hyaluronique
US16/609,283 US20200060959A1 (en) 2017-05-18 2018-05-17 Method for preparing an aqueous hyaluronic acid gel
CA3060431A CA3060431A1 (fr) 2017-05-18 2018-05-17 Procede de preparation d'un gel aqueux d'acide hyaluronique
CN201880031113.4A CN110621294A (zh) 2017-05-18 2018-05-17 制备水性透明质酸凝胶的方法
EP18724248.2A EP3624764A1 (fr) 2017-05-18 2018-05-17 Procédé de préparation d'un gel aqueux d'acide hyaluronique
KR1020197033720A KR20200008560A (ko) 2017-05-18 2018-05-17 수성 히알루론산 겔의 제조 방법
BR112019024106-0A BR112019024106A2 (pt) 2017-05-18 2018-05-17 Método de preparar um gel de ácido hialurônico aquoso
PCT/EP2018/062871 WO2018210999A1 (fr) 2017-05-18 2018-05-17 Procédé de préparation d'un gel aqueux d'acide hyaluronique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1754397A FR3066386B1 (fr) 2017-05-18 2017-05-18 Procede de preparation d'un gel aqueux d'acide hyaluronique
FR1754397 2017-05-18

Publications (2)

Publication Number Publication Date
FR3066386A1 FR3066386A1 (fr) 2018-11-23
FR3066386B1 true FR3066386B1 (fr) 2020-08-28

Family

ID=59297098

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1754397A Active FR3066386B1 (fr) 2017-05-18 2017-05-18 Procede de preparation d'un gel aqueux d'acide hyaluronique

Country Status (8)

Country Link
US (1) US20200060959A1 (fr)
EP (1) EP3624764A1 (fr)
KR (1) KR20200008560A (fr)
CN (1) CN110621294A (fr)
BR (1) BR112019024106A2 (fr)
CA (1) CA3060431A1 (fr)
FR (1) FR3066386B1 (fr)
WO (1) WO2018210999A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111617313B (zh) * 2020-04-29 2022-09-06 天津医科大学眼科医院 一种眼用线性凝胶在作为临床孔源性视网膜脱离药物方面中的应用
CN115572396B (zh) * 2022-12-08 2023-03-24 四川兴泰普乐医疗科技有限公司 一种可梯度降解的透明质酸钠凝胶及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1268955B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Esteri attivi di polisaccaridi carbossilici
NZ521079A (en) * 2000-02-03 2004-08-27 Denki Kagaku Kogyo Kk Hyaluronic acid gel, process for producing the same, and medical material containing the same
WO2005112888A2 (fr) * 2004-05-20 2005-12-01 Mentor Corporation Procede de preparation d'hydrogels polymeres injectables
EP1818344A4 (fr) * 2004-11-15 2012-04-18 Shiseido Co Ltd Methode de synthese d'un gel reticule d'acide hyaluronique
US20060105022A1 (en) * 2004-11-15 2006-05-18 Shiseido Co., Ltd. Process for preparing crosslinked hyaluronic acid gel
DE102005057593A1 (de) * 2005-07-08 2007-01-11 Schwan-Stabilo Cosmetics Gmbh & Co. Kg Zubereitung, insbesondere kosmetische Zubereitung, sowie ihre Herstellung und Verwendung
CN101244290A (zh) * 2007-11-30 2008-08-20 顾其胜 一种用于组织填充的交联透明质酸微粒凝胶的制备方法
FR2968305B1 (fr) * 2010-12-06 2014-02-28 Teoxane Procede de preparation d'un gel reticule
WO2012146031A1 (fr) * 2011-04-26 2012-11-01 北京爱美客生物科技有限公司 Gel composite d'acide hyaluronique et d'hydroxypropylméthylcellulose et procédé de production de celui-ci
CN103834053B (zh) * 2014-02-28 2016-04-27 陕西佰傲再生医学有限公司 一种可注射的交联透明质酸凝胶及其制备方法

Also Published As

Publication number Publication date
EP3624764A1 (fr) 2020-03-25
CA3060431A1 (fr) 2018-11-22
CN110621294A (zh) 2019-12-27
WO2018210999A1 (fr) 2018-11-22
BR112019024106A2 (pt) 2020-06-02
FR3066386A1 (fr) 2018-11-23
US20200060959A1 (en) 2020-02-27
KR20200008560A (ko) 2020-01-28

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