WO2005009143A2 - Novel fluorinated food products and the use thereof for harmonious osseous development - Google Patents

Novel fluorinated food products and the use thereof for harmonious osseous development Download PDF

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Publication number
WO2005009143A2
WO2005009143A2 PCT/FR2004/001991 FR2004001991W WO2005009143A2 WO 2005009143 A2 WO2005009143 A2 WO 2005009143A2 FR 2004001991 W FR2004001991 W FR 2004001991W WO 2005009143 A2 WO2005009143 A2 WO 2005009143A2
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Prior art keywords
food products
fluoride
fluorides
infants
food
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PCT/FR2004/001991
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French (fr)
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WO2005009143A3 (en
Inventor
Albert Margossian
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United Pharmaceuticals S.A.
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Publication of WO2005009143A2 publication Critical patent/WO2005009143A2/en
Publication of WO2005009143A3 publication Critical patent/WO2005009143A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to the field of food, and more particularly to the field of dietetics.
  • It relates more particularly to food or dietetic products intended to ensure a constant and measured supply to the body of fluorine ions.
  • the present invention specifically relates to products which ensure a determined intake of fluoride in the drink or food and, thus, allow a harmonious bone development in infants, while remaining within the limits of the authorized window of daily needs. in fluorine.
  • fluoride intake lies in the fact that drinking water or pharmaceutical preparations, such as mouthwashes or toothpaste, are loaded with fluorides, in particular alkali metal fluorides, without taking daily needs into account fluorides of individuals and that therefore, by this fact, this contribution is uncontrolled.
  • fluorides in particular alkali metal fluorides
  • we cause the growth of young children already showing symptoms of fluorosis that is to say that their organism has been loaded with an excessive amount of fluorides and this results in hyper-calcification which can lead to spontaneous fractures of the bones of the limbs as well as weight loss phenomena which may appear worrying. All these phenomena are defined under the name of "fluorosis phenomena".
  • the solution proposed by the invention therefore consisted in regulating the administration of fluorides according to real needs.
  • fluorine additions will preferably be made by drinking water intended to dilute the milk preparations.
  • adsorbates are incorporated into infant food; they are tasteless and toxic. They can therefore be added to food without fear of introducing a risk of unpleasant or too salty flavor.
  • Fluorides can also be administered in the form of complex derivatives such as phosphofluorides, fluorophosphonates and, in general, any complex rich in fluorine and without toxicity.
  • Liquid preparations can also be administered containing doses of fluorides to achieve effective concentrations of fluorides ranging from 1 mg to 2 mg per day.
  • Mineral or organic fluorides can also be administered to infants from the age of two weeks, dispersed in a food preparation, such as an aqueous liquid such as mineral water, fruit juice, milk or porridge .
  • a food preparation such as an aqueous liquid such as mineral water, fruit juice, milk or porridge .
  • infant milks animal milks or reconstituted powdered milks
  • a water-insoluble fluoride such as calcium fluoride, strontium fluoride or aluminum fluoride
  • These doses are between 0.5 mg and 5 mg per day.
  • fluorides are incorporated into the surface layers of the enamel and reduce the solubility of this tissue in the acids secreted by bacteria, of a carbohydrate nature.
  • the alkali metal fluorides such as - sodium fluoride, - potassium fluoride - lithium fluoride - rubidium fluoride - cesium fluoride alkaline earth metal fluorides, such as: - calcium fluoride, - strontium fluoride, and therapeutically compatible non-toxic metal fluorides, such as: - zinc fluoride - aluminum fluoride - fluoride copper - gadolinium fluoride - gallium fluoride or - manganese fluoride.
  • Fluorides can also be administered in the form of an adsorbate on an organic or inorganic support such as, for example, a support: - of cellulose, - of gelatin, - of alginate xanthan gum, gelan gum,
  • This fluoride load according to the invention provides daily the amount of fluorine required to ensure increased strength of the frame without jeopardizing bone development or causing "fluorosis".
  • the invention therefore relates to solid, liquid or pasty food products containing a determined dose of one or more fluorides added or incorporated into an appropriate nutritive supplement.
  • the invention also relates to food products, liquid or pasty, for infants, containing one or more fluoride (s) diluted in a liquid or gelled vehicle suitable for feeding infants or very young children.
  • the food products according to the invention also contain proteins, preferably water-soluble, vegetable oils, carbohydrates such as lactose or maltodextrins, salts minerals such as sodium, potassium, chlorides, calcium salts, phosphates, magnesium salts, iron salts, zinc salts, iodides, copper salts and / or manganese.
  • proteins preferably water-soluble, vegetable oils
  • carbohydrates such as lactose or maltodextrins
  • salts minerals such as sodium, potassium, chlorides, calcium salts, phosphates, magnesium salts, iron salts, zinc salts, iodides, copper salts and / or manganese.
  • the food preparations according to the invention contain one or more vitamins chosen from vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D3, vitamin E, vitamin Kl, niacin, pantothenic acid, folic acid and biotin.
  • the food preparations according to the invention also contain growth factors for young children, such as choline, taurine, carnitine in racemic or optical form, even active.
  • the vehicle will be breast milk or humanized milk, sugar water, mineral water sparingly loaded with mineral ions, a herbal tea or even a fluid preparation such as a yoghurt previously fluidified., White cheese, soup, tapioca, starch, etc.
  • a particularly advantageous example of the invention will be a solution of sodium fluoride, magnesium fluoride or lithium fluoride in an aqueous vehicle, optionally sweetened, containing from 0.05 to 0.5 mg of fluoride ions under a volume of 1 ml.
  • the administration will be in the form of a gelled or thickened product containing a quantity of fluoride ions adapted to the case considered of infants or very young children.
  • Another object of the invention also relates to more highly caloric food preparations containing one or more fluoride (s) in an excipient or a food or dietetic vehicle, liquid, pasty or solid, suitable for feeding very young children.
  • the excipient will be lactose powder, starch, cellulose so that it can be incorporated into liquid or solid foods.
  • the vehicle will preferably be a milk preparation, such as cottage cheese, yogurts, fruit juices, gelled fruit preparations, honey, sugar syrup, glucose syrup, lipid emulsions, cooked in the water, based on triglycerides and short or medium chain fatty acids, containing a determined quantity of fluorides to ensure a measured intake of fluorides for infants.
  • the food preparations according to the invention can also be solid preparations such as xylitol-based candies or even dry cakes which disintegrate in the mouth, such as macaroons or pralines, so as to obtain preparations having a pleasant flavor, ingestion will not be a problem for very young children.
  • the fluoride content of these food preparations according to the invention varies from 0.05 to 10 mg per 1000 g, and preferably from 0.1 to 0.5 mg per 1000 g, so that their daily consumption provides from 0.1 to 0.2 mg of fluorides in infants.
  • the fluoride concentration of these preparations is adjusted so that overconsumption or even overdose is not likely to cause excessive intake, and, consequently, a risk of fluorosis.
  • the daily intake of fluorine is 100 ⁇ g per day, ie 0.1 mg.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pediatric Medicine (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention relates to nutrition, more specifically to dietetic nutrition, in particular to food compounds permanently and measurably supplying fluorine ions in a quantity ranging from 0.5 to 2.5 mg per day to new-borns. The inventive food compounds are embodied in a solid, liquid and pasty form, can contain a caloric value and used for providing children at the breast with a determined and permanent quantity of fluorides directly or by means of the mother thereof.

Description

« Nouveaux produits alimentaires titrés en fluor et leur utilisation pour assurer un développement osseux harmonieux. » La présente invention se rapporte au domaine de l'alimentation, et plus particulièrement au domaine de la diététique. “New food products titrated in fluorine and their use to ensure harmonious bone development. The present invention relates to the field of food, and more particularly to the field of dietetics.
Elle a plus particulièrement pour objet des produits alimentaires ou diététiques destinées à assurer un apport constant et me- sure à l'organisme en ions fluor.It relates more particularly to food or dietetic products intended to ensure a constant and measured supply to the body of fluorine ions.
La présente invention a spécifiquement pour objet des produits qui assurent un apport déterminé en fluor dans la boisson ou la nourriture et, ainsi, permettent un développement osseux harmo- nieux chez les nourrissons, tout en restant dans les limites de la fenêtre autorisée des besoins journaliers en fluor.The present invention specifically relates to products which ensure a determined intake of fluoride in the drink or food and, thus, allow a harmonious bone development in infants, while remaining within the limits of the authorized window of daily needs. in fluorine.
Le problème actuel de l'apport en fluor réside dans le fait que les eaux de boisson ou les préparations pharmaceutiques, comme les bains de bouche ou les dentifrices, sont chargés en fluorures, notamment en fluorures de métal alcalin, sans tenir compte des besoins quotidiens réels en fluorures des individus et que donc, par ce fait, cet apport est incontrôlé. En conséquence, on provoque la croissance d'enfants jeunes présentant déjà des symptômes de fluorose, c'est à dire que leur organisme a été chargé d'une quantité excessive de fluorures et qu'il en résulte une hyper-calcification qui peut entraîner des fractures spontanées des os des membres ainsi que des phénomènes d'amaigrissement qui peuvent paraître inquiétants. Tous ces phénomènes sont définis sous le nom de « phénomènes de fluorose ».The current problem with fluoride intake lies in the fact that drinking water or pharmaceutical preparations, such as mouthwashes or toothpaste, are loaded with fluorides, in particular alkali metal fluorides, without taking daily needs into account fluorides of individuals and that therefore, by this fact, this contribution is uncontrolled. As a result, we cause the growth of young children already showing symptoms of fluorosis, that is to say that their organism has been loaded with an excessive amount of fluorides and this results in hyper-calcification which can lead to spontaneous fractures of the bones of the limbs as well as weight loss phenomena which may appear worrying. All these phenomena are defined under the name of "fluorosis phenomena".
La solution proposée par l'invention a donc consisté à réguler l'administration des fluorures en fonction des besoins réels.The solution proposed by the invention therefore consisted in regulating the administration of fluorides according to real needs.
C'est pourquoi il est apparu nécessaire de repenser com- plètement le problème de la charge en fluor de l'organisme par le biais de l'alimentation. Cette façon de procéder est souhaitable car, si l'apport en fluor contribue à donner de la dureté aux os et à assurer une résistance certaine de l'émail dentaire et de la dentine aux agressions chimiques ou bactériennes conduisant aux caries, il peut aussi entraîner une surcharge toxique. En outre, pour éviter la survenue de caries pendant la période de la première dentition, il est indispensable que les jeunes enfants reçoivent une charge en fluorures non toxiques qui contribuera à transformer le carbonate de calcium de la matière osseuse en fluorure de calcium (fluoro apatite) insoluble et inattaquable par les agents ca- riogènes.This is why it appeared necessary to completely rethink the problem of the body's fluoride load through of food. This is desirable because, while fluoride intake helps to harden the bones and to ensure certain resistance of the dental enamel and dentin to chemical or bacterial attack leading to cavities, it can also lead to toxic overload. In addition, to avoid the occurrence of cavities during the period of the first dentition, it is essential that young children receive a load of non-toxic fluorides which will help transform the calcium carbonate from bone material into calcium fluoride (fluoro apatite ) insoluble and unassailable by pathogens.
Pour y parvenir, il a paru indispensable d'établir un bilan de l'apport journalier en fluorures dans la nourriture des enfants et de réduire au minimum cet apport externe soit dans l'eau de boisson, soit dans les aliments ou même dans les médicaments, et plus particulièrement dans les dentifrices ou les bains de bouche.To achieve this, it seemed essential to establish a balance of the daily intake of fluorides in children's food and to minimize this external intake either in drinking water, in food or even in medicines. , and more particularly in toothpaste or mouthwashes.
Au contraire, il est apparu souhaitable de fournir aux jeunes enfants cette charge en fluorures par l'intermédiaire de boissons comme le lait, et en particulier le lait maternel, ou de l'eau minérale.On the contrary, it appeared desirable to provide young children with this fluoride load by means of drinks such as milk, and in particular breast milk, or mineral water.
Il s'avère donc souhaitable que tous les jeunes enfants, et même les nourrissons (même lorsqu'ils sont allaités), reçoivent par la boisson ou par le lait maternel une concentration adéquate en fluoru- res qui contribuera à renforcer leur ossature et leur future dentition.It is therefore desirable that all young children, and even infants (even when breastfeeding), receive by drinking or breast milk an adequate concentration of fluorides which will contribute to strengthening their bones and their future. dentition.
Il est également possible, si l'enfant ne reçoit pas l'allaitement maternel, ou nourricier, de lui fournir un lait artificiel ou naturel, chargé en fluorures, de manière à lui fournir un apport satis- faisant en fluorures, correspondant à ses besoins journaliers.It is also possible, if the child does not receive breastfeeding or nursing, to provide him with an artificial or natural milk, loaded with fluorides, so as to provide him with a satisfactory intake of fluorides, corresponding to his needs daily.
Ces apports en fluor se feront de préférence par de l'eau de boisson destinée à diluer les préparations lactées. On peut également, pour éviter des risques de surcharge en fluorures, incorporer dans les laits destinés à l'alimentation des jeunes enfants, ou bien plus généralement dans le liquide du biberon, une dose déterminée de fluorures répondant à leurs besoins journaliers, mais sans excès.These fluorine additions will preferably be made by drinking water intended to dilute the milk preparations. To avoid the risk of fluoride overload, it is also possible to incorporate into milks intended for the feeding of young children, or more generally into the liquid of the bottle, a determined dose of fluorides meeting their daily needs, but without excess. .
Ces adsorbats sont incorporés à la nourriture infantile ; ils sont sans goût et sans toxicité. Ils peuvent donc être ajoutés à la nourriture sans crainte d'y introduire un risque de saveur désagréable ou trop saline.These adsorbates are incorporated into infant food; they are tasteless and toxic. They can therefore be added to food without fear of introducing a risk of unpleasant or too salty flavor.
On peut également administrer les fluorures sous forme de dérivés complexes comme des phospho-fluorures, des fluorophos- phonates et, d'une manière générale, tout complexe riche en fluor et sans toxicité.Fluorides can also be administered in the form of complex derivatives such as phosphofluorides, fluorophosphonates and, in general, any complex rich in fluorine and without toxicity.
En conséquence, on peut ainsi administrer des doses de fluorures qui s'échelonneront, selon l'invention, de 0,5 mg à 2,5 mg chaque jour avec une préférence pour une dose allant de 1 mg à 2 mg, exprimés en ions fluorure, contenues dans les préparations alimentaires selon l'invention.Consequently, it is thus possible to administer doses of fluorides which will range, according to the invention, from 0.5 mg to 2.5 mg each day with a preference for a dose ranging from 1 mg to 2 mg, expressed as ions fluoride, contained in the food preparations according to the invention.
On peut également administrer des préparations liquides contenant des doses de fluorures permettant d'atteindre des concentra- tions efficaces de fluorures, s'échelonnant de 1 mg à 2 mg par jour.Liquid preparations can also be administered containing doses of fluorides to achieve effective concentrations of fluorides ranging from 1 mg to 2 mg per day.
On peut également administrer des fluorures minéraux ou organiques aux nourrissons à partir de l'âge de deux semaines, dispersés dans une préparation alimentaire, telle qu'un liquide aqueux comme de l'eau minérale, du jus de fruit , du lait ou une bouillie.Mineral or organic fluorides can also be administered to infants from the age of two weeks, dispersed in a food preparation, such as an aqueous liquid such as mineral water, fruit juice, milk or porridge .
On peut encore incorporer aux laits pour nourrissons (laits animaux ou laits en poudre reconstitués) des quantités déterminées de préparations de fluorures simples ou complexes et de préfé- rence un fluorure insoluble dans l'eau, comme le fluorure de calcium, le fluorure de strontium ou le fluorure d'aluminium, de manière à fournir aux nourrissons les doses nécessaires de fluorures. Ces doses sont comprises entre 0,5 mg et 5 mg par jour. Ces fluorures s'incorporent dans les couches superficielles de l'émail et réduisent la solubilité de ce tissu dans les acides sécrétés par les bactéries, de nature glucidique.It is also possible to incorporate into infant milks (animal milks or reconstituted powdered milks) determined quantities of simple or complex fluoride preparations and preferably a water-insoluble fluoride, such as calcium fluoride, strontium fluoride or aluminum fluoride, so as to provide infants with the necessary doses of fluorides. These doses are between 0.5 mg and 5 mg per day. These fluorides are incorporated into the surface layers of the enamel and reduce the solubility of this tissue in the acids secreted by bacteria, of a carbohydrate nature.
Parmi les fluorures que l'on peut ainsi incorporer à l'alimentation, on citera plus particulièrement : les fluorures de métal alcalin, comme - le fluorure de sodium, - le fluorure de potassium - le fluorure de lithium - le fluorure de rubidium - le fluorure de césium les fluorures de métal alcalinoterreux, comme : - le fluorure de calcium, - le fluorure de strontium, et les fluorures de métaux non-toxiques thérapeutiquement compatibles, comme : - le fluorure de zinc - le fluorure d'aluminium - le fluorure de cuivre - le fluorure de gadolinium - le fluorure de gallium ou - le fluorure de manganèse. On peut administrer également les fluorures sous forme d'adsorbat sur un support organique ou minéral comme, par exemple, un support : - de cellulose, - de gélatine, - d'alginate de gomme xanthane, de gomme géllane,Among the fluorides which can thus be incorporated into the diet, there may be mentioned more particularly: the alkali metal fluorides, such as - sodium fluoride, - potassium fluoride - lithium fluoride - rubidium fluoride - cesium fluoride alkaline earth metal fluorides, such as: - calcium fluoride, - strontium fluoride, and therapeutically compatible non-toxic metal fluorides, such as: - zinc fluoride - aluminum fluoride - fluoride copper - gadolinium fluoride - gallium fluoride or - manganese fluoride. Fluorides can also be administered in the form of an adsorbate on an organic or inorganic support such as, for example, a support: - of cellulose, - of gelatin, - of alginate xanthan gum, gelan gum,
ou bien encoreor even
- dispersées dans un support gélifié comme un polymère d'acide acrylique, d'acide méthacrylique ou de méthacrylamide L'alimentation des jeunes enfants, n'est pas modifiée par ailleurs. Cette charge en fluorures selon l'invention apporte quotidiennement la quantité de fluor requise pour assurer une solidité accrue de l'ossature sans mettre en cause le développement osseux ni provoquer de « fluorose ».- dispersed in a gelled support such as a polymer of acrylic acid, methacrylic acid or methacrylamide The diet of young children is not otherwise modified. This fluoride load according to the invention provides daily the amount of fluorine required to ensure increased strength of the frame without jeopardizing bone development or causing "fluorosis".
Les résultats obtenus sont très satisfaisants.The results obtained are very satisfactory.
Les enfants alimentés dans ces conditions présentent une dentition saine, peu sensible aux agressions microbiennes liées à la flore buccopharyngée. Ils ne présentent pas de risque de fracture spontanée.Children fed under these conditions have healthy teeth, not very sensitive to microbial attacks linked to the buccopharyngeal flora. They do not present a risk of spontaneous fracture.
L'invention concerne donc des produits alimentaires solides, liquides ou pâteux, renfermant une dose déterminée d'un ou plu- sieurs fluorures additionnés ou incorporés à un complément nutritif approprié.The invention therefore relates to solid, liquid or pasty food products containing a determined dose of one or more fluorides added or incorporated into an appropriate nutritive supplement.
L'invention concerne également les produits alimentaires, liquides ou pâteux, pour nourrissons, renfermant un ou plusieurs fluo- rure(s) dilué(s) dans un véhicule liquide ou gélifié approprié à l'alimentation des nourrissons ou des très jeunes enfants.The invention also relates to food products, liquid or pasty, for infants, containing one or more fluoride (s) diluted in a liquid or gelled vehicle suitable for feeding infants or very young children.
Les produits alimentaires selon l'invention contiennent encore des protéines, de préférences solubles dans l'eau, des huiles vé- gétales, des glucides comme le lactose ou les maltodextrines, des sels minéraux tels que des sels de sodium, de potassium, des chlorures, des sels de calcium, des phosphates, des sels de magnésium, des sels de fer, des sels de zinc, des iodures, des sels de cuivre et/ ou des sels de manganèse.The food products according to the invention also contain proteins, preferably water-soluble, vegetable oils, carbohydrates such as lactose or maltodextrins, salts minerals such as sodium, potassium, chlorides, calcium salts, phosphates, magnesium salts, iron salts, zinc salts, iodides, copper salts and / or manganese.
En outre, les préparations alimentaires selon l'invention contiennent une ou plusieurs vitamines choisies parmi la vitamine A, la vitamine Bl, la vitamine B2, la vitamine B6, la vitamine B12, la vitamine C, la vitamine D3, la vitamine E, la vitamine Kl, la niacine, l'acide pantothénique, l'acide folique et la biotine.In addition, the food preparations according to the invention contain one or more vitamins chosen from vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D3, vitamin E, vitamin Kl, niacin, pantothenic acid, folic acid and biotin.
Les préparations alimentaires selon l'invention contiennent également des facteurs de croissance pour les jeunes enfants, comme la choline, la taurine, la carnitine sous forme racémique ou op- tique, même active.The food preparations according to the invention also contain growth factors for young children, such as choline, taurine, carnitine in racemic or optical form, even active.
Commodément, le véhicule sera du lait maternel ou humanisé, de l'eau sucrée, de l'eau minérale peu chargée en ions minéraux, une tisane ou bien encore une préparation fluide telle qu'un yaourt préalablement fluidifié., du fromage blanc, du potage, du tapioca, de la fécule, etc..Conveniently, the vehicle will be breast milk or humanized milk, sugar water, mineral water sparingly loaded with mineral ions, a herbal tea or even a fluid preparation such as a yoghurt previously fluidified., White cheese, soup, tapioca, starch, etc.
Un exemple particulièrement avantageux de l'invention sera une solution de fluorure de sodium, de fluorure de magnésium ou de fluorure de lithium dans un véhicule aqueux, éventuellement édulco- ré, contenant de 0,05 à 0,5 mg d'ions fluorures sous un volume de 1 ml. L'administration se fera sous forme d'un produit gélifié ou épaissi contenant une quantité d'ions fluorures adaptée au cas considéré des nourrissons ou des très jeunes enfants.A particularly advantageous example of the invention will be a solution of sodium fluoride, magnesium fluoride or lithium fluoride in an aqueous vehicle, optionally sweetened, containing from 0.05 to 0.5 mg of fluoride ions under a volume of 1 ml. The administration will be in the form of a gelled or thickened product containing a quantity of fluoride ions adapted to the case considered of infants or very young children.
Un autre but de l'invention concerne encore des préparations alimentaires plus fortement caloriques contenant un ou plusieurs fluorure(s) dans un excipient ou un véhicule alimentaire ou diététique , liquide, pâteux ou solide, approprié pour l'alimentation des très jeunes enfants. De préférence, l'excipient sera de la poudre de lactose, de l'amidon, de la cellulose pour pouvoir l'incorporer à des aliments liquides ou solides. Le véhicule sera de préférence une préparation lactée, telle que du fromage blanc, des yaourts, des jus de fruits, des préparations de fruits gélifiées, du miel, du sirop de sucre, du sirop de glucose, des émulsions lipidiques, cuites dans l'eau, à base de triglycérides et d'acides gras à chaîne courte ou moyenne, contenant une quantité déterminée de fluorures pour assurer un apport mesuré de fluorures aux nourrissons.Another object of the invention also relates to more highly caloric food preparations containing one or more fluoride (s) in an excipient or a food or dietetic vehicle, liquid, pasty or solid, suitable for feeding very young children. Preferably, the excipient will be lactose powder, starch, cellulose so that it can be incorporated into liquid or solid foods. The vehicle will preferably be a milk preparation, such as cottage cheese, yogurts, fruit juices, gelled fruit preparations, honey, sugar syrup, glucose syrup, lipid emulsions, cooked in the water, based on triglycerides and short or medium chain fatty acids, containing a determined quantity of fluorides to ensure a measured intake of fluorides for infants.
Les préparations alimentaires selon l'invention peuvent également être des préparations solides comme des bonbons à base de xylitol ou même des gâteaux secs qui se délitent dans la bouche, comme des macarons ou des pralines, de manière à obtenir des préparations ayant une saveur agréable dont l'ingestion ne posera pas de problêmes aux très jeunes enfants.The food preparations according to the invention can also be solid preparations such as xylitol-based candies or even dry cakes which disintegrate in the mouth, such as macaroons or pralines, so as to obtain preparations having a pleasant flavor, ingestion will not be a problem for very young children.
La teneur en fluorures de ces préparations alimentaires selon l'invention varie de 0,05 à 10 mg par 1000 g, et de préférence de 0, 1 à 0,5 mg pour 1 000 g, de façon à ce que leur consommation journalière apporte de 0, 1 à 0,2 mg de fluorures au nourrisson. La concentration en fluorures de ces préparations est ajustée de telle sorte qu'une surconsommation ou même un surdosage ne soit pas susceptible de provoquer un apport excessif, et, par voie de conséquence, un risque de fluorose.The fluoride content of these food preparations according to the invention varies from 0.05 to 10 mg per 1000 g, and preferably from 0.1 to 0.5 mg per 1000 g, so that their daily consumption provides from 0.1 to 0.2 mg of fluorides in infants. The fluoride concentration of these preparations is adjusted so that overconsumption or even overdose is not likely to cause excessive intake, and, consequently, a risk of fluorosis.
L'exemple suivant illustre l'invention, sans toutefois la limiter : EXEMPLEThe following example illustrates the invention, without however limiting it: EXAMPLE
Figure imgf000009_0001
Figure imgf000010_0001
Figure imgf000009_0001
Figure imgf000010_0001
Sur la base d'une consommation journalière de 500 ml selon l'invention : les apports journaliers en fluor sont de 100 μg par jour soit 0.1 mg. Based on a daily consumption of 500 ml according to the invention: the daily intake of fluorine is 100 μg per day, ie 0.1 mg.

Claims

R E V E N D I C A T I O N S 1°) Utilisation de produits alimentaires renfermant une dose, déterminée d'un ou plusieurs fluorure(s), additionnée ou dispersée dans un complément nutritif approprié à l'alimentation des nourrissons et des très jeunes enfants en vue de la réalisation d'une préparation titrée contenant du fluor, sans risque de surdosage.CLAIMS 1 °) Use of food products containing a determined dose of one or more fluoride (s), added or dispersed in a nutritive supplement suitable for feeding infants and very young children with a view to achieving a titrated preparation containing fluorine, without risk of overdose.
2°) Utilisation des produits alimentaires solides, liquides ou pâteux se- Ion la revendication 1 , en vue de la réalisation d'une préparation titrée contenant du fluor, destinée à la supplémentation de l'alimentation des nourrissons et des très jeunes enfants, sans risque de surdosage.2 °) Use of solid, liquid or pasty food products according to claim 1, for the production of a titrated preparation containing fluorine, intended for supplementation of the diet of infants and very young children, without risk of overdose.
3°) Utilisation de produits alimentaires, liquides ou pâteux, pour nourrissons selon la revendication 1 , renfermant un ou plusieurs fluorure(s) dilués dans un véhicule liquide ou gélifié approprié pour l'alimentation des nourrissons ou des très jeunes enfants.3 °) Use of food products, liquid or pasty, for infants according to claim 1, containing one or more fluoride (s) diluted in a liquid or gelled vehicle suitable for feeding infants or very young children.
4°) Utilisation de produits alimentaires destinés à l'alimentation des nourrissons et des très jeunes enfants selon la revendication 1, caractérisés en ce que ces produits alimentaires apportent de 0,05 mg à 5 mg d'ions fluorure pour jour dans l'alimentation.4 °) Use of food products intended for the feeding of infants and very young children according to claim 1, characterized in that these food products provide from 0.05 mg to 5 mg of fluoride ions per day in the diet .
5°) Utilisation de produits alimentaires destinés à l'alimentation des nourrissons et des très jeunes enfants selon la revendication 1, caractérisée en ce que ces produits alimentaires apportent de 0, 1 mg à 0,2 mg d'ions fluorure par jour dans l'alimentation.5 °) Use of food products intended for the feeding of infants and very young children according to claim 1, characterized in that these food products provide from 0.1 mg to 0.2 mg of fluoride ions per day in l 'food.
6°) Utilisation de produits alimentaires selon l'une des revendications précédentes, caractérisée en ce que les fluorures sont sous la forme de fluorures métalliques ou de complexes de fluor.6 °) Use of food products according to one of the preceding claims, characterized in that fluorides are in the form of metal fluorides or fluorine complexes.
7°) Utilisation de produits alimentaires selon l'une des revendications précédentes, caractérisés en ce que les fluorures métalliques sont choisis dans le groupe formé des fluorures de métal alcalin, des fluorures de métal alcalino-terreux et des fluorures de métal non-toxiques, thérapeutiquement compatibles.7 °) Use of food products according to one of the preceding claims, characterized in that the metal fluorides are chosen from the group formed by alkali metal fluorides, alkaline earth metal fluorides and non-toxic metal fluorides, therapeutically compatible.
8°) Utilisation de produits alimentaires selon l'une des revendications précédentes, caractérisés en ce que le fluor est apporté par des fluorures complexes, choisis parmi les phosphofluorures et les fluorophosphonates.8 °) Use of food products according to one of the preceding claims, characterized in that the fluorine is provided by complex fluorides, chosen from phosphofluorides and fluorophosphonates.
9°) Utilisation des produits alimentaires selon l'une des revendications 1 à 7, dans laquelle le produit alimentaire titré contient, en outre, des protéi- nés, des glucides, des lipides, des ions minéraux, des vitamines et des facteurs de croissance.9 °) Use of food products according to one of claims 1 to 7, wherein the titrated food product further contains proteins, carbohydrates, lipids, mineral ions, vitamins and growth factors .
10°) Utilisation des produits alimentaires selon la revendication 8, dans laquelle les ions minéraux sont choisis parmi le sodium, le potassium, le chlore, le calcium, le phosphore, le magnésium ,1e fer, le zinc, l'iode, le cuivre et le manganèse.10 °) Use of food products according to claim 8, wherein the mineral ions are chosen from sodium, potassium, chlorine, calcium, phosphorus, magnesium, iron, zinc, iodine, copper and manganese.
11°) Utilisation des produits alimentaires selon la revendication 8, dans laquelle les vitamines sont choisies parmi la vitamine A, les vitamines du groupe B, la vitamine C, les vitamines D, la vitamine E, la biotine, l'acide foli- que, l'acide panthothénique et la vitamine K. 11 °) Use of the food products according to claim 8, in which the vitamins are chosen from vitamin A, vitamins of group B, vitamin C, vitamins D, vitamin E, biotin, folic acid , panthothenic acid and vitamin K.
PCT/FR2004/001991 2003-07-25 2004-07-26 Novel fluorinated food products and the use thereof for harmonious osseous development WO2005009143A2 (en)

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