FR3063730B1 - Composes-clips surfactants pour l'extraction et la stabilisation en solution de proteines membranaires - Google Patents

Composes-clips surfactants pour l'extraction et la stabilisation en solution de proteines membranaires Download PDF

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Publication number
FR3063730B1
FR3063730B1 FR1751922A FR1751922A FR3063730B1 FR 3063730 B1 FR3063730 B1 FR 3063730B1 FR 1751922 A FR1751922 A FR 1751922A FR 1751922 A FR1751922 A FR 1751922A FR 3063730 B1 FR3063730 B1 FR 3063730B1
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FR
France
Prior art keywords
solution
membranary
stabilization
proteins
extraction
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1751922A
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English (en)
Other versions
FR3063730A1 (fr
Inventor
Pierre Falson
Julien Dauvergne
Ahcene Boumendjel
Marine Peuchmaur
Kim Anh Nguyen
Sandrine Magnard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite Claude Bernard Lyon 1 UCBL
Universite Grenoble Alpes
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Claude Bernard Lyon 1 UCBL
Universite Grenoble Alpes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite Claude Bernard Lyon 1 UCBL, Universite Grenoble Alpes filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR1751922A priority Critical patent/FR3063730B1/fr
Priority to CN201780088093.XA priority patent/CN110650967A/zh
Priority to EP17832306.9A priority patent/EP3592754A1/fr
Priority to PCT/FR2017/053857 priority patent/WO2018162806A1/fr
Priority to JP2019548705A priority patent/JP2020510026A/ja
Priority to US16/492,005 priority patent/US11440932B2/en
Publication of FR3063730A1 publication Critical patent/FR3063730A1/fr
Application granted granted Critical
Publication of FR3063730B1 publication Critical patent/FR3063730B1/fr
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

La présente invention se rapporte à un composé de formule (I) : telle que définie dans la description. La présente invention se rapporte également à un procédé d'extraction de protéines membranaires associées à une membrane biologique, comprenant une étape de mise en contact d'une solution aqueuse de protéines membranaires associées à la membrane biologique avec au moins un composé de l'invention. La présente invention se rapporte en outre à un procédé de stabilisation de protéines membranaires en solution dans une solution aqueuse, comprenant une étape (i) consistant à mettre en contact une solution aqueuse d'une protéine membranaire en solution avec au moins un composé de l'invention.
FR1751922A 2017-03-09 2017-03-09 Composes-clips surfactants pour l'extraction et la stabilisation en solution de proteines membranaires Active FR3063730B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR1751922A FR3063730B1 (fr) 2017-03-09 2017-03-09 Composes-clips surfactants pour l'extraction et la stabilisation en solution de proteines membranaires
CN201780088093.XA CN110650967A (zh) 2017-03-09 2017-12-27 用于提取膜蛋白和稳定膜蛋白溶液的表面活性化合物夹
EP17832306.9A EP3592754A1 (fr) 2017-03-09 2017-12-27 Composés-clips surfactants pour l'extraction et la stabilisation en solution de protéines membranaires
PCT/FR2017/053857 WO2018162806A1 (fr) 2017-03-09 2017-12-27 Composés-clips surfactants pour l'extraction et la stabilisation en solution de protéines membranaires
JP2019548705A JP2020510026A (ja) 2017-03-09 2017-12-27 膜タンパク質の抽出及び溶液中での安定化のための表面活性剤化合物−クリップ
US16/492,005 US11440932B2 (en) 2017-03-09 2017-12-27 Surfactant compounds-clips for extraction and stabilization in solution of membrane proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1751922 2017-03-09
FR1751922A FR3063730B1 (fr) 2017-03-09 2017-03-09 Composes-clips surfactants pour l'extraction et la stabilisation en solution de proteines membranaires

Publications (2)

Publication Number Publication Date
FR3063730A1 FR3063730A1 (fr) 2018-09-14
FR3063730B1 true FR3063730B1 (fr) 2021-09-17

Family

ID=59325370

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1751922A Active FR3063730B1 (fr) 2017-03-09 2017-03-09 Composes-clips surfactants pour l'extraction et la stabilisation en solution de proteines membranaires

Country Status (6)

Country Link
US (1) US11440932B2 (fr)
EP (1) EP3592754A1 (fr)
JP (1) JP2020510026A (fr)
CN (1) CN110650967A (fr)
FR (1) FR3063730B1 (fr)
WO (1) WO2018162806A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113880892B (zh) * 2020-07-03 2023-06-27 上海科技大学 一种小分子去垢剂
JP2022164255A (ja) * 2021-04-16 2022-10-27 住友ゴム工業株式会社 膜タンパク質複合体由来タンパク質を精製する方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492501B1 (en) * 1996-12-16 2002-12-10 Jean-Luc Popot Water soluble acrylic membrane-polymer protein amphiphilic complex and application to diagnosis methods
WO2002090533A2 (fr) 2001-05-07 2002-11-14 National Research Council Of Canada Production amelioree de proteines de recombinaison par transfection transitoire de cellules mammaliennes proliferant en suspension
JP2008063267A (ja) * 2006-09-06 2008-03-21 Asahi Kasei Chemicals Corp クリーム状の化粧料
DE102007060599A1 (de) * 2007-12-15 2009-06-18 Merck Patent Gmbh Verfahren zur Extraktion von Membranproteinen
FR2931695B1 (fr) * 2008-05-28 2010-06-25 Centre Nat Rech Scient Procede d'extraction selective de proteines membranaires avec les calixarenes
US9206221B2 (en) * 2012-04-06 2015-12-08 Wisconsin Alumni Research Foundation Amphiphilic compounds

Also Published As

Publication number Publication date
CN110650967A (zh) 2020-01-03
WO2018162806A1 (fr) 2018-09-13
JP2020510026A (ja) 2020-04-02
EP3592754A1 (fr) 2020-01-15
US11440932B2 (en) 2022-09-13
FR3063730A1 (fr) 2018-09-14
US20210130385A1 (en) 2021-05-06

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