FR2913601A1 - Palatable product for cat or dog, useful to serve as medicine, food complement or palatable support for partially coating active substance, comprises glucose syrup, equivalent in dextrose of glucose syrup and antidiarrhoeal additive - Google Patents

Abstract

Palatable product for a cat or dog, to serve as medicine, food complement or palatable support for partially coating an active substance, which is initially independent of the support, comprises glucose syrup (3-50 mass.%), an equivalent in dextrose of glucose syrup (5-60), and at least antidiarrhoeal additive (5%). An independent claim is included for a process of packaging the active substance within the palatable support.

Description

The invention relates to an appetite product for use as a

  medicament, as a dietary supplement or as a palatable carrier for coating an active substance intended for an animal, in particular for dogs, cats, horses, pigs and ruminants, as well as methods for the manufacture and use thereof said product. The administration to animals of active substances orally, especially drugs, is often difficult because of the bad taste of some of these substances and the highly developed sense of smell and taste of these animals. In case of refusal of absorption, the chances of success of the veterinary treatment can drop dramatically. There is therefore a need for a packaging of active substances capable of thwarting the vigilance of animals, in particular dogs, cats, horses, pigs and ruminants. EP 1 562 549 discloses an appetite carrier for an active substance intended for an animal, in particular for a medicament. The matrix of said support comprises at least one sufficiently adhesive tacky surface for fixing the active substance by simple contact of the active substance with the tacky surface. It is suggested to use a neutral matrix, that is to say, having substantially no taste, so that the same matrix can be used for different types of animals. However, no embodiment of such a support is described. In addition, there are antidiarrheal medications, but they can be difficult to ingest animals, including cats and dogs. There is therefore a need for an appetite product, which can be used as a medicament or as a dietary supplement, or to wrap an active substance, and suitable for different types of animals, especially dogs and cats. There is also a need for a method of manufacturing said product. The object of the present invention is to provide such a product. According to the invention, this object is achieved by means of an appetite product intended to serve as a medicament or food supplement, or to coat, at least partially, an active substance that is initially independent of the product, which is remarkable in that it comprises mass percentages, based on the total mass of the product, • at least 5%, preferably at least 15%, more preferably at least 20% of an antidiarrheal additive, preferably selected from the group consisting of the family of smectites, preferably montmorillonite, an active carbon, a pectate, and mixtures thereof, • from 3% to 50% of glucose syrup, the dextrose equivalent (DE) of the glucose syrup being between 5 and 60, preferably between 5 and 40 and preferably between 5 and 15, and, • and, optionally, preferably at least 2%, preferably at least 4%, preferably at least 5% of rice starch, preferably hydrolysed.

  Preferably, the mass percentage of said rice starch is less than 20%, preferably less than 10%, more preferably less than 7%. Preferably, the amount of additive is less than 50%, preferably less than 40%, preferably less than 30%, in percentages by weight based on the total product base. An amount of additive of between 23 and 27%, preferably about 25% is considered optimal. By initially independent active substance, it is to be understood that the product as manufactured does not contain the active substance. By active substance is meant any substance, other than the antidiarrheal additive, which may have a care effect, in the medical and / or cosmetic and / or food sense, prepared for example in the form of tablets, tablets, capsules, pills, or powders. As will be seen in more detail in the following description, a product appetent according to the invention is well accepted by both cats and dogs and, simultaneously, advantageously has an antidiarrheal effect.

  In addition, the presence of the rice starch makes the product sticky. Advantageously, the active substance adheres to it effectively. In combination with glucose syrup, rice starch makes it possible to form a homogeneous, pasty and sticky product, effective for ingesting active substances, both by cats and by dogs.

  Unless otherwise indicated, all percentages are mass percentages, based on the total mass of the product.

  Preferably, the product still has one or more of the following optional characteristics: The product comprises a humectant chosen from alcohols or a mixture thereof, preferably from propylene glycol, glycerol, sorbitol or a mixture of those -this. An amount of a mixture of propylene glycol and glycerol greater than or equal to 3% and / or less than or equal to 15% is preferable, the amount of propylene glycol preferably being greater than or equal to 3%, preferably greater than 5%. and / or less than or equal to 15%, preferably 10%, the amount of glycerol being preferably greater than or equal to 5%, preferably less than 9%, and / or less than or equal to 20%, preferably greater than or equal to 15%. An amount of sorbitol greater than or equal to 3%, preferably 5%, and / or less than or equal to 15%, preferably 10%, is also preferable. More preferably, the product comprises an amount of lecithin greater than or equal to 1%, preferably 3%, and / or less than or equal to 15%, preferably 8%. Advantageously, these characteristics make it possible to obtain a water activity (Aw) of the product of less than 0.75 and a shelf life of up to about 18 months. The product comprises a quantity of proteins of animal origin, preferably chosen from the group formed by flours of poultry, pork, fish and their mixtures, preferably greater than or equal to 5%, preferably 30%, and / or less than or equal to 90%, preferably 50%. The product comprises a quantity of modified starch, preferably modified rice starch, preferably AXFGP (AX Finest Grade Precook) marketed by the company REMY Industries (Belgium) which is rice starch previously hydrolysed , preferably greater than or equal to 4%, and / or less than or equal to 90%, preferably 50%, more preferably 20%. The rice starch is cooked. Preferably it contains more than 90% by weight, preferably more than 95% by weight of amylopectin. Preferably, the rice starch is waxy, i.e. it contains substantially only amylopectin. In comparison, a regular starch contains only about 80% of amylopectin. Advantageously, the high 4 amylopectin content confers a very sticky character to the product and makes it possible to limit its glucose content. The product comprises an amount of fat, preferably selected from oils, fats, emulsifiers or a mixture thereof. A quantity of oil, preferably chosen from vegetable oils, in particular rapeseed and / or sunflower oils, greater than or equal to 0.01%, preferably 1%, and / or less than 10%, of preferably 5%, is desirable. A quantity of fat, preferably of animal origin, in particular duck and / or pork fat, greater than or equal to 0.01%, and / or less than 10%, preferably 2%, is desirable. A quantity of emulsifier greater than or equal to 0.01%, and / or less than 10%, preferably 1%, is still desirable, the preferred emulsifier being the 2901 sold by Brenntag NV. preservatives, preferably consisting of BHA (butylated hydroxylisole) and / or propyl and / or citric acid and / or lactic acid and / or propenoic acid and / or sorbic acid and / or 'Phosphoric acid. A total amount of preservatives greater than or equal to 0.01% and / or less than or equal to 10%, preferably 3% is preferred. Preferred preservatives are selected from Thermox TM, Pet SAVORe, Sorbate or a mixture thereof. An amount of Thermox ™ greater than or equal to 0.01%, and / or less than or equal to 2%, preferably 1%, is desirable. An amount of Pet Savor greater than or equal to 0.5%, preferably 0.7%, and / or less than 5%, preferably 2%, is also desirable. An amount of sorbate, preferably potassium sorbate, greater than or equal to 0.01%, preferably 0.1%, and / or less than 5%, preferably 1.5%, is still desirable. The product comprises an amount of a palatability enhancer, preferably specific to the type of animal for which the product is intended and chosen from Superpremium type products, preferably based on pork liver, preferably 8P enhancers. for dogs and 9P or 9M for cats marketed by SDF Diana, greater than or equal to 1%, preferably 2% and / or less than or equal to 15%, preferably 10%, preferably 6%. The product comprises from 5 to 90% of protein of animal origin, from 4 to 90% of starch, less than 10% of fat and from 0.01% to 10% of at least one preservative, in percentages by weight. based on the total mass of the product. - The mass percentage of the glucose syrup is greater than 5% and / or less than 20%, preferably less than 15%, more preferably less than 10%, or even less than 7%, or even 6.5%. The dextrose equivalent (DE) of the glucose syrup is greater than 10, preferably greater than 15, preferably even 18 and / or less than 25, preferably less than 22, or even less than 40. The product according to the invention may be a medicament, a food supplement or a carrier. When the product appetent according to the invention is a drug, it can be shaped in any form, and especially in the form of pills, tablets, capsules, tablets or powders. The invention also relates to a method of manufacturing an appetite product for treating diarrhea or facilitating ingestion by an animal of an active substance, which method comprises a step in which various constituents are mixed and being remarkable. in that said constituents and their amounts are determined so as to obtain a product according to the invention. The invention also relates to a method for packaging an active substance in a support, said active substance being initially independent of said support and preferably in the form of a pill, tablet, capsule, tablet or powder, in which The user at least partially coats said active substance in said support, which process is remarkable in that the support is a product according to the invention. The invention also relates to a method for preparing a food for an animal, in particular a cat or a dog, according to which a dietary supplement according to the invention is incorporated in said food. The invention also relates to the food thus prepared. The invention finally relates to a method for treating or preventing diarrhea in an animal, in particular in a cat or a dog, which is remarkable in that said animal is administered a product according to the invention. Other features and advantages of the present invention will become apparent on reading the following description and on examining the appended drawing in which: FIG. 1 represents a cross-sectional view of a product according to the invention; FIG. 2 represents a cross-sectional view of the product represented in FIG. 1, after coating of a tablet with the product. In the various figures, identical references have been used to designate identical or similar objects.

  FIG. 1 represents a product 1 comprising a matrix 3 covered at least in part by a layer 5 made of an appetite material or a palatability enhancer. The product 1 is provided in the form of a substantially homogeneous cube that the user tears in two pieces 20 and 22. In FIG. 1, the product 1 is represented in an intermediate state between its substantially cubic initial state and its torn state. in two pieces 20 and 22. The matrix 3 comprises, in this intermediate state, two ends 23 and 23 'connected by a common base 23. The matrix 3, once torn, exposes a contact surface 27 formed of the surfaces 29 and 28 pieces 20 and 22, respectively, delimiting the tear.

  Advantageously, the appetence enhancer layer 5 and the solid shape of the cube protect the matrix 3 from drying out. The life of the product 1 is increased. The matrix 3 is preferably a material with plastic deformation, that is to say that it substantially retains the shape given to it.

  The matrix composition 3 is as previously described. A most preferred composition of the product 1 is the following, with as a percentage by mass, based on the total mass of the product: between 41.5% and 42.5%, preferably about 41.9% for the total of said additive and at least one protein of animal origin selected from the group consisting of flours of poultry, pork, fish and mixtures thereof, preferably poultry meal; between 4% and 5% of a palatability enhancer, preferably Superpremium type marketed by SDF Diana, preferably about 4.5%; between 5.3% and 6.3% of hydrolysed rice starch, preferably of the type AXFGP, preferably about 5.8%; between 0% and 1% sodium chloride, preferably about 0.7%; between 0.01% and 1% sorbate, preferably about 0.7%; between 0.01% and 0.1% of ThermoxTM, preferably about 0.08%; between 11% and 12% glycerol, preferably about 11.5%; between 7% and 8% propylene glycol or sorbitol, preferably about 7.7%; between 5.5% and 6.5% glucose syrup with a dextrose equivalent (DE) of between 8 and 22, preferably about 5.8% glucose syrup with a dextrose equivalent (DE) of about 20; between 2% and 3% oil, preferably sunflower and / or rapeseed, preferably about 2.6%; between 0.01% and 1% fat, preferably duck and / or pork, preferably about 0.6%; between 0.6 and 1.6% of Pet SAVOR, preferably about 1.2%; between 5.2% and 6.2% lecithin, preferably soybean, preferably about 5.7%; between 10.3% and 11.3% water, preferably about 10.8%; between 0.01% and 1% emulsifier, preferably about 0.4%. Surprisingly, this matrix is well accepted by both dogs and cats. It is plastic and has a tacky character that allows an aggregation of the pieces 20 and 22 by simply pressing the hand. The sticky nature allows the attachment of the tablet 9.

  The palatability enhancer, preferably the Superpremium ™, may be present on the surface of the matrix 3 in the form of a layer 5 or may be contained directly within the matrix 3. A preferred method of manufacturing a product according to the invention comprises the following different steps: a) mixing of the constituents in the form of powders, in particular glucose syrup when it is in powder form (if it is in liquid form it will then be incorporated into step b)), and / or proteins of animal origin and / or starch and / or sorbate and / or ThermoxTM and / or salt, so as to obtain a homogeneous powder, b) mixture liquid and / or pasty compounds, in particular a humectant and / or fat, and / or a preservative and / or lecithin and / or water, with said homogeneous powder, c) rest cold, under conditions well known to those skilled in the art to facilitate the passage through the machine, followed an extrusion still cold, in particular by means of a single screw extruder type pasta machine or pusher, so as to obtain a matrix, d) optionally depositing the flavor enhancer on this matrix, so to form a continuous layer or, preferably discontinuous. There are in the latter case areas of the matrix not covered by the enhancer so as to allow handling of the product without contact of the fingers with the flavor enhancer. The latter can indeed release an unpleasant smell for the man. The product obtained can then be packaged, preferably in the form of individually wrapped cubes, to limit their drying and facilitate their handling. The product covered with the appetence enhancer may be previously slit, drilled, or grooved so as to predefine the future contact surfaces with the active substance. The palatability enhancer used in step d) is preferably specific to the animal for which the product is intended. However, according to the invention, in steps a) and b), a proportion of between 3% and 50% of glucose syrop with a DE of between 5 and 60 is chosen, so as to obtain at the end of step c) a matrix suitable for both cats and dogs. Production costs are advantageously reduced. The palatability enhancer may be introduced during steps a) or / and b), all the other constituents being accepted by cats and dogs, the manufacturing costs remain advantageously reduced. It will also be noted that the process for manufacturing the product according to the invention makes it possible to dispense with any cooking step during manufacture. Preferably, the manufacturing method according to the invention does not contain a cooking step between steps a) and d) included. The various steps and the order in which they are described are provided by way of illustrative and non-limiting example. In particular, it can be imagined that steps a) and b) are reversed. Similarly one can very well imagine that the appetite enhancer is introduced within the matrix during one of the steps a) or b). To condition a tablet 9 by means of a product 1 according to the invention such as that shown in Figure 1, a user can proceed as follows.

  The user rips the product 1 into two pieces 20 and 22. By opening the die, the user exposes the surfaces 28 and 29. He then positions the tablet 9 on one of the surfaces 28 and 29, and arranges the pieces 20 and 22 product 1 torn so that the surfaces 28 and 29 are substantially opposite each other. It then exerts an action so as to press against each other these pieces so as to aggregate them. It is also possible to deform the die by hand to increase the contact area between the tablet 9 and the contact surfaces 28 and 29. Preferably, the contact surface covers substantially the entire outer surface of the tablet 9 so as to encompass this last. The surfaces 28 and 29 of the product according to the invention are such that after they have been pressed against each other, they no longer detach themselves spontaneously from one another. By spontaneous means under the sole effect of the elasticity of the matrix, that is to say without intervention of the user.

  Preferably, the tear is sufficiently wide to allow the complete insertion of the tablet 9. Advantageously, the product 1 according to the invention thus allows to encapsulate, to coat or to completely encompass the tablet 9 after reconstitution of the initial cube. No repulsive odor or no unpleasant taste can no longer be released from the tablet 9 inserted in the product 1.

  As it is clear, the packaging of an active substance by means of a product according to the invention is very simple and can be implemented extemporaneously, individually, by the individual himself. It does not require any equipment. Advantageously, the same packaging method and the same products 1 can be used for active substances of very different shapes.

  Advantageously, the user can package several active substances, possibly in different forms (capsule, tablet, tablet, powder, etc.) using the same product 1. The effectiveness of a product according to the invention with outsmart the animals has been tested for dogs and cats. The tested products have the following composition: between 41% and 42% of poultry meal; 4.5% superpremium-type palatability enhancer; approximately 5.8% of AXFGP; about 0.64% sodium chloride; about 0.64% sorbate; about 0.07% ThermoxTM; about 11.5% glycerol; about 7.67% propylene glycol; 5.7% to 5.85% glucose syrup with a dextrose equivalent (D.E.) of about 2.57% of a mixture of oil, fat and Brenntag emulsifier 2901; about 1.24% of Pet SAVOR; about 5.76% of soy lecithin; about 10.8% water; The palatability enhancer is not only included in the powder mixture but also deposited on the outside of the matrix 3 so as to form a layer 5 around the product. The product is then non-sticky, including after tearing into several pieces. In addition, the periphery of the product is particularly palatable, which is particularly advantageous when the animal sniffs the product.

  The tests are conducted under the same conditions for dogs and for cats. The animal is presented twice a day for 5 days with a tablet coated in the product. At each dose, the animal can either eat neither the product nor the tablet, or eat the product but spit out the tablet or eat the product and the tablet.

  Subsequently, the failures of the product represent the percentage of cases where the product is eaten but the tablet spit out, similarly the efficiency corresponds to the percentage of cases where the product and the tablet are eaten. The results of the tests are summarized in Table 1 below: TABLE 1 0/0 for a dog% for a cat Product failures 2.5% 9.5 0/0 Effectiveness 90% 80% As can be seen, the invention provides a very effective product, both for dogs and for cats. Advantageously, this product can be used as a medicament, as a dietary supplement or as a carrier for an initially independent active substance. Naturally, the present invention is not limited to the embodiment described and shown provided by way of illustrative and non-limiting example. In particular, the shape and size of the matrix, the presence and the nature of the palatability enhancer, the presence of a slot, a groove, an incision, a hole, or a bleeding are optional. In addition, the preferred features mentioned above in connection with the description of the figures or the tests, where the product according to the invention is used as a support, are also preferred when the product according to the invention is used as an antidiarrheal medicine or as a dietary supplement, without being associated with an initially independent active substance.

Claims (19)

  1. Appetizing product for a cat or a dog, intended to serve as a medicament, as a dietary supplement or as a palatable support for coating, at least partially, an active substance initially independent of the support, characterized in that it comprises in percentages by weight, on the basis of the total mass of the product, from 3% to 50% of glucose syrup, the dextrose equivalent (DE) of the glucose syrup being between 5 and 60, and at least 5% by weight of antidiarrheal additive.   2. Product according to the preceding claim, comprising at least 15% and less than 50% of said additive.   3. Product according to the preceding claim, comprising at least 20% and less than 30% of said additive.   4. Product according to any one of the preceding claims, the additive being montmorillonite.   5. Product according to any one of the preceding claims, comprising at least 2% rice starch.   6. Product according to the preceding claim, comprising at least 4% rice starch.   7. Product according to any one of the two immediately preceding claims, wherein the rice starch is previously hydrolysed.   The product of any one of claims 5 to 7, wherein the rice starch comprises more than 90% by weight of amylopectin.   9. Product according to the preceding claim, wherein the rice starch is waxy.   10. Product according to the preceding claim, wherein the rice starch is AXFGP.   11. Product according to any one of the preceding claims, characterized in that the mass percentage on the basis of the total mass of the product, the glucose syrup is greater than 5% and less than 10%.   12. Product according to any one of the preceding claims, the dextrose equivalent being greater than 15 and less than 40.   13. Product according to any one of the preceding claims, characterized in that it comprises in percentages by weight on the basis of the total mass of the product: - between 3% and 15% of a mixture of propylene glycol and glycerol, the contents of propylene glycol and glycerol being between 3% and 15% and 5% to 20% respectively, - between 1% and 15% of lecithin, - less than 15% of a palatability enhancer.   14. Product according to any one of the preceding claims, characterized in that it comprises in mass percentage based on the total mass of the product: - from 5% to 90% protein of animal origin, - 4% at 90% starch, less than 10% fat, from 0.01% to 10% of at least one preservative.   15. Product according to any one of the preceding claims, characterized in that it comprises proteins of animal origin selected from the group formed by flours of poultry, pork, fish and their mixtures and / or an enhancer palatability chosen from SuperpremiumTM products   16. Product according to the preceding claim, characterized in that it comprises in percentages by weight, on the basis of the total mass of the product: - between 41.5% and 42.5% for the total of said proteins of animal origin and of said additive, - between 4% and 5% of a SuperpremiumTM palatability enhancer - between 5.3% and 6.3% of hydrolysed rice starch, - between 0% and 1% of salt, - between 0.01% and 1% of sorbate, between 0.01% and 0.1% of ThermoxTM, between 11% and 12% of glycerol, between 7% and 8% of propylene glycol, and between 5.5% and % and 6.5% of glucose syrup with a dextrose equivalent (DE) of between 18 and 22, between 2% and 3% of oil, between 0.01% and 1% of fats, between 0 , 6% and 1.6% of Pet SAVOR. between 5.2% and 6.2% of lecithin, between 10.3% and 11.3% of water, between 0.01% and 1% of emulsifier.   17. A product according to any one of the preceding claims, wherein the additive is selected from the group consisting of a smectite family clay, an activated carbon, a pectate and mixtures thereof.   18. A process for conditioning an active substance in a palatable support, said active substance, intended for an animal, being initially independent of said support, in which the user at least partially coats said active substance in said support, characterized in that the carrier is a product according to any one of the preceding claims. 15   19. The method of packaging according to the preceding claim, characterized in that said active substance is in the form of pills, tablets, capsules, tablets or powder.