FR2837670A1 - Soft gelatin capsules filled with rice bran oil, useful for nutritional, cosmetic and therapeutic applications - Google Patents

Abstract

Soft gelatin capsules filled with rice bran oil are new.

Description

9) Cheeses or products obtained by the process according to claims 1

at 8.

  The present invention relates to a new way of administering and consuming rice bran oil, specifically in the form of flexible gelatin caps of animal, vegetable or marine origin, with a common filling and shaping technique, with variable specifications (sizes, diameter), containing rice bran oil, intended for nutrition, cosmetics or

therapeutic applications.

  o Rice bran oil is a solvent extracted from the shell of brown rice. The oil is still mainly produced in the Orient, especially in Japan and India, and is highly appreciated there as a superior cooking oil with excellent stability and more recently also as a valuable ingredient.

for cosmetic applications.

  It is characterized by a high concentration of monounsaturated and polyunsaturated fatty acids and a

  the highest percentage of unsaponifiables.

  This very stable oil, because it is

  balanced in mono and poly unsaturated acids.

  The fatty acid profile of its rice oil is characterized by approximately 40% oleic acid and 40% linoleic acid, the latter being an extremely important component for the maintenance of

  hydration and elasticity of the skin.

  It is a very rich source of: tocopherols, phytosterols, phytic acid, in gamma oryzanol, IP6

  So (phytic acid, myo-inositol), mono- fatty acids

  unsaturated and fatty-polyunsaturated acids, in acids

  alpha linoleic and alpha-linolenic and orizanol.

  The extraction is done from rice bran (oriza sativa bran), which is extracted from whole rice, this bran 3Set being the grain husk, the unused part is the bran that is separated from the grain before the

grain polishing.

  There are two extraction techniques known to date. A technique consisting in heating the rice bran before pressing it, and another more modern, consisting in passing steam at high pressure in the rice bran, the rice bran oil is the

  content of soft gelatin capsules.

  The quality of the oil is an important factor for its different applications, it depends on the quality of the raw material, rice bran, which must be carefully controlled. The meticulous examination of each container of rice bran is necessary, currently there is an NIR technique, this one, consists in introducing a probe into the container in order to detect the damaged bran, this method considerably reduces the control time of the quality, it is only 3 to 4 minutes, against 3 hours with the old methods

o manual.

  Rice bran oil contains powerful antioxidants that can reduce bad cholesterol (LDL), rice bran oil is known to be the best source of tocotrienol, an antioxidant +5, more powerful than Vitamin E existing in nature, moreover, used for food use, it has a lightness and a delicate flavor, with a high melting point after analysis, (of 213 C), therefore it is not denatured by cooking as opposed to other first cold pressing oils, hence its edibility or

seasoning or frying.

  The administration of rice bran oil is a source of: -TOCOPHEROL, one of the most important substances for the health of the organism. Gifted with antioxidant properties, plays a role in the prevention and management of cardiovascular diseases, cancer and aging, as well as protective properties of the cellular organism. Associated with vitamins A and C, it has a

  antioxidant power three times higher.

  -TOCOTRIENOL, considered as the most precious and the most powerful vitamin E existing in nature,

  recognized for its antioxidant and anti-cancer effects.

  -PHYTOSTEROL, or plant sterols are naturally occurring compounds found in vegetable oils. They have hypocholesteroleminating properties, a regular consumption of phytosteroids allows the reduction of bad cholesterol (L.D.L.),

  thus preventing cardiovascular diseases.

  -GMM ORIZANOL, a mixture of several phytosterols, mainly campesterol, cycloarterol and methyl cycloarterol, linked to ferulic acid, this exerting various and varied activities on the skin, in fact, it increases the flow of blood peripheral, it is an effective UV filter and it reduces the effects of

sun "on the skin.

  -PHYTIC ACID, an effective chelating compound, its presence increases the stability of the oil, it is a metal cleaner with an antioxidant action on the body. -ORIZANOL, a natural antioxidant, allowing o reduction of L.D.L. cholesterol (bad cholesterol)

  without touching the H.D.L. cholesterol (good cholesterol).

-GAMMA ORYZANOL PUR.

  -IP6, PHYTATE, MYO-INOSITOL, IP6 is the major form of phosphorylated inositol Other A applications are attributed to it, in particular in cosmetics for the benefits on the softness of the skin, hair care and maintenance of

body in general.

  - MONO-UNSATURATED FATTY ACIDS, which have an obenefic action on health, they intervene favorably in the metabolism of cholesterol, they help the gallbladder to get rid of excess cholesterol, they are protective of cardiovascular diseases, including oleic acid, Squi is slightly sensitive to oxidation, it also reduces the brittleness of saturated fats to this chemical reaction and has a favorable action on

  "good cholesterol". their rate is from 38 to 44%.

  - POLY-UNSATURATED FATTY ACIDS, which play a role in the construction and functioning of the cells of which they constitute a large part of the membrane, even ensuring its tightness and its

  exchanges with the outside and neighboring cells.

  They are the weak link, the target that free radicals attack during "oxidative stress". They are involved in fat metabolism by lowering cholesterol and triglyceride numbers, favorably improving the ratio between good (HDL) and bad (LDL) ocholesterol, they stimulate the body's defenses, they nourish the skin, giving it a better appearance, repairing tissues, they help nerve cells, by making lecithin and myelin, the insulating sheath of nerve fiber, they 4Improve learning and memory, participate in the quality of vision, they prevent and finally cardiovascular diseases and cancer, which has earned them a prominent place among health foods. In these polyunsaturated fatty acids, Son distinguishes omega-6 and omega-3, these

  protect the body against heart disease

  vascular by an anti-thrombosis action and a

improved circulation.

  -BETACAROTENE, important because it turns into o vitamin A in the body. It has antioxidant properties. It has effects

beneficial on the skin.

  In summary, rice bran oil has an anti

  oxidizing on the organism by the action of its nutrients and antioxidants that it contains, by the components of its chemical formula, it can prevent arteriosclerosis (by reducing L DL), improve the appearance and quality of the skin, hair, prevent certain cancers, prevent inflammations, allergies, ect. Its application is suitable for therapy,

cosmetics and nutrition.

  Rice bran oil, through prostaglandins, allows the body to have better immune defense and a delay in aging, acting on the dysfunctions of the liver and

inflammation in general.

  Well tolerated by the stomach, it stimulates the secretions of pancreatic hormones and bile, has beneficial effects on gastric problems, it is cholagogue, it reduces the phenomena of

gallstones.

  Its consumption is excellent both for childhood and the mature age, the ages presenting problems of mineralization, because its great digestibility results from the full absorption of nutrients, especially vitamins and mineral salts, and contributes to the necessary oléstes for the bone system, its consumption is favorable for all those said to be at risk of diseases that it protects or improves, for any person as a preventive measure for these diseases, maintains the organism, and beautifies the skin, the hair, etc. Rice bran oil is currently taken sororally in the form of liquid but not very common, or even through food, mixed or not with other food products. This mode of consumption requires utensils and packaging in a bottle or in an appropriate container, it has many disadvantages: Taking is impractical because it requires utensils like a bottle and a spoon, difficult to transport daily the dosage is imprecise , in this form of consumption, and O in the case of a therapeutic application, an imprecise dosage, poses a problem for treating a pathology (arteriosclerosis, allergies ...) which can be improved thanks to the properties of bran oil

rice.

  s The taste or consistency of the oil may not be tolerated or accepted by the consumer, such as nausea, nausea, and therefore cause the loss of some of the beneficial effects

for the body.

  oI1 is therefore necessary to develop new forms of administration of rice bran oil

  can help avoid the problems mentioned above

  above. The present invention provides the solution to existing needs consisting in developing a new form of administration of rice bran oil to overcome the consumption disadvantages.

current already mentioned.

  This invention provides soft gelatin capsules containing rice bran oil,

  gelatin isolating the oil from oxidation.

  Soft gelatin capsules have an envelope whose shape is generally spherical, spheroid, oval, oblong, or elongated, in a single piece, with or without small end, as an appendage to facilitate the opening of the capsule, of size and variable weights, ect, allowing a

variable filling.

  The soft gelatin caps can be compartmentalized, i.e. in the capsule there are one or more separations, creating compartments for oil and other nutrients, vitamins, ect, allowing, for example a supply of

water-soluble vitamins.

  The caps are generally elastic and soft using a mixture of water gelatin, and more than one other material containing glycerin, or sorbitol, or proylene glycol, or polyethilene, or glicol and the mixture ... , we can

  add optional dyes and flavorings.

  The gelatin can be of vegetable or marine, or animal, controlled origin constituting the gelatinous envelope and with an approximate size of 5 mm.

o 2 cm.

  The gelatin undergoes extremely strict controls, each batch being analyzed and tested by an approved and independent body, in order to comply with the standards according to the legislation in force in the Sconcerné country. The capsules are filled with rice bran oil. This rice bran oil can contain additives or excipients such as opacifiers, colorants (for example to distinguish capsules whose properties are different), preservatives, it can be enriched with vitamins, trace elements, nutrients and micro-nutrients (such as bioflavonoids, bioretinol, ect ...), flavors, 2Ssaveur agents, emulsifiers, thickeners, bulking agent, fruit extract, essential oils, coating agents, anti- agglomerating, wax (bees, carnanbo, ect.), in synergy with any other vegetable and oleaginous oil, ect ... used in all cosmetic or pharmaceutical or therapeutic compositions.

  substances which can be energized.

  The rice bran oil present in the inventive capsules as a filling product for the capsules, can be alone or combined with other additives, namely commercial bran oil

  virgin or refined with varying acidity.

  Rice bran oil administered in the form of soft gelatin capsules can have an optimal dosage that is strictly controlled in terms of quality, the inventive capsules prevent the presence of any contamination by impurities, and protects

against air oxidation.

  Rice bran oil is compatible with many cosmetic, nutritional and

  therapeutic applications in synergy with these

  ci, amplifying the positive effects of rice bran oil, the capsules can also contain other additives or interesting substances, such as perfumes, flavoring agents, antioxidants, trace elements, micro-nutrients, vitamins, etc. The filler for the cape is rice bran oil with optional other cosmetic and nutritional substances compatible with each other, enriched with vitamins or antioxidants, or essential oils. can be energized, etc.

  Vitamins A, D, E and K, are of the lipo-

  soluble and can be stored by the body, dsont are brought to the body in the presence of fat, for example, the carrot releases much better its beta-carotene seasoned with a little oil than alone, they can participate in the filling formula

  in synergy with rice bran oil.

  2c Vitamin A exists in two forms, retinol and beta-carotene, insoluble in water does not resist light and cooking, Carotenoids, whose leader is beta-carotene, lose from to 30% of their content in heat and light. Vitamin A is unstable in an acidic environment, so bringing it in capsule form is essential to keep all its properties, since the capsules will open in the intestine and not in the stomach. protects from light. Daily needs vary according to the age of the subjects, in fact, the recommended intakes (AQR), ensuring the basic functioning of the organism, are different for an infant, a child (depending on age), a adult man or woman, during pregnancy, while breastfeeding, gelatin capsules containing rice bran oil can be enriched with vitamin A dosed according to the needs of the organism, optimal intakes of vitamins contribute to prevent serious illness and curb aging. Deficiencies are not uncommon, especially for people on a low-fat diet. Vitamin A pre-beta-carotene does not cause an overdose unlike Vitamin A which can be

store in tissue.

  Vitamin D is soluble in oil and sensitive to light, air, heat, and Sacides such as vitamins A, E and K, these vitamins can be components in synergy with the oil of rice bran contained in soft gelatin capsules. In addition, it has a good association with trace elements such as

  oMagnesium, calcium, SilicTum or Zinc.

  Vitamin E or tocopherol is one of the three vitamins with antioxidant properties, with a corollary role in the prevention and management of cardiovascular disease, cancer and aging, but it is above all the most powerful of the protective vitamins . Rice bran oil naturally contains it in high concentrations. It can be combined with vitamins A and C, to fight against aging but

  owith an antioxidant power three times higher.

  It can also be combined with trace elements such as zinc and selenum, always with the aim of antioxidating the body. It stimulates immunity, an interesting anti-inflammatory action against rheumatological pain, it inhibits the adhesion of platelets, which thins the blood, reduces cataracts, decreases the risk of prostate and colon cancer. Regarding its metabolism, taking this vitamin contained in rice bran oil in the form of soft gelatin capsules, is

all indicated.

  Vitamin K, very soluble in fats, but also sensitive to light, in good

  Combination with vitamin D and calaium.

  By taking up the above arguments and the various properties of rice bran oil, the administration and use of the inventive capsules is suitable for the fields of nutrition, cosmetics and therapeutics. Soft gelatin capsules containing rice oil, are innovative in their multiple properties, their content, rice bran oil, 4G alone or with optional other components (for example nutrients, vitamins, ect) is favorable for the maintenance and the good functioning of the human organism, for all the qualities of the rice bran oil developed above, the gelatin caps protect these qualities from oxidation, allows a better administration and absoption, allow precise dosing, are easily transportable, protect vitamins (for example, from light, ect), etc. c Soft gelatin capsules are formed and filled at the same time using a specialized machine. Several stages of preparation are

  before starting to encapsulate, and those

  These are made separately in the production unit, ^ 6 of which here is an example: The gelatin is prepared in a stainless steel tank of 300 liters: the powder is mixed with water and glycerin then heated and mixed under vacuum. The melted gelatin is then decanted in 200 kg mobile tanks in which the colors and flavorings, etc .; using a turbine which ensures the consistency of the gelatinous mass. This mass is then kept at constant temperature until use. A range of mixers, homogenizers, grinders and sievers is used in the preparation of the mixture according to the ingredients. The rice bran oil is decanted in a 200 kg mobile tank, positioned on a floor scale, covered with 3onitrogen if necessary and sealed until the next stage of manufacture. When using a mixture of oils, a Silverson mixer can be

  used to ensure uniform mixing.

  Mixtures composed of several ingredients in 3Ssuspension are prepared by weighing each ingredient individually and placing them in intermediate containers. The excipients, used in the suspension process, are weighed and placed in a homogenizer where the heat melts the ograisses and waxes. Once melted, the active ingredients are then added in the order prescribed in the control documentation. The unit is closed under vacuum to ensure airtightness and a homogenizer is put in place to ensure perfect consistency. After this operation, the content is then sieved, deaerated and decanted in

mobile tanks.

  The gelatin and content tanks are placed in the individual bays of each encapsulating machine. The melted gelatin is pumped to the machine, forming two thin ribbons of gelatin on each side of the machine. These robans then pass over several rolls and finally over the molds

  which determine the size and shape of the capsule.

  The content is transferred from its tank using a pump which infects a precise dose between the two gelatin ribbons before sealing them by the application of pressure and heat. The volume of water used in the preparation of gelatin As makes it very flexible. The capsules then fall on a

  treadmill and are transferred to dryers.

  Although these reduce excess water by 30%, the hoods are not yet dry to be packaged. They are then transferred to trays placed in a drying tunnel where dry air is used to ensure perfect drying. Once dry, the capsules are removed from the drying tunnel and visually inspected. They are then placed in trays, ready for packaging. The capsules are mechanically calibrated to check the uniformity of their size, passed on a conveyor belt and visually inspected, then passed through a metal detector before packaging in bulk in a plastic bag.

  contained in a carton. The capsules are weighed.

  Once the packaging is complete, the plastic bag and the carton are sealed, and the whole is labeled and placed on a stack before being coated with

  plastic film, ready for a final inspection.

  3 $ The entire process is documented and all the materials used have full traceability. They are identified physically and chemically, tested

  by a Quality Assurance Service and labeled.

  The following examples serve to illustrate the way in which the present invention could be used, these examples are possible preparations with formulas of the content of the capsules, but they cannot limit the scope of the present invention.

EXAMPLE 1

  Preparation of soft gelatin capsules containing rice bran oil: s A flexible capsule containing 200 mg of rice bran oil, each capsule will be prepared by encapsulation, each flexible gelatin capsule composition obtained by mixing the gelatin and glycerin according to

^ cUes conventional techniques.

EXAMPLE 2

  Preparation of flexible gelatin capsules containing rice bran oil and vitamins suitable for cavity mounting: The bicompartable flexible capsule contains 300 mg of basic components mixed with different amounts of rice bran oil and vitamins fat-soluble and water-soluble. Using the conventional techniques of manufacturing a compartmentalized capsule, in one of the compartments there is rice bran oil, 0.5-1% of vitamin A and as o. 5-1% of vitamin E, in the other compartment, the water-soluble vitamins, that is to say, 0.5-1 of vitamin B5 and 2.5-10% of vitamin C, in addition, dyes and aromas (in adequate quantity

and sufficient).

3O

EXAMPLE 3

  Preparation of flexible caPsule with rice bran oil and vitamins suitable for the skin and hair: The flexible gelatin capsule has a capacity of 300 mg, its filling material is composed of a preparation of rice bran, oil-soluble vitamins as well as vegetable oil and proteins, these ingredients mixed together. The capacity is composed of rice bran oil, 2.5% vitamin F. 5% silk proteins, 5% hazelnut oil, 3% essential oil, 3% paraffin, 450.5% polyethylene glycol and 0.3% of castor oil, coloring and flavoring in sufficient quantity. The capsules obtained are suitable for maintaining and nourishing the skin and the hair by direct applications.

EXAMPLE 4

  Preparation of soft cape with rice bran oil suitable for blood clotting and o preventing cardiovascular disease: In this case, soft gelatin capsules contain a variable amount of filling material containing bran oil rice and other selected oils, borage oil, fish oils with EPA, soybean oil, sunflower oil, avocado oil, peanut oil, these oils are mixed and constitute the material of

filling the capsule.

o

Claims (10)

claims   1. The flexible capsule containing rice bran oil, which is composed of an envelope of   gelatin filled with rice bran oil.   2. The capsule according to claim 1, characterized in that the gelatin envelope is composed of a mixture of gelatin of animal, marine or vegetable origin, water and optionally synthetic materials.   3. A capsule according to claim 2, characterized in that the glycerin, soritol, propylene glycol, polystethylene glycol are mixed between them.   4. A capsule according to claim 2, characterized in that a gelatin envelope which more is composed of opacifiers, dyes and preservatives.   5. A capsule according to claim 2, characterized in that a gelatin shell   is made of vegetable matter.   6. A capsule according to claim 2, characterized in that a gelatin envelope is composed of optional marine materials colors and flavoring agents.   7. A capsule according to claim 1, characterized in that the rice bran oil is commercial rice bran oil.   8. A cap according to claim 1, characterized in that the selected rice bran oil is composed of rice bran, refined rice bran oil and the mixture thereof. 9. A capsule according to claim 8, characterized in that the rice bran oil is composed of a mixture of pure or refined rice bran oil with an acidity less than or equal to   11 and peroxidation of less than 15.   lO.A capaule according to claim 1 characterized in that the rice bran oil is mixed with additives or substances selected from the group of vitamins, trace elements, energized or not, oils, aromas, perfumes, flavoring agents, colorings, antioxidants mixed together. . 2837670   11. A capsule according to claim 10, characterized in that the vitamins are liposoluble and chosen from vitamins of group A, D, E, F. K, and the mixture of all these components. 12 A capsule according to claim 10, characterized in that the trace elements are chosen from the group of the following components, of calcium, copper, chromium, tin, phosphorus, iron, magnesium, manganese, potassium, selenium,   silicon, iodine, zinc and the mixture of them.   13. A cap according to claim 10, characterized in that the oils are chosen from groups of vegetable oils, oils   and are mixed together.   14.A capsule according to claim 1, supplied with two compartments, one of which contains rice bran oil and other optional liposoluble additives or substances and the other compartment contains substances or vitamins, or the two not being soluble in oil but in water, water-soluble substances. 15.A capsule according to claim 1, characterized in that substances and additives