FR2978456B1 - Systeme baculoviral pour l'expression d'un vecteur de therapie genique - Google Patents

Systeme baculoviral pour l'expression d'un vecteur de therapie genique

Info

Publication number
FR2978456B1
FR2978456B1 FR1156878A FR1156878A FR2978456B1 FR 2978456 B1 FR2978456 B1 FR 2978456B1 FR 1156878 A FR1156878 A FR 1156878A FR 1156878 A FR1156878 A FR 1156878A FR 2978456 B1 FR2978456 B1 FR 2978456B1
Authority
FR
France
Prior art keywords
expression
gene therapeutic
therapeutic vector
baculoviral system
baculoviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1156878A
Other languages
English (en)
French (fr)
Other versions
FR2978456A1 (fr
Inventor
Lionel Galibert
Otto-Wilhelm Merten
Aurelien Jacob
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genethon
Original Assignee
Genethon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1156878A priority Critical patent/FR2978456B1/fr
Application filed by Genethon filed Critical Genethon
Priority to US14/234,988 priority patent/US10017783B2/en
Priority to IN246MUN2014 priority patent/IN2014MN00246A/en
Priority to DK12753763.7T priority patent/DK2737072T3/en
Priority to AU2012288681A priority patent/AU2012288681B2/en
Priority to NO12753763A priority patent/NO2737072T3/no
Priority to PT127537637T priority patent/PT2737072T/pt
Priority to ES12753763.7T priority patent/ES2666278T3/es
Priority to BR112014001859A priority patent/BR112014001859A2/pt
Priority to PCT/FR2012/051791 priority patent/WO2013014400A1/fr
Priority to KR1020147005352A priority patent/KR20140049040A/ko
Priority to PL12753763T priority patent/PL2737072T3/pl
Priority to SG2014006373A priority patent/SG2014006373A/en
Priority to CN201280046259.9A priority patent/CN103827306B/zh
Priority to EP12753763.7A priority patent/EP2737072B1/fr
Priority to CA2843042A priority patent/CA2843042C/fr
Publication of FR2978456A1 publication Critical patent/FR2978456A1/fr
Application granted granted Critical
Publication of FR2978456B1 publication Critical patent/FR2978456B1/fr
Priority to US16/029,870 priority patent/US10767192B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14044—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14041—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/50—Vectors for producing vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2999/00—Further aspects of viruses or vectors not covered by groups C12N2710/00 - C12N2796/00 or C12N2800/00
    • C12N2999/007—Technological advancements, e.g. new system for producing known virus, cre-lox system for production of transgenic animals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR1156878A 2011-07-27 2011-07-27 Systeme baculoviral pour l'expression d'un vecteur de therapie genique Expired - Fee Related FR2978456B1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR1156878A FR2978456B1 (fr) 2011-07-27 2011-07-27 Systeme baculoviral pour l'expression d'un vecteur de therapie genique
SG2014006373A SG2014006373A (en) 2011-07-27 2012-07-27 Baculovirus system for the expression of a gene therapy vector
DK12753763.7T DK2737072T3 (en) 2011-07-27 2012-07-27 BACULOVIRUS SYSTEM FOR THE EXPRESSION OF A GENERATIVE VECTOR
AU2012288681A AU2012288681B2 (en) 2011-07-27 2012-07-27 Baculovirus system for the expression of a gene therapy vector
NO12753763A NO2737072T3 (pl) 2011-07-27 2012-07-27
PT127537637T PT2737072T (pt) 2011-07-27 2012-07-27 Sistema de baculovírus para a expressão de um vetor de terapia genética
ES12753763.7T ES2666278T3 (es) 2011-07-27 2012-07-27 Sistema de baculovirus para expresión de un vector de terapia genética
BR112014001859A BR112014001859A2 (pt) 2011-07-27 2012-07-27 sistema baculoviral para a expressão de um vetor de terapia gênica
US14/234,988 US10017783B2 (en) 2011-07-27 2012-07-27 Baculovirus system for the expression of a gene therapy vector
KR1020147005352A KR20140049040A (ko) 2011-07-27 2012-07-27 유전자 치료 벡터의 발현을 위한 바큘로바이러스 시스템
PL12753763T PL2737072T3 (pl) 2011-07-27 2012-07-27 Układ bakulowirusowy do ekspresji wektora do terapii genowej
IN246MUN2014 IN2014MN00246A (pl) 2011-07-27 2012-07-27
CN201280046259.9A CN103827306B (zh) 2011-07-27 2012-07-27 用于基因治疗载体的表达的杆状病毒系统
EP12753763.7A EP2737072B1 (fr) 2011-07-27 2012-07-27 Systeme baculoviral pour l'expression d'un vecteur de therapie genique
CA2843042A CA2843042C (fr) 2011-07-27 2012-07-27 Systeme baculoviral pour l'expression d'un vecteur de therapie genique
PCT/FR2012/051791 WO2013014400A1 (fr) 2011-07-27 2012-07-27 Systeme baculoviral pour l'expression d'un vecteur de therapie genique
US16/029,870 US10767192B2 (en) 2011-07-27 2018-07-09 Baculovirus system for the expression of a gene therapy vector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1156878A FR2978456B1 (fr) 2011-07-27 2011-07-27 Systeme baculoviral pour l'expression d'un vecteur de therapie genique

Publications (2)

Publication Number Publication Date
FR2978456A1 FR2978456A1 (fr) 2013-02-01
FR2978456B1 true FR2978456B1 (fr) 2015-02-20

Family

ID=46785752

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1156878A Expired - Fee Related FR2978456B1 (fr) 2011-07-27 2011-07-27 Systeme baculoviral pour l'expression d'un vecteur de therapie genique

Country Status (16)

Country Link
US (2) US10017783B2 (pl)
EP (1) EP2737072B1 (pl)
KR (1) KR20140049040A (pl)
CN (1) CN103827306B (pl)
AU (1) AU2012288681B2 (pl)
BR (1) BR112014001859A2 (pl)
CA (1) CA2843042C (pl)
DK (1) DK2737072T3 (pl)
ES (1) ES2666278T3 (pl)
FR (1) FR2978456B1 (pl)
IN (1) IN2014MN00246A (pl)
NO (1) NO2737072T3 (pl)
PL (1) PL2737072T3 (pl)
PT (1) PT2737072T (pl)
SG (1) SG2014006373A (pl)
WO (1) WO2013014400A1 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2966884A1 (en) 2014-11-05 2016-05-12 Research Institute At Nationwide Children's Hospital Methods and materials for producing recombinant viruses in eukaryotic microalgae
SG11202103425YA (en) * 2018-10-05 2021-05-28 Voyager Therapeutics Inc Engineered nucleic acid constructs encoding aav production proteins
CN109609552B (zh) * 2018-12-28 2020-04-14 中国科学院武汉物理与数学研究所 重组腺相关病毒的制备方法、系统及重组杆粒
US11708585B2 (en) * 2018-12-28 2023-07-25 Wuhan Institute Of Physics And Mathematics, Chinese Academy Of Sciences Method, system and recombinant bacmid for preparation of recombinant adeno-associated virus
GB201901571D0 (en) * 2019-02-05 2019-03-27 Oxford Genetics Ltd Inducible AAV sysyem
KR102272651B1 (ko) * 2019-03-28 2021-07-02 충북대학교 산학협력단 외래단백질의 발현량과 발현시간이 증대된 배큘로바이러스
CA3190059A1 (en) * 2020-08-17 2022-02-24 Yu TAO Nucleic acid construct for increasing adeno-associated virus yield, and construction method therefor
CN112852882A (zh) * 2021-02-04 2021-05-28 中吉智药(南京)生物技术有限公司 一种杆状病毒感染昆虫细胞生产aav基因药物的系统及方法
CN114369624B (zh) * 2021-12-30 2023-07-14 华南农业大学 一种降低病毒感染导致的昆虫细胞凋亡的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6723551B2 (en) 2001-11-09 2004-04-20 The United States Of America As Represented By The Department Of Health And Human Services Production of adeno-associated virus in insect cells
AU2002360355B2 (en) 2001-11-09 2005-07-07 Government Of The United States Of America, Department Of Health And Human Services Production of adeno-associated virus in insect cells
AU2003270099A1 (en) * 2002-09-04 2004-03-29 Polymun Scientific Immunbiologische Forschung Gmbh Generation of recombinant influenza virus using baculovirus delivery vector
ATE442450T1 (de) * 2004-03-09 2009-09-15 Eidgenissische Tech Hochschule Neue expressionswerkzeuge für multiproteinanwendungen
GB0702695D0 (en) * 2007-02-12 2007-03-21 Ark Therapeutics Ltd Production of vectors
GB0820631D0 (en) 2008-11-11 2008-12-17 London School Hygiene & Tropical Medicine Vectors
WO2010114948A2 (en) 2009-04-02 2010-10-07 University Of Florida Research Foundation, Inc. An inducible system for highly efficient production of recombinant adeno-associated virus (raav) vectors
EP2292781A1 (en) * 2009-08-17 2011-03-09 Genethon Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions

Also Published As

Publication number Publication date
CA2843042C (fr) 2020-07-21
SG2014006373A (en) 2014-03-28
NO2737072T3 (pl) 2018-07-14
US10017783B2 (en) 2018-07-10
EP2737072A1 (fr) 2014-06-04
CN103827306A (zh) 2014-05-28
US20180305717A1 (en) 2018-10-25
CN103827306B (zh) 2018-10-09
IN2014MN00246A (pl) 2015-09-25
US10767192B2 (en) 2020-09-08
EP2737072B1 (fr) 2018-02-14
DK2737072T3 (en) 2018-05-22
FR2978456A1 (fr) 2013-02-01
US20140349374A1 (en) 2014-11-27
AU2012288681A1 (en) 2014-03-13
WO2013014400A1 (fr) 2013-01-31
AU2012288681B2 (en) 2017-08-17
KR20140049040A (ko) 2014-04-24
CA2843042A1 (fr) 2013-01-31
ES2666278T3 (es) 2018-05-03
PL2737072T3 (pl) 2018-08-31
PT2737072T (pt) 2018-05-08
BR112014001859A2 (pt) 2017-02-21

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