FR2952301A1 - Cosmetic use of histone H4 or at least one inducer of histone H4 expression, as an agent for preventing and/or inhibiting the development of body odors associated with human perspiration - Google Patents

Abstract

Cosmetic use of histone H4 or at least one inducer of histone H4 expression, as an agent for preventing and/or inhibiting the development of body odors associated with human perspiration, is claimed. An independent claim is included for cosmetic method for preventing and/or inhibiting the development of body odors associated with human perspiration comprising applying a composition comprising histone H4 or at least one inducer of histone H4 expression to the skin and/or appendages, in a medium.

Description

The present invention relates to the use of an effective amount of histone H4 or at least one inducer of the expression of histone H4, as an agent preventing and / or inhibiting the development of odors related to human perspiration, including axillary odors. The invention also relates to a method for preventing and / or inhibiting human body odor and especially axillary with these compounds.

Although eccrine or apocrine sweat is poorly odorous when secreted, it may become odorous in a short period of time and present an important gene for the person who secreted it.

There is no real treatment to treat bad smells. Antiperspirants such as metal salts are generally used, which have the effect of limiting or even suppressing the flow of sweat or anti-inflammatory agents such as peroxides and in particular benzoyl peroxide. In addition, since metal salts cause the formation of a partial plug in the sweat duct, they give the consumer the impression of an unnatural sweat control. Finally, they also tend to leave marks on clothing.

There is therefore currently a need for new compounds to treat odors and do not have these disadvantages.

The applicant has therefore sought new products exerting a deodorant action, that is to say products that are able to modify, reduce and / or remove or prevent the development of body odor (this definition is given in the book "Cosmetic Science and Technology Series" - 1988 / Volume 7 chap.10 - Illc). Histones are alkaline proteins present in the nucleus of eukaryotic cells and responsible for the packaging and folding of DNA into structural units called nucleosomes. There are 5 types of histones: the histones H2A, H2B, H3 and H4 deal with the first degree of condensation of the DNA which leads to the structure called "nucleosome" (or "pearl necklace") and the histone H1 deals with the second degree of condensation to stiffen this structure.

The Applicant has now unexpectedly and surprisingly discovered that histone H4 and inducers of histone H4 expression exhibit good self-deodorant activity and do not have the disadvantages of the other known deodorant active ingredients listed above. .

Histone H4 is a peptide composed of 103 amino acids. Its molecular weight is about 11 KDa. It is one of the least evolved proteins in evolution (Kamakaka et al., Genes Dev 2005 Feb 1, 19 (3): 295-310). This peptide is the result of the expression of several genes located in different loci: HIST1 H4A, HIST1 H4B, HIST1 H4C, HIST1 H4D, HIST1 H4E, HIST1 H4F, HIST1 H4H, HIST1 H4I, HIST1 H4J, HIST1 H4K, HIST1 H4L, HIST2H4A, HIST2H4B, HIST4H4 and Hip.

The stimulating effect of histone H4 on glucose transport activity in skeletal muscle has been demonstrated in rats (Louters et al., Biochem J., 1993, 295, p.549-553).

Histone H4, which is holocrine secreted by the sebocytes, is also known as an antimicrobial agent against Staphylococcus aureus and Propionibacterium acnes (Lee et al., Journal of Investigative Dermatology, 2009, 129, p. .2489-2496).

However, it has never been suggested a possible effect of this compound vis-à-vis the bad body odors.

A first object of the invention is the cosmetic use of an effective amount of histone H4 or at least one inducer of histone H4 expression, as a preventive and / or inhibiting agent. the development of body odors related to human perspiration.

Body odors may be particularly axillary. These body odors are the consequence of the development of bacteria species Corynebacteriun striatum and Corynebacterium multifaciens.

According to an advantageous embodiment of the invention, the histone H4 or the inducer of the expression of the histone H4 is present in a composition containing a cosmetically acceptable medium at a concentration of between 0.01 and 30% by weight. weight relative to the total weight of the composition.

Preferentially, the histone H4 or the inducer of the expression of the histone H4 is applied topically to the skin and / or its annexes. By "skin" is meant the entire skin coating, including the scalp and mucous membranes. "Appendices" means all the hairy appendages and in particular the hair and the hair.

The inducer of the expression of the Histone H4 will be chosen preferentially from compounds of peptide, glycosic or lipid nature or organic compounds, glycans, glycopeptides or Vitreoscilla filiformis.

Preferentially Vitreoscilla filiformis will be in live form or purified extract or lysate.

Vitreoscilla filiformis is a non-photosynthetic filamentous bacterium of which one strain was deposited with ATCC under number 15551.

Another object of the invention is a cosmetic method, for preventing and / or inhibiting the development of body odors related to human perspiration, comprising applying to the skin and / or its appendages a composition comprising, in a cosmetically acceptable medium, an effective amount of histone H4 or at least one inducer of the expression of histone H4. By "cosmetically acceptable" is meant compatible with the skin and / or its integuments or mucous membranes which has a pleasant color, odor and feel and which does not generate unacceptable discomfort (tingling, tightness, redness), which may divert the consumer from using this composition.

The composition will preferably be applied to the skin and / or its appendages in the axillary zone.

The skin on which the composition will be applied will preferably be sensitive or weakened.

Galenic forms

The composition according to the invention may be in any of the galenical forms conventionally used for topical application and especially in the form of aqueous gels, aqueous or aqueous-alcoholic solutions. It may also, by addition of a fatty or oily phase, be in the form of lotion-type dispersions, emulsions of liquid or semi-liquid consistency of the milk type, obtained by dispersion of a fatty phase in one phase. aqueous (O / W) or conversely (W / O), or suspensions or emulsions of soft, semi-solid or solid consistency of the cream or gel type, or multiple emulsions (W / O / W or O / W) / H), microemulsions, vesicular dispersions of ionic and / or nonionic type, or wax / aqueous phase dispersions. These compositions are prepared according to the usual methods.

The compositions according to the invention may in particular be packaged in pressurized form in an aerosol device or in a pump bottle; packaged in a device provided with a perforated wall including a grid; packaged in a device equipped with a roll-on applicator, packaged in the form of sticks (sticks), in the form of loose or compacted powder, in this respect they contain the ingredients generally used in this type of product and well known to those skilled in the art.

The compositions according to the invention can be anhydrous. By anhydrous composition is meant a composition containing less than 2% by weight of water, or even less than 0.5% of water, and especially free of water, the water not being added during the preparation of the composition but corresponding to the residual water provided by the mixed ingredients.

The compositions according to the invention can be solid, in particular in the form of a stick or a stick.

By "solid composition" it is meant that the measurement of the maximum force measured in texturometry during the insertion of a probe into the sample of formula must be at least 0.25 Newton, in particular at least equal to 0.30 Newton, especially at least 0.35 Newton, appreciated under precise measurement conditions as follows.

The formulas are poured hot in pots 4 cm in diameter and 3 cm deep. Cooling is done at room temperature. The hardness of the formulas is measured after 24 hours of waiting. The pots containing the samples are characterized in texturometry using a texturometer such as that marketed by Rhéo TA-XT2, according to the following protocol: a ball-type stainless steel probe of diameter 5 mm is brought into contact with the sample at a speed of 1 mm / s. The measurement system detects the interface with the sample with a detection threshold equal to 0.005 newtons. The probe sinks 0.3 mm into the sample at a rate of 0.1 mm / s. The meter records the evolution of the force measured in compression over time, during the penetration phase. The hardness of the sample corresponds to the average of the maximum values of the force detected during the penetration, on at least 3 measurements.

Aqueous phase

The compositions according to the invention intended for cosmetic use may comprise at least one aqueous phase. They are in particular formulated in aqueous lotions or in water-in-oil, oil-in-water or multiple emulsion emulsions (triple oil-in-water-in-oil or water-in-oil-in-water emulsion). such emulsions are known and described for example by C. FOX in "Cosmetics and Toiletries" - November 1986 - Vol 101 - pages 101-112) .The aqueous phase of said compositions contains water and in general other soluble solvents or water-miscible solvents Solvents that are soluble or miscible in water include short-chain monohydric alcohols, for example C 1 -C 4 alcohols such as ethanol, isopropanol, diols or polyols such as ethylene glycol, and the like. , 2-propylene glycol, 1,3-butylene glycol, hexylene glycol, diethylene glycol, dipropylene glycol, 2-ethoxyethanol, diethylene glycol monomethyl ether, triethylene glycol monomethyl ether and sorbitol, more particularly propylene glycol and glycerin, propane 1,3 di ol.

Emulsifiers a) Oil-in-water emulsifiers

Examples of emulsifiers that may be used in oil-in-water emulsions or oil-in-water-in-oil tri-emulsions include, for example, nonionic emulsifiers such as oxyalkylenated fatty acid and glycerol esters (more particularly polyoxyethylenes); oxyalkylenated fatty acid and sorbitan esters; oxyalkylenated fatty acid esters (oxyethylenated and / or oxypropylenated); oxyalkylenated fatty alcohol ethers (oxyethylenated and / or oxypropylenated); sugar esters such as sucrose stearate; and mixtures thereof such as the mixture of glyceryl stearate and PEG-40 stearate.

Mention may also be made of the fatty alcohol / alkylpolyglycoside emulsifying mixtures as described in applications WO 92/06778, WO 95/13863 and WO 98/47610, such as the commercial products sold by the company SEPPIC under the names MONTANOV (D. b) Emulsifiers water-in-oil

Among the emulsifiers that can be used in water-in-oil emulsions or triple water-in-oil-in-water-in-oil emulsions or triple emulsions, there can be mentioned by way of example alkyl dimethicone copolyols. Among the preferred alkyl dimethicone copolyols emulsifiers, mention will be made more particularly of CETYL PEG / PPG-10/1 DIMETHICONE and more particularly of the CETYL PEG / PPG-10/1 DIMETICONE AND DIMETHICONE mixture (INCI name), such as the product sold under the name ABIL® EM90 by the company GOLDSCHMIDT or the mixture (POLYGLYCERYL-4-STEARATE and CETYL PEG / PPG-10 (AND) DIMETHICONE (AND) HEXYL LAURATE) as the product sold under the trade name ABIL® WE09 by the same company .

Among the water-in-oil emulsifiers, mention may also be made of dimethicone copolyols.

Among these preferential dimethicone copolyols emulsifiers, particular use will be made of PEG-18IPPG-18 DIMETHICONE and more particularly the mixture CYCLOPENTASILOXANE (and) PEG-18IPPG-18 DIMETHICONE (INCI name) such as the product sold by Dow Corning under the trade name Silicone DC® 5225 C or KF-6040 from Shin Etsu.

According to a particularly preferred form, use will be made of a mixture of at least one emulsifier alkyl dimethicone copolyols and at least one emulsifier dimethicone copolyols mentioned above.

More particularly, a mixture of PEG-18IPPG-18 Dimethicone and Cetyl PEG / PPG-10/1 DIMETHICONE and even more particularly a mixture of (CYCLOPENTASILOXANE and PEG-18IPPG-18 Dimethicone) and Cetyl PEG / PPG-10 / 1 DIMETHICONE and Dimethicone or (Polyglyceryl-4-stearate and Cetyl PEGIPPG-10 and Dimethicone and Hexyl Laurate).

Among the water-in-oil emulsifiers, mention may also be made of nonionic emulsifiers derived from fatty acid and polyol, alkylpolyglycosides (APG), sugar esters and mixtures thereof.

As nonionic emulsifiers derived from fatty acid and polyol, the fatty acid and polyol esters may be used in particular, the fatty acid having in particular a C 8 -C 24 alkyl chain, and the polyols being, for example, glycerol. and sorbitan.

Examples of fatty acid and polyol esters that may be mentioned include esters of isostearic acid and of polyols, esters of stearic acid and of polyols, and mixtures thereof, in particular esters of isostearic acid and of glycerol. and / or sorbitan.

Stearic acid esters and polyols that may be mentioned include polyethylene glycol esters such as PEG-30 dipolyhydroxystearate.

Examples of glycerol and / or sorbitan esters that may be mentioned are polyglycerol isostearate; sorbitan isostearate; sorbitan isostearate and glycerol, the mixture of sorbitan isostearate and polyglycerol isostearate (3 moles) and mixtures thereof.

The emulsifier may also be chosen from alkylpolyglycosides having an HLB of less than 7. As alkylpolyglycosides of this type, mention may be made of alkylpolyglucosides. This alkylpolyglucoside may be used in admixture with a co-emulsifier, more particularly with a fatty alcohol and in particular a fatty alcohol having the same fatty chain as that of the alkylpolyglucoside, that is to say comprising from 14 to 24 carbon atoms. carbon and having a branched and / or unsaturated chain, and for example isostearyl alcohol when the alkylpolyglucoside is isostearylglucoside, and oleyl alcohol when the alkylpolyglucoside is oleylglucoside, optionally in the form of a composition self-emulsifying, as described for example in WO 92/06778. For example, the mixture of isostearyl glucoside and isostearyl alcohol sold under the name Montanov® WO 18 as well as the mixture octyldodecanol and octyldodecylxyloside may be used.

Mention may also be made of succinic-terminated polyolefins, such as ester-terminated polyisobutylenes and their salts, especially the diethanolamine salts.

The total amount of emulsifiers in the composition will preferably be in the composition according to the invention at contents of active material ranging from 1 to 8% by weight and more particularly from 2 to 6% by weight relative to the total weight of the composition. .

Fatty phase

The compositions according to the invention may contain at least one immiscible organic liquid phase in water called "fatty phase". This generally comprises one or more hydrophobic compounds which render said phase immiscible in water. Said phase is liquid (in the absence of structuring agent) at ambient temperature (20-25 ° C.). Preferably, the organic liquid immiscible organic phase in accordance with the invention is generally constituted generally comprises at least one volatile oil and / or a non-volatile oil and optionally at least one structuring agent.

By "oil" is meant a fatty substance that is liquid at ambient temperature (25 ° C.) and atmospheric pressure (760 mmHg, ie 105 Pa). The oil can be volatile or non-volatile.

For the purposes of the invention, the term "volatile oil" means an oil capable of evaporating on contact with the skin or keratin fiber in less than one hour at ambient temperature and atmospheric pressure. The volatile oils of the invention are volatile cosmetic oils which are liquid at ambient temperature and have a non-zero vapor pressure at ambient temperature and atmospheric pressure, in particular ranging from 0.13 Pa to 40,000 Pa (10-3 to 300 mm Hg).

By "non-volatile oil" is meant an oil remaining on the skin or the keratinous fiber at room temperature and atmospheric pressure for at least several hours and in particular having a vapor pressure of less than 10 -3 mmHg (0.13 Pa). .

The oil may be chosen from all physiologically acceptable and in particular cosmetically acceptable oils, in particular mineral, animal, vegetable, and synthetic oils; in particular volatile and / or nonvolatile hydrocarbon and / or silicone and / or fluorinated oils and mixtures thereof.

Structural Agent The compositions according to the invention comprising a fatty phase may additionally contain at least one structuring agent of said fatty phase, which may be chosen preferably from waxes, pasty compounds, mineral or organic lipophilic gelling agents and mixtures thereof.

It is understood that the amount of these compounds can be adjusted by those skilled in the art so as not to damage the desired effect in the context of the present invention.

Wax (s) Wax is generally a solid, room temperature (25 ° C), solid-reversible liquid / solid state change, solid lipophilic compound having a melting point greater than or equal to 30 ° C up to 200 ° C and especially up to 120 ° C. In particular, the waxes that are suitable for the invention may have a melting point greater than or equal to 45 ° C., and in particular greater than or equal to 55 ° C.

For the purposes of the invention, the melting temperature corresponds to the temperature of the most endothermic peak observed in thermal analysis (DSC) as described in ISO 11357-3; 1999. The melting point of the wax can be measured using a differential scanning calorimeter (DSC), for example the calorimeter sold under the name "MDSC 2920" by the company TA Instruments. The waxes that may be used in the compositions according to the invention are chosen from waxes, solid, at room temperature of animal, vegetable, mineral or synthetic origin, and mixtures thereof.

Illustrative waxes suitable for the invention include hydrocarbon waxes such as beeswax, lanolin wax, and Chinese insect wax, rice bran wax, Carnauba wax Candellila wax, Ouricury wax, Alfa wax, berry wax, shellac wax, Japanese wax and sumac wax; montan wax, orange and lemon waxes, refined sunflower wax, microcrystalline waxes, paraffins and ozokerite, polyethylene waxes, waxes obtained by Fisher-Tropsch synthesis and waxy copolymers as well as their esters.

There may also be mentioned waxes obtained by catalytic hydrogenation of animal or vegetable oils having linear or branched C8-C32 fatty chains. Among these, there may be mentioned isomerized jojoba oil such as trans isomerized partially hydrogenated jojoba oil manufactured or marketed by Desert Whale under the trade reference Iso-Jojoba-50®, sunflower oil hydrogenated castor oil, hydrogenated coconut oil, hydrogenated lanolin oil, and di- (1,1,1-trimethylolpropane) tetrastearate sold under the name Hest 2T-4S® by the company HETERENE.

Mention may also be made of silicone waxes (C30-45 ALKYL DIMETHICONE) and fluorinated waxes.

It is also possible to use the waxes obtained by hydrogenation of castor oil esterified with cetyl alcohol sold under the names Phytowax Ricin 16L64® and 22L73® by the company SOPHIM. Such waxes are described in application FR-A-2792190.

As the wax, a C20-C40 alkyl (hydroxystearyloxy) stearate (the alkyl group comprising from 20 to 40 carbon atoms), alone or in admixture, can be used.

As micro-waxes that can be used in the compositions according to the invention, mention may be made in particular of carnauba micro waxes, synthetic wax micro-waxes, and micro-waxes consisting of a mixture of carnauba wax and polyethylene wax, micro waxes consisting of a mixture of carnauba wax and synthetic wax, polyethylene micro waxes or paraffin waxes and polytetrafluoroethylene micro waxes. The composition according to the invention will preferably comprise a wax content (s) ranging from 3% to 20% by weight relative to the total weight of the composition, in particular from 5% to 15%, more particularly from 6% to 15%.

According to one particular form of the invention, in the context of the anhydrous solid compositions in the form of a stick, use will be made of polyethylene micro-waxes in the form of shape-factor crystallites of at least 2 having a melting point of 70.degree. at 110 ° C and preferably 70 to 100 ° C to reduce or eliminate the presence of layers in the solid composition.

These crystallites in needles and in particular their dimensions can be characterized visually according to the following method.

The wax is deposited on a microscope slide, which is placed on a hot plate. The blade and the wax are heated to a temperature generally at least 5 ° C higher than that of the melting point of the wax or wax mixture considered (e). At the end of the melting, the liquid thus obtained and the microscope slide are allowed to cool to solidify. The observation of the crystallites is carried out using a Leica DMLB100 type optical microscope, with a target selected according to the size of the objects to be viewed, and in polarized light. The dimensions of the crystallites are measured using an image analysis software such as those marketed by Microvision.

The crystallite polyethylene waxes according to the invention preferably have an average length ranging from 5 to 10 μm. By "average length" is meant the dimension given by the statistical size distribution at half of the population, called D50.

A mixture of waxes PERFORMALENE® 400 POLYETHYLENE and PERFORMALENE® 500-L POLYETHYLENE from NEW PHASE TECHNOLOGIES will be used more particularly.

Paste compounds

For the purposes of the present invention, the term "pasty compound" is intended to mean a lipophilic fat compound having a reversible solid / liquid state change, having in the solid state an anisotropic crystalline organization and having, at a temperature of 23.degree. liquid fraction and a solid fraction.

The pasty compound is preferably chosen from synthetic compounds and compounds of plant origin. A pasty compound can be obtained synthetically from starting materials of plant origin.

The pasty compound may be advantageously chosen from: lanolin and its derivatives, polymeric or non-polymeric silicone compounds, polymeric or non-polymeric fluorinated compounds, vinyl polymers, especially olefin homopolymers, olefin copolymers, homopolymers and copolymers of hydrogenated dienes, linear or branched oligomers, homo or copolymers of alkyl (meth) acrylates preferably having a C 8 -C 30 alkyl group, homopolymers and copolymers of vinyl esters having C 8 -C 30 alkyl groups and the homo- and copolymer oligomers of vinyl ethers having C8-C30 alkyl groups, the fat-soluble polyethers resulting from the polyetherification between one or more C2-C100, preferably C2-C50 diols, the esters and their mixtures.

Among the pasty compounds of plant origin, a mixture of soy sterols and pentaerythritol oxyethylenated (5OE) oxypropylene (5 OP), marketed under the reference Lanolide® by the company VEVY, will preferably be chosen.

Lipophilic gelling agents

Mineral Gelling Agents As inorganic lipophilic gelling agents, there may be mentioned optionally modified clays, such as hectorites modified with a C10-C22 ammonium chloride, such as hectorite modified with di-stearyl-dimethyl ammonium chloride, such as for example, that sold under the name 40 Bentone 38V® by the company ELEMENTIS.

It is also possible to mention the optionally hydrophobic fumed silica surface with a particle size of less than 1 μm. It is indeed possible to chemically modify the surface of the silica, by chemical reaction generating a decrease in the number of silanol groups present on the surface of the silica. In particular, it is possible to substitute silanol groups with hydrophobic groups: a hydrophobic silica is then obtained. The hydrophobic groups may be trimethylsiloxyl groups, which are especially obtained by treatment of fumed silica in the presence of hexamethyldisilazane. Silicas thus treated are called "Silica silylate" according to the CTFA (8th edition, 2000). The hydrophobic groups may be dimethylsilyloxyl or polydimethylsiloxane groups, which are especially obtained by treating fumed silica in the presence of polydimethylsiloxane or dimethyldichlorosilane. Silicas thus treated are called "Silica dimethyl silylate" according to the CTFA (8th edition, 2000).

The hydrophobic fumed silica has in particular a particle size that can be nanometric to micrometric, for example ranging from about 5 to 200 nm.

Organic gelling agents

Polymeric organic lipophilic gelling agents are, for example, partially or fully crosslinked elastomeric organopolysiloxanes of three-dimensional structure, ethylcellulose, galactomanans containing from one to six, and in particular from two to four, hydroxyl groups per os, substituted with an alkyl chain. saturated or not, such as guar gum alkylated with C1-C6 alkyl chains, and in particular C1-C3 alkyl chains and mixtures thereof; block copolymers of the "diblock", "triblock" or "radial" type of the polystyrene / polyisoprene, polystyrene / polybutadiene type, of the polystyrene / copoly (ethylene-propylene) type, or even of the polystyrene / copoly (ethylene-butylene) type, mixtures of triblock and radial (star) copolymers in isododecane, for example the mixture of butylene / ethylene / styrene triblock copolymer and ethylene / propylene / styrene star copolymer in isododecane (Versagel® M 5960).

As the lipophilic gelling agent, mention may also be made of polymers having a weight average molecular weight of less than 100,000.

Among the lipophilic gelling agents that can be used in the compositions according to the invention, mention may also be made of dextrin and fatty acid esters, such as dextrin palmitates, in particular such as those sold under the names Rheopearl TL® or Rheopearl KL. ® by the company CHIBA FLOUR. Silicone polyamides of the polyorganosiloxane type can also be used, such as those described in documents US Pat. Nos. 5,874,069, 5,919,441, 6,051,216 and 5,981,680.

These silicone polymers may belong to the following two families: polyorganosiloxanes comprising at least two groups capable of establishing hydrogen interactions, these two groups being located in the polymer chain, and / or polyorganosiloxanes comprising at least two groups capable of establish hydrogen interactions, these two groups being located on grafts or branches.

Salts or antiperspirant complexes

According to one particular form of the invention, the compositions of the invention may contain at least one salt or antiperspirant complex.

By "sweat-treating agent" is meant any substance which, on its own, has the effect of reducing the sensation on the skin of moisture associated with human sweat, of masking human sweat ".

The antiperspirant salts or complexes in accordance with the invention are generally chosen from aluminum or zirconium salts or complexes. They are preferably chosen from aluminum halohydrates; aluminum and zirconium halohydrates, complexes of zirconium hydroxychloride and of aluminum hydroxychloride with or without an amino acid such as those described in US Pat. No. 3,792,068.

The antiperspirant salts or complexes may be present in the composition according to the invention in a proportion of approximately 0.5 to 25% by weight relative to the total weight of the composition.

Deodorant active ingredients The compositions according to the invention may also contain one or more additional deodorant active agents.

The term "deodorant active" refers to any substance capable of masking, absorbing, improving and / or reducing the unpleasant odor resulting from the decomposition of human sweat by bacteria. Deodorant active agents may be bacteriostatic agents or bactericidal agents. acting on the germs of axillary odors, such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (®Triclosan), 2,4-dichloro-2'-hydroxydiphenyl ether, 3 ', 4', 5'- trichlorosalicylanilide, 1- (3 ', 4'-dichlorophenyl) -3- (4'-chlorophenyl) urea (®Triclocarban) or 3,7,11-trimethyldodeca-2,5,10-trienol (®Farnesol); quaternary ammonium salts such as cetyltrimethylammonium salts, cetylpyridinium salts, DPTA (1,3-diaminopropanetetraacetic acid), 1,2 decanediol, glycerol derivatives, for example Caprylic / Capric Glycerides, or Caprylate; Glycerol caprate, Polyglyceryl-2 Caprate, biguanide derivatives such as polyhexamethylene biguanide salts, chlorhexidine and its salts; 4-Phenyl-4,4-dimethyl-2butanol.

Among the deodorant active agents according to the invention, mention may also be made of zinc salts such as zinc salicylate, zinc gluconate and zinc pidolate; zinc sulphate, zinc chloride, zinc lactate, zinc phenolsulfonate; zinc ricinoleate - sodium bicarbonate; salicylic acid and its derivatives such as n-octanoyl-5-salicylic acid - silver zeolites or without silver - alum.

The deodorant active agents may preferably be present in the compositions according to the invention in weight concentrations ranging from 0.01 to 5% by weight relative to the total weight of the composition.

Suspension agents

In order to improve the homogeneity of the product, it is also possible to use one or more suspending agents which are preferably chosen from hydrophobic modified montmorillonite clays, such as hydrophobic modified bentonites or hectorites. There may be mentioned for example the product Stearalkonium Bentonite (CTFA name) (reaction product of bentonite and quaternary ammonium chloride stearalkonium chloride) or the product Disteardimonium Hectorite (CTFA name) (reaction product of hectorite and chloride distearyldimonium).

The suspending agents are preferably present in amounts ranging from 0.1 to 5% by weight and more preferably from 0.2 to 2% by weight relative to the total weight of the composition.

Organic powder

According to one particular form of the invention, the compositions according to the invention will contain, in addition, an organic powder. As used herein, the term "organic powder" means any solid that is insoluble in the medium at room temperature (25 ° C.).

Organic powders that can be used in the composition of the invention include, for example, polyamide particles; polyethylene powders; microspheres based on acrylic copolymers, such as those made of ethylene glycol dimethacrylate / lauryl methacrylate copolymer; polymethyl methacrylate microspheres, hollow methyl methacrylate microspheres (particle size: 6.5 - 10.5 μ), methyl methacrylate / ethylene glycol dimethacrylate copolymer microbeads (size: 6.5-10.5) p); ethylene-acrylate copolymer powders, expanded powders such as hollow microspheres and in particular microspheres formed of a terpolymer of vinylidene chloride, acrylonitrile and methacrylate or microspheres; powders of natural organic materials such as starch powders, especially corn starch, wheat or rice, crosslinked or not, such as starch powders crosslinked with octenyl succinate anhydride, resin microbeads silicone; amino acid powders such as Lauroyllysine powder; the wax microdispersion particles, which preferably have average dimensions of less than 1 μm and in particular from 0.02 μm to 1 μm, and which consist essentially of a wax or a mixture of waxes and their mixtures .

additives

The cosmetic compositions according to the invention may furthermore comprise cosmetic adjuvants chosen from softeners, antioxidants, opacifiers, stabilizers, moisturizing agents, vitamins, bactericides, preservatives, polymers, perfumes, agents and the like. thickeners, propellants or any other ingredient usually used in cosmetics for this type of application.

Of course, those skilled in the art will take care to choose this or these optional additional compounds in such a way that the advantageous properties intrinsically attached to the cosmetic composition according to the invention are not, or not substantially, impaired by the addition or additions. considered. The thickeners, preferably nonionic, may be selected from guar gums and modified or unmodified celluloses such as hydroxypropyl guar gum, cetylhydroxyethylcellulose, silicas.

The thickeners may also be cationic.

The amounts of these various constituents that may be present in the cosmetic composition according to the invention are those conventionally used in compositions for the treatment of perspiration. aerosols

The compositions according to the invention may also be pressurized and packaged in an aerosol device consisting of: (A) a container comprising an antiperspirant composition as defined above, (B) at least one propellant and a dispensing means of said aerosol composition.

Propellants generally used in this type of product and well known to those skilled in the art are, for example, dimethyl ether (DME); volatile hydrocarbons such as n-butane, propane, isobutane, and mixtures thereof, optionally with at least one chlorinated and / or fluorinated hydrocarbon, in particular monofluorotrichloromethane, difluorodichloromethane, tetrafluorodichloroethane and 1,1- difluoroethane. It is also possible to use as propellant carbon dioxide, nitrous oxide, nitrogen or compressed air. The compositions containing the perlite particles as defined above and the propellant (s) may be in the same compartment or in different compartments in the aerosol container. According to the invention, the concentration of propellant generally varies from 5 to 95% by weight pressurized and more preferably from 50 to 85% by weight relative to the total weight of the pressurized composition.

The dispensing means, which forms part of the aerosol device, is generally constituted by a dispensing valve controlled by a dispensing head, itself comprising a nozzle through which the aerosol composition is vaporized. The container containing the pressurized composition may be opaque or transparent. It may be made of glass, polymeric material or metal, optionally coated with a layer of protective varnish. The following examples serve to illustrate the present invention. The amounts are given as a percentage by weight relative to the total weight of the composition.

EXAMPLES

Example 1: Antiperspirant Stick Raw material Content (% by weight) HISTONE H4 ISOPROPYL PALMITATE 15 HYDROGENATED CASTOR OIL 3 CYCLOPENTASILOXANE 20 POLYDECENE 18 PEG-8 DISTEARATE 1,5 STEARYL ALCOHOL 17 PERFUME 1 PPG-14 BUTYL ENTER qs 100 Example 2: Roll hydroalcoholic antitranspirant Raw material Content (% by weight) HISTONE H4 20.5 ALCOHOL DENATURE 40 HYDROXYETHYLCELLULOSE 0.5 PERFUME 1 WATER qs 100 20 18 Example 3: Deodorant aerosol Raw material Content (% by weight) HISTONE H4 1.5 PERFUME 1 ISOBUTANE 55 ALCOHOL DENATURE. qsp 100 Example 4: Deodorant stick Raw material Content (% by weight) HISTONE H4 0.5 TRICLOSAN 1 EDTA 0.5 GLYCERIN 20 PROPYLENE GLYCOL 50 SODIUM STEARATE 5 STEARETH-100 1 BEHENIC ACID 2 PERFUME 1 SODIUM HYDROXIDE qsp pH WATER qs 100

Claims (7)

REVENDICATIONS1. Cosmetic use of an effective amount of histone H4 or at least one inducer of histone H4 expression, as an agent for preventing and / or inhibiting the development of body odors related to human perspiration . 2. Use according to the preceding claim, characterized in that said body odor is of axillary origin. 10 3. Use according to any one of the preceding claims, characterized in that the histone H4 or the inducer of the expression of histone H4 is present in a composition containing a cosmetically acceptable medium, at a concentration of between 0.01. and 30% by weight relative to the total weight of the composition. 15 4. Use according to any one of the preceding claims, characterized in that the histone H4 or the inducer of the expression of histone H4 is applied topically to the skin and / or its annexes. 20 5. A cosmetic process for preventing and / or inhibiting the development of body odors related to human perspiration, comprising applying to the skin and / or its appendages a composition comprising, in a cosmetically acceptable medium, an effective amount histone H4 or at least one inducer of the expression of histone H4. 25 6. Method according to the preceding claim, characterized in that the composition is applied to the skin and / or its annexes in the axillary zone. 7. The method of claim 5 or 6, characterized in that the skin is sensitive or weakened.