FR2972607A1 - Dietary supplement, useful e.g. to induce weight loss, comprises microgranules designed to swell in the stomach, where the microgranules comprise soluble dietary fiber and insoluble dietary fiber - Google Patents

Abstract

Dietary supplement comprises microgranules designed to swell in the stomach, where the microgranules comprise soluble dietary fiber and insoluble dietary fiber, which is in greater quantity compared to soluble dietary fiber. ACTIVITY : Anabolic; Anorectic. MECHANISM OF ACTION : None given.

Description

ORAL ADMINISTRATIVE SUPPLEMENT COMPRISING MICROGRANULES DESIGNED TO INFLATE STOMACH AND INDUCE UNSATURATED EFFECT

Description Technical Field of the Invention

The present invention relates to an orally administrable dietary supplement comprising microgranules designed to swell in the stomach and induce a satiety effect.

The invention also relates to a method of manufacturing such a food supplement.

State of the art

Overweight is defined as an abnormal or excessive accumulation of fat in adipose tissue. Overweight is a major risk factor for a number of chronic diseases, including diabetes, cardiovascular disease, and cancer.

The main indicator of overweight and obesity is body mass index (BMI). The latter corresponds to the body weight in kilograms divided by the square of the height in meters of a person (unit = 10 2972607 -2 kg / m2). In adults, a BMI between 18.5 and 24.9 is normal. A BMI between 25 and 29.9 is overweight and a BMI of 30 and above indicates obesity. These thresholds serve as benchmarks for individual evaluation, but there is evidence that the risk of chronic disease is increasing steadily beyond a BMI of about 22.

The prior art has a number of proposals to help overweight people lose weight.

Devices (eg gastric balloon) can be used to reduce the useful volume of the stomach to limit the feeling of hunger. These devices are usually offered to obese people who need to lose weight. The implementation of these devices requires hospitalization outpatient and can cause abdominal pain and cramps, vomiting, bowel obstruction, etc.

WO2008022857 (Unilever PLC) proposes liquid compositions comprising a specific combination of pectins and alginates to increase satiety in obese subjects. Ingestion of these liquid compositions leads to the formation of a sufficiently rigid gel in the strongly acidic environment prevailing in the stomach, which makes it possible to obtain this satiety effect. The disadvantage associated with these compositions is that they can be used in the form of liquids. Furthermore, their packaging can be reversed by causing inconvenience or unacceptable congestion for the person following a weight loss program and who must for example travel. WO2009015475 (Natural Factors Nutritional Products, INC.) Discloses an orally administrable granular composition for promoting satiety and inducing weight loss. This composition is based on soluble fibers and only allows a modest loss of weight. The prior art also provides various dietary supplements to promote satiety and to induce weight loss. However, most of these food supplements come in the form of powder, capsules or tablets. It is also known that powdered food supplements have poor flow properties and generate dust in the packaging shops. This is particularly detrimental to the filling of unit sachets or capsules for consumers. Furthermore, dietary supplements administered as free powder or in the form of powder contained in capsules tend to agglomerate in the gastric juice to form a dough which dissolves with difficulty, thus limiting the effectiveness of such dietary supplements. and their application to promote satiety and induce weight loss. Moreover, the use of such food supplements in the form of tablets may present discomfort during their administration particularly in persons having difficulty swallowing tablets or who have difficulty swallowing.

In view of this state of affairs, the main objective of the invention is to provide an orally administrable dietary supplement in a form which does not agglomerate in the gastric fluid, which is able to swell in the stomach for effectively reduce the useful volume of the stomach and that allows to capture dietary lipids and to promote a significant loss of weight in a human or animal subject. Another object of the invention is to provide an orally administrable dietary supplement in solid form which is stable and has good flow properties and which does not generate dust in the packaging workshops.

Disclosure of the invention.

The solution proposed by the invention is an orally administrable dietary supplement in a human or animal subject that is remarkable in that it comprises microgranules designed to swell in the stomach and induce a satiety effect in said subject, said microgranules having soluble dietary fiber and insoluble dietary fiber. Insoluble dietary fiber being predominant over soluble dietary fiber.

Such microgranules absorb water in the stomach and swell to form balloons or three-dimensional fiber networks that trap the lipids ingested during the meal. The lipids thus entrapped are not digested and are eliminated directly in the stool. Moreover, by swelling, the microgranules according to the invention take up space in the stomach and induce a ballast effect, thus generating a feeling of satiety.

The Applicant has shown that, thanks to the microgranules according to the invention, such a dietary supplement makes it possible on the one hand to promote satiety and on the other hand to effectively capture the lipids brought by the diet, thus limiting their absorption and storage in the body, thereby helping to combat unwanted weight gain and induce significant weight loss in a human or animal subject, particularly in a human subject having a BMI of from about 25 to about 30 In the context of the invention, the term "weight loss" means the loss of a portion of the total weight in a human or animal subject, in particular the loss of a portion of the fat mass; "Satiety", the sensation felt when one is no longer hungry. Preferentially, the insoluble dietary fiber mainly comes from a carrot extract. The carrot, or Daucus carota var. sativus, belongs to the family Apiaceae. In practice, a dry carrot extract obtained from carrot puree (Daucus carota) is used, the juice of which is completely separated by conventional extraction and separation techniques known to those skilled in the art. Such an extract contains soluble fibers (pectins) and insoluble fibers (cellulose and hemicellulose), minerals and a small fraction of lipids and proteins. The carrot extract is preferably present in the microgranules for at least 20% w / micrograms, preferably at least 40% w / microgranules.

The carrot extract used preferably has a total fiber content (soluble and insoluble fiber) of between 50% and 99%, advantageously between 60% and 95%, preferably about 92%, by weight relative to the total dry weight. carrot extract. The total fiber content 2972607 -6 being determined by the official method No. 56-20 modified by the American Association of Cereal Chemists (AACC). The carrot extract used consists mainly of insoluble fibers, the weight ratio between insoluble fibers and soluble fibers being between 1.02 and 20, advantageously between 1.5 and 10, preferably about 6.

Such a carrot extract has a fat retention capacity of between 300% and 500% and a high water absorption capacity of between 1500 and 3000%, for example about 1800%. Fat retention capacity and absorbency are determined by the modified AACC Method No. 56-20.

The microgranules according to the invention may also comprise other insoluble dietary fibers originating, for example, from an extract of apple and / or oats, in combination or not with the insoluble dietary fiber coming from the carrot extract. Such insoluble fibers make it possible to optimize the action of the dietary supplement to promote satiety, to limit the absorption of dietary lipids and to induce weight loss, but also to normalize the functions of the colon, to regulate the intestinal transit. and fight against the tendency to constipation.

Insoluble dietary fiber from apples and / or oats is present in microgranules at less than 10% w / microgranules. The apple fibers used are derived from apples (Pyrus ma / us) after separation of the juice by standard extraction techniques and separation known to those skilled in the art. They have a total fiber content (soluble and insoluble fiber) of about 63% by weight based on the total weight of the dry matter. The insoluble fibers and soluble fibers respectively represent about 67% and 33% by weight based on the total weight of the dry matter. The apple fibers are advantageously used in the present invention in the form of a fine powder of which about 98% of the particles have a diameter of less than 315 μm and 60% of the particles have a diameter of less than 150 μm. The apple fibers may be present in the microgranules at a content of less than or equal to 10% per micrograms, advantageously at a content ranging from 3 to 4% by weight / microgranules, preferably at a content of approximately 3.5%. w / pmicrogranules.

The oat fiber used may be obtained by any conventional method of extraction and purification known to those skilled in the art from oat shell envelopes (Aven sativa). Preferably, the oat fibers have a total fiber content (soluble and insoluble fiber) of about 96% by weight relative to the total weight of the dry matter and a water content of less than 8% by weight relative to the total weight dry matter. The insoluble fibers and soluble fibers respectively represent about 93% and 3% by weight based on the total weight of the dry matter. The oat fibers are used in the present invention in the form of a fine powder of which at most 14% of the particles have a diameter greater than 32 μm and at most 0.5% of the particles have a diameter greater than 71 μm. The oat fibers may be present in the microgranules at a content of less than or equal to 10% w / micrograms, preferably at a level of from 3 to 4% w / microgranules, preferably at a level of about 3.5 The microgranules according to the invention also comprise soluble dietary fibers originating from a brown algae Ascophy // um nodosum extract, in particular to enhance the capacity of the microgranules to swell in the stomach and to promote the growth of the microgranules. satiety effect. Ascophy // um nodosum brown algae extract contains a lipase and / or α-amylase and / or α-D-glucosidase inhibitor, and makes it possible to confer on the microganules digestive enzyme inhibition properties. involved in the assimilation of fats and / or sugars of the food bolus in order to reduce the accumulation of fats in the body and to fight against the global intake of calories and to induce a loss of weight. To optimize this effect, the content of this extract of brown alga Ascophy // um nodosum is between 2% and 30% p / microgranules.

In the context of the present invention, the term "lipase inhibitor" means a compound capable of inhibiting the action of gastric and pancreatic lipases responsible for the metabolism and absorption of fat. "Α-Amylase Inhibitor": a compound capable of inhibiting the action of α-amylase which is involved in the digestion of carbohydrates, for example α-amylase secreted by the salivary glands and by the pancreas . "Α-D-Glucosidase Inhibitor" a compound capable of inhibiting the action of α-D-glucosidase which hydrolyzes the disaccharides and / or the polysaccharides connected by an α- (1,4) bond to release by example glucose.

Ascophy // um nodosum or Ascophy // e nodosa is a marine algae classified in the family Fucaceae. The extract of Ascophy // um 2972607 -9 nodosum brown algae used in the microgranules according to the invention may be prepared by any extraction and purification method known to those skilled in the art.

The microgranules according to the invention further comprise soluble fibers from an apple extract to help strengthen the swelling properties, but also to enrich them with polyphenolic compounds, including phloridzine, which can modulate the post-glycemia. prandial and regulate the absorption of cholesterol, in order to reduce the storage of fats. This apple extract is preferably present in the microgranules at a content of less than or equal to 5% w / micrograms.

Preferentially, the microgranules of the invention have a median size of less than 5000 microns, preferably less than 2500 microns and a bulk density of approximately 0.66 g / cm 3. Advantageously, these microgranules are stable, have good flow properties for filling capsules and do not generate dust in the packaging workshops.

The dietary supplement is advantageously in the form of capsules comprising the microgranules. Any other equivalent dosage form and allowing oral administration may be considered, for example in the form of tablets. 25

Claims (5)

REVENDICATIONS1. Food supplement for oral administration in a human or animal subject, characterized in that it comprises microgranules designed to swell in the stomach and induce a satiety effect in said subject, said microgranules comprising soluble dietary fiber and dietary fiber insoluble, said insoluble dietary fiber being predominant in relation to soluble dietary fiber. 2. Food supplement according to claim 1, characterized in that the weight ratio between insoluble fiber and soluble fiber is between 1.02 and 20, preferably between 1.5 and 10. 3. Food supplement according to one of the preceding claims, characterized in that the insoluble dietary fiber mainly comes from a carrot extract. 20 4. Food supplement according to one of the preceding claims, characterized in that the microgranules comprise insoluble dietary fiber from apple and / or oats. 5. Food supplement according to one of the preceding claims, characterized in that the microgranules comprise soluble dietary fiber from an extract of brown alga Ascophy // um nodosum. 5. Dietary supplement according to one of the preceding claims, characterized in that the microgranules comprise soluble dietary fiber from an apple extract. 7. Food supplement according to one of the preceding claims, characterized in that it is in the form of capsules. 10