FR2847426A1 - Use of fruit and vegetable extracts with peroxidase- and catalase-like ability to destroy hydrogen peroxide as dietary supplements, for skin protection and to prepare cosmetic, dermatological and veterinary products - Google Patents
Use of fruit and vegetable extracts with peroxidase- and catalase-like ability to destroy hydrogen peroxide as dietary supplements, for skin protection and to prepare cosmetic, dermatological and veterinary products Download PDFInfo
- Publication number
- FR2847426A1 FR2847426A1 FR0214623A FR0214623A FR2847426A1 FR 2847426 A1 FR2847426 A1 FR 2847426A1 FR 0214623 A FR0214623 A FR 0214623A FR 0214623 A FR0214623 A FR 0214623A FR 2847426 A1 FR2847426 A1 FR 2847426A1
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- France
- Prior art keywords
- hydrogen peroxide
- plant extracts
- catalase
- dermatological
- fruit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nutrition Science (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
Abstract
Description
Il a été largement démontré que les systèmes peroxydatifs tels que l'eauIt has been widely demonstrated that peroxidative systems such as water
oxygénée et les lipoperoxydes, conduisent à la formation de molécules toxiques pour l'organisme. oxygenated and lipoperoxides, lead to the formation of molecules toxic to the body.
Radicaux libres, eau oxygénée, sont des oxydants produits naturellement par l'organisme, dans les mitochondries. Ils interviennent au cours de la phagocytose, leur accumulation est dangereuse. Free radicals, hydrogen peroxide, are oxidants produced naturally by the body, in the mitochondria. They intervene during phagocytosis, their accumulation is dangerous.
De tels systèmes peroxydatifs ont surtout pour origine l'intervention des radicaux libres, tel l'anion superoxyde 020 qui génère l'eau oxygénée H202,conduisant à des radicaux hydroxyles qui interviennent dans le processus de lipoperoxydation. Such peroxidative systems mainly originate from the intervention of free radicals, such as the superoxide anion 020 which generates hydrogen peroxide H202, leading to hydroxyl radicals which are involved in the lipoperoxidation process.
Or les espèces réactives d'oxygène comme l'anion superoxyde, les radicaux hydroxyles ainsi Io que l'eau oxygénée, provoquent la formation de systèmes inflammatoires, en dégradant une However, reactive oxygen species such as the superoxide anion, hydroxyl radicals as well as oxygenated water, cause the formation of inflammatory systems, degrading a
variété de molécules intra et extra -cellulaires. variety of intra and extra-cellular molecules.
Aussi, la déficience en antioxydants et enzymes protectrices peut dans certaines circonstances, par exemple dans le cas d'une brlure, ne plus être en mesure d'inactiver les polynucléaires neutrophiles. C'est ainsi que pour certains auteurs, une augmentation du niveau de l'eau I5 oxygénée et du radical superoxyde produits par les macrophages, serait la cause majeure du Also, the deficiency in antioxidants and protective enzymes may in certain circumstances, for example in the case of burns, no longer be able to inactivate neutrophils. Thus for some authors, an increase in the level of hydrogen peroxide and the superoxide radical produced by macrophages, would be the major cause of
stress oxydatif et des dommages cellulaires qui en sont la conséquence. oxidative stress and the cellular damage that results from it.
Ainsi, par exemple, en cas de déficience d'antioxydants naturels, tel le glutathion réduit, principal antioxygène de l'organisme, il a été constaté, la présence d'eau oxygénée dans l'humeur vitrée et dans la rétine. (MAUGER T, LANSON L. J. Toxicol. Cutaneous Ocul 2 0 1992, 44 (4) 369) Que des cellules épithéliales soumises à 2 nM d'eau oxygénée, accusent une chute de glutathion réduit, de plus de 80% (FERRANDELLI J et Col. Neuropatho Exp. Neurol. 1971 60 638) Que l'eau oxygénée induit le stress oxydatif du muscle cardiaque (JANERO D et Col. J. Cell.Physiol. 1991 149 (3) 247) Chez le végétal, au stade de dépassement du mrissement des fruits, on observe une 2 5 augmentation du peroxyde d'hydrogène, cette maturité pouvant être retardée par inhibition de l'eau oxygénée (PAULS K THOMPSON J- Plant Physiol. 1984 75 1152) So, for example, in case of deficiency of natural antioxidants, such as reduced glutathione, the main antioxidant in the body, it has been found, the presence of hydrogen peroxide in the vitreous humor and in the retina. (MAUGER T, LANSON LJ Toxicol. Cutaneous Ocul 2 0 1992, 44 (4) 369) That epithelial cells subjected to 2 nM hydrogen peroxide show a fall in glutathione reduced by more than 80% (FERRANDELLI J and Col Neuropatho Exp. Neurol. 1971 60 638) That hydrogen peroxide induces the oxidative stress of the heart muscle (JANERO D and Col. J. Cell.Physiol. 1991 149 (3) 247) In plants, at the stage of overcoming When fruits ripen, an increase in hydrogen peroxide is observed, this maturity being able to be delayed by inhibition of hydrogen peroxide (PAULS K THOMPSON J- Plant Physiol. 1984 75 1152)
Chez les fumeurs, l'activité des macrophages augmentant, provoque une production anormalement élevée d'eau oxygénée. Aussi une déficience en catalase ou en peroxydases ( enzymes anti-peroxydantes) peut conduire à de graves états pathologiques. In smokers, the activity of macrophages increasing, causes an abnormally high production of oxygenated water. Also a deficiency in catalase or peroxidases (anti-peroxidizing enzymes) can lead to serious medical conditions.
Aujourd'hui, on sait qu'il existe une alimentation oxydative qu'il est impératif de combattre grâce aux propriétés antiradicalaires et antilipoperoxydes des légumes et des fruits. ( brevets NO 97 07273 et NO 99 11752) Quant à la destruction du peroxyde d'hydrogène (H202) en dehors des enzymes spécifiques, et surtout du glutathion, il n'a jamais été décrit jusqu'ici, que des aliments étaient en mesure de le décomposer. Today, we know that there is an oxidative diet that it is imperative to fight thanks to the anti-radical and anti-lipoperoxid properties of vegetables and fruits. (patents NO 97 07273 and NO 99 11752) As for the destruction of hydrogen peroxide (H202) apart from specific enzymes, and especially glutathione, it has never been described until now, that food was able to break it down.
m -2m -2
Il a été observé, ce qui est surprenant, que certains extraits de légumes et fruits alimentaires étaient doués d'une activité destructrice du peroxyde d'hydrogène (H202) similaire à celle des enzymes: peroxydases et catalase, conduisant à la formation d'eau et d'oxygène moléculaire. It has been observed, which is surprising, that certain extracts of vegetables and edible fruits were endowed with a destructive activity of hydrogen peroxide (H202) similar to that of enzymes: peroxidases and catalase, leading to the formation of water and molecular oxygen.
Ces extraits végétaux alimentaires ont fait l'objet de travaux mettant en lumière leurs propriétés antiradicalaires et particulièrement leur propriétés antilipoperoxydes. Le milieu These plant food extracts have been the subject of work highlighting their anti-free radical properties and particularly their anti-lipoperoxid properties. The middle
réactionnel de ces activités étant lipophile ( oxydation des matières grasses) Dans le cadre de l'invention l'activité anti-peroxyde d'hydrogène se réalise en milieu hydrophile. reaction of these activities being lipophilic (oxidation of fatty substances) In the context of the invention, the anti-hydrogen peroxide activity is carried out in a hydrophilic medium.
La présente invention a pour objet de réaliser des extraits végétaux alimentaires à partir de The object of the present invention is to produce plant food extracts from
JO légumes ou de fruits caractérisés par leur activité anti-peroxyde d'hydrogène. OJ vegetables or fruits characterized by their anti-hydrogen peroxide activity.
Voici quelques exemples des capacités anti-peroxyde d'hydrogène, pour 1 g d'extraits de fruits et de légumes, exprimées en microgrammes d'oxygène; les mesures étant effectuées par potentiométrie. Here are some examples of the anti-hydrogen peroxide capacities, for 1 g of fruit and vegetable extracts, expressed in micrograms of oxygen; the measurements being carried out by potentiometry.
Légumes et Fruits Microgrammes d'oxygène éliminés Chou brocoli 4800 Petit pois 3754 Endive 3600 Basilic 2813 Oignon 2695 Persil 2481 Tomate 2447 Mas 2084 Haricot vert 1855 Fraise 1600 Carotte 1582 Poireau 1543 Orange 658 Poire 310 Extrait d'un vin de Bordeaux 5200 La présente invention a pour objet la réalisation d'extraits destinés à être utilisés comme Vegetables and Fruit Micrograms of oxygen eliminated Broccoli cabbage 4,800 Peas 3,754 Endive 3,600 Basil 2,813 Onion 2,695 Parsley 2,481 Tomato 2,447 Mas 2084 Green bean 1,855 Strawberry 1,600 Carrot 1,582 Leek 1,543 Orange 658 Pear 310 Extract from a Bordeaux wine 5,200 The present invention has for object the production of extracts intended to be used as
compléments alimentaires, mais également en application cutanée dans les domaines de la cosmétique, de la dermatologie humaine et animale. food supplements, but also for skin application in the fields of cosmetics, human and animal dermatology.
Dans le cadre de l'invention, on choisira après avoir effectué des mesures d'activité antiperoxydes d'hydrogène, les extraits de légumes et de fruits, dont on pourra faire des 3 5 mélanges, à partir de ceux donnant les résultats les plus élevés pour l'élimination de ce type In the context of the invention, after having carried out measurements of hydrogen antiperoxide activity, the extracts of vegetables and fruits, of which mixtures can be made, will be chosen from those giving the highest results. for the elimination of this type
d'O2 actif Dans ce cas, l'activité de l'oxygène actif est systématiquement inhibée. Le nombre de légumes ou de fruits capables d'être doués de hautes propriétés anti- peroxyde d'hydrogène se trouve ainsi limité. active O2 In this case, the activity of active oxygen is systematically inhibited. The number of vegetables or fruits capable of being endowed with high anti-hydrogen peroxide properties is thus limited.
-3 Afin de combattre les peroxydes exogènes, plus particulièrement d'origine alimentaire, mais principalement le peroxyde d'hydrogène endogène, les extraits de légumes et de fruits seront choisis en fonction de leurs capacités anti-peroxyde d'hydrogène. Ils seront utilisés comme compléments alimentaires, sous forme de gélules, comprimés, capsules, en solution aqueuse -3 In order to combat exogenous peroxides, more particularly of food origin, but mainly endogenous hydrogen peroxide, the extracts of vegetables and fruits will be chosen according to their anti-hydrogen peroxide capacities. They will be used as food supplements, in the form of capsules, tablets, capsules, in aqueous solution
par exemple.for example.
Les extraits de légumes et de fruits caractérisés par leur action antiperoxydique( H202) seront avantageusement incorporés dans des préparations destinées à être appliquées sur la peau pour la protéger des effets agressifs des radiations solaires ou de toute autre agression déclenchant un processus oxydatif inflammatoire, par activation des cellules phagocytaires, productrices IO d'eau oxygénée (blessures, brlures, action microbienne) The extracts of vegetables and fruits characterized by their anti-oxidant action (H202) will advantageously be incorporated into preparations intended to be applied to the skin to protect it from the aggressive effects of solar radiation or any other aggression triggering an inflammatory oxidative process, by activation phagocytic cells, producing IO of oxygenated water (wounds, burns, microbial action)
C'est ainsi, que pour les compléments alimentaires, on aura recours à titre d'exemple à des extraits tels que ceux de Brocoli, doués d'une forte capacité anti-peroxyde d'hydrogène, tandis que dans le cadre d'application cutanée, on aura recours par exemple à des extraits comme ceux, de petit pois ou d'endive. Thus, for food supplements, we will use, for example, extracts such as Broccoli, endowed with a strong anti-hydrogen peroxide capacity, while in the context of skin application , we will use for example extracts like those, pea or endive.
I5 Il est bien connu, que les radiations solaires sont agressives pour la peau, provoquant I5 It is well known that solar radiation is aggressive to the skin, causing
l'altération du tissu conjonctif et de ce fait, une activation des polynucléaires neutrophiles, producteurs, de l'anion superoxyde et d'eau oxygénée. Ceci montre tout l'intérêt d'avoir recours aux extraits de légumes et de fruits dans les préparations cosmétiques contre le vieillissement prématuré de la peau. the alteration of the connective tissue and therefore an activation of the neutrophils, producers, of the superoxide anion and of oxygenated water. This shows the advantage of using vegetable and fruit extracts in cosmetic preparations against premature aging of the skin.
2 0 Exemples non limitatifs de compositions contenant des extraits de légumes et de fruits destructeurs du peroxyde d'hydrogène, destinées à la réalisation de compléments alimentaires ou à l'application cutanée. Pour les compléments alimentaires, on introduit des extraits permettant d'obtenir une capacité anti-peroxyde d'hydrogène minimale de 100 tg/02 par prise. Les extraits utilisés en application cutanée sont introduits à la concentration minimale de Non-limiting examples of compositions containing extracts of vegetables and fruits destructive of hydrogen peroxide, intended for the production of food supplements or for skin application. For food supplements, extracts are introduced to obtain a minimum anti-hydrogen peroxide capacity of 100 tg / 02 per dose. The extracts used in skin application are introduced at the minimum concentration of
2 5 1 OOig/O2 de capacité anti-peroxyde d'hydrogène par gramme d émulsion. 2 5 1 OOig / O2 of anti-hydrogen peroxide capacity per gram of emulsion.
En Compléments Alimentaires -Sous forme de gélules de 200 mg Extrait de brocoli 42 mg Capacité anti-peroxyde: 200 J'g/02 -Sous forme de comprimés de 200 mg Extrait d'endive: 55 mg Capacité anti-peroxyde: 200 pig/O2 -4 En Application Cutanée 1) Excipient...................... 95g Extrait d'endive.............. 5g (éliminant 3600 kg /02 par g) Soit par g d'émulsion, une capacité destructrice d'oxygène peroxydique de 180g 02 2) Excipient. .94g Extrait de petit pois.5g ( éliminant 3754 ktg/02 par g) Extrait de Mas.7g ( éliminant 2084 ptg/ 02 par g) Soit une capacité destructrice d'oxygène peroxydique de 188>g /02 et de 146kg/02 par g de crème -5 In Food Supplements -In the form of capsules of 200 mg Broccoli extract 42 mg Anti-peroxide capacity: 200 J'g / 02 -In the form of tablets of 200 mg Endive extract: 55 mg Anti-peroxide capacity: 200 pig / O2 -4 In Skin Application 1) Excipient ...................... 95g Endive extract .............. 5g (eliminating 3600 kg / 02 per g) Or per g of emulsion, a destructive capacity of peroxide oxygen of 180g 02 2) Excipient. .94g Pea extract. 5g (eliminating 3754 ktg / 02 per g) Mas extract. 7g (eliminating 2084 ptg / 02 per g) Or a destructive capacity of peroxidic oxygen of 188> g / 02 and 146kg / 02 per g of cream -5
Claims (3)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0214623A FR2847426B1 (en) | 2002-11-22 | 2002-11-22 | FOOD VEGETABLE ANTI-HYDROGEN PEROXIDE |
PCT/FR2003/003445 WO2004047563A1 (en) | 2002-11-22 | 2003-11-21 | Use of food plants for their hydrogen peroxide destroying activity |
AU2003295049A AU2003295049A1 (en) | 2002-11-22 | 2003-11-21 | Use of food plants for their hydrogen peroxide destroying activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0214623A FR2847426B1 (en) | 2002-11-22 | 2002-11-22 | FOOD VEGETABLE ANTI-HYDROGEN PEROXIDE |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2847426A1 true FR2847426A1 (en) | 2004-05-28 |
FR2847426B1 FR2847426B1 (en) | 2006-02-24 |
Family
ID=32241503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0214623A Expired - Fee Related FR2847426B1 (en) | 2002-11-22 | 2002-11-22 | FOOD VEGETABLE ANTI-HYDROGEN PEROXIDE |
Country Status (3)
Country | Link |
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AU (1) | AU2003295049A1 (en) |
FR (1) | FR2847426B1 (en) |
WO (1) | WO2004047563A1 (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998000024A1 (en) * | 1996-06-28 | 1998-01-08 | Viva America Marketing, Inc. | Nutritional supplement composition and use |
US5895652A (en) * | 1996-07-29 | 1999-04-20 | Longevity Institute International | Method of metabolic adjuvanation and cellular repair |
EP1064855A1 (en) * | 1998-03-19 | 2001-01-03 | Sunstar Inc. | Foods, medical treatments and method relating to effects of promoting the growth of (lactobacillus bifidus), preventing allergy and lowering human cholesterol level |
JP2001131046A (en) * | 1999-11-04 | 2001-05-15 | Pola Chem Ind Inc | Hydrogen peroxide eliminant and cosmetic material containing the same |
JP2001253831A (en) * | 2000-03-10 | 2001-09-18 | Yukiyo Iwai | Skin care preparation |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU196553B (en) * | 1984-11-12 | 1988-12-28 | Tibor Keri | Cosmetic composition for skin-regeneration containing extract of green beans |
FR2798561B1 (en) * | 1999-09-21 | 2001-11-02 | Jean Morelle | COMPOSITIONS FOR FOOD AND COSMETIC USE, CHARACTERIZED BY THEIR ANTILIPOPEROXIDE PROPERTIES |
FR2804318B1 (en) * | 2000-01-31 | 2002-12-27 | Serobiologiques Lab Sa | SUN PROTECTION PRODUCTS |
US20030091518A1 (en) * | 1999-12-20 | 2003-05-15 | Gilles Pauly | Cosmetic and/or pharmaceutical preparations |
FR2808443B1 (en) * | 2000-05-05 | 2004-06-04 | Nuxe Lab | MOISTURIZING COSMETIC AND / OR DERMATOLOGICAL COMPOSITION WITH IMPROVED STABILITY |
FR2834718B1 (en) * | 2002-01-15 | 2004-12-24 | Cognis France Sa | COSMETIC AND / OR PHARMACEUTICAL ACTIVE SUBSTANCES |
-
2002
- 2002-11-22 FR FR0214623A patent/FR2847426B1/en not_active Expired - Fee Related
-
2003
- 2003-11-21 AU AU2003295049A patent/AU2003295049A1/en not_active Abandoned
- 2003-11-21 WO PCT/FR2003/003445 patent/WO2004047563A1/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998000024A1 (en) * | 1996-06-28 | 1998-01-08 | Viva America Marketing, Inc. | Nutritional supplement composition and use |
US5895652A (en) * | 1996-07-29 | 1999-04-20 | Longevity Institute International | Method of metabolic adjuvanation and cellular repair |
EP1064855A1 (en) * | 1998-03-19 | 2001-01-03 | Sunstar Inc. | Foods, medical treatments and method relating to effects of promoting the growth of (lactobacillus bifidus), preventing allergy and lowering human cholesterol level |
JP2001131046A (en) * | 1999-11-04 | 2001-05-15 | Pola Chem Ind Inc | Hydrogen peroxide eliminant and cosmetic material containing the same |
JP2001253831A (en) * | 2000-03-10 | 2001-09-18 | Yukiyo Iwai | Skin care preparation |
Non-Patent Citations (6)
Title |
---|
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; November 2001 (2001-11-01), PHAN TOAN-THANG ET AL: "Protective effects of curcumin against oxidative damage on skin cells in vitro: Its implication for wound healing.", XP002251423, Database accession no. PREV200200040617 * |
DATABASE WPI Section Ch Week 200149, Derwent World Patents Index; Class B04, AN 2001-453935, XP002251424 * |
DATABASE WPI Section Ch Week 200206, Derwent World Patents Index; Class B04, AN 2002-044554, XP002251425 * |
JOURNAL OF TRAUMA INJURY INFECTION AND CRITICAL CARE, vol. 51, no. 5, November 2001 (2001-11-01), pages 927 - 931, ISSN: 1079-6061 * |
OKADA YOSHINORI ET AL: "Scavenging effect of water soluble proteins in broad beans on free radicals and active oxygen species.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 46, no. 2, February 1998 (1998-02-01), pages 401 - 406, XP002251421, ISSN: 0021-8561 * |
RISO P ET AL: "Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage?", AMERICAN JOURNAL OF CLINICAL NUTRITION 69 (4) 712-718 1999 DEP. OF FOOD SCI. & TECH., DIV. OF HUMAN NUTR., UNIV. OF MILAN, 20-133 MILAN, ITALY. E-MAIL NUTR_LAB(A)IMIUCCA.CSI.UNIMI.IT, XP002251422 * |
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Publication number | Publication date |
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WO2004047563A1 (en) | 2004-06-10 |
AU2003295049A1 (en) | 2004-06-18 |
FR2847426B1 (en) | 2006-02-24 |
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