FR2861991B1 - Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose - Google Patents

Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose

Info

Publication number
FR2861991B1
FR2861991B1 FR0313134A FR0313134A FR2861991B1 FR 2861991 B1 FR2861991 B1 FR 2861991B1 FR 0313134 A FR0313134 A FR 0313134A FR 0313134 A FR0313134 A FR 0313134A FR 2861991 B1 FR2861991 B1 FR 2861991B1
Authority
FR
France
Prior art keywords
glucosidase inhibitors
mucoviscidose
therapy
gen
delf508
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0313134A
Other languages
English (en)
French (fr)
Other versions
FR2861991A1 (fr
Inventor
Frederic Becq
Caroline Norez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite de Poitiers
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite de Poitiers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0313134A priority Critical patent/FR2861991B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS, Universite de Poitiers filed Critical Centre National de la Recherche Scientifique CNRS
Priority to PCT/FR2004/002858 priority patent/WO2005046672A2/fr
Priority to EP04805405A priority patent/EP1680105B1/fr
Priority to HR20090159T priority patent/HRP20090159T1/xx
Priority to AU2004289083A priority patent/AU2004289083B2/en
Priority to DK04805405T priority patent/DK1680105T3/da
Priority to ZA200603726A priority patent/ZA200603726B/en
Priority to US10/578,328 priority patent/US7973054B2/en
Priority to CNB2004800382212A priority patent/CN100534432C/zh
Priority to CA2545133A priority patent/CA2545133C/fr
Priority to PL04805405T priority patent/PL1680105T3/pl
Priority to KR1020067010948A priority patent/KR100979276B1/ko
Priority to NZ547261A priority patent/NZ547261A/en
Priority to RU2006119914/14A priority patent/RU2358725C2/ru
Priority to SI200431106T priority patent/SI1680105T1/sl
Priority to PT04805405T priority patent/PT1680105E/pt
Priority to AT04805405T priority patent/ATE423561T1/de
Priority to DE602004019674T priority patent/DE602004019674D1/de
Priority to ES04805405T priority patent/ES2321725T3/es
Priority to JP2006538890A priority patent/JP4740868B2/ja
Priority to KR1020107004147A priority patent/KR20100038452A/ko
Priority to BRPI0416228-5A priority patent/BRPI0416228A/pt
Publication of FR2861991A1 publication Critical patent/FR2861991A1/fr
Priority to IL175453A priority patent/IL175453A/en
Priority to NO20062617A priority patent/NO336904B1/no
Application granted granted Critical
Publication of FR2861991B1 publication Critical patent/FR2861991B1/fr
Priority to CY20091100518T priority patent/CY1110468T1/el
Priority to US13/116,482 priority patent/US8242136B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
FR0313134A 2003-11-07 2003-11-07 Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose Expired - Fee Related FR2861991B1 (fr)

Priority Applications (26)

Application Number Priority Date Filing Date Title
FR0313134A FR2861991B1 (fr) 2003-11-07 2003-11-07 Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose
PT04805405T PT1680105E (pt) 2003-11-07 2004-11-05 Utilização de inibidores de glucosidase para o tratamento de mucoviscidose
HR20090159T HRP20090159T1 (en) 2003-11-07 2004-11-05 Use of glucosidase inhibitors for therapy of mucovisidosis
AU2004289083A AU2004289083B2 (en) 2003-11-07 2004-11-05 Use of glucosidase inhibitors for therapy of mucovisidosis
DK04805405T DK1680105T3 (da) 2003-11-07 2004-11-05 Anvendelse af en glukosidaseinhibitorer til behandling af mucoviscidose
ZA200603726A ZA200603726B (en) 2003-11-07 2004-11-05 Use of glucosidase inhibitors for therapy of mucovisidosis
US10/578,328 US7973054B2 (en) 2003-11-07 2004-11-05 Use of glucosidase inhibitors for therapy of mucovisidosis
CNB2004800382212A CN100534432C (zh) 2003-11-07 2004-11-05 葡糖苷酶抑制剂在粘液粘稠病治疗中的应用
CA2545133A CA2545133C (fr) 2003-11-07 2004-11-05 Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose
PL04805405T PL1680105T3 (pl) 2003-11-07 2004-11-05 Zastosowanie inhibitorów glukozydazy do leczenia mukowiscydozy
KR1020067010948A KR100979276B1 (ko) 2003-11-07 2004-11-05 글루코시다제 억제제를 포함하는 낭성 섬유증 치료용 약제학적 조성물
NZ547261A NZ547261A (en) 2003-11-07 2004-11-05 Use of glucosidase inhibitors for therapy of mucovisidosis
RU2006119914/14A RU2358725C2 (ru) 2003-11-07 2004-11-05 Применение ингибиторов глюкозидазы для терапии муковисцидоза
SI200431106T SI1680105T1 (sl) 2003-11-07 2004-11-05 Uporaba inhibitorjev glukozidaze za zdravljenje mukoviscidoze
PCT/FR2004/002858 WO2005046672A2 (fr) 2003-11-07 2004-11-05 Utilisation d’inhibiteurs de glucosidase pour une therapie de la mucoviscidose
BRPI0416228-5A BRPI0416228A (pt) 2003-11-07 2004-11-05 uso de inibidores glucosidade para terapia de mucovisidose
AT04805405T ATE423561T1 (de) 2003-11-07 2004-11-05 Verwendung von glucosidase-hemmern zur behandlung von mukoviszidose
ES04805405T ES2321725T3 (es) 2003-11-07 2004-11-05 Utilizacion de inhibidores de glucosidasa para un tratamiento de la mucoviscidosis.
JP2006538890A JP4740868B2 (ja) 2003-11-07 2004-11-05 膵線維症の治療のためのグルコシダーゼ阻害剤の使用
KR1020107004147A KR20100038452A (ko) 2003-11-07 2004-11-05 글루코시다제 억제제를 포함하는 낭성 섬유증 치료용 약제학적 조성물
EP04805405A EP1680105B1 (fr) 2003-11-07 2004-11-05 Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose
DE602004019674T DE602004019674D1 (de) 2003-11-07 2004-11-05 Verwendung von glucosidase-hemmern zur behandlung von mukoviszidose
IL175453A IL175453A (en) 2003-11-07 2006-05-04 Use of glucosidase inhibitor, 1-butyl,2-hydroxymethyl-piperidine-3alpha,4beta,5-triol, for the preparation of a medicament for therapy of mucoviscidosis
NO20062617A NO336904B1 (no) 2003-11-07 2006-06-07 Anvendelse av glukosidaseinhibitorer for fremstilling av medikamenter for behandling av mukovisidose
CY20091100518T CY1110468T1 (el) 2003-11-07 2009-05-14 Χρηση αναστολεων γλυκοσιδασης για μια θεραπεια της κυστικης ινωσεως
US13/116,482 US8242136B2 (en) 2003-11-07 2011-05-26 Use of glucosidase inhibitors for therapy of mucovisidosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0313134A FR2861991B1 (fr) 2003-11-07 2003-11-07 Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose

Publications (2)

Publication Number Publication Date
FR2861991A1 FR2861991A1 (fr) 2005-05-13
FR2861991B1 true FR2861991B1 (fr) 2008-01-18

Family

ID=34508347

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0313134A Expired - Fee Related FR2861991B1 (fr) 2003-11-07 2003-11-07 Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose

Country Status (24)

Country Link
US (2) US7973054B2 (https=)
EP (1) EP1680105B1 (https=)
JP (1) JP4740868B2 (https=)
KR (2) KR100979276B1 (https=)
CN (1) CN100534432C (https=)
AT (1) ATE423561T1 (https=)
AU (1) AU2004289083B2 (https=)
BR (1) BRPI0416228A (https=)
CA (1) CA2545133C (https=)
CY (1) CY1110468T1 (https=)
DE (1) DE602004019674D1 (https=)
DK (1) DK1680105T3 (https=)
ES (1) ES2321725T3 (https=)
FR (1) FR2861991B1 (https=)
HR (1) HRP20090159T1 (https=)
IL (1) IL175453A (https=)
NO (1) NO336904B1 (https=)
NZ (1) NZ547261A (https=)
PL (1) PL1680105T3 (https=)
PT (1) PT1680105E (https=)
RU (1) RU2358725C2 (https=)
SI (1) SI1680105T1 (https=)
WO (1) WO2005046672A2 (https=)
ZA (1) ZA200603726B (https=)

Families Citing this family (20)

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EP2932982B1 (en) 2005-05-17 2018-10-03 Amicus Therapeutics, Inc. A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives
AU2007241622A1 (en) * 2006-04-24 2007-11-01 Academisch Medisch Centrum Improved treatment of cystic fibrosis
ES2573498T3 (es) 2006-05-16 2016-06-08 Amicus Therapeutics, Inc. Opciones de tratamiento para la enfermedad de Fabry
EP2352828B1 (en) * 2008-09-11 2015-02-25 Galapagos N.V. Method for identifying compounds useful for increasing the functional activity and cell surface expression of cf-associated mutant cystic fibrosis transmembrane conductance regulator
ITFE20080032A1 (it) * 2008-10-23 2010-04-24 Azienda Ospedaliera Istituti Ospit Alieri Di Vero Effetto anti infiammatorio del miglustat cellule dell'epitelio bronchiale
GB201000499D0 (en) 2010-01-13 2010-03-03 Fleet George W J Treatment of cystic fibrosis
WO2011095772A2 (en) 2010-02-04 2011-08-11 Summit Corporation Plc Novel iminosugar therapeutics
GB201006434D0 (en) 2010-04-19 2010-06-02 Summit Corp Plc Novel iminosugar combinations
KR20200032244A (ko) 2012-03-07 2020-03-25 아미쿠스 세라퓨틱스, 인코포레이티드 폼페병의 치료를 위한 고농도 알파-글루코시다제 조성물
KR20160055916A (ko) * 2013-09-16 2016-05-18 이머전트 바이롤로지 엘엘씨 데옥시노지리마이신 유도체 및 그의 이용 방법
FR3017536B1 (fr) 2014-02-18 2017-05-26 Univ La Rochelle Compositions pour la prevention et/ou le traitement de pathologies liees a l'alpha-glucosidase
WO2016054231A1 (en) 2014-09-30 2016-04-07 Amicus Therapeutics, Inc. Highly potent acid alpha-glucosidase with enhanced carbohydrates
KR102510941B1 (ko) 2015-12-30 2023-03-20 아미쿠스 세라퓨틱스, 인코포레이티드 폼페병 치료용의 강화된 산 알파-글루코시다제
US10227577B2 (en) 2016-03-30 2019-03-12 Amicus Therapeutics, Inc. Method for selection of high M6P recombinant proteins
IL325155A (en) 2016-03-30 2026-02-01 Amicus Therapeutics Inc Formulations containing recombinant acid alpha-glucosidase
EP3448410A1 (en) * 2016-04-29 2019-03-06 Institut Pasteur Methods and compositions for modifying cystic fibrosis transmembrane conductance regulator activity
US10478427B2 (en) * 2016-07-07 2019-11-19 National University Corporation Chiba University Therapeutic agent for fibrosis and inhibitor of nuclear translocation of phosphorylated smad
EP3624831B1 (en) 2017-05-15 2023-03-29 Amicus Therapeutics, Inc. Recombinant human acid alpha-glucosidase
AU2018278247B2 (en) * 2017-06-01 2022-07-28 Idorsia Pharmaceuticals Ltd Crystalline form of N-butyldeoxygalactonojirimycin
CN108187051A (zh) * 2018-01-30 2018-06-22 中国药科大学 α-L-岩藻糖苷酶及抑制剂用于制备防治心肌缺血损伤的药物的用途

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TW275621B (https=) * 1992-10-27 1996-05-11 Merck & Co Inc
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ID21411A (id) * 1997-12-10 1999-06-10 Takeda Chemical Industries Ltd Agen untuk mengobati daya tahan glukosa yang berisiko tinggi rusak
US6274597B1 (en) * 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A
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AU7398900A (en) * 1999-09-23 2001-04-24 Hospital For Sick Children, The Three-dimensional structure and crystal of a class i alpha1,2-mannosidase, and methods of use thereof
US20050053625A1 (en) * 2001-10-30 2005-03-10 Block Timothy M Method of treating viral infections
US7081260B2 (en) * 2002-10-29 2006-07-25 Council Of Scientific And Industrial Research α-Glucosidase inhibitors from a natural source
PT2441467E (pt) 2003-01-31 2015-10-12 Sinai School Medicine Terapia combinada para o tratamento de transtornos associados a uma deficiência proteica
US7071341B2 (en) * 2003-02-28 2006-07-04 Council Of Scientific And Industrial Research α-Glucosidase inhibitors and their synthesis from a natural source

Also Published As

Publication number Publication date
CA2545133A1 (fr) 2005-05-26
AU2004289083B2 (en) 2009-12-03
FR2861991A1 (fr) 2005-05-13
PL1680105T3 (pl) 2009-07-31
PT1680105E (pt) 2009-05-20
NO336904B1 (no) 2015-11-23
ZA200603726B (en) 2007-12-27
DK1680105T3 (da) 2009-06-29
KR20060130058A (ko) 2006-12-18
NO20062617L (no) 2006-07-25
EP1680105A2 (fr) 2006-07-19
KR20100038452A (ko) 2010-04-14
IL175453A (en) 2012-09-24
KR100979276B1 (ko) 2010-08-31
ATE423561T1 (de) 2009-03-15
US8242136B2 (en) 2012-08-14
SI1680105T1 (sl) 2009-08-31
DE602004019674D1 (de) 2009-04-09
ES2321725T3 (es) 2009-06-10
WO2005046672A2 (fr) 2005-05-26
CA2545133C (fr) 2013-04-16
CY1110468T1 (el) 2015-04-29
IL175453A0 (en) 2008-03-20
US20070213357A1 (en) 2007-09-13
CN1897933A (zh) 2007-01-17
RU2006119914A (ru) 2007-12-20
NZ547261A (en) 2009-11-27
EP1680105B1 (fr) 2009-02-25
HRP20090159T1 (en) 2009-05-31
JP4740868B2 (ja) 2011-08-03
JP2007510699A (ja) 2007-04-26
AU2004289083A1 (en) 2005-05-26
US20110269795A1 (en) 2011-11-03
US7973054B2 (en) 2011-07-05
RU2358725C2 (ru) 2009-06-20
WO2005046672A3 (fr) 2005-09-15
BRPI0416228A (pt) 2007-01-02
CN100534432C (zh) 2009-09-02

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