FR2908044A1 - Complex, useful to prepare composition to treat alopecia, comprises protein, calcium, mineral comprising sodium, potassium, magnesium, phosphorus and sulfur, oilgo-element having selenium, manganese, iron, zinc and copper and acetic acid - Google Patents

Abstract

Complex comprises (%): proteins (0.4-0.45); calcium (0.5-0.51); mineral comprising sodium (1.7-2.5), potassium (0.11); magnesium (0.05); phosphorus (0.055-0.06) and sulfur (0.1); an oilgo-elements comprising selenium (29 ppm), manganese (4.5 ppm), iron (4.4 ppm), zinc (2 ppm) and copper (0.4 ppm); and an acetic acid (4.70). An independent claim is included for a preparation of the complex comprising combining the hen eggs provided with their shells (3), marine gray salt (80 g) and vinegar of white wine (7[deg] 1L).

Description

The present invention relates to a novel complex based on

  protein and calcium from eggshell, minerals, trace elements and acetic acid. This new complex of natural origin is characterized in that it consists of proteins derived mainly from the eggshell and calcium from the calcite of the eggshell. According to the invention, the proteins and calcium are in a protein / calcium ratio ranging from 0.8 to 0.9. According to the invention, the complex contains: - proteins: 0.40 to 0.45% - calcium: 0.50 to 0.51% - minerals: sodium, potassium, magnesium, phosphorus, sulfur whose respective contents are: - sodium 1.70 to 2.50% - potassium 0.11% - magnesium 0.05% - phosphorus 0.055 to 0.060% - sulfur 0.10% - trace elements: selenium, manganese, iron, zinc, copper of which 20 the respective contents are: selenium 29.0 ppm-manganese 4.5ppm iron 4.4ppm zinc 2.0 ppm 25-copper 0.4 ppm acetic acid 4.70% According to an advantageous embodiment of the object of the invention, acetic acid is added in the form of vinegar. According to an advantageous embodiment, the sodium is added in the form of sea salt. The present invention relates to the preparation of the complex resulting from the combination between them, raw chicken eggs with their shells, wine vinegar and sea salt. 2908044 -2- 1) The ingredients are used in the following proportions: - chicken eggs 3 - marine gray salt 80 g - white wine vinegar 7 1 L 5 2) The procedure is as follows: fill a vat with white wine vinegar, add salt, dissolve by stirring. Add the raw eggs with their shells, immersing them one by one so as not to break them. Leave to rest for a month without shaking. Remove the eggs one by one delicately, this time so as not to perforate the shell membranes. Filter the solution thus obtained. If desired, a complex according to the present invention can be obtained using guinea fowl eggs as well as red wine or cider vinegar. According to the invention, the raw materials are of exclusively natural origin and provide in a balanced mixture, proteins and calcium essentially from the shell, to which are added the minerals: sodium, potassium, magnesium, phosphorus, sulfur and oligo -Selenium, manganese, iron, zinc, copper mainly from vinegar and sea salt.

  The study of the composition of the eggshell shows that it contains on average 3.3% of proteins constituting its frame. These proteins play a major role in the processes of calcification of the shell by crystallizing about 95.1% of minerals, mainly calcium carbonate crystals in the form of calcite. Proteins and calcium absorbed within the organic matrix are therefore very closely involved in the construction of the crystalline microstructure of the shell which contributes to its strength. Protein, calcium, mineral salts and trace elements are naturally present in our body and are essential for its proper functioning. Calcium is a key player. It is found involved in multiple metabolic actions involved in particular in the construction of the structure of the skin. Currently, many theories attempt to account for all the complex phenomena involved in the processes that lead to aging and deterioration of the functioning of vital organ cells, pushing them under certain unfavorable conditions for cell suicide. (apoptosis). According to scientists, nutritional deficiencies or hyperproduction of free radicals would also be responsible for a large number of cell damage. We talk about replicative and metabolic senescence. Whether brought by the environment 10 (pollution, cigarette smoke, radiation ...) or generated by the cells during their metabolic reactions, free radicals can disrupt the replication of DNA during cell division and reduce their ability to regenerate. They can also destroy cell membranes, deform cellular proteins responsible for calcium transport which is unable to play its role of intercellular messenger. The cells do not communicate anymore, lose their cohesion, disorganize seriously injuring the tissues. At the level of the skin, all of these changes lead to the acceleration of cutaneous aging and in certain conditions to the deterioration of the tissues and the appearance of diseases, dermatoses, eczema, psoriasis, pruritus, alopecia. It is now established that a correlation exists between cellular aging and alopecia. The reproductive cells of the hair follicles are normally programmed to regenerate and to give rise to new hair in an uninterrupted manner thanks to growth cycles set between 25 to 30 cycles which have a duration of 2 to 5 years, are sufficient in number. to renew the hair for a lifetime. With age, the hormonal receptors of these target organs become particularly sensitive to the deleterious action of dihydrotestosterone formed from testosterone by the action of 5 alpha reductase. Slowing down the rate of cell divisions and the deterioration of the functioning of the hair follicles results in a decrease in growth cycles which rapidly run out from 2908044 -4- a few years to a few months. The hair clears and if we do not stop the fall, we witness the permanent loss of hair. According to the invention, the complex is specially designed to be applied to the scalp and skin. The active ingredients: proteins, calcium, minerals, trace elements and acetic acid are in the form of a pH 5.5 solution favoring their dermal absorption and bioavailability. By its composition, the complex brings to the heart of the cells damaged or broken down all the nutrients necessary for the restoration of cellular functioning. It is able to reproduce at the level of the structures of the skin, the mechanisms of natural solidity resulting from the affinity of proteins and calcium in the formation of the shell. By restoring the calcium metabolism, the complex reinforces the cohesion of the cutaneous tissues and helps fight against skin aging.

The present invention relates to the formulation of compositions used in the treatment of alopecia, skin and scalp conditions. The compositions are characterized in that they contain the complex associated or not with one or more active components intended to potentiate its effects such as essential oils and / or plant extracts and can therefore be proposed according to the specific need to be treated, in one or more of their indications. Thus the formulations of the compositions are diverse and require the knowledge and experience of the skilled person.

The invention is illustrated without being limited in any way by the following examples which describe the formulation of a hair fall arrest composition together with a report of clinical experiments and the formulation of an antipruritic composition used in the treatment of eczema.

Example 1: Anti-hair loss hair lotion a) - Prepare a vinegar of plants by macerating for one month in white wine vinegar 7: 5g of nettle spiny roots, 5g of nettle pungent leaves, 5g of burdock 2908044 -5- 5g of thyme flowers, 5g of nasturtium seeds, for a liter of vinegar. b) - Proceed according to the invention, to obtain the complex of plants by combining the salt, eggs and vinegar of plants in the following proportions: - chicken eggs 3 - sea salt 80g - plant vinegar iL c ) -Procede the formulation - lavender essential oil 0,40g -alkylphenol-polyglycolether 5, OOg - perfume composition 1, OOg -complexe of plants 100, OOg The demonstration of the effectiveness of the hair composition according to the example is based on clinical trials carried out at the Saint Louis Hospital in Paris in the department of scalp diseases. The study of the impact on the hair formula was performed using the trichogramma method. Patients, men or women, were selected according to a marked tendency to hair loss. 40 cases were selected: 22 males, 18 females, 20 13 to 65 years old. The results obtained are remarkable. At the end of the clinical study and the anamnesis, it is found a stop of hair loss in 80% of cases. In the trichogram analysis, the fall arrest effect is objectified by hair regrowth for one-third of the cases in the frontal area and for half of the cases in the temporal zones. Women also perform well when they are menopausal or already menopausal. The formula is used for both men and women. Because of the effectiveness of the formula on seborrhea in 70% of cases, pruritus in 80% and pityriasis in 82% of cases, the composition was proposed in these indications; whether they are associated or isolated. Example 2: Ointment used in the treatment of pruritus and eczema. 5 a) - Prepare a vinegar of plants by macerating for a month in white wine vinegar 7: 5g of wild thought flowers, 5g of sarsaparilla roots, 5g of elm pyramidal barks, 5g of juniper 10 berries, 5g of sweet woodruff, for a liter of vinegar. b) - Proceed according to the invention, to obtain the complex of plants by combining the salt, eggs and vinegar of plants in the following proportions: - chicken eggs 3 - marine gray salt 80g 0,40g - vinegar plants iL c) -Process the formulation - essential oil of lavender 15 - essential oil of geranium 0,15g - essential oil of niaouli 0,10g - essential oil of sage 0,10g 20 - complex of plants 25, OOg - oil of d olive 25, OOg - wool fat qs 100, OOg

Claims (10)

  1) - Complex characterized in that it contains: - proteins: 0.40 to 0.45% - calcium: 0.50 to 0.51% - minerals: sodium, potassium, magnesium, phosphorus, sulfur whose respective contents are: - sodium 1.70 to 2.50% - potassium 0.11% - magnesium 0.05% - phosphorus 0.055 to 0.060% - sulfur 0.10% - trace elements: selenium, manganese, iron, zinc, copper whose respective contents are: selenium 29.0ppm-manganese 4.5ppm iron 4.4ppm zinc 2.0ppm copper 0.4ppm acetic acid 4.70%   2) - Complex according to claim 1 characterized in that the proteins and calcium come mainly from the chicken egg shell and / or the guinea fowl egg and are in a protein / calcium ratio of 0.8 at 0.9.   3) - Complex, according to claim 1 and 2, characterized in that the calcium comes essentially from the calcium carbonate crystals of the shell in the form of calcite.   4) - Complex, according to claims 1, 2 and 3 characterized in that it contains 4.70% acetic acid in the form of white wine vinegar, red wine or cider. 15 2908044 -8-   5) - Complex according to claims 1, 2, 3 and 4 characterized in that the sodium is added in the form of marine gray salt.   6) - Complex, according to claims 1, 2, 3, 4 and 5 characterized in that the raw materials are of exclusively natural origin. 5   7) - Preparation of the complex, according to each of the preceding claims, characterized in that it results from the combination between them, raw chicken eggs with their shells, wine vinegar and seawater salt in the following proportions : - chicken eggs 3 10 - marine gray salt 80g - white wine vinegar 7 1L   8) - Complex according to one of claims 1 to 6, characterized in that the active ingredients: proteins, calcium, minerals, trace elements, and acetic acid are in the form of a solution of pH 5.5 promoting their absorption dermal and bioavailability.   9) - Use of a complex according to one of claims 1 to 6 for the preparation of a composition for the treatment of alopecia, diseases of the skin and scalp.   10) - Compositions containing the complex according to one of claims 1 to 6 associated or not with one or more active components for potentiating its effects such as essential oils and / or plant extracts.