FR2857826A1 - Food product containing fluorides intended to provide controlled amounts of fluoride to pregnant women, lactating women, babies and very young children - Google Patents

Abstract

Food products in solid, liquid or paste form containing a fixed dose of one or more fluorides added to a nutritional supplement suitable for pregnant women : Independent claims are included for (1) food products in solid, liquid or paste form intended to contribute to the nutrition of pregnant women in the third trimester of pregnancy containing one or more fluorides associated with a suitable nutritional supplement; (2) food products for babies in liquid or paste form containing one or more fluorides diluted in a liquid or gelled vehicle suitable for the nutrition of babies and very young children; (3) strongly calorific alimentary preparations intended for the nutrition of lactating women containing one or more fluorides in an excipient or an alimentary or dietetic vehicle in liquid, paste or solid form which is strongly calorific and suitable for the nutrition of women during lactation.

Description

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  Process for charging foods with fluorine and their use to ensure a harmonious bone development.

  The present invention relates to the field of nutrition and more particularly to the field of dietetics.

  It relates more particularly to food or dietary compositions intended to ensure a constant intake and measured in the body in fluorine ions.

  The present invention specifically relates to compositions which provide a fluorine intake in the milk and thus allow harmonious bone development in infants, while remaining within the allowed window of daily fluorine requirements.

  The current problem with fluoride intake is that drinking water or pharmaceutical preparations, such as mouthwashes or toothpastes, are loaded with fluorides, especially alkali metal fluorides, without regard to daily needs. fluorides of individuals and therefore, as a result, this intake is uncontrolled. Consequently, the growth of young children who already have symptoms of fluorosis is caused, that is, their body has been loaded with an excessive amount of fluoride and the result is a hyper-calcification which can lead to spontaneous fractures of the bones of the limbs as well as slimming phenomena that may seem disturbing. All these phenomena are defined under the name of fluorescence phenomena.

  The solution proposed by the invention therefore consisted in regulating the administration of fluorides as a function of actual needs.

  Therefore, it has become necessary to completely rethink the problem of the body's fluorine load through the diet. This procedure is desirable because, if the fluorine intake contributes to hardness of the bones and to ensure a certain resistance of dental enamel and dentine to chemical or bacterial attack leading to caries, it can also lead to toxic overload. In addition, in order to prevent the occurrence of caries during the period of the first dentition, it is essential that young children receive a non-toxic fluoride filler which will contribute to converting the calcium carbonate of the bone material into calcium fluoride (fluoro). apatite) insoluble and unassailable by cariogenic agents.

  To achieve this, it seemed essential to draw up a balance sheet of the daily intake of fluoride in children's food and to minimize this external supply either in the drinking water, in the food or even in the medicines. and more particularly in toothpastes or mouthwashes.

  On the contrary, it has been found desirable to provide young children with this fluoride charge through beverages such as milk, and in particular breast milk, or mineral water.

  It is therefore desirable that all young children, and even infants, to the extent that they are breastfed, receive adequate breast milk concentration through breast milk which will help strengthen their skeleton and future dentition.

  It is also desirable to provide pregnant women, during pregnancy and especially in the final stage of pregnancy (approximately four months postpartum), with a fair calculated amount of fluoride which can already be guaranteed in the pregnancy. feeding the fetus, a balanced intake of fluorine particularly suited to bone growth.

  It is also possible, if the child does not receive breastfeeding, or nurturing, to provide him with artificial or natural milk, loaded with fluorides, so as to provide him with a satisfactory fluoride intake, corresponding to his daily needs. .

  These fluorine additions will preferably be made: by administration to the pregnant woman of foods containing fluorides, or by administration to lactating women, a fluoride intake in the form of food compositions according to the invention, so that their milk contains the appropriate and necessary amount of fluoride.

  Preferably, to avoid the risk of overloading of fluorides, it may also be incorporated in the milks intended for the feeding of young children, or more generally in the liquid of the bottle, a fixed dose of fluorides meeting their daily needs. but without excess.

  The fluorides which should be incorporated into the feed are preferably soluble alkali metal fluorides in milk or water, such as sodium, potassium, ammonium, lithium fluorides. but also less soluble fluorides such as: magnesium fluoride, strontium fluoride, tin fluoride, and in general: any fluoride whose metal is devoid of toxicity. The fluorides in the form of adsorbate can also be administered on an organic or inorganic support such as, for example, a support of: cellulose, gelatin, alginate, xanthan gum, gum gel, or else still: - dispersed in a gelled support such as a polymer of acrylic acid, methacrylic acid or methacrylamide.

  These adsorbates are incorporated into the maternal food or infant food; they are tasteless and without toxicity. They can be added to the food without fear of introducing a risk of unpleasant or too salty taste.

  The fluorides can also be administered in the form of complex derivatives such as phosphorofluorides, fluorophosphonates and, in general, any complex rich in fluorine and without toxicity.

  Accordingly, it is possible to administer to pregnant women doses of fluoride which will range in accordance with the invention from 0.5 mg to 2.5 mg each day with a preference for a dose ranging from 1 mg to 2 mg, expressed in fluoride ions, contained in the food preparations according to the invention.

  Lactating women can also be administered fluoride doses to achieve effective fluoride concentrations, ranging from 1 mg to 2 mg per day.

  Mineral or organic fluorides can also be administered to infants from two weeks of age, dispersed in a food preparation such as an aqueous liquid such as mineral water, fruit juice or milk.

  It is also possible to incorporate into infant milks (animal milks or reconstituted powdered milk) specific amounts of simple or complex fluorides and preferably a water-insoluble fluoride such as calcium fluoride, strontium fluoride or fluoride. aluminum, so as to provide infants with the necessary doses of fluorides. These doses are between 0.5 mg and 5 mg per day.

  These fluorides are incorporated in the superficial layers of the enamel and reduce the solubility of this tissue in the acids secreted by the bacteria, of carbohydrate nature.

  Indeed, the transplacental passage of fluoride ions has been demonstrated in the second trimester of pregnancy in pregnant women. Therefore, there is a technical and sanitary possibility of administering to the pregnant woman, from this moment on, effective doses of fluoride which will provide the fetus a possibility of imprennination by them.

  There is therefore a particular interest and a real need to add the food of the pregnant woman of food supplements containing fluorides, either in the form of liquids, beverages, or in the form of solid products, providing fluoride inputs. at doses between 0.5 mg and 2.5 mg per day.

  Among the fluorides that can thus be incorporated into the diet, mention will be made more particularly of: - alkali metal fluorides such as - sodium fluoride, - potassium fluoride - lithium fluoride rubidium fluoride - fluoride of cesium - alkaline earth metal fluoride such as 10 - calcium fluoride, - strontium fluoride, - and non-toxic metal fluorides therapeutically compatible, such as: - zinc fluoride - aluminum fluoride - fluoride copper - gadolinium fluoride - gallium fluoride or - manganese fluoride. The diet of pregnant or lactating women, as well as that of young children, is not changed elsewhere. This fluoride feed according to the invention provides daily the amount of fluorine required to provide improved strength of the framework without compromising bone development or causing fluorosis.

  The results obtained are very satisfactory. Children fed in these conditions have a healthy dentition, not very sensitive to microbial attacks related to the oral flora.

  The invention therefore relates to solid food products, liquid or pasty, containing a fixed dose of one or more fluorides added to a nutritional supplement suitable for feeding the pregnant woman during the last trimester of pregnancy.

  The invention also relates to liquid or pasty food products for infants, containing one or more fluoride (s) diluted (s) in a liquid or gelled vehicle suitable for feeding infants or very young children.

  Conveniently, the vehicle will be breast milk or humanized, sugar water, mineral water low in mineral ions, herbal tea or a fluid preparation such as a previously thinned yogurt.

  A particularly advantageous example of the invention will be a solution of sodium fluoride or of magnesium fluoride or of lithium fluoride in an aqueous vehicle, optionally sweetened, containing from 0.5 to 5 mg of fluoride ions in a volume of 1 ml. Administration will be in the form of a gelled product containing a quantity of fluoride ions adapted to the case considered infants or very young children.

  Another object of the invention also relates to high caloric food preparations containing one or more fluoride (s) in a food or diet vehicle or dietetic, liquid, pasty or solid, for feeding allantantes women.

  Preferably, the excipient will be lactose powder, starch, cellulose to make capsules. The carrier will preferably be a milk product, such as cottage cheese, yogurts, fruit juices, gummy fruit preparations, honey, sugar syrup, glucose syrup, lipid emulsions, cooked in the form of milk products. water, based on triglycerides and short or medium chain fatty acids, containing a determined amount of fluoride to ensure a measured fluoride intake to the breastfeeding woman.

  The food preparations according to the invention can also be solid preparations such as chocolate bars or fruit pastes, xylitol candies or even biscuits such as macaroons or pralines, so as to obtain preparations having a pleasant flavor which ingestion will not pose any problems.

  The fluoride content of these food preparations according to the invention varies from 1 to 10 mg per 100 g so that their daily consumption provides from 1 to 2 mg of fluoride to the nursing woman. The fluoride concentration of these preparations is adjusted so that overconsumption is not likely to cause an overdose and, consequently, a risk of fluorosis.

Claims (10)

CLAIMS AND E V E N D I C A T IO N S   1) Solid, liquid or pasty food products containing a fixed dose of one or more fluorides with a nutritional supplement appropriate for the diet of pregnant women.   2) solid food products, liquid or pasty, according to claim 1, intended to contribute to the diet of pregnant women during the last trimester of pregnancy, characterized in that they contain one or more fluorides associated with a suitable nutritional supplement .   3) Infant food products, liquid or pasty, containing one or more fluorides diluted in a liquid or gelled vehicle suitable for feeding infants or very young children.   4) Highly caloric food preparations intended for feeding lactating women characterized in that they contain one or more fluorides in a food or diet vehicle, liquid, pasty or solid, highly caloric suitable for feeding foodstuffs. women breastfeeding.   5) Food products for use in the diet of pregnant women according to claim 1, characterized in that they provide from 0.5 mg to 2.5 mg of fluoride ions in food supplements.   6) Food products for use by infants and very young children, characterized in that they provide from 0.5 mg to 5 mg of fluoride ions per day in the diet.   7) Highly caloric food products for feeding lactating women, characterized in that they provide from 1 mg to 2 mg of fluoride ions per day in food compositions.   8) Food products according to one of the preceding claims, characterized in that the fluorides are in the form of fluoride metal fluoride complexes.   9) food products according to one of the preceding claims, characterized in that the metal fluorides are selected from the group consisting of alkali metal fluorides, alkaline earth metal fluorides and non-toxic metal fluorides, therapeutically compatible.   10) Food products according to one of the preceding claims, characterized in that the fluorine is provided by complex fluorides selected from phosphofluorides and fluorophosphonates.   1 1) Use of food products according to one of the preceding claims, for the realization of a preparation containing fluorine for the supplementation of the diet of pregnant women, lactating women, and / or infants, in fluoride, without risk of overdo30 wise.