FR2966152B1 - Nouveaux derives de benzothiophene, presentant une activite inhibitrice de la tnap - Google Patents

Nouveaux derives de benzothiophene, presentant une activite inhibitrice de la tnap

Info

Publication number
FR2966152B1
FR2966152B1 FR1058542A FR1058542A FR2966152B1 FR 2966152 B1 FR2966152 B1 FR 2966152B1 FR 1058542 A FR1058542 A FR 1058542A FR 1058542 A FR1058542 A FR 1058542A FR 2966152 B1 FR2966152 B1 FR 2966152B1
Authority
FR
France
Prior art keywords
inhibitory activity
benzothiophene derivatives
novel benzothiophene
tnap inhibitory
tnap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1058542A
Other languages
English (en)
Other versions
FR2966152A1 (fr
Inventor
Rene Buchet
Stephane Pellet-Rostaing
Marc Lemaire
Lei Chang
Lina Li
Saida Mebarek
Florence Popowycz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite Claude Bernard Lyon 1 UCBL
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Claude Bernard Lyon 1 UCBL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite Claude Bernard Lyon 1 UCBL filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR1058542A priority Critical patent/FR2966152B1/fr
Priority to PCT/FR2011/052416 priority patent/WO2012052668A1/fr
Publication of FR2966152A1 publication Critical patent/FR2966152A1/fr
Application granted granted Critical
Publication of FR2966152B1 publication Critical patent/FR2966152B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR1058542A 2010-10-19 2010-10-19 Nouveaux derives de benzothiophene, presentant une activite inhibitrice de la tnap Expired - Fee Related FR2966152B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR1058542A FR2966152B1 (fr) 2010-10-19 2010-10-19 Nouveaux derives de benzothiophene, presentant une activite inhibitrice de la tnap
PCT/FR2011/052416 WO2012052668A1 (fr) 2010-10-19 2011-10-17 Nouveaux derives de benzothiophene, presentant une activite inhibitrice de la tnap

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1058542A FR2966152B1 (fr) 2010-10-19 2010-10-19 Nouveaux derives de benzothiophene, presentant une activite inhibitrice de la tnap

Publications (2)

Publication Number Publication Date
FR2966152A1 FR2966152A1 (fr) 2012-04-20
FR2966152B1 true FR2966152B1 (fr) 2013-03-15

Family

ID=43707958

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1058542A Expired - Fee Related FR2966152B1 (fr) 2010-10-19 2010-10-19 Nouveaux derives de benzothiophene, presentant une activite inhibitrice de la tnap

Country Status (2)

Country Link
FR (1) FR2966152B1 (fr)
WO (1) WO2012052668A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016054056A1 (fr) * 2014-10-01 2016-04-07 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Procedes de traitement de pxe avec des inhibiteurs de tnap

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119693B2 (en) 2007-05-08 2012-02-21 Sanford-Burnham Medical Research Institute Tissue non-specific alkaline phosphatase inhibitors and uses thereof for treating vascular calcification

Also Published As

Publication number Publication date
WO2012052668A1 (fr) 2012-04-26
FR2966152A1 (fr) 2012-04-20

Similar Documents

Publication Publication Date Title
FR23C1017I2 (fr) Derives de quinoline-8-sulfonamide ayant une activite anticancereuse
FR17C1040I2 (fr) Derive antiviraux de 2,5-dibenzimidazol-5-yl-1-phenyl-pyrrolidine
SMT201600216B (it) Ottaidropirrolo[3,4.c]pirroli disostituiti come modulatori del recettore di orexina
ECSP12011946A (es) Derivados de dioxa- biciclo [3.2.1] octano- 2 ,3,4- triol
DE112009004699A5 (de) Elektrochirurgisches System
BR112013003245A2 (pt) derivados de heteroarilpiperidina e -piperazina como fungicidas
BRPI1012770A2 (pt) derivados de tiofeno
CO6910204A2 (es) Derivados de 5-flúor-4-imino-3-(sustituido)-3,4-dihidropirimidin-2(1h)ona
BRPI0908130A2 (pt) Produto
DK2344471T3 (da) 7-piperidinalkyl-3,4-dihydroquinolon-derivat
UY33125A (es) Diaza-espiro-[5,5]-undecanos
BRPI1014077A2 (pt) Derivados de tiazolilperidina como fungicidas
BR112013014615A2 (pt) produto de base de sabor concentrado
FR2943897B1 (fr) Distributeur de produit.
BRPI0906357A2 (pt) Derivados de oxazepinopirimidona arilamida substituídos
FR2934751B1 (fr) Tondeuse de type autoportee
BRPI0918134A2 (pt) derivado de prostaglandina i2
FR2960924B1 (fr) Distributeur hydraulique.
FR2957207B1 (fr) Groupe electromoteur distribue.
BRPI1016192A2 (pt) derivados de soxazol.
DK2442870T3 (da) Pyrazinooxazepin-derivater.
SMT201500166B (it) Derivato di 1,2,4-triazolone
DK2701487T3 (da) Polynukleotider, der koder for enzymer fra jute-lignin- biosyntesevejen
CU23864B1 (es) Nuevos derivados no peptídicos como antagonistas b1 de la bradiquinina
BRPI1010523A2 (pt) compostos de 1,1,1-triflúor-2-hidróxi-propil-2,3-di-arila ou heteroarila substituída

Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 7

ST Notification of lapse

Effective date: 20180629