FR2776184A1 - Lotion to prevent hair loss containing vegetable extracts - Google Patents

Abstract

Hair lotion comprising the following, in a cosmetically acceptable excipient (A) an aqueous extract of the mushroom Lentinus edodes, rich in 1,3- beta -1,6- beta glucanes, (B) procyanidolic oligomers extracted from grape seed epidermis, and (C) the essential oil extracted from flowers of Cananga odorata (Ylang-ylang essence). The compositions preferably contain 1 - 20 parts L. edodes extract, 0.1 - 15 parts procyanidolic oligomers, and 8 - 80 parts of C. odorata extract, the total of these ingredients comprising 1 - 20% by weight, especially 1.5 - 15%, of the final composition. The cosmetic excipients may be water, lower mono-alcohols, glycols, glycol ethers, fatty acid esters, animal or vegetable oils, and the like. Other components that may be present include perfumes, colors, preservatives, vitamins, anti-UV agents, emulsifiers, surfactants, thickeners, and pH regulators.

Description

Anti-hair loss cosmetic composition The present invention

  relates to a hair loss cosmetic composition based on plant extracts intended for the prevention of

  certain alopecia, and in particular androgenic alopecia.

  Common alopecia, or androgenic alopecia, has various causes that are still poorly understood and uncontrolled. Among other factors, there are genetic, endocrine,

  immunological and / or inflammatory.

  This type of alopecia which affects more particularly hornmmes, but also to a lesser extent women, is characterized by an increase in the proportion of hair in the telogen phase, a decrease in the diameter of the hair in the anagen phase and, for advanced alopecia. , by replacing a large number of hairs

  terminals with fine down-like hair.

  The Applicant has found that it is possible to prevent hair loss in the context of ancdrogenic alopecia by improving the general condition of the scalp, in particular by means of - stimulation of the immune defenses of the connective tissue of the scalp , - trapping of free radicals, - strengthening of the walls of the capillaries of the scalp, - maintenance of asepsis of the scalp, and - an increase in the production of native collagen

  resulting in a strengthening of the extracellular matrix.

  All of these beneficial effects resulting in a healthy scalp can be obtained thanks to the original association of three plant extracts having cosmetic properties and

interesting dermatology.

  The object of the present invention is therefore a hair-loss cosmetic composition, characterized in that it comprises, in a cosmetically acceptable excipient, (A) an aqueous extract of the Lentinus Edodes mushroom rich in 1,3- [3-D- 1,6- [5-Dglucanes, (B) procyanidolic oligomers extracted from the grape seed cuticle, and (C) essential oil extracted from Cctanang Odorata flowers. Lentinus Edodes, the raw material providing the component (A) of the anti-hair loss cosmetic composition of the present invention, is a superior edible fungus from the Agaricaceae family, very popular in Asia. The aqueous extract of this mushroom contains

  lentinan, a neutral glucan resulting from the 1.3 chain of 3- units

  D-glucose with, on average, two ramifications 1,6- [3-D-glucose for 5

  main chain glucose units.

  Lentinan can be extracted from the fungus containing it according to

  a simple method of extraction with water described below in Example 1.

  The yield of immunostimulatory active ingredient is approximately 0.3 to

  0.4% compared to the starting dry matter.

  Component (B) of the composition of the present invention is formed by complex oligomers of plant origin called procyanidolic oligomers (OPC). These are oligomers of

  polyphenols such as catechin and epicatechin.

  These oligomers can be extracted in the form of a complex mixture also containing monomers and dimers, for example from the bark of conifers or from the grape seed cuticle. The extraction process and the therapeutic use of these procyanidolic oligomers are disclosed in US patent 4,698,360. Currently, a number of laboratories offer extracts

  standardized with guaranteed OPC content.

  The OPCs extracted from the grape seed cuticle are used in the composition of the present invention in particular for. their

powerful anti-radical power.

  In fact, we have been able to demonstrate that OPCs have a capacity to trap free radicals, and in particular particularly harmful oxygen radicals, which is clearly superior to that of

  Vitamin E (cx-tocopherol) commonly used in this application.

  It has also been shown that OPCs have in vitro an inhibitory action on the proteolytic enzymes elastase and collagenase and glycosidases which are hyaluronidase and [3-glucurodinase, all these proteins being involved in the renewal of the main constituents of the extravascular matrix (collagen , elastin and hyaluronic acid). The third component (C) of the anti-fall composition according to the invention is an essential oil extracted from Cananga Odorata flowers, better known under the name of Ylang-Ylang essence. The main places for planting and harvesting these trees are currently the Comoros and, to a lesser extent, Nosy-Bé, a small island in the north of Madagascar. The oil is extracted there by distillation at

  water in stills usually at the harvest site itself.

  Cananga Odorata essential oil is renowned and used in its countries of origin for its antiseptic properties and its healing power. The three components described above are combined in variable proportions to give a mixture of active ingredients which will be

  then incorporated into a suitable cosmetic excipient.

  The mixture of active principles (components (A), (B) and (C)) used consists of - from 1 to 20 parts by weight of extract of Lentinus Edodes, - from 0.1 to 15 parts by weight of oligomers procyanidoliques, and - from 8 to 80 parts by weight of Cananga Odorata essential oil,

  the sum of these three components being equal to 100 parts by weight.

  This mixture of components (A), (B) and (C), after mixing with a cosmetically acceptable excipient, represents from 1 to 20% by weight,

  preferably 1.5 to 15% by weight of the anti-cosmetic composition

fall of the present invention.

  The cosmetically acceptable excipient is chosen from water, lower monoalcohols such as ethanol or isopropanol, glycols such as diethylene glycol, glycol ethers such as alkyl ethers of ethylene glycol or diethylene glycol, esters fatty acids, vegetable and animal oils or the like, all of these

  components can be used alone or as a mixture.

  The cosmetic compositions of the present invention may contain, in addition to components (A), (B) and (C) and the excipient, any cosmetic adjuvant commonly used in hair products, such as, for example, perfumes, dyes,

  preservatives, vitamins, anti-UV agents, emulsions-

  nants, surfactants, thickeners, regulating agents

  pH or other similar additives.

  The cosmetic compositions thus obtained can be

  present as a lotion, milk, cream or gel.

  The anti-fall compositions of the present invention not being rinsed off after application, it is important to ensure that they do not leave a greasy deposit on the hair or give them a

touch loaded.

  A preferred form of presentation of the compositions of the present invention is therefore an alcoholic lotion which

evaporates after application.

  Another object of the present invention is the use of the cosmetic compositions described above for the non-therapeutic preventive treatment of hair loss, and in particular of androgenic alopecia.

  The present invention further relates to a method. no-

  therapeutic treatment for preventing hair loss, consisting in regularly applying, one or more times a day, a composition according to the present invention to the area of the scalp to be treated and to do it

  penetrate the scalp with a light massage.

  It is understood that the above description has not been given

  as a purely illustrative and non-limiting example and that variants or modifications may be made thereto within the framework of the present invention. Concrete examples illustrating the invention will now go

  be given without being limiting in nature.

Example 1

  Preparation of an aqueous extract of Lentinus Edodes 1 kg of dried Lentinus Edodes is ground in a Henri knife mill. The powder obtained is extracted with 3 times 10 liters of boiling distilled water. The suspension is stirred for 30 minutes at 90 ° C. and filtered through a 50-liter Buchner filter on a layer of Celite (filtration aid). Concentrate to 5 liters in a Luwa thin-layer evaporator, then freeze-dry the concentrated solution in a

lyophilize Serail.

  1 kg of dried Lentinus Edodes provides between 30 and 40% extract

  dry containing about 1% of active ingredient immunostimulant.

Example 2

  Four anti-fall cosmetic compositions are prepared from a mixture of anti-fall active principles having the following composition: * Lentinus Edodes extract 13% * procyanidolic grape seed oligomers 7% * Cananga Odorata essential oil 80% Lotion anti-fall hydroalcoholic

  mixture of active principles anti-fall 1.5 g.

  ethanol (96%) 30.0 g aqueous extract of Solanum 10.0 g

perfume q. s.

conservative q. s.

  demineralized water q. s. 100 g Anti-fall hydroalcoholic gel mixture of active anti-fall ingredients 3.0 g ethanol (96%) 10.0 g Carbomer 0.5 g tris (hydroxymethyl) aminomethane 0.5 g

conservative q. s.

perfume q. s.

  demineralized water q. s. 100 g Anti-hair loss milk mixture of active principles anti-hair loss 5.0 g self-emulsifying glycerol stearate 4.5 g corn oil 4.0 g cetyl alcohol 0.5 g Tropceolum majus extract 1.0 g xanthan gum 0.8 g

conservative q. s.

perfume q.s.

  demineralized water q. s. 100 g Anti-fall hydroalcoholic lotion mixture of anti-fall active ingredients 15.0 g diethylene glycol monoethyl ether 30.0 g propylene glycol 5.0 g ethanol (96%) 15.0 g demineralized water q. s. 100g

Example 3

  Evaluation of the anti-fall activity in vivo The hydroalcoholic lotion of Example 2 above containing 1.5% by weight of mixture of active principles was tested in vivo on a group of male volunteers showing signs of androgenic alopecia. The number of volunteers recruited after the so-called "three comb comb" test (number of hairs collected greater than 10) was initially 20. Four of these volunteers had to be excluded from the study because the proportion of hair in the telogen phase at day D 0 was too weak

  (<6%) so that we can assume androgenic alopecia.

  The examination method used is a videotrichogram examination. This method involves shaving one or more small areas of the scalp and photographing them during the day of shaving and then a few days after. The comparison of the two photos makes it possible to determine - the number of hairs in the anagen phase which have grown during this period and - the number of hairs in the telogen phase whose growth is zero. The table below presents the results of the videotrichograms carried out on day D 0 and on day D 56 respectively on 16 and 14 volunteers (two of the volunteers not having presented themselves to the study on day D56) having used, between these two dates , the hydroalcoholic lotion

  of Example 2 with a daily application.

  The statistical analysis of the results is made by the t-test of

  Bilateral student on paired data.

Table 1

  number of hair in telogen phase hair in anagen phase total of number proportion number proportion hair (in%) (in%)

  J 45.4 + 3.5 6.3 + 0.9 13.5 + 1.6 39.2 + 2.9 86.5 + 1.6

  J 56 '42, 6 + 3.3 4.4 + 1.0 9.6 2.0 38.3 + 2.7 90.4 + 2.0

  We note that the total number of hairs does not vary after 56

  days of application of the fall protection lotion of Example 2 (p = 0.1465).

  The results however show a significant decrease, between D 0 and D 56, in the number of hairs in the telogen phase (p = 0.019). The proportion of hair in the telogen phase decreases for 86% of

  volunteers and it goes from 13.5 + 1.6% to 9.6 + 2.0%.

  The proportion of hair in the anagen phase does not vary after 56

  days of application of the tested anti-hair loss lotion.

  These results allow us to conclude that the anti-fall lotion tested has a significant anti-fall effect after only 56 days of treatment.

Claims (11)

  1. Anti-hair loss cosmetic composition, characterized in that it comprises, in a cosmetically excipient acceptable,   (A) an aqueous extract of the Lentinus Edodes fungus rich in 1,3-3D-1,6-3-D-glucans, (B) of the procyanidolic oligomers extracted from the grape seed cuticle, and (C) of the essential oil extracted from Cawtanga Odorata flowers. 2. Anti-fall cosmetic composition according to claim 1, characterized in that the mixture of components (A), (B) and (C) consists of - from 1 to 20 parts by weight of extract of Lentinus Edodes - from 0 , 1 to 15 parts by weight of procyanidolic oligomers, and from 8 to 80 parts by weight of essential oil of Cananga Odorata,   the sum of these three components being equal to 100 parts by weight.   3. Anti-hair loss cosmetic composition according to one of the   Claims 1 and 2, characterized in that the proportion of said   mixture of components (A), (B) and (C) is between 1 and 20% 7 in   weight of the total cosmetic composition.   4. cosmetic anti-fall composition according to claim 4, characterized in that the proportion of said mixture of components (A), (B) and (C) is between 1.5 and 15% by weight of the composition total cosmetic.   5. Anti-hair loss cosmetic composition according to any one   of claims 1 to 4, characterized in that the excipient   cosmetically acceptable is chosen from water, monoalcohols   laughers, glycols, glycol ethers, fatty acid esters, vegetable or animal oils or other similar substances, or mixtures of these compounds.   6. Anti-fall cosmetic composition according to any one   Claims 1 to 5, characterized in that it also contains   one or more cosmetic additives chosen from perfumes, dyes, preservatives, vitamins, anti-UV agents, emulsifiers, surfactants, thickeners, agents   pH regulators or other similar additives.   7. Composition according to any one of claims 1 to   6, characterized in that it is in the form of a gel, a cream, lotion or milk.   8. Composition according to claim 7, characterized by the   fact that it comes in the form of a hydroalcoholic lotion.   9. Use of the cosmetic composition according to one   any of claims 1 to 8 in non-preventive treatment   therapeutic of hair loss.   10. Use of the cosmetic composition according to one   any of claims 1 to 8 in non-preventive treatment   therapy of androgenic alopecia.   11. Non-therapeutic method for preventing hair loss, characterized in that the anti-hair loss cosmetic composition is applied regularly, one or more times a day.   according to any one of claims 1 to 8 on the scalp area   to be treated and let it penetrate with a light massage.